Instructions for use of vitamin B2 (riboflavin)

Many microelements and vitamins play an important role in the proper functioning of the human visual organs. The strain on the eyes of the average person in the modern world is excessively high, so it is important to pay special attention to vision. If necessary or for the purpose of prevention, doctors advise using vitamin drops.

pharmachologic effect

Riboflavin or vitamin B2 is characterized by easy absorption and good solubility in water. In combination with other microelements, it plays a key role in maintaining human health. Like other B vitamins , riboflavin supports energy production and also takes an active part in the metabolism of fats, carbohydrates and proteins.

Vitamin B2 (riboflavin) is essential in the formation of red blood cells and helps oxygenate the blood during breathing.

In addition, Vitamin B2 stimulates the production of antibodies and is also necessary for regulating the growth of the human body and reproductive function. Among other things, this vitamin is of great importance for the health of the skin, nails, hair growth and overall good health, including participating in the regulation of the thyroid gland. It also helps prevent or treat many types of eye diseases , including some types of cataracts .

Pharmacodynamics and Pharmacokinetics

Vitamin B2 binds to hydrogenase , kinase and synthase . Riboflavin is a precursor to flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). Antioxidant activity mainly stems from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant glutathione.

Riboflavin belongs to the prosthetic group of flavin enzymes, which allows it to function as a hydrogen transporter during tissue respiration and regulate redox reactions. Reduced glutathione is a cofactor of selenium-containing glutathione peroxidases. Glutathione peroxidase is the main antioxidant enzyme. Reduced glutathione is produced by the FAD-containing enzyme glutathione reductase .

The substance is easily absorbed in the upper gastrointestinal tract, due to absorption and subsequent phosphorylation in the gastrointestinal mucosa, blood cells and liver. This vitamin mainly accumulates in the kidneys, adrenal glands and liver, but, nevertheless, its nucleotides are tightly bound to apoenzyme proteins, so when it is excreted, urine may turn light yellow. Protein binding is 60%. The half-life of the substance is 60-84 minutes.

Overdose symptoms

Hypervitaminosis of vitamin B2 is less common than hypovitaminosis. Riboflavin is a water-soluble substance, so excess nutrient intake is easily excreted in the urine, provided the function of the urinary system is preserved. Signs of overdose in the form of increased adverse reactions may be observed in patients with reduced filtration capacity of the kidneys. With a pronounced excess of the substance, dyspeptic disorders similar to the manifestations of gastritis may occur. If atypical symptoms are detected, you should stop taking the drug and consult a doctor.

Indications for use

Riboflavin (vitamin B2) is indicated for use in cases of hypo- and ariboflavinosis .

In addition, the drug is prescribed for use in certain diseases, such as:

  • hemeralopia (a disease characterized by deterioration of vision function at night and in the evening), in this case riboflavin is prescribed together with retinol ;
  • conjunctivitis (a disease of the organs of vision characterized by inflammation of the outer membrane of the eye);
  • iritis (a disease of the organs of vision characterized by inflammation of the iris);
  • keratitis (a disease of the organs of vision characterized by inflammation of the cornea);
  • long-term non-healing wounds and ulcers of various etymologies;
  • radiation sickness (a disease that develops as a result of exposure to ionizing radiation);
  • eczema (a disease of the upper layer of the epidermis, characterized by the appearance of a rash and burning sensation);
  • Botkin's disease (a disease of the liver tissue, expressed by inflammation) and other liver diseases;
  • dysfunction of the gastrointestinal tract;
  • iron deficiency anemia (a disease characterized by a sharp decrease in hemoglobin in the blood, which develops as a result of impaired intake, absorption or excretion of iron).

Instructions for use of Riboflavin (Method and dosage)

Riboflavin tablets are taken orally in the following dosages:

  • For the treatment of low Riboflavin levels (riboflavin deficiency) in adults: 5-30 mg Riboflavin (vitamin B2) per day in divided doses.
  • To prevent migraines : 400 mg Riboflavin (vitamin B2) per day. In this case, treatment may take up to three months before positive results appear.
  • To prevent the development of cataracts and treat eye diseases: the daily diet is approximately 2.6 mg of Riboflavin (vitamin B2). Also, Riboflavin is combined with Niacin in a proportion of 3 grams. vitamin B2 and 40 g. Niacin daily.

Instructions for use of Vitamin B2 for various age groups:

  • children aged 0 to 6 months - recommended dose of vitamin 0.3 mg per day;
  • children aged 7 to 12 months - recommended dose of vitamin 0.4 mg per day;
  • children aged 1 to 3 years – recommended dose 0.5 mg per day;
  • children aged 4 to 8 years - the recommended dose of vitamin per day is 0.6 mg;
  • children aged 9 to 13 years – recommended dose of vitamin 0.9 mg per day;
  • men aged 14 years and older - the recommended dose of vitamin 1.3 mg per day;
  • women aged 14 to 18 years - recommended dose of vitamin 1 mg per day;
  • women over 18 years of age - the recommended dose of vitamins is 1.1 mg per day;
  • Women during pregnancy are recommended to take vitamin B2 in the amount of 1.4 mg per day;
  • for nursing mothers in the amount of 1.6 mg per day.

Riboflavin eye drops, instructions for use

Eye drops 0.01% in the form of a vitamin solution are prescribed for use in various ophthalmological diseases in the dosage: 1 drop in each eye 2 times a day. The duration of treatment is determined by a specialist individually, depending on the disease, its course and severity.

Riboflavin-Mononucleotide, instructions for use

Riboflavin-Mononucleotide in ampoules is characterized by excellent solubility in water, which makes it possible to administer the solution both intramuscularly and intravenously. The solution is administered intramuscularly to adults at a dose of 0.01 g (1 ml of 1% solution) once a day. The duration of treatment is from 10 to 20 days and is determined by the attending physician.

For children, intramuscular administration of Riboflavin-Mononucleotide is prescribed at 0.005 - 0.01 g. The first stage of treatment is carried out for 3 to 5 days in a row. The second stage of treatment involves administering the solution 2-3 times a week.

Who are vitamin eye drops recommended for?

Since the moment when computers and mobile phones have become an integral part of human life, the visual organs of most technology lovers are regularly subjected to excessive stress. Not only modern gadgets, but also other processes, for example, reading in transport, negatively affect vision. To protect a person from possible eye diseases and pathologies caused by modern living conditions, ophthalmologists often recommend eye drops to patients.

Vitamin eye drops are prescribed:

  • People over 60 years old, in case of age-related changes that lead to deterioration of vision;
  • When the patient suffers from farsightedness or myopia (vitamins prevent the progression of diseases);
  • If a person regularly spends a long time at the computer (5 hours a day or more). Often these are office workers, fans of computer games, freelancers;
  • Patients diagnosed with cataracts or glaucoma;
  • Patients with diabetes mellitus;
  • People with varicose veins.

Interaction with other drugs

The interaction of vitamin B2 (riboflavin) with other drugs has been studied quite thoroughly. Experts note that alcohol impairs the absorption of the active substance in the intestines. antidepressants ( tricyclic or phenothiazines affect the absorption process , so the recommendation for a single dose of Riboflavin can be changed at the discretion of the professional in patients receiving these drugs.

The simultaneous use of Riboflavin and Probenecid reduces the absorption of the active substance in the gastrointestinal tract, therefore, at the discretion of the physician, the dosage of the active substance can be increased in patients using Probenecid.

general information

Vitamin B2 is necessary for the eyes to function properly. The vitamin preparation improves the transport of oxygen to tissues, ensures complete transmission of visual impulses to the brain, and takes part in metabolic processes at the cellular level.

NameRiboflavin, eye drops
Active substanceRiboflavin
and Borisov plant
Manufacturer countryRussia and Belarus

Vitamin B2 is a water-soluble element. Once on the cornea, the substance begins to act almost immediately, affecting local metabolism.

Riboflavin analogs

Level 4 ATC code matches:
Medobiotin

Calcium Pantothenate

Volvit

Nicotinamide

Alpha Tocopherol Acetate

Pyridoxine Hydrochloride

Pyridoxine

Vitrum Vitamin E

There are quite a lot of analogues of Riboflavin on the modern pharmaceutical market. Basically, all of them are presented in the form of drugs for the treatment of ophthalmic diseases. The most popular of them are:

  • Vial;
  • Systeine-Ultra;
  • Sofradex;
  • Viagamox;
  • Ciloxane;
  • Korneregel;
  • Xalacom;
  • Uniclofen;
  • Phloxal;
  • Vitabact;
  • Oftarimin;
  • Tobradex;
  • Taurine;
  • Vitafacol;
  • Vicein;
  • Catalin;
  • Optinol;
  • Quinax;
  • Khrustalin;
  • Normax;
  • Visine;
  • Inosine+nicotinamide+riboflavin+succinic acid.

Reviews about Riboflavin

On thematic forums, users very often discuss the benefits of this drug. The main issue raised on specialized resources is the correct intake of Vitamin B2. Reviews are mostly positive, but user opinions are almost equally divided on where exactly the necessary vitamin should come from - from food or dietary supplements .

People who believe that it is necessary to add synthetic vitamins and dietary supplements to the daily diet argue that the modern rhythm of life and the environmental situation do not leave a chance for modern man to obtain all the necessary nutrients naturally, without the use of vitamin-mineral complexes and health courses.

Their opponents, in turn, recall that synthetic vitamins, including vitamin B2, are not always sufficiently absorbed in the body, and in certain cases can have a toxic effect.

Also on forums, the question very often arises about what is better to take - monovitamin preparations, such as Riboflavin, or multivitamin complexes? Even experts who claim that for preventive purposes one should resort to the help of vitamin-mineral complexes cannot answer this unequivocally, but if there is a specific deficiency of vitamin B2, it is necessary to take it, but this must be done under the strict supervision of a doctor.

special instructions

Riboflavin is a vitamin supplement for the eyes that helps support the functioning of the lens and the conduction of nerve impulses to the brain. Drops with B2 do not impair vision and do not affect reaction speed, so they are allowed to be used by vehicle drivers and people working with moving mechanisms.

The medication has only a local effect, so it can be used for any somatic and endocrine disorders. A small amount of glucose included in the medicinal liquid is not a contraindication for the treatment of ophthalmic problems in diabetes: the substance does not enter the general bloodstream and does not affect blood glucose levels.

Before instilling the drug for prophylactic purposes, you should consult a specialist. The riboflavin solution used will only be useful if B2 deficiency is detected in the body. In other cases, the medicine will not harm the organ of vision, but will not provide a therapeutic effect.

Riboflavin price, where to buy

The price of Riboflavin is quite low, so this drug is often prescribed for the treatment of hypovitaminosis and other diseases.

The price of Riboflavin tablets varies, but usually varies within certain limits. You can buy Riboflavin in tablets at a price of 75 to 80 rubles, depending on the number of tablets in the package.

Riboflavin eye drops are somewhat more expensive and can be purchased for approximately 180 rubles per 10 ml.

  • Online pharmacies in RussiaRussia

Vitamins for the eyes: how are eye drops used?

Doctors recommend using vitamin-containing eye drops in courses, but it is not advisable to use them constantly. As a rule, a 30-day break is taken after two to three months of therapy. It is important to understand that eye vitamins can only be used for preventive purposes, as a factor that helps inhibit or prevent the development of diseases. Sometimes these drugs are part of drug therapy aimed at generally strengthening the eyesight. It should be remembered that in some cases prevention can play a decisive role, so people with certain pathologies of the visual organs should not underestimate the benefits of vitamins.

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