Composition per 1 tablet:
Active substance:
potassium iodide - 0.131 mg (corresponding to 0.1 mg of iodine);
Excipients:
lactose monohydrate, magnesium hydroxycarbonate, gelatin, sodium carboxymethyl starch, colloidal silicon dioxide, magnesium stearate.
Description: round flat-cylindrical tablets of white or almost white color, with a chamfer and a score on one side.
Pharmacotherapeutic group: thyroxine synthesis regulator - iodine drug ATC code: H03SA
Analogues of Iodomarin
Level 4 ATC code matches:
Blue Yod
Potassium iodide
Synonyms of Iodomarin 100 are: Antisturmin , children's Iodine Vitrum , Iodide 100 , Iodine Vitrum 100 mcg , Iodandin 100 mcg , Iodbalance 100 mcg , Microiodide 100 , Potassium iodide Renewal 100 mcg .
Structural analogues of Iodomarin 200: 9 months Potassium iodide , Iodine Vitrum 100 mcg , Iodine Vitrum 200 mcg , Iodantine 200 mcg , Iodine balance 200 mcg , Microiodide 200 , Potassium iodide Renewal 200 mcg .
Iodine balance or Iodomarin - which is better?
Iodbalance and Iodomarin are generic drugs. Having analyzed why they are prescribed, how to take both drugs, the range of contraindications, as well as possible drug interactions, we can conclude that the only difference between the drugs is a slight difference in price ( Iodine balance is slightly cheaper than its analogue).
Pharmacological properties
Pharmacodynamics
Iodine is a vital trace element that is a component of the thyroid hormones - thyroxine and triiodothyronine. Thyroid hormones are involved in the development of all organs and systems, in the regulation of metabolic processes in the body: they are responsible for the exchange of proteins, fats, carbohydrates and energy in the body, regulate the activity of the brain, the nervous and cardiovascular systems of the reproductive and mammary glands, as well as the growth and child development.
Iodine deficiency is especially dangerous for children, adolescents, pregnant and lactating women.
Reviews about Yodomarin
Reviews for Iodomarin 100, like reviews for Iodomarin 200, are mostly positive. Using the drug for medicinal purposes can reduce the symptoms of the disease; when taking the tablets for preventive purposes, many people note a decrease in irritability, an improvement in general well-being and memory, and an increase in concentration.
There are no less good reviews for Iodomarin during pregnancy. In women, the use of this remedy helps prevent the development of iodine deficiency conditions and associated diseases, normalize the metabolism of proteins , lipids and carbohydrates , and ensure normal activity of the brain and cardiovascular system .
iodine intake is the key to normal physical and mental development.
In some reviews, people write that taking Iodomarin helped them bring their weight to normal levels. So, can the drug be used for weight loss? Endocrinologists answer that it is possible, but only according to the doctor’s indications.
In a number of situations, excess weight is a consequence of decreased thyroid function , and then it is impossible to lose it either with the help of diets or with the help of physical activity.
The manufacturer does not recommend taking Iodomarin for hypothyroidism , excluding, however, those cases where the disease is associated with obvious iodine .
It should be remembered that is responsible of the secretion of thyroid hormones , but the hypothalamic hormones, which, in turn, are controlled by the cerebral cortex, are responsible for regulating the influence of the pituitary gland on the thyroid gland .
Thyroid hormones also influence the pituitary gland , hypothalamus , a number of endocrine glands , the course of metabolic processes, and the condition of internal organs and their systems.
Thus, uncontrolled use of Iodomarin for the purpose of losing weight can provoke serious disturbances in the usual rhythm of thyroid activity and, as a consequence, the entire endocrine system of the body with all the ensuing consequences.
To gently stimulate thyroid function and activate metabolic processes, it is recommended to first review your diet, supplementing it with foods high in iodine (seafood, onions, garlic, eggplants, beets, radishes, persimmons, grapefruits, etc.), or at least replacing regular iodized salt.
Iodomarin is used as a dietary supplement. You can take it for weight loss only after consulting a doctor and not exceeding the recommended dose.
Pharmacokinetics
Suction
When taken orally, potassium iodide is almost completely absorbed in the small intestine.
Distribution
The average volume of distribution for healthy individuals is approximately 23 L (38% of body weight). The normal plasma iodine concentration ranges from 0.1 to 0.5 μg/dL. Accumulates in the thyroid gland, salivary glands, mammary glands and stomach tissues. The concentration in saliva, gastric juice and breast milk is approximately 30 times higher than in blood plasma.
Removal
Excreted by the kidneys, the concentration of iodine in urine relative to creatinine (mcg/g) is an indicator of its intake into the body.
Iodomarin price, where to buy
The price of Iodomarin 100 in Russian pharmacies is about 145 rubles for package No. 100, the price of Iodomarin 200 is about 215 rubles for package No. 100 and about 135 rubles for package No. 50.
How much does Yodomarin cost in Ukraine?
You can buy Iodomarin 100 No. 100 for an average of 70-77 UAH, the cost of Iodomarin 200 is from 58 UAH (for package No. 50)
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Iodomarin 100 tablets 0.1 mg 100 pcs. Menarini-Von Heyden/Berlin Chemie
134 rub. order - Iodomarin for the expectant mother tablets 140 mg 30 pcsToll Manufacturind Services SL
RUR 366 order
- Iodomarin 200 tablets 0.2 mg 50 pcs. Berlin-Chemie AG/Menarini von Heyden GmbH
RUB 131 order
Pharmacy Dialogue
- Iodomarin (tab. 100 µg No. 100) Berlin-Chemie AG/Menarini
127 RUR order
- Iodomarin (tab. 200 µg No. 50) Berlin-Chemie AG/Menarini
RUB 143 order
- Iodomarin (tab. 200 µg No. 100) Berlin-Chemie AG/Menarini
RUB 204 order
- Iodomarin for the expectant mother tablets 140 mg No. 30Toll Manufacturing
403 rub. order
show more
Pharmacy24
- Iodomarin 100 mg No. 100 tablets Menarine von Heyden GmbH/ Berlin Chemi AG (Menarine Group), Nimechchina/Nimechchina
107 UAH.order - Iodomarin 200 mg No. 50 tablets Menarini von Heyden GmbH/ Berlin Chemi AG (Menarini Group), Nimecchina/Nimecchina
107 UAH order
PaniPharmacy
- Iodomarin tablets Iodomarin tablets 100 µg No. 100 Germany, Berlin-Chemie
108 UAH order
- Iodomarin tablets Iodomarin tablets 200 µg No. 50 Germany, Berlin-Chemie
111 UAH order
show more
Contraindications
- hypersensitivity to potassium iodide and/or any excipient in the drug;
- manifest hyperthyroidism;
- subclinical hyperthyroidism - in doses exceeding 150 mcg of iodine per day;
- solitary toxic adenomas of the thyroid gland and functional autonomy of the thyroid gland (focal and diffuse), nodular toxic goiter (with the exception of preoperative therapy for the purpose of blocking the thyroid gland);
- lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome;
- Dühring's herpetiformis (senile) dermatitis.
The drug should not be used for hypothyroidism, except in cases where the development of the latter is caused by severe iodine deficiency. The use of the drug should be avoided during therapy with radioactive iodine, the presence or suspicion of thyroid cancer.
Side effects of the drug Iodomarin
To assess the frequency of adverse effects, the following parameters were used: very often: ≥1/10; often: ≥1/100 and ≤1/10; ≥ sometimes: 1/1000 and ≤1/100; rare: ≥1/10,000 and ≤1/1000; very rare: ≤1/10,000, unknown (estimate not possible due to lack of data). From the endocrine system: very rarely - if there are significant autonomous areas in the thyroid gland, when using the drug in a daily dose of 150 mcg of iodine, hyperthyroidism can become manifest. When using the drug in adults at a dose of 300 mcg to a maximum of 1000 mcg of iodine per day, iodine-induced hyperthyroidism may develop in some cases. The prerequisite for this in most cases is the presence of diffuse or limited foci of autonomy in the thyroid gland. First of all, this applies to elderly patients with a long course of the disease. From the immune system: very rarely - hypersensitivity reactions (angioedema).
Use during pregnancy and breastfeeding
During pregnancy and breastfeeding, the need for Iodine increases, so it is especially important to use the drug Yodomarin® 100 in sufficient doses to ensure adequate intake of iodine into the body. Potassium iodide passes through the placenta and into breast milk. If a nursing woman takes potassium iodide, additional administration of the drug to breastfed infants is not required.
The use of the drug during pregnancy and breastfeeding is possible only in recommended doses. When carrying out therapy, it is necessary to take into account the amount of iodine supplied with food.
Directions for use and doses
When determining the required dose of Yodomarin® 100, regional and individual characteristics of iodine intake from food must be taken into account. This is especially important when prescribing the drug to newborns and children under 4 years of age.
Prevention of iodine deficiency diseases: Newborns and children:
50−100 mcg of iodine per day (1/2 - 1 tablet of the drug Yodomarin® 100);
Adolescents and adults:
100−200 mcg of iodine per day (1−2 tablets of Yodomarin® 100);
During pregnancy and breastfeeding:
100−200 mcg of iodine per day (1−2 tablets of Yodomarin® 100).
Prevention of goiter relapse after its surgical removal or after completion of goiter treatment with thyroid hormone preparations: 100−200 mcg of iodine daily (1−2 tablets of the drug Yodomarin® 100).
Treatment of euthyroid goiter: Newborns and children:
100−200 mcg of iodine per day (1−2 tablets of the drug Yodomarin® 100);
Adolescents and young adult patients:
200 mcg of iodine per day (2 tablets of Iodomarin® 100).
The daily dose of the drug should be taken in one dose, after meals, with a sufficient amount of liquid. When prescribing the drug to newborns and children under 3 years of age, it is recommended to dissolve the tablet in a small amount (1 tablespoon) of boiled water at room temperature.
The use of the drug for prophylactic purposes is carried out for, as a rule, several months or years, and often throughout life.
For the treatment of goiter in newborns, in most cases, 2-4 weeks are sufficient; in children, adolescents and adults it usually takes 6−12 months or more.
The duration of treatment is determined by the doctor.
Side effects
Treatment of non-toxic diffuse goiter in newborn infants, children and adolescents, as well as the use of Iodomarin for preventive purposes (at any age), as a rule, does not provoke side effects.
In rare cases, against the background of long-term use of the drug, the development of iodism - aseptic inflammation of the skin and mucous membranes in places where iodine is released (in the area of the paranasal sinuses , salivary glands , respiratory tract ).
It manifests itself in the form of “cold” symptoms (lacrimation, conjunctivitis , runny nose , cough , “ iodine fever ”, etc.), bronchitis , the appearance of a metallic taste in the mouth and a characteristic odor from the mouth, increased salivation, urticaria , increased thirst, staining oral cavity, diarrhea , cramps , weakness, dizziness, soreness and burning sensation in the throat, a special skin rash (iododerma) and “iodine” acne. Vomit is yellow or blue.
, exfoliative dermatitis or Quincke's edema may develop .
When using the drug in a dose exceeding 150 mcg/day, latent (masked) hyperthyroidism often becomes manifest ( true hyperthyroidism ).
Long-term use of the drug at a dose exceeding 300 mcg/day can provoke iodine-induced thyrotoxicosis (the likelihood of its development is especially high in elderly patients who of goiter for a sufficiently long period of time; in the presence of Graves' disease or nodular goiter ).
Overdose
Symptoms:
staining of the mucous membranes brown, reflex vomiting (if there are starch-containing components in the food, the vomit becomes blue), abdominal pain and diarrhea (blood may be present in the stool). In severe cases, dehydration and shock may develop. In rare cases, esophageal stenosis has occurred. Cases of death were observed only after taking large amounts of iodine (30-250 ml of iodine tincture).
In rare cases, long-term overdose of potassium iodide can lead to the development of so-called “iodism”, i.e. iodine intoxication: metallic taste in the mouth, swelling and irritation of the mucous membranes (runny nose, conjunctivitis, gastroenteritis, bronchitis). Potassium iodide can activate latent inflammatory processes such as tuberculosis. Possible development of edema, erythema, acne-like and bullous rash, hemorrhage, fever and irritability.
Treatment for acute intoxication:
gastric lavage with a solution of starch, protein or 5% sodium thiosulfate solution until all traces of iodine are removed. Symptomatic treatment of water-electrolyte imbalances, anti-shock therapy.
Treatment for chronic intoxication:
withdrawal of potassium iodide.
Treatment of iodine-induced hypothyroidism:
abolition of potassium iodide, normalization of metabolism with the help of thyroid hormones.
Treatment of iodine-induced thyrotoxicosis:
for mild forms of treatment is not required; in severe forms, thyreostatic therapy is required (the effect of which is always delayed). In severe cases (thyrotoxic crisis), intensive therapy, plasmapheresis or thyroidectomy are necessary.
In the case of hyperthyroidism, we cannot talk about an overdose as such, since hyperthyroidism can be caused by an amount of iodine that is normal in other countries.
Registration number: P N013943/01 dated July 18, 2007 Trade name: Iodomarin® 100 International nonproprietary or generic name: potassium iodide Dosage form: tablets
Composition per 1 tablet:
Active substance:
potassium iodide - 0.131 mg (corresponding to 0.1 mg of iodine);
Excipients:
lactose monohydrate, magnesium hydroxycarbonate, gelatin, sodium carboxymethyl starch, colloidal silicon dioxide, magnesium stearate.
Description: round flat-cylindrical tablets of white or almost white color, with a chamfer and a score on one side.
Pharmacotherapeutic group: thyroxine synthesis regulator - iodine drug ATC code: H03SA
Pharmacological properties
Pharmacodynamics
Iodine is a vital trace element that is a component of the thyroid hormones - thyroxine and triiodothyronine. Thyroid hormones are involved in the development of all organs and systems, in the regulation of metabolic processes in the body: they are responsible for the exchange of proteins, fats, carbohydrates and energy in the body, regulate the activity of the brain, the nervous and cardiovascular systems of the reproductive and mammary glands, as well as the growth and child development.
Iodine deficiency is especially dangerous for children, adolescents, pregnant and lactating women.
Pharmacokinetics
Suction
When taken orally, potassium iodide is almost completely absorbed in the small intestine.
Distribution
The average volume of distribution for healthy individuals is approximately 23 L (38% of body weight). The normal plasma iodine concentration ranges from 0.1 to 0.5 μg/dL. Accumulates in the thyroid gland, salivary glands, mammary glands and stomach tissues. The concentration in saliva, gastric juice and breast milk is approximately 30 times higher than in blood plasma.
Removal
Excreted by the kidneys, the concentration of iodine in urine relative to creatinine (mcg/g) is an indicator of its intake into the body.
Indications for use
- prevention of iodine deficiency diseases, incl. endemic goiter (especially in pregnant and lactating women);
- prevention of goiter recurrence after its surgical removal or after completion of goiter treatment with thyroid hormone preparations;
- treatment of diffuse euthyroid goiter in newborns, children, adolescents and young adult patients.
Contraindications
- hypersensitivity to potassium iodide and/or any excipient in the drug;
- manifest hyperthyroidism;
- subclinical hyperthyroidism - in doses exceeding 150 mcg of iodine per day;
- solitary toxic adenomas of the thyroid gland and functional autonomy of the thyroid gland (focal and diffuse), nodular toxic goiter (with the exception of preoperative therapy for the purpose of blocking the thyroid gland);
- lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome;
- Dühring's herpetiformis (senile) dermatitis.
The drug should not be used for hypothyroidism, except in cases where the development of the latter is caused by severe iodine deficiency. The use of the drug should be avoided during therapy with radioactive iodine, the presence or suspicion of thyroid cancer.
Use during pregnancy and breastfeeding
During pregnancy and breastfeeding, the need for iodine increases, so it is especially important to use the drug Yodomarin® 100 in sufficient doses to ensure adequate intake of iodine into the body. Potassium iodide passes through the placenta and into breast milk. If a nursing woman takes potassium iodide, additional administration of the drug to breastfed infants is not required.
The use of the drug during pregnancy and breastfeeding is possible only in recommended doses. When carrying out therapy, it is necessary to take into account the amount of iodine supplied with food.
Directions for use and doses
When determining the required dose of Yodomarin® 100, regional and individual characteristics of iodine intake from food must be taken into account. This is especially important when prescribing the drug to newborns and children under 4 years of age.
Prevention of iodine deficiency diseases: Newborns and children:
50-100 mcg of iodine per day (1/2 - 1 tablet of Yodomarin® 100);
Adolescents and adults:
100-200 mcg of iodine per day (1-2 tablets of Yodomarin® 100);
During pregnancy and breastfeeding:
100-200 mcg of iodine per day (1-2 tablets of Yodomarin® 100).
Prevention of goiter relapse after its surgical removal or after completion of goiter treatment with thyroid hormone preparations: 100-200 mcg of iodine daily (1-2 tablets of the drug Yodomarin® 100).
Treatment of euthyroid goiter: Newborns and children:
100-200 mcg of iodine per day (1-2 tablets of Iodomarin® 100);
Adolescents and young adult patients:
200 mcg of iodine per day (2 tablets of Iodomarin® 100).
The daily dose of the drug should be taken in one dose, after meals, with a sufficient amount of liquid. When prescribing the drug to newborns and children under 3 years of age, it is recommended to dissolve the tablet in a small amount (1 tablespoon) of boiled water at room temperature.
The use of the drug for prophylactic purposes is carried out for, as a rule, several months or years, and often throughout life.
For the treatment of goiter in newborns, in most cases, 2-4 weeks are sufficient; in children, adolescents and adults it usually takes 6-12 months or more.
The duration of treatment is determined by the doctor.
Side effect
Rarely, allergic reactions may occur: skin rash, Quincke's edema.
Overdose
Symptoms:
staining of the mucous membranes brown, reflex vomiting (if there are starch-containing components in the food, the vomit becomes blue), abdominal pain and diarrhea (blood may be present in the stool). In severe cases, dehydration and shock may develop. In rare cases, esophageal stenosis has occurred. Cases of death were observed only after taking large amounts of iodine (30-250 ml of iodine tincture).
In rare cases, long-term overdose of potassium iodide can lead to the development of so-called “iodism”, i.e. iodine intoxication: metallic taste in the mouth, swelling and irritation of the mucous membranes (runny nose, conjunctivitis, gastroenteritis, bronchitis). Potassium iodide can activate latent inflammatory processes such as tuberculosis. Possible development of edema, erythema, acne-like and bullous rash, hemorrhage, fever and irritability.
Treatment for acute intoxication:
gastric lavage with a solution of starch, protein or 5% sodium thiosulfate solution until all traces of iodine are removed. Symptomatic treatment of water-electrolyte imbalances, anti-shock therapy.
Treatment for chronic intoxication:
withdrawal of potassium iodide.
Treatment of iodine-induced hypothyroidism:
abolition of potassium iodide, normalization of metabolism with the help of thyroid hormones.
Treatment of iodine-induced thyrotoxicosis:
for mild forms of treatment is not required; in severe forms, thyreostatic therapy is required (the effect of which is always delayed). In severe cases (thyrotoxic crisis), intensive therapy, plasmapheresis or thyroidectomy are necessary.
In the case of hyperthyroidism, we cannot talk about an overdose as such, since hyperthyroidism can be caused by an amount of iodine that is normal in other countries.
Interaction with other drugs
Iodine deficiency increases, and iodine excess decreases, the effectiveness of hyperthyroidism treatment with antithyroid drugs. Therefore, before or during treatment for hyperthyroidism, it is recommended to avoid any iodine intake if possible. On the other hand, antithyroid drugs inhibit the conversion of iodine into an organic compound in the thyroid gland and, thus, can cause the formation of goiter.
Substances that enter the thyroid gland through the same mechanism as iodides can compete with iodine and inhibit its uptake by the thyroid gland (for example, perchlorate, which also inhibits the recycling of iodides within the thyroid gland). Iodine absorption may also be reduced when using drugs that do not themselves enter the thyroid gland, for example, thiocyanate in concentrations exceeding 5 mg/dl.
Iodine uptake by the thyroid gland and its metabolism are stimulated by endogenous and exogenously administered thyroid-stimulating hormone (TSH).
Simultaneous treatment with high doses of iodine and lithium salts can contribute to the occurrence of goiter and hypothyroidism. High doses of potassium iodide in combination with potassium-sparing diuretics can lead to hyperkalemia.
special instructions
It should be taken into account that during drug therapy in patients with renal failure, hyperkalemia may develop. Before starting therapy, it is necessary to exclude the presence of hyperthyroidism or nodular toxic goiter in the patient, as well as a history of these diseases. If there is a predisposition to autoimmune thyroid diseases, the formation of antibodies to thyroid peroxidase is possible. Saturation of the thyroid gland with iodine can prevent the accumulation of radioactive iodine used for therapeutic or diagnostic purposes. In this regard, it is not recommended to take the drug before carrying out activities using radioactive iodine.
Impact on the ability to drive vehicles and other mechanisms
The use of the drug Iodomarin® 100 does not affect the ability to drive vehicles and machines.
Release form
Tablets 0.1 mg. 50 or 100 tablets in dark glass bottles, with a polyethylene plug cap with a shock absorber. 1 bottle with instructions for use of the drug in a cardboard box.
Storage conditions
At a temperature not higher than 25 °C. Keep out of the reach of children!
Best before date
3 years. Do not use after expiration date.
Vacation conditions
Available without a prescription.
Manufacturer
Berlin-Chemie AG Tempelhofer Weg 83 12347 Berlin Germany or Menarini-Von Heyden GmbH Leipziger Strasse 7-13 01097 Dresden Germany
Organization receiving complaints from consumers:
LLC "Berlin-Chemie/A. Menarini", Russia 123112, Moscow, Presnenskaya embankment, 10, Business Center "Tower on Naberezhnaya", Block B, tel., fax.
Interaction with other drugs
Iodine deficiency increases, and iodine excess decreases, the effectiveness of hyperthyroidism treatment with antithyroid drugs. Therefore, before or during treatment for hyperthyroidism, it is recommended to avoid any iodine intake if possible. On the other hand, antithyroid drugs inhibit the conversion of iodine into an organic compound in the thyroid gland and, thus, can cause the formation of goiter.
Substances that enter the thyroid gland through the same mechanism as iodides can compete with iodine and inhibit its uptake by the thyroid gland (for example, perchlorate, which also inhibits the recycling of iodides within the thyroid gland). Iodine absorption may also be reduced when using drugs that do not themselves enter the thyroid gland, for example, thiocyanate in concentrations exceeding 5 mg/dl.
Iodine uptake by the thyroid gland and its metabolism are stimulated by endogenous and exogenously administered thyroid-stimulating hormone (TSH).
Simultaneous treatment with high doses of iodine and lithium salts can contribute to the occurrence of goiter and hypothyroidism. High doses of potassium iodide in combination with potassium-sparing diuretics can lead to hyperkalemia.
special instructions
It should be taken into account that during drug therapy in patients with renal failure, hyperkalemia may develop. Before starting therapy, it is necessary to exclude the presence of hyperthyroidism or nodular toxic goiter in the patient, as well as a history of these diseases. If there is a predisposition to autoimmune thyroid diseases, the formation of antibodies to thyroid peroxidase is possible. Saturation of the thyroid gland with iodine can prevent the accumulation of radioactive iodine used for therapeutic or diagnostic purposes. In this regard, it is not recommended to take the drug before carrying out activities using radioactive iodine.
