Nimesil granules d/susp. for oral administration 100mg pack 2g N9

Probably all people, as soon as pain appears, willfully resort to known medications that relieve pain, instead of studying the instructions or consulting with a specialist. In order for as many people as possible to avoid harm from this approach, in the article we will describe one of those pharmacological products that are used most often, talk about the dosage and method of taking it, as well as contraindications.

This remedy is Nimesil, a drug belonging to the NSAID group. This abbreviation stands for “non-steroidal anti-inflammatory drug.” The release form of this medicine is granulated powder for suspension. Packaged in sachets of two grams. You can buy individually or in boxes of thirty bags, which also come with instructions.

"Nimesil": reviews for osteochondrosis

The advantages of Nimesil are obvious. This drug is a very popular analgesic and anti-inflammatory agent. It is usually prescribed to those who have back or joint pain, to those who have suffered injuries, dislocations, and sprains. In addition to pain relief and fighting inflammation, Nimesil also reduces fever. This drug is available in powder form, which accelerates its absorption into the blood. Thanks to this, it is faster than the well-known aspirin in terms of speed of action. The main advantage of Nimesil is that long-term use of this product does not impair its tolerance by the body.

Yes, the duration of use of this drug does not in any way affect how well it is tolerated. But it is still important to consider contraindications.

What is the drug made from and how does it work?

"Nimesil" contains the main and additional components. Here's what it contains:

• nimesulide. This is the main component. It is a COX (cyclooxygenase) inhibitor. Nimesulide stops the release of inflammatory agents, thereby eliminating pain;
• maltodextrin;
• ketomacrogol;
• anhydrous citric acid;
• sucrose;
• orange juice, thanks to which the medicine has a pleasant orange smell.

The main active ingredient of Nimesil is nimesulide.

All these ingredients, except nimesulide, are auxiliary in this medicine. Thanks to them, it quickly has an anti-inflammatory and analgesic effect, and reduces temperature.

Active ingredients of Nimesil

This medication is a light yellow powder with a slight orange odor. "Nimesulide", which is its main component, is supplemented with additives for taste and smell:

• flavoring;
• sucrose;
• lemon acid.

In addition, the preparation also contains cetomacrogol 1000. This substance is an auxiliary ingredient not only for medicines. It is used by perfume companies and food manufacturers. Cetomacrogol is a solubilizer. Simply put, it allows components to dissolve that otherwise cannot do so. This substance can also be used as an emulsifier. In short, it can be used to connect the incompatible.

What kind of substance is nimesulide and how does its action manifest itself? This component is a non-steroidal anti-inflammatory drug that belongs to the sulfonanilide group. It is not an antibiotic, although it is a derivative of one of them - a sulfonamide. Nimesulide blocks enzymes that are important for the production of prostaglandins - physiologically active substances, due to which the affected areas begin to swell, ache, and become inflamed. Although these substances were so named because they were first isolated from seminal fluid, they are produced throughout the body. Prostaglandins trigger a full-fledged chain reaction. Their effects affect the cardiovascular system as well as the immune system.

The active substance inhibits the activity of enzymes that contribute to pain

The action of most NSAIDs is aimed at stopping or at least slowing down the production of prostaglandins. These drugs block the enzymes that are needed to make these substances from essential fatty amino acids. The other two drugs, aspirin and ibuprofen, have approximately the same effect on the human body. In contrast, Nimesil does not interfere with the functioning of gastrointestinal enzymes, despite the fact that it blocks similar ones that are involved in the production of prostaglandins. But even this gentle action does not save you from the harmful effects of the drug on the mucous membrane of the digestive system, liver, and so on, if they are affected by diseases.

Nimesil

Use during pregnancy and breastfeeding

Like other drugs of the NSAID class that inhibit prostaglandin synthesis, nimesulide can adversely affect pregnancy and/or embryo development and can lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired renal function, which can lead to renal failure with oligodyramnia, to an increased risk of bleeding, decreased uterine contractility, and the occurrence of peripheral edema. In this regard, the drug is contraindicated during pregnancy and breastfeeding.

Use for liver dysfunction

The drug is contraindicated in liver failure or any active liver disease.

Use for renal impairment

In patients with renal failure, Nimesil should be used with caution, as renal function may deteriorate.
If the condition worsens, treatment with Nimesil should be stopped. The drug is contraindicated in severe renal failure (creatinine clearance <30 ml/min). In patients with mild to moderate forms of renal failure (creatinine clearance 30-80 ml/min), there is no need for dose adjustment.

Use in children

The drug is contraindicated in children under 12 years of age.

Adolescents (ages 12 to 18 years): Based on the pharmacokinetic profile and pharmacodynamic characteristics of nimesulide, no dose adjustment is necessary in adolescents.

special instructions

Undesirable side effects can be minimized by using the minimum effective dose of the drug for the shortest possible short course.

Nimesil should be used with caution in patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease), since exacerbation of these diseases is possible.

The risk of gastrointestinal bleeding, ulceration or perforation of an ulcer increases with increasing dose of NSAIDs in patients with a history of ulcers, especially those complicated by bleeding or perforation, and in elderly patients, so treatment should be started with the lowest possible dose. Patients receiving drugs that reduce blood clotting or inhibit platelet aggregation also have an increased risk of gastrointestinal bleeding. If gastrointestinal bleeding or ulcers occur in patients taking Nimesil, treatment with the drug should be discontinued.

Since Nimesil is partially excreted by the kidneys, its dosage for patients with impaired renal function should be reduced, depending on the level of urination.

There is evidence of rare cases of liver reactions. If signs of liver damage appear (itching, yellowing of the skin, nausea, vomiting, abdominal pain, dark urine, increased activity of liver transaminases), you should stop taking the drug and consult your doctor.

Despite the rarity of visual impairment in patients taking nimesulide concomitantly with other NSAIDs, treatment should be stopped immediately. If any visual disturbance occurs, the patient should be examined by an ophthalmologist.

The drug can cause fluid retention in tissues, so patients with high blood pressure and cardiac problems should use Nimesil with extreme caution.

In patients with renal or heart failure, Nimesil should be used with caution, as renal function may deteriorate. If the condition worsens, treatment with Nimesil should be stopped.

Clinical studies and epidemiological data suggest that NSAIDs, especially at high doses and with long-term use, may lead to a small risk of myocardial infarction or stroke. There is insufficient data to exclude the risk of such events when using nimesulide.

The drug contains sucrose, this should be taken into account by patients suffering from diabetes mellitus (0.15-0.18 XE per 100 mg of the drug) and those on a low-calorie diet. Nimesil is not recommended for use in patients with rare hereditary diseases of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltose deficiency.

If signs of a “cold” or acute respiratory viral infection occur during treatment with Nimesil, the drug should be discontinued.

Nimesil should not be used simultaneously with other NSAIDs.

Nimesulide can change the properties of platelets, so caution must be exercised when using the drug in people with hemorrhagic diathesis, however, the drug does not replace the preventive effect of acetylsalicylic acid in cardiovascular diseases.

Elderly patients are especially susceptible to adverse reactions to NSAIDs, including life-threatening gastrointestinal bleeding and perforation, deterioration of renal, liver and cardiac function. When taking the drug Nimesil for this category of patients, proper clinical monitoring is necessary.

Like other drugs of the NSAID class that inhibit prostaglandin synthesis, nimesulide can adversely affect pregnancy and/or embryo development and can lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired renal function, which can lead to renal failure with oligodyramnia, to an increased risk of bleeding, decreased uterine contractility, and the occurrence of peripheral edema. In this regard, nimesulide is contraindicated during pregnancy and lactation. The use of the drug Nimesil can negatively affect female fertility and is not recommended for women planning pregnancy. When planning a pregnancy, consultation with your doctor is necessary.

There is evidence of the occurrence in rare cases of skin reactions (such as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) to nimesulide as well as to other NSAIDs. At the first signs of a skin rash, damage to the mucous membranes or other signs of an allergic reaction, Nimesil should be discontinued.

The effect of the drug on the ability to drive vehicles and operate machinery.

The effect of the drug Nimesil on the ability to drive vehicles and operate machinery has not been studied, therefore, during treatment with the drug Nimesil, caution should be exercised when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

When is the drug prescribed?

Doctors prescribe this medication when the patient feels acute pain. The indications are as follows:

• pain caused by injuries;
• tendinitis;
• pain from menstruation (in women);
• tooth pain;
• osteoarthrosis, osteochondrosis;
• myalgia;
• bursitis;
• arthritis;
• rheumatoid arthritis;
• arthralgia.

The drug is prescribed for pain caused by both diseases of the spine and pathologies of internal organs

For quite a long time, this medicine was prescribed for common colds and other pathologies that increase body temperature. However, this is now a dubious indication: Nimesil is now prescribed only if none of the other NSAIDs helps. It is especially often used for back pain caused by pathologies of the locomotor system, in particular osteochondrosis.

Nimesil granules d/susp. for oral administration 100mg pack 2g N9

Registration Certificate Holder

Laboratori GUIDOTTI SpA (Italy)

Dosage form

Medicine - Nimesil® (Nimesil®)

Description

Granules for preparation of suspension for oral administration

in the form of a light yellow granular powder with an orange odor.

1 pack (2 g)

nimesulide 100 mg

Excipients

: ketomacrogol 1000, sucrose, maltodextrin, anhydrous citric acid, orange flavor.

2 g - laminated paper bags (9) - cardboard packs. 2 g - laminated paper bags (15) - cardboard packs. 2 g - laminated paper bags (30) - cardboard packs.

Indications

• treatment of acute pain (back pain, lower back pain; pain syndrome in the musculoskeletal system, including injuries, sprains and dislocations of joints, tendonitis, bursitis; toothache);
• symptomatic treatment of osteoarthritis with pain syndrome;
• algodismenorrhea.

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use.

Contraindications for use

• history of hyperergic reactions, for example, bronchospasm, rhinitis, urticaria, associated with taking acetylsalicylic acid or other NSAIDs, incl. nimesulide;
• history of hepatotoxic reactions to nimesulide;
• concomitant (simultaneous) use of drugs with potential hepatotoxicity, for example, paracetamol or other analgesic or non-steroidal anti-inflammatory drugs;
• inflammatory bowel diseases (Crohn's disease, ulcerative colitis) in the acute phase;
• period after coronary artery bypass surgery;
• fever in infectious and inflammatory diseases;
• complete or partial combination of bronchial asthma, recurrent nasal polyposis or paranasal sinuses with intolerance to acetylsalicylic acid and other NSAIDs (including a history);
• peptic ulcer of the stomach and duodenum in the acute phase, a history of ulcers, perforation or bleeding in the gastrointestinal tract;
• a history of cerebrovascular hemorrhage or other bleeding, as well as diseases accompanied by bleeding;
• severe blood clotting disorders;
• severe heart failure;
• severe renal failure (creatinine clearance <30 ml/min), confirmed hyperkalemia;
• liver failure or any active liver disease;
• children under 12 years of age;
• pregnancy and breastfeeding;
• alcoholism, drug addiction;
• hypersensitivity to the components of the drug.

With caution
: severe forms of arterial hypertension, type 2 diabetes mellitus, heart failure, coronary heart disease, cerebrovascular diseases, dyslipidemia/hyperlipidemia, peripheral arterial disease, smoking, CC < 60 ml/min, anamnestic data on the presence of ulcerative lesions of the gastrointestinal tract, infections, caused by Helicobacter pylori; elderly age; long-term previous use of NSAIDs; severe somatic diseases; concomitant therapy with the following drugs: anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid, clopidogrel), oral glucocorticosteroids (for example, prednisolone), selective serotonin reuptake inhibitors (for example, citalopram, fluoxetine, sertraline).

The decision to prescribe Nimesil should be based on an individual risk-benefit assessment when taking the drug.

pharmachologic effect

Non-steroidal anti-inflammatory drug from the sulfonamide class. Has anti-inflammatory, analgesic and antipyretic effects. Nimesulide acts as an inhibitor of the cyclooxygenase enzyme responsible for the synthesis of prostaglandins and inhibits mainly cyclooxygenase-2.

Drug interactions

Pharmacodynamic interactions:

When used together with glucocorticosteroids, the risk of gastrointestinal ulcers or bleeding increases.

When used together with antiplatelet agents and selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, the risk of gastrointestinal bleeding increases.

NSAIDs may enhance the effect of anticoagulants such as warfarin. Due to the increased risk of bleeding, this combination is not recommended and is contraindicated in patients with severe coagulation disorders. If combination therapy cannot be avoided, careful monitoring of blood clotting parameters is necessary.

Diuretics

:

NSAIDs may weaken the effect of diuretics.

In healthy volunteers, nimesulide temporarily reduces the excretion of sodium under the influence of furosemide, to a lesser extent the excretion of potassium, and reduces the diuretic effect itself.

The combined use of nimesulide and furosemide leads to a decrease (by approximately 20%) in the area under the congestion curve.

From the respiratory system

: infrequently - shortness of breath; very rarely - exacerbation of bronchial asthma, bronchospasm.

From the digestive system

: often - diarrhea, nausea, vomiting; infrequently - constipation, flatulence, gastritis; very rarely - abdominal pain, dyspepsia, stomatitis, tarry stools, gastrointestinal bleeding, ulcer and/or perforation of the stomach or duodenum; very rarely - hepatitis, fulminant hepatitis, jaundice, cholestasis, increased activity of liver enzymes.

From the urinary system

: rarely - dysuria, hematuria, urinary retention;
very rarely - renal failure, oliguria, interstitial nephritis. General disorders
: rarely - malaise, asthenia; very rarely - hypothermia.

Others

: rarely - hyperkalemia.

special instructions

Undesirable side effects can be minimized by using the minimum effective dose of the drug for the shortest possible short course.

Nimesil should be used with caution in patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease), since exacerbation of these diseases is possible.

The risk of gastrointestinal bleeding, ulceration or perforation of an ulcer increases with increasing dose of NSAIDs in patients with a history of ulcers, especially those complicated by bleeding or perforation, and in elderly patients, so treatment should be started with the lowest possible dose. Patients receiving drugs that reduce blood clotting or inhibit platelet aggregation also have an increased risk of gastrointestinal bleeding. If gastrointestinal bleeding or ulcers occur in patients taking Nimesil, treatment with the drug should be discontinued.

Since Nimesil is partially excreted by the kidneys, its dosage for patients with impaired renal function should be reduced, depending on the level of urination.

There is evidence of rare cases of liver reactions. If signs of liver damage appear (itching, yellowing of the skin, nausea, vomiting, abdominal pain, dark urine, increased activity of liver transaminases), you should stop taking the drug and consult your doctor.

Despite the rarity of visual impairment in patients taking nimesulide concomitantly with other NSAIDs, treatment should be stopped immediately. If any visual disturbance occurs, the patient should be examined by an ophthalmologist.

The drug can cause fluid retention in tissues, so patients with high blood pressure and cardiac problems should use Nimesil with extreme caution.

In patients with renal or heart failure, Nimesil should be used with caution, as renal function may deteriorate. If the condition worsens, treatment with Nimesil should be stopped.

Clinical studies and epidemiological data suggest that NSAIDs, especially at high doses and with long-term use, may lead to a small risk of myocardial infarction or stroke. There is insufficient data to exclude the risk of such events when using nimesulide.

The drug contains sucrose, this should be taken into account by patients suffering from diabetes mellitus (0.15-0.18 XE per 100 mg of the drug) and those on a low-calorie diet. Nimesil is not recommended for use in patients with rare hereditary diseases of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltose deficiency.

If signs of a “cold” or acute respiratory viral infection occur during treatment with Nimesil, the drug should be discontinued.

Nimesil should not be used simultaneously with other NSAIDs.

Nimesulide can change the properties of platelets, so caution must be exercised when using the drug in people with hemorrhagic diathesis, however, the drug does not replace the preventive effect of acetylsalicylic acid in cardiovascular diseases.

Elderly patients are especially susceptible to adverse reactions to NSAIDs, including life-threatening gastrointestinal bleeding and perforation, deterioration of renal, liver and cardiac function. When taking the drug Nimesil for this category of patients, proper clinical monitoring is necessary.

Like other drugs of the NSAID class that inhibit prostaglandin synthesis, nimesulide can adversely affect pregnancy and/or embryo development and can lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired renal function, which can lead to renal failure with oligodyramnia, to an increased risk of bleeding, decreased uterine contractility, and the occurrence of peripheral edema. In this regard, nimesulide is contraindicated during pregnancy and lactation. The use of the drug Nimesil can negatively affect female fertility and is not recommended for women planning pregnancy. When planning a pregnancy, consultation with your doctor is necessary.

There is evidence of the occurrence in rare cases of skin reactions (such as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) to nimesulide as well as to other NSAIDs.
At the first signs of a skin rash, damage to the mucous membranes or other signs of an allergic reaction, Nimesil should be discontinued. The effect of the drug on the ability to drive vehicles and operate machinery.
The effect of the drug Nimesil on the ability to drive vehicles and operate machinery has not been studied, therefore, during treatment with the drug Nimesil, caution should be exercised when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Storage conditions

Storage conditions:

List B. Store in a dry place, protected from light and out of reach of children, at a temperature not exceeding 25 °C.

Best before date

Best before date:

2 years.

Do not use after the expiration date stated on the package.

Use during pregnancy and breastfeeding

Restrictions during pregnancy - Contraindicated. Restrictions when breastfeeding - Contraindicated.

Like other drugs of the NSAID class that inhibit prostaglandin synthesis, nimesulide can adversely affect pregnancy and/or embryo development and can lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired renal function, which can lead to renal failure with oligodyramnia, to an increased risk of bleeding, decreased uterine contractility, and the occurrence of peripheral edema. In this regard, the drug is contraindicated during pregnancy and breastfeeding.

Use for renal impairment

Restrictions for impaired renal function - Contraindicated.

In patients with renal failure, Nimesil should be used with caution, as renal function may deteriorate. If the condition worsens, treatment with Nimesil should be stopped. The drug is contraindicated in severe renal failure (creatinine clearance <30 ml/min).

In patients with mild to moderate forms of renal failure (creatinine clearance 30-80 ml/min), there is no need for dose adjustment.

Use for liver dysfunction

Restrictions for liver dysfunction - Contraindicated.

The drug is contraindicated in liver failure or any active liver disease.

Use in elderly patients

Restrictions for elderly patients - Use with caution.

The drug is prescribed with caution to elderly patients. Elderly patients are especially susceptible to adverse reactions to NSAIDs, including life-threatening gastrointestinal bleeding and perforation, deterioration of renal, liver and cardiac function. When taking the drug Nimesil for this category of patients, proper clinical monitoring is necessary.

When treating elderly patients, the need to adjust the daily dose is determined by the doctor based on the possibility of interaction with other drugs.

Use in children

Restrictions for children - Contraindicated.

The drug is contraindicated in children under 12 years of age.
Adolescents (ages 12 to 18 years):
Based on the pharmacokinetic profile and pharmacodynamic characteristics of nimesulide, no dose adjustment is necessary in adolescents.

Terms of sale

The drug is available with a prescription.

Contacts for inquiries

BERLIN-CHEMIE/MENARINI PHARMA GmbH (Germany)

BERLIN-CHEMIE/A.MENARINI LLC

123317 Moscow, Presnenskaya embankment. 10 Business, Block B Tel.; Fax

Combination of Nimesil with other medications

If you are planning to combine Nimesil with any other medications, you should first consult a specialist. If you use this medicine together with some other drugs, firstly, it will increase the likelihood of bleeding, and secondly, their effect will be weakened.

For example, taking Nimesil along with antiplatelet medications is a bad idea, since this can greatly increase the likelihood of bleeding in the gastrointestinal tract.

If you take this medicine along with anticoagulants, their effect will be increased, but the likelihood of bleeding will also increase. So for those with impaired coagulation, NSAIDs are very rarely prescribed. If you need to take Nimesil, you should monitor blood clotting as carefully as possible.

When combining Nimesil with lithium preparations, it is also necessary to continuously monitor physical indicators. Taking a drug containing nimesulide makes the elimination of lithium slower, thereby increasing the concentration of this metal in the blood and its toxicity.

If you use Nimesil with methotrexate drugs, the negative effect of the latter also increases.

"Nimesil" is not allowed to be taken simultaneously with every drug

Using nimesulide preparations together with diuretics or furosemide is also not a very good idea: the effect of these two types of drugs will be weakened.

When should you not take Nimesil, what are its side effects?

This medication should not be used to treat children. Even in the most extreme case, the patient's age should in no case be less than twelve years.

Also, this drug should not be taken in case of severe liver and kidney diseases, ulcerations and erosions, or diabetes mellitus.

It cannot be used for the following pathologies if they arose as a result of the use of non-steroidal anti-inflammatory drugs:

• bronchospasms;
• hives;
• allergic rhinitis.

You should not take Nimesil if hepatotoxic reactions to non-steroidal anti-inflammatory drugs are detected.

It is also not used in combination with the following:

• paracetamol;
• analgesics;
• any non-steroidal anti-inflammatory drugs, except, in fact, Nimesil itself.

Here is a list of pathologies and their stages for which this drug is unsuitable:

• exacerbation of intestinal inflammation;
• rehabilitation period after coronary artery bypass surgery;
• fever coupled with infections;
• complete/partial combination of asthma with recurrent polyposis of the nasal/paranasal sinuses;
• exacerbation of gastrointestinal ulcers;
• cerebrovascular bleeding;
• tendency to bleeding, hemorrhage;
• a serious form of cardiovascular failure;
• liver poisoning;
• alcoholism;
• drug addict.

Before starting to take the drug, you should consult your doctor to avoid any complications.

Finally, Nimesil should not be used by those who are highly sensitive to any of its components.

Nimesil granules for suspension. 100mg 2g pack. 30 pcs

Undesirable side effects can be minimized by using the drug in the minimum effective dose with the minimum duration of use necessary to relieve pain. There is evidence of very rare cases of serious liver reactions, including deaths, associated with the use of nimesulide-containing drugs. If symptoms similar to signs of liver damage appear (anorexia, itching, yellowing of the skin, nausea, vomiting, abdominal pain, dark urine, increased activity of liver transaminases), you should immediately stop using the drug Nimesil® and consult a doctor. Repeated use of Nimesil® in such patients is contraindicated.

Liver reactions, which are in most cases reversible, have been reported with short-term use of the drug.

While using the drug Nimesil®, the patient should refrain from taking other analgesics, including NSAIDs (including selective COX-2 inhibitors).

The drug Nimesil® should be used with caution in patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease), since exacerbation of these diseases is possible.

The risk of gastrointestinal bleeding, peptic ulcer/perforation of the stomach or duodenum increases in patients with a history of ulcerative lesions of the gastrointestinal tract (ulcerative colitis, Crohn's disease), as well as in elderly patients, with an increase in the dose of NSAIDs, so treatment should begin with the lowest possible dose. In such patients, as well as in patients who require the simultaneous use of low doses of acetylsalicylic acid or other drugs that increase the risk of complications from the gastrointestinal tract, it is recommended to additionally prescribe gastroprotectors (misoprostol or proton pump blockers). Patients with a history of gastrointestinal disease, especially older patients, should report new gastrointestinal symptoms (especially symptoms that may indicate possible gastrointestinal bleeding) to their physician.

Nimesil® should be prescribed with caution to patients taking drugs that increase the risk of ulceration or bleeding (oral corticosteroids, anticoagulants such as warfarin, selective serotonin reuptake inhibitors or antiplatelet agents such as acetylsalicylic acid).

If gastrointestinal bleeding or ulcerative lesions of the gastrointestinal tract occur in patients taking the drug imesil®, treatment with the drug must be stopped immediately.

Given reports of visual impairment in patients taking other NSAIDs, if any visual impairment occurs, the use of Nimesil should be immediately discontinued and an ophthalmological examination performed.

The drug may cause fluid retention in tissues, so patients with arterial hypertension, renal and/or heart failure, coronary heart disease, peripheral arterial disease and/or cerebrovascular diseases, with risk factors for developing cardiovascular diseases (for example: hyperlipidemia, diabetes mellitus, in smokers), Nimesil® should be used with extreme caution. If the condition worsens, treatment with Nimesil® should be discontinued.

The drug contains sucrose, this should be taken into account by patients suffering from diabetes mellitus (0.15-0.18 XE per 100 mg of the drug) and those on a low-calorie diet. The drug Nimesil® is not recommended for use in patients with fructose intolerance, sucrose-isomaltose deficiency or glucose-galactose malabsorption syndrome.

If signs of a “cold” or acute respiratory viral infection occur while using the drug Nimesil®, the drug should be discontinued.

Nimesulide can change the properties of platelets, so caution must be exercised when using the drug in people with hemorrhagic diathesis, however, the drug does not replace the preventive effect of acetylsalicylic acid in cardiovascular diseases.

Elderly patients are especially susceptible to adverse reactions to NSAIDs, including the risk of life-threatening gastrointestinal bleeding and perforation, and decreased renal, liver, and cardiac function. When taking Nimesil® for this category of patients, proper clinical monitoring is necessary.

There is evidence of the occurrence in rare cases of skin reactions (such as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) when taking NSAIDs, including nimesulide. At the first manifestations of a skin rash, damage to the mucous membranes or other signs of an allergic reaction, taking Nimesil® should be stopped immediately.

The effect of the drug on the ability to drive vehicles and other mechanisms

The effect of the drug Nimesil® on the ability to drive vehicles and machines has not been studied, therefore, during treatment with the drug Nimesil®, care should be taken when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Preparation of a suspension from powder

Each Nimesil sachet contains one dose of the drug. The suspension should be prepared as follows:

• prepare half a glass of boiled water at ambient temperature;
• pour a dose of the drug from the sachet there;
• mix as thoroughly as possible.

It is unacceptable that the water temperature is too high or low. And every particle must be dissolved.

If everything is done correctly, the resulting suspension can be used.

How to use Nimesila suspension?

The prepared drug is drunk a couple of times a day, one sachet. Each of them contains one hundred mg of nimesulide. The dose of the medicine lasts for a quarter of a day while it fights inflammation and swelling. It is recommended to take this medication after meals. It is unacceptable to store the finished suspension. It must be drunk immediately after preparation.

This medication should never be prescribed to children and adolescents under twelve years of age. Greater care is also required when prescribing it to older people. Due to the negative effect of the drug base on the liver and kidneys, patients in whom these organs are unhealthy should first consult a specialist to adjust the dose.

Instructions for use NIMESIL

Undesirable side effects can be minimized by using the lowest effective dose for the shortest duration necessary to control disease symptoms, as well as gastrointestinal and cardiovascular risks, below).

If there is no improvement in symptoms, drug therapy should be discontinued.

Rare cases of serious liver reactions, including very rare cases of death, have been reported associated with the use of nimesulide-containing medicinal products. Patients who experience symptoms similar to those of liver damage during treatment with Nimesil® (for example, anorexia, nausea, vomiting, abdominal pain, fatigue, dark urine) or patients whose laboratory tests of liver function deviate from normal values, should discontinue treatment with the drug. Repeated administration of nimesulide is contraindicated in such patients. Liver damage, most reversible, has been reported after short-term exposure to the drug.

During treatment with Nimesil®, the patient should refrain from taking other analgesics. The concomitant use of Nimesil® and other NSAIDs, including selective cyclooxygenase-2 inhibitors, should be avoided.

Patients receiving nimesulide who develop flu-like or cold-like symptoms should discontinue treatment with the drug.

Elderly patients:

Elderly patients have an increased incidence of adverse reactions to non-steroidal anti-inflammatory drugs, especially the incidence of gastrointestinal bleeding and perforation, which can be fatal to the patient.

Gastrointestinal bleeding, ulcer and ulcer perforation:

Gastrointestinal bleeding, ulceration and ulcer perforation may be life-threatening if the patient's medical history shows similar problems occurring when taking any non-steroidal anti-inflammatory drugs during treatment (regardless of the elapsed time), with or without the presence of dangerous symptoms, or the presence of history of serious gastrointestinal disorders.

The risk of gastrointestinal bleeding, ulceration, or perforation of an ulcer increases with increasing doses of nonsteroidal anti-inflammatory drugs, in patients with a history of ulcers, especially those complicated by hemorrhage or perforation, and in elderly patients. For these patients, treatment should be started with the lowest possible dose. For these patients, as well as patients taking concomitant low-dose aspirin or other drugs that increase the risk of gastrointestinal disease, combination therapy with protective agents (eg, misoprostol or proton pump inhibitors) should be considered.

Patients with gastrointestinal toxicity, especially the elderly, should report any unusual gastrointestinal symptoms (especially gastrointestinal bleeding). This is especially important in the initial stages of treatment. Patients taking concomitant medications that may increase the risk of ulceration or bleeding, such as oral corticosteroids, anticoagulants such as warfarin, selective serotonin reuptake inhibitors, or antiplatelet agents such as aspirin, should be advised to use the drug with caution.

If gastrointestinal bleeding or ulcers occur in patients receiving Nimesil®, treatment with the drug should be discontinued.

NSAIDs should be prescribed with caution to patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease), since exacerbation of these diseases is possible.

Disorders of the cardiovascular and cerebrovascular systems:

Patients with arterial hypertension and/or a history of mild/moderate acute heart failure, as well as patients with fluid retention and edema as a reaction to the use of NSAID therapy, require appropriate monitoring of their condition and consultation with a physician.

Clinical studies and epidemiological data suggest that some nonsteroidal anti-inflammatory drugs, especially at high doses and when used for long periods of time, may lead to a small risk of arterial thrombotic events (eg, myocardial infarction or stroke). There is insufficient data to exclude the risk of such events when using nimesulide.

In patients with uncontrolled hypertension, acute heart failure, established coronary artery disease, peripheral arterial disease and/or cerebrovascular disease, nimesulide should be prescribed after careful evaluation. An equally careful consideration of the condition should be performed before initiating long-term treatment in patients with risk factors for cardiovascular disease (eg, hypertension, hyperlipidemia, diabetes mellitus, smoking).

In patients with renal or heart failure, Nimesil® should be used with caution, as the drug may worsen renal function. If the condition worsens, treatment should be discontinued.

Elderly patients are particularly susceptible to adverse reactions to NSAIDs, including gastrointestinal bleeding and perforation, and deterioration of renal, hepatic, and cardiac function. Therefore, appropriate clinical monitoring is advisable.

Since nimesulide can affect platelet function, it should be prescribed with caution to patients with bleeding diathesis. However, Nimesil® does not replace acetylsalicylic acid in the prevention of cardiovascular diseases.

There are very rare reports of serious skin reactions to non-steroidal anti-inflammatory drugs, some of which can be fatal. Including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Patients are at very high risk of such reactions if, with a previously prescribed course of treatment, the onset of the reaction in most cases occurred during the first month of treatment. Nimesil® should be discontinued at the first signs of a skin rash, damage to the mucous membranes and other signs of an allergic reaction.

Nimesil® contains sucrose. This drug should not be prescribed to patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase deficiency.

Impact on the ability to drive vehicles and operate machinery

Studies on the effects of nimesulide-containing drugs on the ability to drive vehicles and operate machines and mechanisms have not been conducted. Despite this, patients experiencing headache, dizziness or drowsiness after taking Nimesil® should not drive a vehicle, machinery or machinery.

The nuances of using this medicine

If you read the instructions for Nimesil, you can find out how to minimize the likelihood of side effects from the drug. Here you just need to follow some rules of application:

• By taking the product after meals, you can reduce the likelihood of getting gastrointestinal pathologies;
• until the course ends, you cannot drink a drop of alcohol;
• It is best to use just enough of the drug to help, but no more. For example, if you have a cold, you can take just a couple of sachets twice a day instead of the three recommended for the flu and its symptoms;
• when the symptoms are reduced, and inflammation, temperature and pain are relieved, Nimesil should be stopped;
• a possible increase in body temperature during the Nimesil course is a sign that the active component of the medicine is not suitable for the patient, and the use of this drug should be immediately interrupted.

Video - How to properly dilute Nimesil?

Are pregnant women allowed to take the drug?

"Nimesil" is a drug belonging to the class of NSAIDs and inhibits the production of prostaglandins. This means that it can harm the fetus or its mother. Also, the drug may cause the ductus arteriosus to be blocked prematurely. The following pathologies sometimes develop because of it:

• hypertension in the pulmonary artery;
• renal dysfunction, as a result of which the appearance of renal failure, aggravated by oligodyramnia, cannot be excluded;
• bleeding;
• weakening of uterine contractility;
• peripheral edema.

Pregnant women should refrain from using Nimesil

So, it is clear: the drug is absolutely incompatible with a healthy pregnancy. Lactation is also a contraindication.

NIMESIL (granules)

.
We also have another, no less effective non-steroidal anti-inflammatory drug, which, unlike Nimesil, costs a penny, but it is difficult to find on sale and you will have to run around looking for it, review here - Piroxicam It is easier to buy Nimesil at the nearest pharmacy. I first became acquainted with this drug more than 10 years ago. It was a very difficult extraction of a molar tooth. When they pulled it out, it broke off and they removed it in parts, cutting the gums. The jaw was very much torn apart. Nimesil was prescribed in the morning and evening for several days, so that after the anesthesia wore off, the pain would not bother me and the wound would not become inflamed.

We also use Nimesil for SEVERE toothache. Surely many people have their own trusted dentist and don’t want to go to the first one they come across. But toothache appears unexpectedly, sometimes the pain from one tooth spreads to the entire jaw, sometimes even the cheek enlarges and swells. And before making an appointment with your doctor, you still need to wait a day, or even two... Or the toothache appeared on the weekend, and you just need to wait until Monday and relieve the suffering. Nimesil will come to the rescue again; if you drink it before bed, the pain will soon subside and you will sleep peacefully all night. The effect comes quickly and lasts quite a long time.

Nimesil successfully fights not only muscle pain, but also joint pain, and also has an antipyretic effect. That is why we sometimes take it when we have a severe cold, when all our bones begin to ache from the elevated temperature.

My husband has had chronic osteochondrosis for many years, but exacerbations occur once a year and sometimes twice, accompanied by very severe pain when moving and stiffness. We follow the doctor's instructions. The first thing to do is to reduce the acute pain and immediately begin a course of complex treatment, the results of which will last for a long time, up to a year. You can relieve acute pain at the initial stage of treatment with Nimesil, or resort to another drug, review here - Diclofenac. And only then I treat my husband comprehensively, treatment of chronic osteochondrosis.

It would seem that Nimesil is simply wonderful and very effective. But we use it only in VERY EXTREME CASES, and not as a course. Moreover, due to the huge number of contraindications and side effects, it is not suitable for everyone. Although all non-steroidal anti-inflammatory drugs are toxic and harmful to one degree or another, especially for the liver.

The finished solution does not taste bad, with a slight orange aftertaste. Personally, I don’t have any stomach problems, but even while taking it I noticed a slight heartburn. But my husband’s stomach began to ache after use, but he has minor problems with the gastrointestinal tract. That’s why I use injections more often for my husband.

The drug has an age limit of up to 12 years.

Nimesil can only be used by those who have healthy kidneys, liver, stomach, etc. More details can be found in the instructions for use, which should be carefully studied before taking the drug; it may be contraindicated for you.

Side effects, the list is very long.

The drug is very effective, but unfortunately it is extremely toxic and is not suitable for everyone.

To summarize, I would like to highlight the pros and cons.

Pros.

-Quick and fairly long-lasting effect. -Wide spectrum of action. -Availability - available in any pharmacy. - Possibility to purchase individually. -Neutral and pleasant taste.

Minuses.

-Age limit. -High price. -It won’t suit many people due to contraindications. -Side effect. -Not very suitable for course use due to TOXICITY.

Based on what was written above, we do not use Nimesil for long-term course use, only in EXCEPTIONAL CASES, as an emergency first aid. Moreover, the phrase from the instructions “about rare cases of death”, to put it mildly, does not inspire coursework at all.

I will be glad if my review was useful to you. And be healthy!

How does Nimesil interact with other medications?

Pharmacodynamics

If you use Nimesil with glucocorticosteroids, you can get a gastrointestinal ulcer/bleeding.

Combining it with antiplatelet drugs and SSRIs, say fluoxetine, can increase the likelihood of GI bleeding.

The effects of anticoagulants such as warfarin may be increased by taking NSAIDs. But the increased likelihood of bleeding makes this combination much less useful. For those who have serious problems with coagulation, this is even more contraindicated. If it is impossible to do without this combination, you should carefully monitor how well the blood clots.

Interaction with diuretics

"Nimesil", like any other NSAID drug, can make the effect of diuretics weaker. If the patient is not sick with anything else, nimesulide slows down the excretion of sodium for some time due to the effect of furosemide, somewhat less - the excretion of potassium, and indeed the result of using a diuretic. If the drug nimesulide and furosemide are used simultaneously, the result is a 1/5 decrease in the area under the concentration-time curve, and also a decrease in the cumulative excretion of furosemide without distorting the renal clearance of the same drug. So if kidney/heart pathologies are detected, this combination should be used with extreme caution.

You should be careful with the combination of Nimesil and diuretics

ACE inhibitors and angiotensin-2 receptor antagonists in combination with Nimesil

If you use these two types of drugs together with NSAIDs, it is possible that the effect of the former will be weaker. If there is even mild renal failure, this sometimes spoils the functioning of the kidneys and provokes their acute failure. It is already irreversible. All this must be taken into account if a person uses Nimesil with ACE inhibitors or angiotensin-2 receptor antagonists. So great caution is required from a specialist if he prescribes such a combination of medications. Especially if the patient has reached old age. The patient needs to drink a lot of water, and the functioning of his kidneys must be kept under very close control throughout the entire duration of such therapy.

How does Nimesil interact pharmacokinetically with other medications?

NSAIDs are known to impair the elimination of lithium from the human body, thereby increasing its toxicity and blood levels. When prescribing nimesulide to someone who is taking lithium drugs, the doctor is obliged to monitor how much lithium accumulates in the patient’s blood.

No significant problems have been identified caused by the combination of Nimesil with any of the following drugs:

• glibenclamide;
• digoxin;
• cimetidine;
• antacids.

“Nimesil” can be combined with some drugs without problems

When prescribing a patient to take nimesulide with a time interval between it and methotrexate of less than a day, the doctor must be careful: this can increase the level of methotrexate in the blood, and the harm from it too.

Due to their effect on renal prostaglandins, nimesulide and other inhibitors of this substance sometimes increase the nephrotoxicity of cyclosporines.

How do other medications interact with nimesulide?

According to research, the following medications displace nimesulide from binding zones:

• tolbutamide;
• salicylic acid;
• valproic acid.

Although this was found in blood plasma, nothing similar was seen in clinical use.

Powder Nimesil (MENARINI) - reviews

Nadezhda S
https://flap.rf/Medicine/Nimesil/Reviews/6748993

I came to him a couple of times when I had an acute toothache, and I also tried to relieve the pain in my hand after a bruise. There are different drugs based on Nimesulide, but for some reason this particular one showed strong side effects for me. Namely - nausea, nagging pain in the liver and gallstones, slight dizziness. With all this, the toothache disappeared, and the pain in the arm decreased significantly. That is, there is an analgesic effect, but after taking it, I didn’t know what was better - to endure the pain or feel the side effects.

I’ve never taken it for a cold, so I can’t say, although it helped my husband well. But it seems to me that this drug is too ambiguous in terms of the number of side effects to be used as an antipyretic for colds. It’s better to take something easier or just lie down and sweat with raspberries and honey. Although it is clear that people consume all these powders only because for many the hospital employer does not really approve. My father-in-law worked as a crane operator for a private construction company. There, only one's own death can be a significant reason not to show up for work. Sometimes he simply lives on such powders. But then my liver also ached. In general, we somehow decided not to use this drug.

At the same time, I read that if consumed on an empty stomach it can cause nausea. However, it was on a full stomach that I felt sick. I read that it is already available in capsules, but we drank it in powder. It’s not very convenient, since you need to do unnecessary movements - dilute it with water. The resulting solution does not taste pleasant, but it is drinkable.

There are drugs that are much nastier.

Tracef

https://otzyv.expert/individualnaya-neperenosimost-toshnota-slabost-1813116

Advantages:

• Have not found

Flaws:

• side effect

Medical corporations give doctors and pharmaceuticals additional financial incentives for a new product, but this does not mean that all this should be taken at face value. It all depends on the formula and the degree of deduction; the cheaper the production, the more expensive the medicine reaches the end consumer; marketers are forced to do this, since the ministries of health of many countries impose bans on certain pharmaceutical developments. At the first request for “something painkiller,” you will be offered NEXT or NIMESIL. those who try these drugs for the first time will experience all types of side effects at once until you are convinced that this is normal, then adaptation. Once was enough for me. Further hospitalization, diagnosis of toxic poisoning.

Dangerous for those who are not vaccinated at all.

Annettechka

https://otzovik.com/review_3384814.html

Advantages:

• No

Flaws:

• Side effect

Hi all! I very often have to take non-steroidal anti-inflammatory drugs for back pain...

Sometimes it hurts so much that neither ointments, nor rubbing, nor a bath help, and then you have to resort to pills.

The last time at an appointment with a neurologist, I was prescribed Nimesil, after reading the instructions I was unpleasantly surprised by the consequences after using this powder, or rather, the instructions say that the drug can cause erosion in the gastrointestinal tract. But I still started taking it, as always, hoping for chance.

At the time of taking the drug, I did not have any stomach problems, but after the course horror began, cramps and pain in the abdomen began, at that very moment I remembered the side effects of this drug.

Naturally, I ran to the doctor, gastroscopy showed gastritis, thank God there were no erosions, but I still can’t cure gastritis, so decide whether you need a painkiller that cures one thing and cripples another (((

General impression:

If you want gastritis, take nimesil!

Anonymous642468

https://otzovik.com/review_2650126.html

Advantages:

• not detected

Flaws:

• dangerous side effect

The doctor prescribed a course due to lymph inflammation. node behind the ear and trigeminal neuritis.

2-3 hours after taking it, pain began throughout the body. It only lasted me 3 days, of which I couldn’t sleep for two nights due to severe abdominal pain, pain in the solar plexus, severe pain in the back up to the shoulder blades, and pain in the spine itself. At first, due to nausea and abdominal pain, I decided that it was poisoning, but there were no other signs such as “diarrhea”. Taking Polysorb reduced acute abdominal pain, but the symptoms remained. For the sake of the purity of the experiment, after another terrible night I did not take this remedy. As a result, these symptoms did not recur. Hallelujah, I'm still alive.

General impression:

Did not help. severe pain in the abdomen and back

ksenia91

https://irecommend.ru/content/ostorozhno-pobochnye-yavleniya

Advantages:

• very fast action
• relieves toothache

Flaws:

• quickly passing pain relief effect
• effect on the kidneys
• Possible adverse reactions
• has many contraindications

After treating tooth pulpitis, cleaning the canals and filling them, the doctor warned that the tooth would hurt when bitten, but I had no idea how much it would hurt... It was as if half of my jaw had been torn apart, my gums were swollen, it was impossible to touch the tooth even with my tongue, not to chew something...

On the recommendation of a doctor, I bought Nimesil to prepare a suspension, naturally without instructions, I read it on the Internet. I noticed that it has a lot of contraindications and side effects. I decided that this would not affect me, because I am as healthy as an elephant))) I drank it, after 20 minutes the pain disappeared. I was able to eat, and I’m sitting happy...

After 3 hours, my KIDNEYS hurt!!!! Pain in the lower back area, spreading on both sides from the spine to the sides... There was just a spasm that didn’t let me go for about 20 minutes, then it slowly calmed down.

The instructions indicate that the drug is excreted 50% by the kidneys, delays the excretion of sodium and potassium... So I no longer take this drug =((

By the way, after this the toothache returned, so Nimesil only relieves the pain, and then only for 3-4 hours, while some remedies, such as Pentalgin, help for 8 hours...

Take it carefully, everyone’s body is different, I didn’t think it would affect me like that))

quality

https://instrukciya-otzyvy.ru/114-nimesil-po-primeneniyu-analogi-poroshok-granuly-dlya-prigotovleniya-suspenzii-bol.html

My shoulder hurt (possibly a pinched nerve due to playing sports). I drank Nimesil as expected, 1 sachet 2 times a day. On the third day, a disgusting property appeared, sweat of a poisonous yellow color began to stand out. I dirtied all my clothes. Although there is no such side effect in the instructions.

Lacrimosa7002

https://citykey.net/review/zhutkovataya-istoriya-pro-nimesil

Probably everyone knows about the drug Nimesil. I once had a good attitude towards this remedy, a normal remedy for symptomatic use - it does not cure, but it anesthetizes and reduces the inflammatory process, what’s wrong with that.

But then I found out one case, and since then I have never bought Nimesil or recommended it to anyone, well, out of harm’s way. An incident from life: a man had a toothache, but to get to the dentist he had to wait - the man had a plane flight, not too long, about 6 hours. And this man took Nimesil to reduce the pain. During the flight, my uncle became ill, and as a result he developed Lyell’s syndrome (I won’t write these terrible details here, it would simply be incorrect on my part, you can look up on the Internet what kind of Lyell’s syndrome this is). Thank God that the ambulance team turned out to be not only really ambulance, but also qualified - the guy was saved, but not only he himself spent those hours on the plane in hell, but also all the other passengers and staff - believe me, it was a terrible sight, and then another long painful period of rehabilitation. But the main thing is that he survived, and this is practically a miracle.

So, Nimesil. In no way do I blame the drug itself, it’s just a matter of chance. This could happen when taking any other painkiller, and not only - almost any existing medicine. I was just so impressed by this case that I decided to share it. But I took Nimesil and I’m alive and well, I don’t even cough.

Everything is individual. And this is just bad, probably. The drug is not harmless; it has many side effects and contraindications. But he is the only one who helps many people out.

I can't give a low score, I'll give it a three. There are too many difficulties with this Nimesil. Most of the instructions are occupied by a list of all kinds of adverse reactions, no less contraindications, so... I wouldn’t risk it.

Oksana1982

Advantages:

• easy to use

Flaws:

• doesn't help me!

I have been suffering from headaches for a very long time, so I tested almost all painkillers on myself! This powder was recommended to me at the pharmacy; I took three sachets to try. At the first attack of headache, I diluted the powder in water, drank it... Neither half an hour nor an hour later the pain subsided, I drank another sachet, the pain did not even dull. The next time the headache wasn't so bad, the powder helped! This is a remedy for mild pain!

I don’t want to continue using these drugs anymore! I will look for something effective!

Similar means

The doctor may prescribe some other remedy that will act in much the same way as Nimesil. The composition in this case will also be similar to this medicine. A specialist can prescribe an analogue if the patient is allergic to one or another component of this drug. But usually in such a way that it does not cause any “side effects”. The main analogues of "Nimesil" are as follows:

• "Kokstral";
• "Nimesulide";
• "Remisid";
• "Nise";
• "Aponil";
• "Nimika";
• "Nimulid";
• "Nimegesic";
• "Nimid."

"Nimid"

Complete analogues of this product

All medications containing nimesulide are complete analogues, that is, identical products. They are available in any form. In terms of properties, indications and contraindications, these analogues are similar to Nimesil. They are made by many pharmaceutical companies. Manufacturers' technologies differ, albeit slightly. So there are many differences between drugs produced by different companies:

• chances of “side effects”;
• bioavailability;
• strength of effects.

Here are the analogues of Nimesil that are more widely known than others:

• nimesulide tablets. , Russian, “Obolenskoye”, “Izvarino-Farma”, “Berezovsky”;
• "Nimulex granulate". Manufacturer: in Romania;
• "Flolide granulate." in Italy;
• Nimesulide Teva tablets. Manufacturer: Bluepharma Industria in Portugal.

"Nimesulide Teva"

Any nimesulide tablets should be taken either during a meal or after completing it. They should be washed down with not too much water at ambient temperature. The dose and course are the same as for Nimesil.

Since the end of 2013, you can purchase another analogue of the drug “Nimesil”. This is “Affida Fort” - a full-fledged analogue, which is also produced in the form of granulate - the raw material from which the suspension is made. It is manufactured by .

Reviews for osteochondrosis

94% of people taking Nimesil and participating in the survey noted that the drug is incredibly effective if taken to suppress the discomfort caused by spinal osteochondrosis. Here are some reviews.

Alexander, 38 years old:

“Nimesil, as well as most of its analogs, helps me with pain associated with osteochondrosis. The first time I took it for two weeks, according to the doctor’s recommendations, and now I resort to it only when necessary. By the way, it also eliminates toothache well and for a long time.”

Olga, 52 years old:

“This is the only drug that helped me with terrible pain in the spine (osteochondrosis). The popular drugs Movalis and Mydocalm did not help me at all, unfortunately.”

Review of "Nimesil" for osteochondrosis

Zhanna, 31 years old:

“I have been suffering from severe back pain for many years. I have been examined more than once, used physiotherapy and therapeutic massages. I consulted a neurologist, osteopathic doctors, even chiropractors, then there were leeches, gravity couches, massage. I can’t say that it was all in vain, but the effect did not last long. After some time, the pain worsened again. Sometimes you just want to cry from hopelessness. Doctors recommend pain relief.

For quite a long time I could not find a suitable painkiller for myself. Then I came to the conclusion that of all the medications I tried, only two helped me: Nimesil and Nice. Both contain the main active ingredient nimesulide.

Nimesil is a powder that needs to be dissolved in a small amount of warm water. It begins to act after 15-20 minutes. Sometimes the pain disappears completely, sometimes not completely, I don’t even know what to connect this with. But the effect, whatever one may say, is quite good. Of course, you shouldn’t get carried away with it, as side effects may develop in the gastrointestinal tract. “I believe that it should be taken strictly on the doctor’s recommendation.”

Evgeniy, 68 years old:

“I took the drug almost every day: I poured the contents into my mouth and washed it down with water (I was never able to prove to him that the powder needed to be dissolved). The effect develops within 30 minutes. The pain under the influence of Nimesil becomes less intense, almost imperceptible, and even a certain flexibility appears. True, the pain does not completely subside even after the blockade. The only way to get rid of pain for a day or two is, oddly enough, 100 g of regular vodka. However, you won’t last long with this method of treatment either.”

Nimesil®

Undesirable side effects can be minimized by using the drug in the minimum effective dose with the minimum duration of use necessary to relieve pain.

There is evidence of very rare cases of serious reactions from the liver, including cases of death, associated with the use of nimesulide-containing drugs. If symptoms similar to signs of liver damage appear (anorexia, itching, yellowing of the skin, nausea, vomiting, abdominal pain, dark urine, increased activity of liver transaminases), you should immediately stop using the drug Nimesil® and consult a doctor. Repeated use of Nimesil® in such patients is contraindicated.

Liver reactions, which are in most cases reversible, have been reported with short-term use of the drug.

While using the drug Nimesil®, the patient should refrain from taking other analgesics, including NSAIDs (including selective COX-2 inhibitors).

The drug Nimesil® should be used with caution in patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease), since exacerbation of these diseases is possible.

The risk of gastrointestinal bleeding, peptic ulcer/perforation of the stomach or duodenum increases in patients with a history of gastrointestinal ulceration (ulcerative colitis, Crohn's disease), as well as in elderly patients, with an increase in the dose of NSAIDs, so treatment should begin with the lowest possible dose. In such patients, as well as in patients who require the simultaneous use of low doses of acetylsalicylic acid or other drugs that increase the risk of complications from the gastrointestinal tract, it is recommended to additionally prescribe gastroprotectors (misoprostol or proton pump blockers). Patients with a history of gastrointestinal disease, especially older patients, should report new gastrointestinal symptoms (especially symptoms that may indicate possible gastrointestinal bleeding) to their physician.

Nimesil should be administered with caution to patients taking drugs that increase the risk of ulceration or bleeding (oral corticosteroids, anticoagulants such as warfarin, selective serotonin reuptake inhibitors or antiplatelet agents such as acetylsalicylic acid).

If gastrointestinal bleeding or gastrointestinal ulceration occurs in patients taking Nimesil®, treatment with the drug must be stopped immediately.

Given reports of visual impairment in patients taking other NSAIDs, if any visual impairment occurs, the use of Nimesil should be immediately discontinued and an ophthalmological examination performed.

The drug may cause fluid retention, therefore, in patients with arterial hypertension, renal and/or heart failure, Nimesil® should be used with extreme caution. If the condition worsens, treatment with Nimesil® should be discontinued.

Clinical studies and epidemiological data suggest that NSAIDs, especially at high doses and with long-term use, may lead to a small risk of myocardial infarction or stroke. There is insufficient data to exclude the risk of such events when using nimesulide.

Patients with arterial hypertension, renal and/or heart failure, coronary heart disease, peripheral arterial disease and/or cerebrovascular diseases, with risk factors for the development of cardiovascular diseases (for example: hyperlipidemia, diabetes mellitus, smokers) should take Nimesil® use with extreme caution. If the condition worsens, treatment with Nimesil® should be discontinued.

The drug contains sucrose, this should be taken into account by patients suffering from diabetes mellitus (0.15-0.18 XE per 100 mg of the drug) and those on a low-calorie diet. The drug Nimesil® is not recommended for use in patients with fructose intolerance, sucrose-isomaltose deficiency or glucose-galactose malabsorption syndrome.

If signs of a “cold” or acute respiratory viral infection occur while using the drug Nimesil®, the drug should be discontinued. Nimesulide can change the properties of platelets, so caution must be exercised when using the drug in people with hemorrhagic diathesis, however, the drug does not replace the preventive effect of acetylsalicylic acid in cardiovascular diseases.

Elderly patients are especially susceptible to adverse reactions to NSAIDs, including the risk of life-threatening gastrointestinal bleeding and perforation, and decreased renal, liver, and cardiac function. When taking Nimesil® for this category of patients, proper clinical monitoring is necessary.

There is evidence of rare cases of skin reactions (such as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) when taking NSAIDs, including nimesulide. At the first manifestations of a skin rash, damage to the mucous membranes or other signs of an allergic reaction, taking Nimesil® should be stopped immediately.