Amoxicillin Sandoz®
Before starting amoxicillin therapy, the patient should be interviewed in detail regarding previous hypersensitivity reactions to penicillins, cephalosporins and other beta-lactams.
In patients who are hypersensitive to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.
Serious hypersensitivity reactions (including anaphylactoid and severe cutaneous adverse reactions), sometimes fatal, have been reported in patients receiving penicillin therapy. The development of these reactions is more likely in persons with a history of hypersensitivity to penicillin, as well as in persons with atopy. If an allergic reaction occurs, discontinue amoxicillin therapy and institute appropriate alternative treatment.
There have been rare cases of hypersensitivity reactions such as allergic acute coronary syndrome (Kounis syndrome), in the event of which, when taken together with amoxicillin, appropriate treatment is required.
During treatment, it is necessary to monitor the state of function of the hematopoietic organs, liver and kidneys. Increased activity of liver enzymes and changes in the number of blood cells were reported.
With long-term use, cases of superinfection and candidiasis (especially vulvovaginal candidiasis) may develop.
When taking almost all antibacterial drugs, it is possible to develop antibiotic-associated colitis up to a life-threatening condition. This should be taken into account if diarrhea occurs during antibiotic therapy or after its completion. If antibiotic-associated colitis develops, drug therapy should be stopped immediately and the attending physician should be consulted to prescribe appropriate treatment. The use of drugs that inhibit intestinal motility is contraindicated.
The occurrence of generalized erythema with fever accompanied by pustules at the beginning of therapy may be a symptom of acute generalized exanthematous pustulosis (AGEP). This adverse drug reaction requires discontinuation of treatment with amoxicillin and is a contraindication for its further use in any situation.
The use of amoxicillin should be avoided if the patient is suspected of developing infectious mononucleosis, since its use during treatment of this disease can lead to the appearance of a measles-like rash.
The Jarisch-Herxheimer reaction has been observed following the use of amoxicillin in patients with Lyme disease. Its direct cause is the bactericidal activity of amoxicillin against the bacteria that cause Lyme disease, the spirochete Borrelia burgdorferi.
Patients should be reassured that this reaction is a common and usually self-limiting consequence of antibiotic use in patients with Lyme disease.
Treatment must continue for 48-72 hours after the disappearance of clinical signs of the disease.
Convulsions may occur in patients with impaired renal function or in patients receiving high doses of the drug or with predisposing factors (for example, a history of seizures, treatment for epilepsy, or meningitis).
In case of renal failure, it is necessary to adjust the dosage regimen depending on the degree of renal failure.
In patients with reduced diuresis, crystalluria was very rarely observed, mainly during parenteral therapy. When using high doses
Amoxicillin is recommended to maintain adequate fluid intake and diuresis to reduce the possibility of crystalluria associated with the use of the drug. In patients with a catheterized bladder, catheter patency should be checked regularly.
Increased prothrombin time has been rarely reported in patients receiving amoxicillin. Patients who are indicated for simultaneous use of indirect anticoagulants should be observed by a specialist. Dose adjustment of indirect anticoagulants may be necessary. There is a possibility that increased concentrations of amoxicillin in serum and urine may influence the results of some laboratory tests. When using chemical methods, high concentrations of amoxicillin in the urine may cause false-positive test results.
To determine the presence of glucose in urine during treatment with amoxicillin, it is recommended to use enzymatic glucose oxidase methods. The use of amoxicillin may distort the results of the quantitative determination of estriol in pregnant women.
It is necessary to use the drug with caution in the elderly, pregnant women, and during lactation.
When using amoxicillin to treat Helicobacter pylori infections, you should take into account the information provided in the text of the instructions for medical use of other concomitantly used drugs.
Special precautions when disposing of unused drug
There is no need for special precautions when disposing of unused drug.
Buy Amoxicillin Sandoz film-coated tablets 1000 mg No. 12 in pharmacies
Amoxicillin Sandoz Buy Amoxicillin Sandoz in pharmacies DOSAGE FORMS film- coated tablets 1000 mg
MANUFACTURERS Sandoz GmbH (Austria)
GROUP Antibiotics of the penicillin group
INTERNATIONAL NON-PROPENTED NAME Amoxicillin
SYNONYMS Amoxisan, Amoxicillin, Amoxicillin DS, Amoxicillin trihydrate, Amoxicillin sodium salt sterile, Amosin, Clamoxil LA, Ospamox, Flemoxin Solutab, Hiconcil, Ecobol
PHARMACOLOGICAL ACTION Antibacterial (bactericidal). Stable in an acidic environment, food intake does not affect absorption. Easily passes histohematic barriers, except for the unchanged BBB, and penetrates most tissues and organs; accumulates in therapeutic concentrations in peritoneal fluid, urine, contents of skin blisters, pleural effusion, lungs, intestinal mucosa, female genital organs, middle ear fluid, gall bladder and bile, fetal tissues. Partially metabolized to form inactive metabolites, excreted unchanged by the kidneys and liver. A small amount is excreted in breast milk. The action develops 15-30 minutes after administration and lasts 8 hours. It has a wide spectrum of antimicrobial action, including Staphylococcus spp., except for penicillinase-producing strains, Streptococcus spp., Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Proteus mirabilis, some Salmonella strains , Shigella, Klebsiella and Haemophilus influenzae.
INDICATIONS FOR USE Infections of the respiratory tract and ENT organs (bronchitis, pneumonia, tonsillitis, acute otitis media, pharyngitis, sinusitis), genitourinary system (urethritis, cystitis, pyelonephritis, endometritis, uncomplicated gonorrhea), skin and soft tissues, gastrointestinal tract (peritonitis, enterocolitis, cholecystitis, cholangitis, typhoid fever); leptospirosis, listeriosis, meningitis, Lyme disease (borreliosis), prevention of endocarditis and surgical infection; combination therapy of gastritis and peptic ulcer (in combination with metronidazole), sepsis (in combination with aminoglycosides).
CONTRAINDICATIONS Hypersensitivity (including to other penicillins, cephalosporins, carbapenems), allergic diathesis, bronchial asthma, hay fever, infectious mononucleosis, lymphocytic leukemia, history of gastrointestinal diseases (especially colitis associated with the use of antibiotics).
SIDE EFFECTS Nausea, vomiting, diarrhea, pain in the anus, stomatitis, glossitis; agitation, anxiety, insomnia, confusion, behavior changes, headache, dizziness, convulsive reactions; difficulty breathing, tachycardia; joint pain; interstitial nephritis; dysbiosis, superinfection, oral or vaginal candidiasis, pseudomembranous or hemorrhagic colitis; moderate increase in the level of transaminases in the blood, transient anemia, thrombocytopenic purpura, eosinophilia, leukopenia, neutropenia and agranulocytosis; allergic reactions: exfoliative dermatitis, exudative erythema multiforme, Stevens-Johnson syndrome, anaphylactic shock, maculopapular rash, itching, urticaria, Quincke's edema, reactions similar to serum sickness.
INTERACTION Reduces the effect of estrogen-containing oral contraceptives, reduces clearance and increases the toxicity of methotrexate. Enhances the absorption of digoxin. Excretion is slowed down by probenecid, sulfinpyrazone, acetylsalicylic acid, indomethacin, oxyphenbutazone, phenylbutazone and other drugs that suppress tubular secretion. Antibacterial activity is reduced by bacteriostatic chemotherapeutic agents and antacids, and increased by aminoglycosides and metronidazole. Allopurinol - increases the occurrence of skin rashes.
METHOD OF APPLICATION AND DOSAGE Set individually depending on the severity and localization of the infection, the sensitivity of the pathogen. The duration of treatment depends on the severity of the disease and the effectiveness of therapy.
OVERDOSE Symptoms: nausea, vomiting, diarrhea, water and electrolyte imbalance. Treatment: gastric lavage, administration of activated carbon, saline laxatives, correction of water and electrolyte balance; hemodialysis.
SPECIAL INSTRUCTIONS Use with caution for urticaria and hay fever. Renal, liver and hematopoiesis function should be periodically monitored during long-term therapy. Treatment must be continued for 48-72 hours after the disappearance of clinical signs of the disease. During pregnancy and lactation, it is used for health reasons, taking into account the expected effect for the mother and the potential risk for the fetus or child. During the course, breastfeeding is excluded. It should be taken into account that the granules when preparing the suspension contain sugar. When determining glucose in urine, false positive results and changes in the results of determining urobilinogen are possible. For more information, see the naming instructions.
STORAGE CONDITIONS Store in a cool, dry place at room temperature, away from children.
Amoxicillin Sandoz tablet p/o film 500mg 12 pcs
Before prescribing Amoxicillin Sandoz®, you must make sure that the strains of microorganisms that cause the infectious disease are sensitive to the drug. In case of severe infectious and inflammatory processes of the gastrointestinal tract, accompanied by prolonged diarrhea or nausea, it is not recommended to take Amoxicillin Sandoz® orally due to possible low absorption of the drug.
When treating mild diarrhea during a course of treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; You can use kaolin- or attapulgite-containing antidiarrheal drugs. If diarrhea is severe, consult a doctor.
If severe persistent diarrhea develops, the development of pseudomembranous colitis (caused by Clostridium difficile) should be excluded. In this case, Amoxicillin Sandoz® should be discontinued and appropriate treatment prescribed. In this case, drugs that slow down gastrointestinal motility are contraindicated.
During a course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.
It is possible that superinfection may develop due to the growth of microflora that is insensitive to it, which requires a corresponding change in antibacterial therapy.
In patients who are hypersensitive to penicillins, cross-allergic reactions with other beta-lactam antibiotics are possible.
Treatment must continue for another 48-72 hours after the disappearance of clinical signs of the disease.
When using estrogen-containing oral contraceptives and amoxicillin simultaneously, other or additional methods of contraception should be used if possible.
Amoxicillin Sandoz® is not recommended for the treatment of acute respiratory viral infectious diseases due to low effectiveness.
Particular caution is recommended for patients with allergic diathesis or bronchial asthma, or a history of gastrointestinal diseases (in particular, colitis caused by antibiotic treatment). When taking Amoxicillin Sandoz® for a long time, nystatin, levorin or other antifungal drugs should be prescribed simultaneously.
It is not recommended to consume ethanol during treatment.
The use of Amoxicillin Sandoz® does not affect the results of the enzymatic test for glycosuria, however, false-positive results of a urine test for glucose are possible.
While taking Amoxicillin Sandoz®, it is recommended to drink plenty of fluids to prevent the formation of amoxicillin crystals in the urine.
Impact on the ability to drive vehicles and perform other activities that require concentration and speed of psychomotor reactions.
Due to the potential for side effects such as drowsiness, headache and confusion, caution should be exercised when engaging in potentially hazardous activities that require increased concentration and psychomotor speed.
Amoxicillin Sandoz
The incidence of side effects is given in accordance with the following scale: very common - more than 10%, common - from 1 to 10%, infrequent - from 0.1% to 1%, rare - from 0.01 to 0.1%, very rare - less
From the cardiovascular system: frequent: tachycardia, phlebitis; rare: decreased blood pressure; very rare: prolongation of the QT interval.
Blood and lymphatic system disorders, common: eosinophilia, leukopenia; rare: neutropenia, thrombocytopenia, agranulocytosis; very rare: anemia (including hemolytic), thrombocytopenic purpura, pancytopenia.
From the nervous system: frequent: drowsiness, headache, dizziness; rare: nervousness, agitation, anxiety, ataxia, behavior changes, peripheral neuropathy, restlessness, sleep disturbance, depression, paresthesia, tremor, confusion, convulsions; very rare: hypersthesia, impaired vision, smell and tactile sensitivity, hallucinations.
From the genitourinary system: rare: interstitial nephritis, increased concentration of creatinine in the blood serum.
From the gastrointestinal tract and liver: dysbacteriosis, taste changes, stomatitis, glossitis; common: nausea, diarrhea, increased liver parameters (ALT, AST, alkaline phosphatase, gamma-glutamyltransferase), increased bilirubin concentration in the blood serum; rare: vomiting, dyspepsia, epigastric pain, hepatitis, cholestatic jaundice; very rare: acute liver failure, diarrhea mixed with blood, pseudomembranous colitis, the appearance of a black color of the tongue.
From the musculoskeletal system: rare: arthralgia, myalgia, tendon diseases including tendinitis; very rare: tendon rupture (possible bilaterally and 48 hours after the start of treatment), muscle weakness, rhabdomyolysis.
Skin disorders: common: pruritis, rash; rare: urticaria; very rare: photosensitivity, swelling of the skin and mucous membranes, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
From the endocrine system: rare: anorexia; very rare: hypoglycemia, especially in patients with diabetes mellitus.
From the respiratory system: rare: bronchospasm, dyspnea; very rare: allergic pneumonitis.
General: rare: general weakness; very rare: increased body temperature.
Other: difficulty breathing, vaginal candidiasis; rare: superinfection (especially in patients with chronic diseases or reduced body resistance), reactions similar to serum sickness; isolated cases: anaphylactic shock.
An overdose may be manifested by symptoms such as nausea, vomiting, diarrhea, water and electrolyte imbalance, nephrotoxicity, crystaluria, and epileptic seizures. To treat an overdose, the use of activated carbon, symptomatic therapy, correction of water-electrolyte imbalance, and possible hemodialysis are indicated.
