Deca (Nandrolone decanoate) how to take, side effects

Chemical properties

Nandrolone Decanoate ( Nandrolone Decanoate ) is a medicine, an anabolic steroid with a weak androgenic effect . Abroad, Nandrolone Phenylpropionate - a white or yellowish powder with a creamy tint, which has a specific odor. The product is practically insoluble in water, poorly soluble in ethyl alcohol , but soluble in acetone and chloroform . Decanoate is synthesized in the form of yellow or white crystals, which are poorly soluble in water, but are highly soluble in ether , ethyl alcohol, acetone, and various oils.

The molecular weight of the compound is approximately 274.4 grams per mole. As part of the preparations, the substance is most often found in the form of an oily, thick solution for injection.

Nandrolone has greater pharmacological activity than testosterone . Therefore, it is often used as a doping . In the human body, the substance is produced naturally from testosterone . The International Olympic Committee closely monitors the blood levels of this compound in athletes. The maximum permissible concentration in urine is 2 nanograms per ml for both men and women.

How to combine Deca with other steroids

It’s not so often that you meet people who choose nandrolone as the only steroid in their cycle. Rather, this is the lot of testosterone and trenbolone. Usually drugs that are synergists are combined. The regimen of taking nandrolone with methandrostenolone is considered effective. Even greater effectiveness is achieved by those who include testosterone in the complex with nandrolone (the ratio of nandrolone to testosterone is 1:2). The second method is also a kind of insurance against problems with potency. A combination of the three drugs listed above is the best option for those who want to gain weight in the shortest possible time.

It is worth warning zealous followers of dubious ideas who take everything they are told on faith. The use of nandrolone with other progestins (anadrol, trenbolone) is dangerous and can lead to negative consequences and cause a long-term withdrawal from anabolic steroids.

Pharmacodynamics and pharmacokinetics

After penetration into the systemic bloodstream, the substance interacts with specific receptor proteins located on the surface of target organs. In this way, a complex connection between the receptor and Nandrolone is formed, and the substance can freely move into the hyaloplasm , breaking through the cell membrane. Next, the compound penetrates through the nuclear membrane directly into the cell nucleus diffusion regulatory genes .

The drug stimulates the processes of synthesis of deoxyribonucleic acid and ribonucleic acid , some other structural acids, enhances tissue respiration and oxidative phosphorylation in skeletal muscles. As a result of these processes, muscle mass increases and active burning of fat deposits occurs. Creatine phosphate and ATP accumulate in skeletal muscles , the growth of male genital organs is accelerated, and the formation of secondary sexual characteristics is stimulated.

The growth zones located in the bones become calcified and the skeleton stops growing. Also Nandrolone Decanoate ( Nandrolone Decanoate ) stimulates spermatogenesis , sebaceous and male reproductive glands. When using large dosages of the drug, suppression of Leydig cells of endogenous sex hormones decreases , since the pituitary gland ceases to produce luteinizing and follicle-stimulating hormone .

Within 3-7 days after injection of the substance, the anabolic effect of the drug appears. In the glandular and integumentary epithelium , bones and muscles, reparative processes are activated, the speed and completeness of absorption of amino acids from the small intestine increases. This effect is especially noticeable when eating foods rich in proteins . erythropoietin is stimulated and anabolic processes in the brain are activated. If iron supplements are prescribed in parallel, the antianemic effect of treatment is manifested.

K-dependent blood coagulation factors in the liver tissue is disrupted the lipid profile of the blood plasma changes. The drug also promotes the development of edema due to the processes of reabsorption of fluid and sodium in the kidneys.

After administering 100 mg of Nandrolone oil solution intramuscularly, the maximum concentration in the blood is observed after 7-12 days. When used orally, the bioavailability of the drug is about 2%, while injections provide 100% absorption. In the body, the substance is metabolized in the liver, forming 17-ketosteroids . The drug is excreted mainly in urine, the rest in feces. The half-life is about a week. The drug is completely eliminated from the body within 3 weeks.

Use of deck by women

In the middle of the last century, nandrolone found wide use in the treatment of women. Moreover, representatives of traditional medicine considered it a fairly effective drug. Then athletes paid attention to 19-nortestosterone and actively used it until the nineties, until studies conducted by Heinonen and Goossens cast a shadow on the drug. The first experiment involved women taking fifty milligrams of nandrolone decanoate every three to four days. As a result, half of the subjects began to experience the phenomenon of virilization. The second experiment did not lead to the same. True, nothing was reported regarding the magnitude of the doses. Of course, women taking one hundred milligrams of nandrolone decanoate per week raises questions, but limiting the dose to thirty milligrams administered once every two weeks can be considered acceptable. This fact was proven by an experiment that took place in 1996, when no virilization phenomena were recorded with a similar method of administration. Dear ladies who have nevertheless chosen Deca as a means to achieve their goal, I would like to advise not to rush to extremes and start with a dose of fifty milligrams once every ten days, gradually increasing it to seventy-five to one hundred milligrams in the same period of time. The first signs of virilization should be a signal to stop taking the drug.

Indications for use

Nandrolone is prescribed:

• for diabetic retinopathy ;
• to increase the rate of generation and catabolism in chronic infectious diseases, after operations, severe injuries, and with steroid myopathy ;
• for Werdnig-Hoffman syndrome ;
• to eliminate anemia caused by metastases from malignant tumors , drugs, salts of heavy metals ;
• patients with progressive muscular dystrophy ;
• to eliminate hypocalcemia in senile and postmenopausal osteoporosis , after treatment with GCS ;
• for anemia due to kidney disease, myelofibrosis , myelosclerosis , myeloid aplasia of the bone marrow ;
• to stimulate growth in children with growth hormone deficiency ;
• for inoperable breast carcinoma (women) in the postmenopausal period or after oophorectomy .

Pharmacological properties of the drug Retabolil

Nandrolone (17β-hydroxyestr-4-en-3-one decanoate) is a testosterone derivative. Unlike testosterone, it has a more pronounced androgenic effect (data obtained during studies on receptors, as well as in preclinical and clinical studies). Nandrolone stimulates human erythropoiesis, as indicated by an increase in the number of red blood cells, an increase in the level of hematocrit and hemoglobin. This effect is used therapeutically to treat anemia caused by bone marrow hypoplasia or decreased erythropoietin production as a result of chemotherapy. If the recommended doses are observed, androgenic effects (for example, virilization) are rarely observed. Nandrolone does not contain a C17 α-alkyl group, which is associated with impaired liver function and the development of cholestasis. Pharmacokinetics. Nandrolone decanoate is slowly released from the injection site and enters the bloodstream. The half-life is 6 days. The ester is quickly converted in the blood to nandrolone with a half-life of ≤1 hour. The total time of hydrolysis of nandrolone decanoate, its distribution and excretion is 4.3 hours. Nandrolone is metabolized in the liver. Nandrolone metabolites (19-norandrosterone, 19-noretiocholanolone and 19-norepiandrosterone) are detected in urine. Their pharmacological activity is unknown.

Contraindications

The medicine is contraindicated:

• if allergic to the active substance;
• patients with prostate carcinoma or hypertrophy ;
• for malignant neoplasms of the mammary gland in men;
• women with breast carcinoma with hypercalcemia ;
• pregnant women;
• with ischemia ;
• patients with severe atherosclerosis ;
• if the patient has a tendency to develop edema due to heart failure, chronic or acute liver and kidney diseases ( nephritis );
• during lactation;
• alcoholics and patients with alcoholic damage to the liver, kidneys or heart.

Side effects

Adverse reactions most often develop when using large dosages of the drug.

The medicine may cause:

• iron deficiency anemia , progression of atherosclerosis , peripheral edema;
• painful sensations in the abdomen, vomiting and nausea, disturbances in the liver ( jaundice );
• violations of blood clotting processes, bleeding;
• leukemia-like syndrome;
• headaches, disturbances in normal breathing, darkening of stool, vomiting with blood and other signs of hepatonecrosis ;
• hepatic purpura;
• hepatocellular carcinoma , spermatogenesis ;
• pain in the right side, dark urine, discoloration of stool, yellowing of the skin and other symptoms of cholestatic hepatitis .

Women may also experience:

• amenorrhea or dysmenorrhea ;
• increased hair growth, clitoral growth, voice changes;
• hypercalcemia.

The nature of adverse reactions that occur in men depends on age.

In the prepubertal period, men may experience: penis growth, accelerated formation of secondary sexual characteristics, skin rashes, acne , priapism , acceleration or cessation of growth, skin hyperpigmentation.

In the postpubertal period, the following are observed: an increase in the frequency of the urge to urinate, gynecomastia , an increase in the sensitivity and density of the mammary glands.

Male patients develop prostate carcinoma or .

Instructions for use (Method and dosage)

According to the instructions for Nandrolone, the oil solution is administered intramuscularly , deeply.

The dosage and duration of treatment depends on the indications.

Instructions for use of Nandrolone Decanoate for anemia

When treating anemia with this drug, it is recommended to prescribe iron supplements in parallel. On average, the dosage for men is from 100 to 200 mg of the substance, once every 7 days.

Women are prescribed 50-100 mg of the drug, once a week.

The duration of treatment is determined by the attending physician.

Instructions for Nandrolone Decanate as an anabolic steroid

It is recommended for men to administer no more than 200 mg of the drug at a time, for women – no more than 100 mg (from 50 to 100). The injection is given once every 7-28 days.

For children aged 2 to 14 years, dosages of 25-50 mg are recommended. The frequency of administration is the same as for adults.

The course of treatment is up to 12 weeks. 2 months after the last injection, the course can be taken again.

During treatment, it is recommended to follow a protein diet.

Nandrolone Phenylpropionate is prescribed for the treatment of breast carcinoma in a dosage of 50 to 100 mg. The medicine is administered intramuscularly , deeply, once every 7 days.

A course of Nandrolone Phenylpropionate can be taken under the supervision of a specialist. The duration of treatment is determined by the doctor.

Properties of nandrolone

The structural difference between nandrolone and testosterone is the absence of methyl group 19 in the first molecule, which became the reason for the spread of the name 19-nortestosterone. This gave the substance the ability to better stabilize androgen receptors. In other words, the duration of action of nandrolone increases approximately two to three times compared to the duration of action of testosterone, and the longer the receptor remains activated, the more protein is synthesized by the cell. There is also a negative point: free nandrolone degenerates into dihydronandrolone (DHN), which is two to three times less effective than nandrolone, impairs the ability of nerve fibers to transmit signals, which negatively affects neuromuscular stimulation and libido. True, nandrolone is not so active in the prostate and skin, so athletes taking this drug are less susceptible to acne, prostate hypertrophy, and baldness.

The effect of aromatase on the course of nandrolone is not so significant. But as a result of a chemical reaction, estrogen is still produced, albeit in small quantities. We should not forget about the progestogenic activity of 19-nortestosterone. Those whose total dose of the drug exceeds six hundred milligrams per week put themselves at risk of developing gynecomastia.

Interaction

Nandrolone phenylpropionate and decanoate enhance the effect of indirect anticoagulants, insulin, antiplatelet agents oral diabetes medications

Preparations containing sodium, corticosteroids , mineralcorticoids , and corticotropin increase water retention in the body and increase the likelihood of edema and acne.

The medicine weakens the pharmacological effect of somatotropic hormone and its derivatives.

The substance protects the liver when combined with hepatotoxic drugs .

special instructions

Despite the fact that the medicine has practically no androgenic properties, it should be prescribed to women with extreme caution, after assessing the ratio of the risk of adverse reactions and the benefits of therapy. Treatment with the drug can be combined with glucocorticosteroids , radiation therapy and cytostatics .

Particular caution should be taken in case of epilepsy, glaucoma and migraine . Periodic monitoring of intraocular pressure , the condition of the prostate gland and liver function tests is necessary.

If the patient has a progressive malignant neoplasm , then the duration of treatment with the drug is determined by the attending physician depending on the patient's condition.

Drugs containing (Analogs)

Level 4 ATC code matches:
Deca-Durabolin

Retabolil

Preparations based on Nandrolone: ​​Deca-Durabolin, Phenobolin solution for injection in oil, Nandrolone Decanoate Norma , Nandrolone D 20% solution, Retabolil , Nandrolone Decanoate , Nandrobolin 250 .

Dosage methods

Achieving a noticeable effect from taking nandrolone is possible at dosages of two hundred milligrams per week and above. Some professional athletes prescribed a daily dose of eight hundred milligrams. How practical this is these days is difficult to say. Indeed, recently there has been a tendency to abandon nandrolone decanoate. World-class bodybuilders consider this drug to be exhausted and obsolete. However, people who do not think about sports achievements and simply want to have a beautiful body can be advised to set an upper limit for themselves of one gram of nandrolone per week.

Nandrolone decanoate has a fairly long half-life, so it is advisable to stick to one injection per week. True, there is another opinion. Many people believe that to maintain stable hormone levels, it is better to introduce long-lasting drugs into the body more often.

Reviews about Nandrolone

Reviews of Nandrolone Dean are left mainly by athletes who want to improve their performance, accelerate muscle growth and reduce their fat percentage. Reviews are mostly good, the product is well tolerated, the most common side effects are headache, back pain and allergic reactions. Women rarely use this drug, but note that in low dosages its androgenic effect is practically not manifested.

Reviews about Nandrolone Phenylpropionate are also good. The medicine has established itself as an effective assistant in the fight against breast carcinoma in women. It is used less often by athletes. Adverse reactions occur no more often than stated in the instructions.

Price, where to buy Nandrolone

You can buy Nandrolone either in a pharmacy chain with a prescription from a doctor, or order it in an online store (increased risk of purchasing a counterfeit). The price of Nandrolone Phenylpropionate is approximately 260 rubles for 5 ampoules, each with a capacity of 1 ml, and a dosage of 100 mg per ml. buy Nandrolone Decanate in the form of an oil solution for injection for 2000 rubles, 10 ml, 200 mg of active ingredient per 1 ml of product. The price of Nandrolone Decanate as part of the drug Retabolil is approximately 250 rubles, 1 ampoule, dosage 50 mg per 1 ml.

Nandrolone decanoate for women

I would like to immediately note that I do not encourage women to use nandrolone, moreover, I am even against women using steroids in general, but I will not hide the fact that women use steroids, including nandrolone, which is used very actively by the female sex.

No matter how acute this issue is, no matter how eloquent statements there have been on this topic and there have been no disputes, girls use nandrolone and this is a fact. Moreover, the use of nandrolone by women is to some extent even more successful compared to the male body.

Among my clients there are quite a few girls, including representatives of the fair sex, who have used nandrolone repeatedly and very, very successfully.

Of course, I am not saying that nandrolone is safe for women. There are no safe substances among anabolic steroids. But for many who are interested in bodybuilding or powerlifting and want to develop their body to new levels, this drug is one of the best and most suitable for the female body.

Those representatives of the fairer sex who purposefully take a more risky path in order to better progress in strength sports, they must approach the use of nandrolone consciously, as with most steroids.

If the dosage is not chosen correctly and without a preliminary examination of the body, the use of nandrolone can immediately begin with a lot of troubles, which are described above in the topic of side effects. In addition to all this, you should not avoid systemic examination of the body during the entire course. And remember that the use of steroids can negatively affect your ability to conceive a child, so avoid steroids if you are still planning to have children, or at least do not take cycles longer than six weeks and do not use large dosages of steroids. It is best if you work under the supervision of a specialist.

Nandrolone course for women

Girls, if you still decide to approach the use of the drug on your own, then you should not get carried away with increasing the dosage and increasing the duration of the course. The female body is structured differently from the male body, so hormonal changes will be different, and the effectiveness of the drug will be more pronounced even with small dosages.

I recommend using short nandrolone ester, also known as Nandrolone phenylpropinate, the optimal dosage would be 30-50 mg intramuscularly, three times a week, for 6-8 weeks and then discontinuation of the course. For the first experience, I recommend starting with 30 mg and doing a course for 8 weeks.

During the course, it is advisable to use oral contraceptives as chosen by your doctor - this will help stabilize cycles and possibly avoid losing them, but not guaranteed.

* Draw your attention! Be sure to do a health check before the course and repeat the check throughout the course. You can read about what tests you need to take before a course of steroids and during the course in this article.

As for recovery after the course, after canceling a short and simple course, Antiestrogens are not used, as is the case with the male body, and normalization of hormonal levels requires time and suitable conditions that will help restore cycles and normalize hormonal levels. Similar rest and nutrition measures will help, as in the case of men, after each course of steroids. You can read more about the events here, where the 12th point will also come in handy, only in your favor accordingly :)

If there is a need to restore hormones after a complex course of steroids, then the use of antiestrogens and other substances cannot be avoided, and the situation will need to be analyzed individually, which requires individual treatment. I will not publicly give recommendations and treatment methods due to many peculiarities.