Capttopril is a drug that helps to quickly lower blood pressure due to its vasodilating effect. Despite all the benefits of the medication, with its long-term use, the patient may develop addiction, which is manifested by the inability to lower blood pressure levels. Therefore, to prevent this effect, experts recommend replacing the drug with drugs that have similar effects. All analogues of Captopril contain the same active substance, providing an identical therapeutic effect. However, when choosing a high-quality analogue, it is necessary to take into account that on the pharmaceutical market there are both direct substitutes for the drug and generics that differ in composition and effect.
Why replace Captoril?
With long-term use of Captopril, hypotensive patients may experience a lack of therapeutic effect after taking the medication. This effect is due to a decrease in effectiveness with constant exposure to the same concentration of the active substance on the body. As a result, the body's sensitivity to the action of the drug gradually decreases, and the previous hypotensive effect is achieved by increasing the dose of the drug, which causes complications. In such a situation, it is necessary to select another similar medication, but it is not recommended to do this on your own.
A cardiologist will help you select a suitable substitute for an antihypertensive drug after a thorough diagnosis of the patient’s condition.
Contraindications for use
In some cases, taking the drug is excluded:
- pregnancy period (2nd and 3rd trimester);
- GW period (entirely);
- angioedema;
- hypersensitivity, individual intolerance to captopril or excipients;
- simultaneous use with the drug "Aliskiren" (should be excluded by people suffering from diabetes or having renal failure).
Analogues in composition
All drug substitutes are selected according to the international drug classification system, that is, taking into account the composition, indications for use, and therapeutic effect.
When selecting the optimal analogue, it is necessary to take into account the concentration of the active substance, the dose, which a cardiologist will help to adjust
The analogues listed below contain the active substance captopril, which has an antihypertensive effect. However, with the same composition of substitutes, they may have different concentrations of the active substance, so the patient must decide which is better in the treatment of arterial hypertension.
Analogues selected according to their chemical structure are the most suitable substitutes.
Captopril substitutes identical in chemical composition of the active component
Angiopril
Belongs to the group of ACE inhibitors. Promotes the expansion of large arteries, thereby reducing the load on the myocardium. The hypotensive effect does not depend on the concentration of the hormone that increases blood pressure, since stabilization of blood pressure occurs with both normal and reduced renin levels.
With long-term use of the drug, the myocardial walls are restored and blood circulation in the necrotic area of the heart muscle is improved.
The decrease in pressure is not accompanied by an attack of tachycardia and does not lead to a decrease in the oxygen demand of the heart muscle. The duration of the hypotensive effect is achieved by increasing the dose of the drug.
Blockordil
It is a modern drug from the group of ACE inhibitors. It has a pronounced hypotensive effect and prevents narrowing of the walls of blood vessels.
An optimal decrease in blood pressure is observed within an hour after taking the tablet. The duration of the effect is about 11 hours. The maximum therapeutic effect is achieved within 1 month from the start of using the product.
Normopres
A combined drug that has an antihypertensive effect. It contains a certain concentration of the active component captopril and hydrochlorothiazide. Used for arterial hypertension.
The dosage of the drug is selected individually, depending on the severity of the clinical picture. Tablets are taken 60 minutes before meals, since the presence of food in the digestive tract slows down the absorption of the active components.
Achievement of the maximum therapeutic effect occurs after 6–8 weeks. It is recommended to adjust the dose after 1.5 months from the start of the therapeutic course, if symptoms do not require a rapid increase in dosage.
"Captopril": main characteristics
The drug is a light-colored tablet with a characteristic odor. It is also available in the form of capsules of a similar composition. The active ingredient is captopril (1 tablet contains 25 mg). The therapeutic effect is based on inhibition of the action of the ACE enzyme.
Available in cardboard packaging of 10 tablets. Store at room temperature (no more than 25 degrees) and moderate humidity. The shelf life is 4 years from the date of issue. Dispensed from pharmacies only with a prescription.
Analogues according to indications and method of use
If the patient has certain contraindications to taking the substance captopril, then analogues are selected according to the following criteria:
- Indications for use (arterial hypertension, chronic heart failure, history of heart attack).
- Mechanism of action (vasodilator and antispasmodic effect).
- Method of administration (medicines are taken internally, starting with a minimum dose, gradually increasing it to the maximum).
Substitutes may contain various auxiliary components, as pharmacologists try to modify drugs to achieve maximum therapeutic effectiveness. Therefore, when choosing an analogue, you need to carefully study the instructions to clarify the composition in order to reduce the risk of developing individual intolerance to the drug.
Berlipril
The drug contains an active component - enalapril, which, when entering the body, is converted into enalaprilat under the action of enzymes, thereby blocking the conversion of the hormone that causes vasoconstriction.
The drug is available in tablet form
As a result, the drug has an anti-vasoconstrictor effect, while reducing peripheral resistance in the circulatory system.
According to the instructions for use of the medicine, it is prescribed for internal use. The tablets are taken in their entirety, regardless of the time of meal, with plenty of water. The dose of the medication is selected taking into account the stage of the pathological process, the severity of symptoms, and the presence of concomitant diseases.
Enalapril Hexal
The active component of the drug is enapril, which eliminates the narrowing of coronary vessels, which can effectively reduce systolic and diastolic blood pressure.
Tablets contain 5 mg of active ingredient
Most of the drug is absorbed in the digestive system, while eating does not affect its activity.
Patients who are concomitantly taking diuretics should consider the possibility of increased hypotensive effects. Thus, when taking the starting dose of Enalapril, the risk of developing arterial hypotension increases.
Before starting treatment, it is necessary to check the functional capacity of the excretory system, since if kidney function is impaired, the single dose should be reduced.
After abrupt withdrawal of the drug, a sharp increase in blood pressure may occur.
Renitek
The active ingredient in the drug is enalapril maleate. The drug is classified as a specific, long-acting ACE inhibitor. Regular use of Renitec helps to increase renal blood flow, while the level of glomerular filtration remains stable.
In people suffering from arterial hypertension, blood pressure normalizes, regardless of the position of the body in space. Complete stabilization of pressure is observed within several weeks from the start of the therapeutic course. An abrupt break in the course of treatment does not cause a sharp increase in blood pressure.
Dapril
The active ingredient in the drug is lisinopril, at a concentration of 20 mg. The effect after taking the tablet occurs after 2 hours, but the maximum concentration of the active component in the bloodstream is achieved after 5 hours and lasts for 24 hours.
For patients diagnosed with hypertension, dose selection is carried out individually depending on blood pressure and the severity of associated symptoms. For patients who have a violation of the functional ability of the excretory system, dose selection should be carried out taking into account creatinine clearance.
Lizoril
The medication contains the active component lisinopril at a concentration of 2.5 mg. The effect of Lisiropril is observed within 60 minutes after taking the tablet; the optimal effect is achieved after 6 hours. The therapeutic effect for arterial hypertension occurs after a two-day course of treatment, and complete stabilization of blood pressure is observed after 1 month.
Analogues of antihypertensive drugs can only be prescribed by a cardiologist or the attending physician, who constantly monitors the patient’s general condition during the entire therapeutic course.
Side effects
When taking Catopril, side effects may occur from different organ systems - nervous, circulatory, digestive and others. Main manifestations:
- sleep disorders;
- drowsiness;
- pancytopenia;
- problems with taste (reversible);
- nausea, vomiting;
- pain, heaviness in the abdomen;
- diarrhea;
- dizziness;
- dyspnea;
- feeling of dry mouth;
- ulcer of the stomach walls;
- constipation.
The following manifestations are much less common:
- anorexia;
- confusion;
- depressive states;
- headache;
- heartbeat disturbance;
- exacerbation of autoimmune diseases;
- rhinitis;
- bronchospasm;
- eosinophilic pneumonia;
- pancreatitis;
- angioedema;
- nephrotic syndrome;
- impotence;
- febrile conditions.
Attention!
In case of overdose, shock, stupor, bradycardia, and symptoms of renal failure may occur. In this case, urgent gastric lavage and administration of activated charcoal are indicated (30 minutes after the Captopril tablet). In case of emergency, you should seek emergency help.
Inexpensive analogues
On the pharmacological market there are inexpensive analogues of the drug that have the same quality characteristics and effectiveness, but are much cheaper in cost than the original drugs.
Cheap drug analogues can provide significant assistance in the treatment of arterial hypertension
When producing substitutes for expensive substitutes, you must follow some rules:
- Compliance with the proportion of active substances, that is, their concentration and quality indicators.
- Compliance with international standards.
- Maintaining an equivalent to the original in terms of speed and degree of suction.
When purchasing a cheap antihypertensive analogue, patients should be careful, since there is a risk of buying a counterfeit, which contains a low-quality active component. Such a remedy may be ineffective in the fight against high blood pressure and have many side effects.
Enalapril
Enalapril tablets are intended for daily use, which allows you to normalize blood pressure levels throughout the day. Thanks to the prolonged action, the patient can take only one tablet per day. With long-term use of the drug, pressure stabilizes, reducing the risk of sudden changes in the direction of increase or decrease.
The medication, unlike other substitutes, has a milder effect, but at the same time has a prolonged effect
The medicine is not used to provide emergency assistance in relieving an arterial crisis.
As a rule, Enalapril is combined with other drugs that are aimed at eliminating arterial hypertension, improving excretory function, and restoring cardiac activity.
Lisinopril
The antihypertensive effect occurs 60 minutes after taking the required dose, reaching the maximum concentration of the active substance is noted after 5 hours.
The cost of the product depends on the dosage of the active ingredient and the number of tablets in the package
The tableted drug is intended for combination therapy, in combination with other antihypertensive medications. When treating elderly patients, you should be careful, as they have impaired absorption of lisinopril.
Enam
Inexpensive but effective antihypertensive drug. Enam reduces blood pressure due to its mild diuretic effect.
The chemical composition of the tablets varies depending on the concentration of the main active ingredient
The medication helps stimulate the circulatory system and respiratory function of the body, and also normalizes blood flow in the renal arteries.
Before starting the therapeutic course, it is necessary to discontinue diuretics, as well as medications containing potassium, since Enam prevents the excretion of the microelement from the body.
Popular substitutes
The most popular analogues of Captopril, which are widely used in the treatment of hypertension, are:
- Vitopril. Prescribed both as a combination treatment of hypertension and as primary therapy.
- Ramilong plus. The drug is not intended for the treatment of hypertension at the initial stage. It is used as a combination treatment after individual dose selection.
- Enap. Systematic use leads to an improvement in the quality of life of hypertensive patients and reduces the risk of complications from the cardiovascular system.
- Rami Sandoz. Regular use helps reduce distal resistance in the circulatory system.
A wide selection of analogues allows you to select the most optimal one, depending on the stage of the pathological process and the age group of the patient. Before changing medications, you should consult with a specialist to exclude the possibility of an irrational choice of an antihypertensive drug.
Reviews
Antonina Petrovna, 60 years old As prescribed by a cardiologist, I have been taking Captopril for 1 year; the medicine is inexpensive and accessible to pensioners. However, its long-term use is contraindicated and is recommended only in exceptional cases with a sharp increase in blood pressure. The attending physician tried to select a high-quality, inexpensive analogue that would correspond to the stage of the disease. The choice was made on Enalapril Darnytsia, I am satisfied with the results.
Gennady, 47 years old I took Captorpil for 2 years; at the beginning of treatment, it helped bring my blood pressure back to normal when taking the minimum dose. Subsequently, the dosage had to be increased, since the usual concentration did not give the necessary hypotensive effect. The doctor recommended replacing the medicine with its analogue (lisinopril), which has a prolonged effect. The drug helps to quickly stabilize blood pressure levels without causing palpitations. After using the tablets, I did not find any side effects.
Varvara, 40 years old After experiencing side effects from taking Captopril, I tried to replace it with the medication Enalapril Hexal. The only drawback of the product is that it does not have a long-term effect, so it must be taken 2 times a day. At the moment I am using the minimum dosage, it helps maintain normal blood pressure and does not cause complications.
