Compound
The suppository contains natamycin as an active ingredient. Additional components include: cetyl alcohol , adipic acid , solid fat, sorbitan trioleate , polysorbate 80, sodium bicarbonate.
Pifamucin ointment. The main component is natamycin . Auxiliary components: propylene glycol, cetostearic alcohol, sodium lauryl sulfate, purified water, decyl letate, methyl parahydroxybenzoate, cetyl wax ether, propyl parahydroxybenzoate.
Pifamucin tablets. The active ingredient in the tablets is natamycin , auxiliary ingredients: kaolin, white beeswax, polyvinylpyrrolidone , titanium dioxide, sucrose, magnesium stearate, kaolin, methyl parahydroxybenzoate, gelatin, gum arabic, potato starch, calcium carbonate, lactose, triacetin.
Pharmacodynamics and pharmacokinetics
The principle of action of the drug is based on the binding of sterols in the cell membrane, violating their integrity, which causes the death of the microorganism. The drug affects yeast-like fungi (especially Candida albicans), yeast , dermatophytes , pathogenic fungi .
Natamycin is active when used topically, has no systemic effect, and is not absorbed through mucous membranes or skin. The enteric coating of the tablets determines the effect of the drug in the intestines.
Pharmacological properties of the drug Pimafucin
Natamycin is a broad-spectrum antifungal polyene antibiotic of the macrolide group. It has a fungicidal effect. Natamycin binds sterols of cell membranes, disrupting their integrity and functions, which leads to the death of microorganisms. Most pathogenic fungi, especially Candida albicans, are sensitive to natamycin. Dermatophytes are less sensitive to natamycin. There are no cases of resistance to natamycin in clinical practice. The drug does not have a sensitizing effect. Not a single case of allergy was identified during treatment with the drug or during its production. Natamycin tablets, due to their enteric coating, act only in the intestines. Natamycin is active when applied topically and is practically not absorbed in the digestive tract, from the surface of the skin and mucous membranes. The drug in the form of vaginal suppositories acts quickly and effectively against candidal vaginitis. The therapeutic effect is also manifested in the presence of vaginal discharge, inflammation and itching, including the upper, less accessible parts of the vagina. The drug is quickly distributed into the vagina, forming a foamy mass, which contributes to the uniform and complete distribution of the active substance over the entire surface of the vagina. Currently existing methods failed to detect natamycin, used intravaginally, and its metabolites in the blood plasma and biological fluids of the body, which indicates the absence of a systemic effect of the drug.
Indications for use
Pimafucin cream is prescribed for fungal infections of the nail plates, skin and mucous membranes, including vulvovaginitis , balanoposthitis , vulvitis , vaginitis , ringworm , otitis media caused by fungi or complicated by candidiasis, candidiasis of the nails and skin .
Pimafucin tablets are effective for fungal diseases of the external auditory canal, mucous membranes, and oral cavity. It is prescribed for intestinal candidiasis , after therapy with corticosteroids , antibiotics , cytostatics , vulvovaginitis , vulvitis , vaginitis , acute atrophic or pseudomembranous candidiasis with cachexia .
Pimafucin suppositories are prescribed for balanoposthitis , vulvovaginitis , vulvitis , vaginitis caused by Candida fungi.
Indications for use and contraindications
The abstract recommends the use of Pimafucin for patients:
- with intestinal candidiasis;
- acute pseudomembranous and atrophic fungal infection with extreme exhaustion of the body, weak immunity, after antibiotic therapy, treatment with cytostatics or glucocorticosteroids;
- damage to the skin and mucous membranes in the presence of vaginitis, vulvitis, vulvovaginitis.
The drug is not prescribed to patients with individual intolerance to its components.
Instructions for use of Pimafucin (Method and dosage)
Pimafucin suppositories, instructions for use. Used intravaginally. For vulvovaginitis , vulvitis and vaginitis , 1 suppository is administered for 3-6 days. It must be administered in the “lying down” position, as deeply as possible, before bedtime, once a day. If treatment of vaginitis does not help, then you should take tablets - 10-20 days, 1 tablet four times a day. For men, use cream during treatment. The duration of treatment is determined in each case individually. After the symptoms of the disease disappear, treatment should be continued for several more days.
Instructions for the cream. For external use. The ointment should be applied to the affected areas one to several times a day for balanoposthitis , vulvovaginitis and vulvitis . If symptoms persist, suppositories or tablets are prescribed. For dermatomycosis (including diaper rash in children and candidiasis of the nails and skin), the suspension should be applied to the nails and skin up to 4 times a day.
For mycosis of the external auditory canal, the affected area should be lubricated with cream up to four times a day, after cleaning the ear. After use, it is necessary to place a turunda made of cotton or wool into the ear canal. The duration of treatment is determined individually. After the symptoms completely disappear, it is necessary to continue treatment for several days.
Instructions for use of tablets. For intestinal candidiasis, are prescribed 1 tablet four times a day, children - 1 tablet twice a day. On average, the course of treatment lasts a week.
special instructions
Under the influence of body temperature, vaginal suppositories quickly dissolve, forming a foamy mass, due to which the active substance is distributed evenly. For recurrent or chronic infections, therapy can be supplemented with cream or tablets.
Cetyl alcohol, which is part of the suppositories, can cause a burning sensation in the genital area. Candle therapy should be interrupted during menstruation. During treatment with suppositories, sexual intercourse may not be excluded. However, both partners should be examined, and if a lesion is detected, Pimafucin cream for men should be used. Treatment with ointment for men occurs in the manner prescribed by the instructions. When having sexual intercourse during treatment, barrier contraceptives should be used.
It is possible to prescribe Pimafucin to newborns.
How long can you take Pimafucin
The duration of use of the drug is directly related to the severity of the disease, and may also vary depending on whether the lesion is recurrent or primary. A disease that appears for the first time is treated with three or six suppositories. A mild form of thrush can be cured in three days. In more severe cases, six-day therapy is prescribed. When the patient complains of repeated episodes of damage, treatment is prescribed for up to 20 days. If you have a regular sexual partner, you need to treat him too. During treatment, sexual rest is not necessary, but barrier contraceptives must be used.
Pimafucin's analogs
Level 4 ATC code matches:
Colistin
Alpha Normix
Analogs of tablets: drugs Alpha Normix and Nystatin-Health .
Analogues in the form of suppositories: Nystatin , Livarol , Clotrimazole . The price of analog candles is from 37 to 320 rubles.
Pimafucin has a cheaper analogue - Nystatin , a domestically produced drug, similar in action.
Clotrimazole or Pimafucin - which is better?
Clotrimazole is available in the form of suppositories and cream. The course of treatment usually lasts about a week, the drug is well tolerated, which reduces the risk of side effects to a minimum. However, it may cause allergic reactions to any of its components. If the disease is detected in a woman, thrush ointment for men is used. According to experts, Pimafucin is more effective when used topically and it almost does not enter the systemic bloodstream. Therefore, it can also be used to treat pregnant women.
Which is better: Terzhinan or Pimafucin?
Terzhinan is produced in the form of vaginal tablets; it can be prescribed not only in the presence of the disease, but also for its prevention. The average duration of drug treatment is 10 days. It is also easily tolerated and can be used before childbirth.
Special instructions for the use of the drug Pimafucin
Vaginal suppositories quickly dissolve under the influence of body temperature, forming a voluminously spreading foamy mass, which contributes to the uniform distribution of the active substance. In case of chronic or recurrent infection, local treatment can be supplemented with tablets and cream. The use of natamycin in tablet form may be associated with the development of an acute attack of porphyria, therefore, the use of the drug is considered unsafe for patients with this disease. Cetyl alcohol, which is part of vaginal suppositories, can cause an allergic reaction. During menstruation, therapy is interrupted. When using suppositories, there is no need to avoid sexual intercourse. During pregnancy and breastfeeding . Pimafucin can be prescribed during pregnancy and lactation. Children . Natamycin in the form of film-coated tablets is used in children over 3 years of age; in the form of a cream - used in children of all age categories; in the form of vaginal suppositories - not used in children. The ability to influence reaction speed when driving vehicles and working with machinery . Does not affect.
Pimafucin during pregnancy and lactation
There are no contraindications for taking the drug for pregnant women or while breastfeeding. Tablets, creams and suppositories are used for thrush both in the early stages of pregnancy and in later stages. Most often, Pimafucin suppositories are prescribed during pregnancy, rather than other forms of this medicine. The drug is non-toxic and safe for the fetus both during the 1st trimester and 2nd trimester, as well as during lactation. However, to minimize the risk, it is better to take suppositories during lactation, or cream. Use of the drug is as indicated in the instructions.
Side effect
Therapeutic manipulations can cause the appearance of non-standard responses of the body. Taking Pumafucin can provoke the appearance of:
- attacks of nausea;
- dyspeptic disorders with diarrhea.
Side effects occur on the first day of using the tablets and disappear spontaneously during treatment. If these symptoms or other reactions not described in the instructions occur, the patient should visit the attending physician and describe in detail the changes that have occurred in the general condition.
Reviews about Pimafucin
On the forums, the overwhelming majority of patients report a positive effect after using the medicine. However, there are cases when there is no improvement in the condition or it even worsens. There are also claims about the short-term effect of treatment for thrush and other diseases.
Pifamucin for thrush , according to patients, helps by quickly eliminating its symptoms. Moreover, the cream is effective for both women and men. Pimafucin tablets for thrush also help in the treatment and prevention of candidiasis.
Reviews about the tablets are most often good; patients write about the fast and effective action of the medicine and the complete absence of side effects. Reviews of Pimafucin suppositories for thrush report that they relieve itching faster than when taking tablets, as they act locally. There are no negative reviews about Pimafucin cream; it helps well with fungal diseases and is easily tolerated. Most often, the ointment is prescribed to men. Positive reviews during pregnancy note that the drug does not affect the development of the fetus and is very well tolerated, quickly eliminating the disease.
Pimafucin price, where to buy
The price of Pimafucin cream in Ukraine is 87 UAH, in particular in Kharkov the ointment costs about 81 UAH.
In Russia, the price of Pimafucin tablets is 360 rubles, in Belarus the cost of the medicine in tablets is 133.5 thousand rubles.
The price of Pimafucin suppositories for thrush is 270-380 rubles. In Odessa, candles No. 3 cost 123 UAH, candles No. 6 – 213 UAH.
You can find out how much the suppositories cost and buy other forms of the drug directly at the pharmacy.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Pimafucin vaginal suppositories.
100 mg 3 pcs Temmler Italy S.r.L. RUB 257 order
Pharmacy Dialogue
- Pimafucin cream (tube 30g)Temmler
RUB 493 order
- Pimafucin vaginal suppositories 100 mg No. 3Temmler
RUB 257 order
- Pimafucin (tab. 100 mg No. 20) Yamanouchi
RUB 684 order
- Pimafucin vaginal suppositories 100 mg No. 6 Temmler
RUR 545 order
- Pimafucin (100 mg tablet No. 20)Astellas Pharma
RUR 673 order
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Pharmacy24
- Pimafucin 100 mg No. 3 vaginal suppositories Temmler Italy S.r.l., Italy
149 UAH.order - Pimafucin 100 mg No. 6 suppositories Temmler Italy S.r.l., Italy
287 UAH order
- Pimafucin 2% 30 g cream Temmler Italy S.r.l, Italy
146 UAH order
- Pimafucin 100 mg N20 tablets Astellas Pharma Europe B.V., Netherlands
431 UAH. order
PaniPharmacy
- Pimafucin suppository Pimafucin vaginal suppositories 100 mg No. 6 Italy, Temmler Italia
296 UAH. order
- Pimafucin tablets Pimafucin film-coated tablets 100 mg No. 20 Netherlands, Astellas Pharma Europe
489 UAH. order
- Pimafucin cream Pimafucin cream 2% 30g No. 1 Italy, Temmler Italia
169 UAH order
- Pimafucin suppository Pimafucin vaginal suppositories 100 mg N3 Italy, Temmler Italia
166 UAH order
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