Dragee "Evening (VHM)" - valerian + hops + mint: instructions for use, reviews

Dragee Evening VHM - for sound sleep even with menopausal nervous system disorders

Increased irritability and nervousness can be caused by various reasons. The occurrence of psychoemotional disorders is not always provoked by external factors. Very often, the culprit is the body itself, or rather, malfunctions in its systems due to age-related hormonal changes. This happens, for example, in women during menopause. Dragee Evening VHM , containing powders of well-known herbs with a sedative and hormone-like effect, will gently and safely relieve sleep disturbances even with menopausal disorders of the nervous system.

Dragee Evening instructions for use

Drop form Packaging 100 pcs.

Pharmacological action Thanks to the natural complex of substances, EVENING dragee has sedative, tranquilizing, regulating cardiac activity and moderate hypotensive properties, and is a mild antispasmodic agent. VALERIAN - has a multifaceted effect on the body. It has a calming effect on the excited nervous system. Valerian regulates the activity of the heart, acting through the central nervous system on palpitations. Valerian improves the secretory function of the gastrointestinal tract, relieves spasms of the esophagus, helps regulate the secretion and excretion of bile. The therapeutic effect of valerian is due to the complex of substances it contains, and, above all, essential oil and alkaloids. In rhizomes and roots the amount of essential oil reaches 2%. Valerian preparations are used as a sedative for insomnia, nervous agitation, neuroses of the cardiovascular system, tachycardia, as well as for epilepsy, asthma, migraines, spasms of the gastrointestinal tract and in the treatment of neurodermatitis. Sometimes valerian is used in combination with bromine preparations, cardiac and sedatives. In folk medicine, valerian is used in the form of infusions, decoctions, extracts and powders. An infusion of the root is used during menopause, after illnesses, as an appetite improver and general tonic. MINT - restores strength, eliminates nervous overexcitation, nervousness due to lack of sleep. Reduces skin reactivity during nervous overexcitation or contact with irritating substances, increases the protective functions of the epidermis, and evens out skin color. Pharmacological properties of mint: choleretic, antispasmodic, anti-inflammatory, antiseptic, reduces the processes of fermentation and putrefaction in the intestines, restorative, wound healing, diuretic. It has an antispasmodic effect on the blood vessels of the brain: for dizziness, nausea, vomiting, motion sickness in transport, for disorders of the vestibular system, it optimizes cerebral circulation. Mint has an anti-inflammatory and analgesic effect for caries, gum inflammation, and stomatitis. Eliminates bad breath associated with digestive disorders. Relieves an attack of heartburn, relieves cramps and colitis in the stomach and intestines. Has antiviral activity. Eliminates muscle pain. Makes menstruation less painful. HOPS - contains cellulose, pectin, glucose, fructose, organic and mineral acids: malic, citric, succinic, oxalic, phosphoric, silicon, copper salts, iron, sulfur, amino acids. The fruits (cones) contain essential oil, the bitter substance lipulin, ascorbic, hop tannin, humulenic and valeric acids, trimethylamine, resin, gum, coloring and tannins, choline, bitters, hypoxanthine, wax, phytoncides. Hops preparations have a calming, diuretic, anti-inflammatory, antispasmodic and analgesic effect. They are used for increased nervous and sexual excitability, insomnia, neurasthenia, radiculitis, kidney disease, painful menstruation, nocturnal emissions, menopause. Particularly effective for cystitis and urethritis. Hops are used for neuroses, hysteria, neuralgia, headaches, lack of appetite, gastritis, cholecystitis, kidney and bladder diseases, jaundice, multiple abscesses as a result of metabolic disorders, helminthic infestations, diseases of the spleen, scrofula.

Indications : Used for increased nervous and sexual excitability, insomnia, neurasthenia, radiculitis, kidney disease, painful menstruation, nocturnal emissions, menopause. Particularly effective for cystitis and urethritis. Hops are used for neuroses, hysteria, neuralgia, headaches, lack of appetite, gastritis, cholecystitis, kidney and bladder diseases, jaundice, multiple abscesses as a result of metabolic disorders, helminthic infestations, diseases of the spleen, scrofula.

Contraindications: individual intolerance to the components of the EVENING dragee. It is recommended to consult a doctor before use.

Use during pregnancy and breastfeeding Consult a doctor

Ingredients: 1 dragee weighing 0.18 g contains sugar, lactose, 0.036 g of valerian root, 0.006 g of hops, molasses, peppermint oil, beeswax glazing agent.

Directions for use and dosage: Evening Dragee should be taken by adults and children over 12 years of age, 1-2 tablets 3 times a day with meals, as a mild sedative. Duration of treatment – ​​1 month.

Side effects Allergic reactions

Storage conditions Store in a dry, cool place.

Shelf life: 2 years.

Advantages of the herbal remedy Evening VCM over other herbal sedatives

Dragee Evening VHM is a complex of plant components with a sedative effect - valerian root and rhizomes, hop fruits, peppermint leaves. What is its fundamental difference from drugs with a similar composition?

• Whole parts of plants with all their rich composition are used, and not extracts from them. Any extract is only a tiny fraction of the entire variety of biologically active substances that nature has endowed the plant with. Extracts always contain residues of the chemicals used during extraction.
• Processing of plant raw materials is carried out using ultra-low temperatures (-175°C). This allows you to preserve all, even the most capricious, substances, for example, valepotriates. This is impossible when using extraction and heat treatment.
• The company producing Vecherny VKhM itself grows plants for its preparations in ecologically clean areas of the Penza region, located at a considerable distance from industrial centers. This allows you to control the quality of the product at all stages of its production.
• High content of active substances. Most medications based on valerian rhizomes contain a standard dosage of the plant – 20 mg. The Evening VHM dragee contains 35 mg of valerian. This means that its sedative effect is more than 1.5 times stronger than its analogues.

The therapeutic effects and scope of application of Evening VCM are varied and are due to the complex composition of plant compounds included in the drug. Let's name the main ones.

Dragee Biokor Evening - reviews

Alexander

This tablet from Biokor solves my sleep problems wonderfully. I have deep and sound sleep with him. And during the day it helps to calm down. An excellent natural safe product. And necessary! Life is nervous, you need to somehow cope with nervousness so as not to take problems too seriously

Valeria

In my experience, this is an excellent remedy. Biokor tablets help me perfectly against insomnia and support me during nervous stress. I take it regularly, the effect is very good. Moreover, the composition is natural, without chemicals, it is not a medicine, but a dietary supplement. I rate it an A

Gulchik

Good day everyone, the pharmacy didn’t have glycine and so I decided to buy these green pills. They helped me right away, I was already late for work today. I slept like a baby and seemed to become calmer. You can say the pills are helping me, I only took one before bed. Good health to everyone

Anna

I don’t know who it doesn’t help)) I sleep like the dead from 2 tablets. First 1 piece and after half an hour another one. I hope it's not addictive

Damn it, damn it

They help normally. Manufacturers of psychotropics wrote bad reviews to push their neediness!

margo2565

https://otzovik.com/review_1280674.html

Attention!

Before using medications, consult a specialist!

Advantages:

• affordable price

Flaws:

• individual intolerance to components

There are different situations in life, when I had one of them, I had to buy a sedative, I didn’t go to the doctor for a synthetic one, but at the pharmacy the pharmacist advised me to buy an evening pill, like this

The composition includes rhizomes with the roots of valerian officinalis, hop cones, peppermint oil - as you can see, everything is natural, in combination it works well and does not give any side effects.

The package contains two blisters of fifteen tablets each

I took two tablets a day, the composition of these herbs worked well on me, I coped with my sleep problem quickly and had a fairly easy awakening.

Valerian has a calming and antispasmodic effect, hops and mint complement the effect of valerian.

The drug is natural, intended for anxiety, stress, sleep disorders, and does not cause drug dependence.

bust11111988

https://otzovik.com/review_1516853.html

Attention!

Before using medications, consult a specialist!

Advantages:

• Cheap, chemical-free, effective remedy

Flaws:

• No

Modern everyday life is filled with stressful situations. And sometimes all this daily hustle and bustle affects healthy sleep. Probably everyone has encountered this at least once. How do you deal with stress, sleep disturbances, and anxiety? I found a good and harmless remedy for myself - the “Evening” dragee.

What kind of jelly bean is this? This is a biologically active food supplement and is a mild sedative. The box says that these tablets are not a medicine. Ingredients: sugar, rhizome with valerian root, hop cones, peppermint oil. The tablets look small, round and green, one tablet contains 0.18 g. There are 30 tablets in a package.

Tablets can be taken from 14 years of age with meals, 1-2 tablets 3 times a day. I only take it before bed. I have enough. There are no contraindications as such, only individual intolerance. I take pills during lactation. The recommended duration of use is 1 month. Shelf life 2 years.

I really liked the price - 50 rubles. Inexpensive, but the effect will not take long to arrive. That's why I recommend it to everyone. Without any chemicals, cheap. Yes, and valerian has a therapeutic effect on such common diseases as migraine, tachycardia, hysteria.

Manufactured in Penza, Russia, LLC.

Good night to you!!! Do not be ill!

Yuri Malov

https://www.piluli.ru/product/Drazhe_vechernee/review

At first I didn’t believe in these pills, but now I’ve changed my mind. They really work. In general, I rarely go to doctors, and our attitude towards medicine is complex. But here I decided to try it and didn’t regret it. I usually drink three evening drinks at night to help me fall asleep quickly. If I get nervous at work, I can take a couple of tablets during the day. The packaging is convenient and takes up little space – also a plus. I always carry it with me. Overall a good quality product.

Lada

https://www.piluli.ru/product/Drazhe_vechernee/review

These pills help me a lot. Recently I got nervous at work. My head became very dizzy and I fainted. Doctors say tachycardia. At first I was pleased. They said it was not a disease. Then they upset me. They say you can get coronary disease and then a heart attack. We recommended Evening. I took two courses. She became calm like a boa constrictor. I walk and don’t react to anything. I was pleased with the result; the money was well spent. Now I recommend the evening to my friends and girlfriends. My friend's husband asked me to buy it for her. I recommend!

Fouremed

Advantages:

• Effect
• price

Flaws:

• didn't watch

Details

Hello! I tried a lot of drugs based on pharmaceutical chemistry and they didn’t really help, and although I’m not a fan of dietary supplements, I agreed to the so-called experiment with a friend. And I started taking the Biocor supplement.

By the end of the week, my sleep returned to normal, I became less irritable, and the microclimate in the family improved, and, accordingly, my intimate life. Now I fall asleep like a baby and even have positive and cheerful dreams.

I no longer have anxiety like before and I really liked the drug. Now I even take it when I have an important meeting and I’m very worried, also when flying on an airplane. But before, I was generally afraid to fly. And now for work I don’t drive a car, but save time and prefer to fly, it’s faster.

And all thanks to this effective Biokor product.

I am very pleased with the result, including my husband.

Thank you for your attention!

(AnnaBashura1) Anna

https://www.imho24.ru/recommendation/11886/

I like it

Advantages:

• Helps normalize sleep

Flaws:

• Did not find

Many problems greatly affect our sleep, and therefore if we do not get enough sleep, then this all greatly affects our general condition. Irritability and rudeness are one of the points by which a person can understand that he still needs to do something and somehow help himself. One friend advised me to take a course of this “Evening” pill from Biokor. There are 60 tablets, so they will last quite a long time, and this despite the fact that you need to take two tablets a month. Accordingly, one package is enough for a whole month, and this is the course of application. I can say for sure that they help cope with insomnia and normalize the general condition of the body; I completely forgot about the bad mood.

Anonymous

https://ok.ru/biokor/topic/65942428778751

Advantages:

• They help
• normalize sleep.

Flaws:

• No

Good afternoon everyone. The problem of insomnia comes to me from time to time. I try to take medications without addictive effects, preferably natural ones. Once I was buying valerian at a pharmacy, and they advised me to take the “Evening” pill. It was not expensive, the composition was natural. Started taking it. I drank this pill only at night, although according to the instructions you can take it three times a day. They taste good. They begin to take effect within two weeks. That is, the pills have a cumulative effect. A large jar of 120 tablets costs 80 rubles. Now I always buy it for future use and keep it on my nightstand. It turns out something like this: you drink a jar and the need for a remedy for insomnia disappears for three months, then the body itself tells you that you can drink more. I drank a similar pill from another manufacturer. Dragee Evening from Parapharm. Also not a bad product with a similar composition. Or Evening Dragee with motherwort from Biokor, where the composition is more classic, valerian and motherwort. I liked the drug from Biokor better; out of all the Evening Dragee I tried, I give preference to these little green tablets. I recommend. Sleep definitely becomes stronger and more peaceful. Be healthy! "

Iron nerves and good sleep

All herbs included in the Evening VCM .

In medicinal valerian, experts counted more than 120 compounds that provide the sedative effect of the plant [1]. Valepotriates, alkaloids valerin and hatinin, sesquiterpenes valerenic acid and valeranone, isovaleric acid, borneol, flavonoids, the amino acid glutamine, and gamma-aminobutyric acid have a particularly strong effect on the human nervous system. The compounds activate the work of gamma-aminobutyric acid (GABA), a substance that “cools” an overexcited nervous system, improves its signal transmission, replenishes the inhibitory neurotransmitter and prevents its destruction.

Doctor of Medicine, Master of Science in Public Health from Ireland Kathi J. Kemper, in her scientific work on valerian (“Valerian (Valeriana officinalis)”, 1999 [2]), states that the sedative power of valerian officinalis is similar to that of synthetic drugs from the group of barbiturates and benzodiazepines. The latter have a powerful sedative and hypnotic effect. However, their use causes addiction and aftereffects - lethargy, weakness, irritability, nausea, drowsiness. Valerian is absolutely safe.

Soviet doctors used the sedative properties of the plant long before the discoveries of their Western European colleagues. The chief therapist of the army during the Great Patriotic War, B.E. Votchal, wrote: “Valerian, at first glance, is not a very effective sedative. It was found that it has an effect in some ways similar to Aminosin . It relieves anxiety. It does not give any side effects and, when used correctly, is a very valuable drug” [3]. The drug that the scientist mentions is a synthetic drug for the treatment of severe mental disorders and has a huge list of serious side effects that threaten the patient’s life. But what did the founder of Russian clinical pharmacology mean when he spoke about the correct use of the plant?

Could it be that “the whole valerian root should be considered as an active substance”, as recommended already in 2007 by the Committee on Herbal Products of the European Medicines Agency [4]? If this is so, then the Evening VHM is what you need. Cryoprocessing technology allows you to preserve ALL natural pharmacologically active compounds of the whole plant root, in contrast to extracts. The therapeutic effectiveness of tablets of finely ground raw materials of rhizomes with valerian roots is 2.5 times higher than that of valerian extract tablets (O. M. Khishova, 1997-1999 [5]).

It is also worth noting that the hypnotic effect of valerian is cumulative in nature and makes itself felt after 0.5-1 month of daily use . According to the observations of specialists from the University of Surrey (England) DA Diaper and I. Hindmarch, this effect is more pronounced in patients with objective sleep disorders than in healthy people [6].

Common hop fruits also contain a large amount of biologically active substances that affect the functional state of the nervous system. The main ones are the following.

• Bitter α- and β-acids . The former are represented by humulone, cohumulone, adhumulon, prehumulon, posthumulon, the latter - lupulone, colupulone, adlupulone, prelupulone and postlupulone. They have a pronounced sedative and antidepressant effect (K. Lee et al., 1993 [7]; H. Schiller, A. Forster et al., 2006 [8]; P. Zanoli, M. Zavatti et al. , 2005 [9], 2007 [10]) and are comparable to that of valerian.
• Chalcones (xanthohumol, isoxanthohumol, desmethylxanthohumol) and proanthocyanidins protect nervous tissue from the destructive effects of free radical oxidation (MN Diaz, B. Frei and others, 1997 [11]; JF Stevens, CL Miranda and others, 2002 [12]) , and the antioxidant activity of xanthohumol exceeds that of vitamin E and genistein (CL Miranda et al., 2000 [13]). According to I. A. Zavalishin, M. N. Zakharova (1996 [14]) and Yu. A. Aleksandrovsky (1991 [15]), the active activity of free radicals is a key link in the death of neurons .
• Flavonols and dihydroflavonols. According to a study by M.A. Alekseeva, candidate of pharmaceutical sciences (2005), hop fruits contain up to 0.6% dihydroquercetin, a powerful natural antioxidant [16]. Quercetin, kaempferol and myricetin were also found. These substances not only neutralize the effects of free radicals. Myricetin protects nerve cells from the action of toxins and prevents the development of Alzheimer's disease. Together with quercetin, this substance protects nerve cells in the brain during cerebral circulation disorders leading to oxygen and glucose deficiency (KS Panickar, RA Anderson, 2011 [17]). Kaempferol protects the neurons of the brain regions responsible for maintaining and contracting muscle tissue (subcortical nuclei) from the influence of neurotoxins, thereby preventing the development of Parkinson's disease. This compound also restores the concentration of the nerve signal transmitter dopamine to normal levels.
• Essential oil. Contains the volatile alcohol 2-methyl-3-buten-2-ol, which has a sedative effect (R. Hänsel et al., 1980 [18]; R. Wohlfart et al., 1983 [19]; ​​H. Schiller et al., 2006 [20]).
• Lupulin. This is a mixture of various substances - resins, fat, essential oil, ash, covering hop fruits and having a calming effect on the central nervous system. It has long been noticed that when collecting plant cones without gloves, a feeling of fatigue and drowsiness appears.

The diverse influence of common hop fruits on the functional state of the nervous system was studied by specialists from the Institute of General and Experimental Biology of the Siberian Branch of the Russian Academy of Sciences (Ulan-Ude) Ya. G. Razuvaeva, N. V. Kabachuk and colleagues [21]. During experiments on animals, they found that the plant is capable of:

• reduce the level of emotionality;
• reduce anxiety and fear;
• stimulate cognitive functions of the brain - memory, attention, thinking, imagination and others, have an anti-amnestic effect;
• reduce the severity of stress changes in internal organs;
• reduces by 25% the number of low-active (hyperchromic) neurons in the hippocampus and cerebral cortex, increases the number of functionally active (hypochromic) nerve cells (D. D. Orlovskaya, 1986 [22]);
• drowse;
• exhibit antidepressant properties;
• provide an anti-aggressive effect;
• protect nervous tissue from the action of free radicals, activate the body’s antioxidant system;
• normalize blood clotting under conditions of prolonged stress and thereby prevent the formation of blood clots (it has been proven that under prolonged stress, blood clotting increases);
• exhibit an antihypoxic effect (L.V. Pastushenkov, E.E. Lesiovskaya, 1991 [23]), helping to increase the reserve life time by 19-28% depending on the type of hypoxia (blood, tissue, normobaric);
• stimulate GABAergic neurotransmission.

Evening VHM tablet – peppermint leaves – also has a moderate sedative effect . According to the authoritative reference book of medicinal products, VIDAL, in medical practice the plant is used to treat increased excitability of the nervous system, neuroses, and mild sleep disorders.

The therapeutic effects of mint are largely due to the components of the essential oil - menthol, menthone, pinene and limonene . The most studied (60%) of them is menthol. When taken orally, the substance irritates the cold receptors of the oral mucosa. This leads to increased production and release of endorphins - substances that improve mood, overall well-being, give vigor, and protect against the negative effects of stress.

In addition, peppermint contains isovaleric acid esters , which act on the hypothalamus in a similar way to the antipsychotic drug chlorpromazine: they change the transition of nerve impulses from the cerebral cortex to the subcortex and thereby reduce emotional reactions.

By the way, both menthol and isovaleric acid are part of the famous sedative drug “Validol”.

In 2022, V.V. Dementieva, a specialist at Samara National Research University named after S.P. Korolev, studied the effect of peppermint on the behavior of laboratory animals [18][24]. It was found that the plant has an anti-stress effect, reduces anxiety levels, and changes the activity of the serotonergic and dopaminergic systems of the brain .

In the same year, specialists from the State Nikitsky Botanical Garden A. M. Yarosh, V. V. Tonkovtseva I. A. Batura and colleagues studied the effect of mint on elderly people - women 50-90 years old [25]. It turned out that the plant has a positive effect on the psycho-emotional state of the subjects, significantly and significantly reducing the manifestations of anxiety and depression, improving the general condition, well-being, mood, reducing psychological stress, increasing efficiency, vigor, and attention .

Evening (valerian+hops+mint) (dietary supplement) dr 0.2g N50

pharmachologic effect

Thanks to the natural complex of substances, EVCHERNEY dragee has sedative, tranquilizing, regulating cardiac activity and moderate hypotensive properties, and is a mild antispasmodic.
VALERIAN has a multifaceted effect on the body. It has a calming effect on the excited nervous system. Valerian regulates the activity of the heart, acting through the central nervous system on palpitations. Valerian improves the secretory function of the gastrointestinal tract, relieves spasms of the esophagus, helps regulate the secretion and excretion of bile.

The therapeutic effect of valerian is due to the complex of substances it contains, and, above all, essential oil and alkaloids. In rhizomes and roots the amount of essential oil reaches 2%.

Valerian preparations are used as a sedative for insomnia, nervous agitation, neuroses of the cardiovascular system, tachycardia, as well as for epilepsy, asthma, migraines, spasms of the gastrointestinal tract and in the treatment of neurodermatitis. Sometimes valerian is used in combination with bromine preparations, cardiac and sedatives. In folk medicine, valerian is used in the form of infusions, decoctions, extracts and powders. An infusion of the root is used during menopause, after illnesses, as an appetite improver and general tonic.

MINT restores strength, eliminates nervous overexcitation, nervousness due to lack of sleep. Reduces skin reactivity during nervous overexcitation or contact with irritating substances, increases the protective functions of the epidermis, and evens out skin color.

Pharmacological properties of mint: choleretic, antispasmodic, anti-inflammatory, antiseptic, reduces the processes of fermentation and putrefaction in the intestines, restorative, wound healing, diuretic.

It has an antispasmodic effect on the blood vessels of the brain: for dizziness, nausea, vomiting, motion sickness in transport, for disorders of the vestibular system, it optimizes cerebral circulation. Mint has an anti-inflammatory and analgesic effect for caries, gum inflammation, and stomatitis. Eliminates bad breath associated with digestive disorders. Relieves an attack of heartburn, relieves cramps and colitis in the stomach and intestines. Has antiviral activity. Eliminates muscle pain. Makes menstruation less painful.

HOPS - contains cellulose, pectin, glucose, fructose, organic and mineral acids: malic, citric, succinic, oxalic, phosphoric, silicon, copper salts, iron, sulfur, amino acids.

The fruits (cones) contain essential oil, the bitter substance lipulin, ascorbic, hop tannin, humulenic and valeric acids, trimethylamine, resin, gum, coloring and tannins, choline, bitters, hypoxanthine, wax, phytoncides. Hops preparations have a calming, diuretic, anti-inflammatory, antispasmodic and analgesic effect.

Indications

Used for increased nervous and sexual excitability, insomnia, neurasthenia, radiculitis, kidney disease, painful menstruation, nocturnal emissions, menopause. Particularly effective for cystitis and urethritis. Hops are used for neuroses, hysteria, neuralgia, headaches, lack of appetite, gastritis, cholecystitis, kidney and bladder diseases, jaundice, multiple abscesses as a result of metabolic disorders, helminthic infestations, diseases of the spleen, scrofula.

Contraindications

individual intolerance to the components of the EVENING dragee. It is recommended to consult a doctor before use.

Use during pregnancy and breastfeeding

The doctor's consultation

Compound

1 dragee weighing 0.18 g contains sugar, lactose, 0.036 g of valerian root, 0.006 g of hops, molasses, peppermint oil, beeswax glazing agent.

Directions for use and doses

Evening dragees are taken by adults and children over 12 years of age, 1-2 dragees 3 times a day with meals, as a mild sedative. Duration of treatment – ​​1 month.

Side effects

Allergic reactions

Storage conditions

Store in a cool dry place.

Best before date

2 years.

Evening ICM is a source of phytoestrogens. Indicated for women during menopause

All three components of the Evening VXM contain phytoestrogens.

These substances are not hormones in the full sense of the word. They are only similar in structure and molecular weight to female sex hormones. However, this gives them wide opportunities to influence the body of the weaker half of humanity. Phytoestrogens, like a master key to a keyhole, bind to the same receptors as estrogens: α-receptors located in the female reproductive organs, and β-receptors scattered throughout all organs and tissues . Moreover, they have a more pronounced affinity for the latter.

This explains the ability of plant compounds not only to reduce the severity and number of manifestations of menopausal syndrome (hot flashes, sweating, headaches, irritability, insomnia), but also to have a therapeutic effect in atherosclerosis, osteoporosis, diseases of the cardiovascular system and malignant tumors. Phytoestrogens:

• reduce the number of atherosclerotic plaques;
• thin the blood;
• reduce the level of “bad” cholesterol, increase cholesterol;
• neutralize the destructive effects of free radicals, increase the resistance of the vascular endothelium to it, strengthen the vascular walls;
• suppress the absorption of glucose in the intestine;
• activate collagen synthesis in the skin;
• prevent malignant degeneration of healthy tissue cells, suppress the division of cancer cells, significantly reduce metastases in women with positive estrogen-dependent breast cancer;
• promote the absorption of calcium and phosphorus;
• gently normalize blood pressure;
• strengthen the immune system.

Acting as an easy substitute for female sex hormones, phytoestrogens improve a woman’s appearance, slow down the aging process, and block the negative effects of estrone (an intermediate hormone from the estrogen group, which is converted to estradiol in young women), for example, estrogen-dependent proliferation of endometrial tissue.

Valerian officinalis began to be used relatively recently for menopause. In 2013, Iranian specialists from two large educational institutions of the country - Islamic Azad University and the University of Medical Sciences. Sh. Beheshti - P. Mirabi and F. Mojab published the results of a study on the effect of valerian on the condition of menopausal women [26].

68 women aged 45 to 55 years were divided into two groups: experimental and control. Subjects from the first group received capsules filled with crushed valerian root (255 mg) daily for 2 months, and those from the second group received the same capsules filled with starch. After a month, the scientists noted that the frequency of hot flashes in the experimental group had decreased significantly and their severity had decreased .

Earlier, in 2006, similar results were obtained by another Iranian researcher from Shahre-Kord University of Medical Sciences A. Kazemian [27].

It has been suggested (AF Berman, 1999 [28]; KP Jones, 2000 [29]) that the estrogenic activity of valerian is provided by volatile oily substances, including monoterpenes, sesquiterpenes and valepotriates.

Phytotherapist A. N. Alefirov calls the flavone apigenin as a phytoestrogen in valerian [30]. True, the scientist equates the estrogenic activity of this substance to zero, believing that it is not apigenin itself that works in a woman’s body, but its metabolites (transformation products).

According to Iranian scientists, the estrogenic activity of various plants ranges from 1/50 to 1/2000 of steroid hormones [31]. Moreover, phytoestrogens, unlike synthetic estrogens, do not cause any serious side effects.

Valerian can also affect the quality of sleep in postmenopausal women. It is known that almost half of women suffer from insomnia during this period. In 2010, this was proven by specialists from the Tehran University of Medical Sciences (Iran) MS Simin, BS Neda and colleagues, who conducted a clinical study involving 100 women 50-60 years old suffering from insomnia [32]. 30% of women taking valerian experienced improved sleep.

the Evening VHM dragee – common hop – also has a powerful estrogen-like effect on a woman’s hormonal background . Its estrogenic activity is 1,250,000 g of estrone per 1000 g of plant weight [33]. For comparison, the famous female herb, red clover, has 10 g of estrone per 1000 g of plant weight [33].

8-prenylnaringenin (8-PN) was found in the fruits of the plant This substance in an experiment (J. Pitkin, 2012 [34]) demonstrated 40 (!) times greater affinity for α-receptors than for β-receptors . In 2006, F. Roelens, N. Heldring and colleagues proved that 8-prenylnaringenin reduces the level of pituitary hormones responsible for the production of estrogens and testosterone (follicle-stimulating and luteinizing hormones) [35].

Also found in hop fruits is the substance isoxanthohumol , which, under the influence of intestinal microflora, can be converted into 8-prenylnaringenin (D. Szkutnik-Fiedler, M. Jedrzejczyk et al., 2010 [36]). By the way, the latter is useful not only for the female body, but also for the male one. In women, it accumulates in the mammary glands and stimulates breast growth (S. Bolca, J. Li, D. Nikolic et al., 2010 [37]); in representatives of the stronger half of humanity, it increases the volume of ejaculate, the number of sperm and, as a result, , probability of conception (E. Ricci, S. Noli, S. Ferrari et al., 2022) [38].

In 2005, specialists from the Catholic University of Leuven (Belgium) V. Jerkovic, D. Callemien and C. Collin discovered another group of substances with estrogenic activity in hops [39]. These are stilbenes - resveratrol and its glycoside piceid. In addition to hormone-like effects, they demonstrate powerful antioxidant, antiplatelet, anti-inflammatory, cardioprotective, antitumor, antiviral and neuroprotective properties.

Many women know that excess estrogen can cause pathological growth of the inner layer of the endometrium and are afraid to take phytoestrogens. In the case of hops, these fears are completely unfounded. The fact is that the plant contains substances that can activate progesterone receptors and thereby neutralize the negative effects of 8-prenylnaringenin (SE Geller, L. Studee, 2005 [40]).

At the moment, there is a large number of studies proving the ability of hop fruits to reduce such symptoms of menopause as hot flashes, decreased libido, vaginal dryness and osteoporosis (F. Roelens, N. Heldring et al., 2006 [35]; J. Pitkin, 2012 [34]). The plant affects bone density by increasing the amount and activity of the enzyme (alkaline phosphatase), which ensures phosphorus-calcium metabolism.

The fact that peppermint contains compounds with estrogen-like activity was known half a century ago. In 1975, Candidate of Biological Sciences M.F. Shakhova identified β-sitosterol . 206 mg of this substance was found in 100 g of dry plant material [41].

β-sitosterol is the most studied phytosterol today. It has high potential for treating various diseases. Numerous studies organized in clinics in the USA, Japan, Finland, and Russia suggest that the main pharmacological property of phytoestrogen is hypocholesterolemic. The substance causes a decrease in the level of cholesterol in the blood plasma, suppressing the absorption by the intestinal walls of both cholesterol synthesized in the liver and cholesterol supplied with food (AM Lees, HYI Mok, RS Lees and others, 1977 [42]). It is advisable to use it for the prevention of atherosclerosis and in the treatment of vascular disease. β-sitosterol is used to treat and alleviate the symptoms of prostate adenoma (TI Wilt, 1999 [43]; E. G. Privalova, V. G. Nikityuk, 1999 [44]). The substance also reduces the risk of cancer of the colon, breast, stomach, lungs, affects the state of the immune system and pathological inflammatory reactions.

Regular long-term use of mint can reduce high levels of androgens in women and reduce the resulting hair growth in places unusual for the female body, for example, on the face. In 2004, researchers from Turkey M. Akdogan, A. Kocak, E. Cicek and colleagues, in experiments on male rats, found that peppermint reduces the level of testosterone circulating in the blood plasma by 23% [45].

Dragee Evening VHM can be recommended for everyone to fall asleep easier, and especially for menopausal women, since the herbs included in the composition help to gently eliminate the symptoms of hormonal decline.

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