Compound
The film-coated tablets contain the active component levocetirizine dihydrochloride. Additional components: microcrystalline silicon cellulose, lactose monohydrate, low-substituted hyprolose, magnesium stearate.
The tablet shell consists of: hypromellose, titanium dioxide, lactose monohydrate, macrogol and triacetin. Oral drops also contain the active component levocetirizine dihydrochloride. Additional components: glycerol , propylene glycol, sodium saccharinate and acetate trihydrate, methyl parahydroxybenzoate, propyl parahydroxybenzoate, glacial acetic acid, purified water.
Composition of the drug.
Chloropyramine hydrochloride.
Excipients: lactose monohydrate, potato starch, sodium carboxymethyl starch, talc, gelatin and stearic acid.
How it works.
Chloropyramine - prevents the development and facilitates the course of allergic reactions, blocks certain histamine receptors - this is a local effect.
As a result, manifestations of allergic reactions - lacrimation, profuse rhinitis, swelling, cough, various rashes simply do not make themselves felt. But the same receptors are also in the brain, and they are responsible for the hypnotic effect. Therefore, taking suprastin is accompanied by weakness, drowsiness, fatigue and absent-mindedness.
When taken orally, the effect appears within 15-30 minutes, the maximum effect develops within 1 hour and lasts approximately 3-6 hours.
Pharmacodynamics and pharmacokinetics
Suprastinex affects the histamine-dependent stage of various allergic reactions, reduces the migration of eosinophils, reduces vascular permeability, reducing the release of inflammatory mediators. While taking this drug, allergic manifestations develop less frequently and their course is significantly improved. In addition, there is an antiexudative and antipruritic effect, without causing sedative, antiserotonergic and anticholinergic effects.
The therapeutic effect of the drug develops 12-60 minutes after taking a single dose and persists throughout the day.
Suprastinex is characterized by rapid absorption, while eating does not affect the usefulness of this process, but reduces its speed. 90% of the active substance binds to plasma proteins. When metabolized from part of the substance in the liver, an inactive metabolite . Complete elimination of the drug from the body occurs within 96 hours, mainly through the kidneys.
Composition of the medicine
Suprastin, or rather its active substance, is a blocker of H-histamine receptors. This pharmacological group and, accordingly, medications related to it have an anti-allergic effect and are used to reduce or completely eliminate severe allergic reactions to a particular irritant.
Allergies can occur due to animals
The main component of Suprastin - chloropyramine - is included in the list of vital and essential drugs (vital and essential drugs), which is approved by the Government of the Russian Federation for the purpose of state regulation of prices for drugs.
Chloropyramine blocks H-histamine receptors. What does it mean? As soon as chloropyramine exerts its inhibitory effect on the receptors, they become immune to histamine, which in turn triggers the body’s reaction, which we used to call allergies. Also, chloropyramine partially blocks M-cholinergic receptors, after which an antiemetic and antispasmodic effect is observed.
Chloropyramine from the intestinal lumen, where it enters after administration, is quickly absorbed into the systemic circulation. After this, it enters the central nervous system, evenly distributed in the tissues.
Suprastin helps not only against allergies, but also has a calming, hypnotic, and antipruritic effect. Increases capillary permeability and relieves spasm from smooth muscles.
Indications for use
The drug is prescribed for symptomatic treatment of: year-round and seasonal allergic rhinitis and conjunctivitis , manifested by itching , sneezing, rhinorrhea, lacrimation, conjunctival hyperemia;
- hay fever - hay fever;
- urticaria , such as chronic idiopathic urticaria ;
- Quincke's edema;
- allergic dermatoses , accompanied by itching and rashes.
Indications
Conditions and diseases for which Suprastin can be prescribed both in tablets and ampoules:
- hives;
- skin rash;
- allergies (nutritional or caused by insect bites);
- serum sickness with fever developing after the administration of immunobiological drugs;
- allergic rhinitis;
- food or drug allergic reaction of varying severity and localization;
- skin itching of various origins;
- allergic conjunctivitis;
- acute or chronic course of eczema;
- contact dermatitis;
- as an adjuvant for angioedema and systemic anaphylactic hypersensitivity reactions.
Also, Sinusitis can be prescribed to reduce swelling of the mucous membrane of the middle ear and nose during infections of the ENT organs (sinusitis, otitis media).
Contraindications for use
Suprastinex is not recommended for use if:
- hypersensitivity to the drug;
- severe renal failure ;
- children under 6 years old - tablets, up to 2 years old - drops, due to lack of information about their effect on the child’s body;
- lactation, pregnancy;
- lactose intolerance, hereditary form of lactase deficiency or glucose-galactose malabsorption syndrome.
Caution is required when treating patients with chronic renal failure and the elderly.
Contraindications
Taking Suprastin is contraindicated in the following conditions:
- acute attacks of bronchial asthma;
- stomach ulcer;
- angle-closure glaucoma;
- treatment with MAO inhibitors;
- arrhythmia;
- acute myocardial infarction;
- prostate hyperplasia;
- urinary retention;
- hypersensitivity to ethylenediamine derivatives;
- allergy to the active or excipients of the drug;
- pregnancy and lactation;
- age up to 3 years;
- Administration of the solution to newborns and premature infants is contraindicated.
Side effects
When treated with Suprastinex, side effects may develop that affect the functioning of the immune system, for example: various allergic reactions .
In addition, disturbances in the activity of the nervous system are possible: severe drowsiness, headache , high fatigue , asthenia, migraine , and so on.
Deviations in metabolism, functioning of the respiratory system, gastrointestinal tract, subcutaneous fat and some other systems and organs are also possible.
Interaction with alcohol
Suprastin is contraindicated to take with alcoholic beverages
Suprastin should not be taken with alcohol. The sedative and hypnotic effect, which is observed when taking Suprastin, increases when mixed with alcohol-containing drinks. Also, such a “cocktail” can provoke:
- dizziness;
- blurred vision;
- a state close to panic;
- nervous excitability;
- dry mouth;
- euphoria;
- unstable stool;
- nausea;
- convulsions;
- vomit;
- tremor;
- tachycardia;
- ocular hypertension;
- a sharp drop in blood pressure;
- arrhythmia;
- urinary retention;
- lethargy;
- drowsiness.
Instructions for use of Suprastinex (Method and dosage)
This drug in any form is intended to be taken orally, before or during meals. In this case, the tablets are taken as a whole, washed down with water, and the instructions for use recommend measuring Suprastinex drops into a spoon or glass of water. It is necessary to take the medicine immediately after dissolution.
The daily dose of the drug is intended for one dose. Adults and elderly patients, as well as children over 6 years of age, are prescribed one tablet or 20 drops per day. The maximum dosage should not be higher than 5 mg
For young patients 2-6 years old, it is recommended to take the drug in drops of 1.25 mg for 2 doses per day - that’s 5 drops each time. The maximum permissible dosage is 2.5 mg.
For patients with impaired renal function, the dosage regimen is determined taking into account individual characteristics. Patients with chronic renal failure are prescribed half the permissible form. Complex forms of the disease are a contraindication for use.
Liver dysfunction does not require any special changes in dosage and therapeutic regimen. If patients are found to have simultaneous dysfunction of the liver and kidneys, the dosage is reduced.
The duration of treatment depends on the complexity of the disease. The fact is that for various deviations, the therapeutic course can last either a week or six months.
Suprastinex drops for oral administration 20ml
A country
Hungary
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Levocetirizine
Compound
Active substance: levocetirizine dihydrochloride.
pharmachologic effect
Pharmacodynamics. Antiallergic agent. Enantiomer of cetirizine; competitive histamine antagonist; blocks H1-histamine receptors, the affinity for which is 2 times higher than that of cetirizine. Affects the histamine-dependent stage of allergic reactions; reduces the migration of eosinophils, reduces vascular permeability, limits the release of inflammatory mediators. Prevents the development and facilitates the course of allergic reactions, has an antiexudative (decongestant), antipruritic effect; has virtually no anticholinergic and antiserotonergic effects. In therapeutic doses it has virtually no sedative effect. The action begins 12 minutes after taking a single dose in 50% of patients, after 1 hour in 95% and continues for 24 hours. Pharmacokinetics. Pharmacokinetics is linear. Rapidly absorbed when taken orally; food intake does not affect the completeness of absorption, but reduces its speed. Bioavailability - 100%. The time to reach maximum concentration is about 0.9 hours, the maximum concentration is 207 ng/ml. The volume of distribution is about 0.4 l/kg. Protein binding - 90%. Less than 14% of the drug is metabolized in the liver by O-dealkylation to form a pharmacologically inactive metabolite. The half-life is 7-10 hours. The total clearance is about 0.63 ml/min/kg. Completely eliminated from the body within 96 hours. Excreted by the kidneys (approximately 85%). In case of renal failure (creatinine clearance less than 40 ml/min), clearance is reduced (in patients on hemodialysis - by 80%), the half-life is extended. Less than 10% is removed during hemodialysis. Passes into breast milk.
Indications for use
Symptomatic treatment of: year-round and seasonal allergic rhinitis and conjunctivitis (itching, sneezing, rhinorrhea, lacrimation, conjunctival hyperemia); hay fever (hay fever); urticaria, incl. chronic idiopathic urticaria; Quincke's edema; allergic dermatoses, accompanied by itching and rashes.
Mode of application
For oral administration. The drug must be taken with meals or on an empty stomach. The required number of drops should be measured using a dropper into a tablespoon or glass of water. Drops should be taken orally immediately after dilution. It is recommended to take the daily dose at one time. The recommended dose for adults and children over 6 years of age, elderly patients (provided normal kidney function) is 5 mg (1 ml drops or 20 drops from a dropper) per day. The maximum daily dose should not exceed 5 mg. Children aged 2 to 6 years - the daily recommended dose is 2.5 mg in two doses in equal doses of 1.25 mg (2 times 0.25 ml drops = 2x5 drops from a dropper). The maximum daily dose should not exceed 2.5 mg. Patients with impaired renal function. The frequency of dosage should be determined individually in accordance with renal function. In patients with chronic renal failure with creatinine clearance (CC) from 30 to 49 ml/min, the dose should be reduced by 2 times (5 mg (1 ml drops or 20 drops from a dropper) every other day); with CC from 10 to 29 ml/min, the dose must be reduced by 3 times (5 mg (1 ml drops or 20 drops from a dropper) every 3 days). In severe renal failure (creatinine clearance less than 10 ml/min), the drug is contraindicated. Patients with impaired liver function. When prescribing the drug to patients with isolated liver dysfunction, no dose changes are required. For patients with concomitant impairment of liver and kidney function, dose adjustment is recommended. Duration of taking the drug. The duration of use depends on the disease. When treating persistent allergic rhinitis (symptoms 4 days/1 week or lasting more than 4 weeks), treatment is continued throughout the period of exposure to allergens. The course of treatment for hay fever is determined by the doctor; on average, it lasts 1-6 weeks. For chronic diseases (year-round rhinitis, chronic idiopathic urticaria), the course of treatment may be longer in consultation with the doctor. There is clinical experience with the drug for up to 6 months.
Interaction
Interaction studies of levocetirizine have shown no clinically significant interactions with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, glipizide and diazepam. Combined use with macrolides or ketoconazole did not cause significant changes in the ECG. Theophylline (400 mg/day) reduces the total clearance of levocetirizine by 16%. In this case, the pharmacokinetics of theophylline does not change. Levocetirizine does not enhance the effects of ethanol, however, in sensitive patients, concomitant use of levocetirizine with ethanol or other CNS depressants may cause CNS effects.
Side effect
From the immune system: very rarely - allergic reactions, including anaphylaxis. From the metabolic side: very rarely - weight gain. From the central and peripheral nervous system: often - drowsiness, headache, increased fatigue; infrequently - asthenia; rarely - migraine, dizziness. From the respiratory system: very rarely - dyspnea. From the gastrointestinal tract: often - dry mouth, infrequently - abdominal pain; very rarely - nausea, dyspepsia. From the subcutaneous fat: very rarely - angioedema, skin itching, rash, urticaria. From laboratory parameters: very rarely - changes in functional “liver” tests. If any side effects occur, including .h. not specified in the instructions, you must consult a doctor.
Contraindications
Hypersensitivity to the active (including piperazine derivatives) or any auxiliary component of the drug; severe renal failure (creatinine clearance less than 10 ml/min); children under 2 years of age (due to lack of clinical data); pregnancy and lactation period.
Overdose
Symptoms of overdose in adults include drowsiness, in children - agitation, anxiety, which are replaced by drowsiness. Treatment: there is no specific antidote. Symptomatic and supportive therapy and gastric lavage are recommended. Hemodialysis is ineffective.
special instructions
With caution. Chronic renal failure of mild to moderate severity, old age (possible decrease in glomerular filtration). Use during pregnancy and lactation. Use of the drug during pregnancy is contraindicated, since controlled clinical studies on the safety of the drug in pregnant women have not been conducted. If it is necessary to use the drug during lactation, it is recommended to stop breastfeeding. The drug is not recommended for use in children under 2 years of age due to insufficient data on the use of the drug. During the treatment period, it is recommended to refrain from drinking ethanol. Drops can cause allergic reactions (sometimes late), as they contain methyl parahydroxybenzoate and propyl parahydroxybenzoate. Impact on the ability to drive vehicles and operate machinery. During the treatment period, it is recommended to refrain from engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Overdose
Cases of overdose with Suprastinex can cause drowsiness , and excessive agitation and anxiety , often followed by drowsiness .
This requires treatment with gastric lavage and mandatory examination by a doctor. A specific antidote has not been developed, so symptomatic and supportive treatments are recommended. However, hemodialysis is ineffective.
special instructions
The drug in tablet form contains lactose, so it is not prescribed to patients suffering from intolerance to this substance, hereditary lactase deficiency or glucose-galactose malabsorption syndrome.
Drops for internal use are not recommended for children under 2 years of age, since their effect on young patients has not been sufficiently studied. In addition, drops can lead to the development of allergic reactions to the components of this medicine.
During treatment, patients taking this drug should refrain from performing hazardous work that requires special attention and quick reactions.
Analogs
Synonyms of Suprastin (containing the same active ingredient) are Chlorpyramin, Chlorpyramin-Ferein, Chlorpyramin-Eskom.
Suprastin's analogs
Medicines with a similar therapeutic effect: Histafen, Diazolin, Kestin, Ketotifen, Clarotadine, Lomilan, Loratadine, Suprastinex, Erius.
Analogs in effect cannot always ideally replace the drug chosen by the doctor, so replacement is possible only after consultation.
Suprastin/Tavegil
The active component of Tavegil is clemastine. Tavegil is characterized by high efficiency. The mechanism of action and the resulting effect from the drugs are similar.
Suprastin/Cetrin
Cetrin is intended for adults and children over 6 years of age, and in syrup form for children over 2 years of age. Cetrin penetrates perfectly into the skin, so allergic reactions that manifest themselves in this way are stopped quite quickly.
This drug has a less pronounced manifestation of the body's negative reaction to administration. Suprastin, unlike Cetrin, is considered a more effective drug.
Suprastin/Zyrtec
Zyrtec is a generic version of Cetrin, as it contains the same substance - cetirizine.
Suprastin/Diazolin
The active ingredient of Diazolin is mebhydrolintac. It is weaker than Suprastin and is characterized by less sedative effect.
Suprastin/Zodak
Zodak basically contains cetirizine dihydrochloride. There is no sedative effect. Zodak, compared to Suprastin, is weaker, but the effect of taking it lasts longer. Suprastin eliminates allergic reactions faster and is applicable for severe conditions.
Suprastin/Loratadine
Loratadine does not have a sedative effect and does not enhance the effects of alcohol.
Suprastin/Claritin
The active ingredient in Claritin is loratadine. The characteristics of the main drug (Loratadine) are the same.
When choosing a particular drug, be sure to consult your doctor.
Interaction
According to laboratory studies, the interaction of levocetirizine and pseudoephedrine, cimetidine, Ketoconazole, Erythromycin, Azithromycin, Glipizide, Diazepam does not have important clinical significance. The combination with Ketoconazole and macrolides does not affect changes in ECG parameters.
Concomitant use with Theophylline may reduce the overall clearance of levocetirizine without changing the kinetics of Theophylline .
Suprastinex's analogs
Level 4 ATX code matches:
Cetrilev
Cetirizine
Zyrtec
Zodak
Alerzin
Tsetrin
Cetirinax
L-Cet
Levocetirizine
Glenzeth
Parlazin
Aleron
Xizal
The main analogues of Suprastinex are represented by the following drugs: Levocetirizine Dihydrochloride, Glencet, Zodak, Xizal, Zenaro, Levocetirizine-Teva, Cesera and Elcet .
Reviews of Suprastinex
In recent years, the popularity of antihistamines has increased manyfold. However, as reviews of Suprastinex show, only some people take this remedy.
According to experts, they also prescribe other, more well-known medications to their patients, for example, Fenistil, Loratadine .
Some users say that they took the drug in drops as part of complex therapy for infectious and inflammatory diseases accompanied by manifestations of various forms of allergic reactions. In all cases, reviews of Suprastinex drops are positive, since the medicine turned out to be highly effective and helped not only alleviate, but even eliminate the manifestations of allergies.
Therefore, we can note the effectiveness of this drug, especially since none of the users report the development of side effects. Despite this, before starting treatment it is necessary to consult a competent specialist.
Suprastinex price, where to buy
The price of Suprastinex tablets in Russian pharmacies and online pharmacies starts from 230 rubles.
You can buy Suprastinex in drops for internal use at a cost of 270-350 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Suprastinex tablets p.p.o.
5 mg 14 pcs. Egis 408 rub. order - Suprastinex tablets p.p.o. 5mg 7 pcs Egis
RUB 244 order
- Suprastinex drops for internal use. approx. 5mg/ml 20mlEgis
RUB 321 order
