Buy MIG film-coated tablets 400 mg No. 20 in pharmacies

Pharmacodynamics and pharmacokinetics

Mig 400 tablets contain ibuprofen , which is an analgesic with antipyretic and anti-inflammatory properties. It indiscriminately inhibits COX-1 and COX-2 , as well as prostaglandin .

The analgesic properties of the drug are most pronounced in cases of inflammatory pain. The analgesic effect is not of the narcotic type.

After taking the tablets orally, the medicine is well absorbed from the gastrointestinal tract. The maximum plasma concentration of the active ingredient is reached approximately 120 minutes after taking tablets at a dosage of 400 mg.

99% bound to plasma The active component is slowly distributed in the synovial fluid . It is biotransformed in the liver through carboxylation and hydroxylation of the isobutyl group. Pharmacologically inactive metabolites .

Plasma half-life is 2-3 hours. in the form of metabolites and their conjugates . A small part of the drug is excreted unchanged in urine and bile.

How Mig works

The action of the drug is based on ibuprofen. This substance is from the group of non-steroidal anti-inflammatory drugs of the first group. Mig relieves pain well, especially pain in bones and joints, as well as headaches and toothaches, so it is often chosen as a painkiller for fractures and dislocations.

At the same time, due to its ability to relieve inflammation, Mig can be used as an analgesic for pain of inflammatory etiology.

An excellent antipyretic, Mig effectively reduces body temperature when needed. Acting directly on the thermoregulation center, it restores the processes of heat production and release. If you take a headache pill when your body temperature does not exceed normal values, the drug will not affect the thermometer readings.

It is important to remember that taking antipyretics is indicated only when the body temperature has risen above 38.5℃. Exceptions may be cases when the patient experiences febrile convulsions even at a value of 37℃.

Indications for use

The drug is indicated for use for:

• headache;
• toothache;
• pain in muscles and joints;
• fever due to colds and flu ;
• migraine;
• neuralgia;
• menstrual pain.

If you need to find out why Mig 400 tablets will help in each specific case, it is advisable to consult a doctor.

Contraindications

This product is prohibited for use when:

• hemorrhagic diathesis;
• hypersensitivity to the components of the drug;
• erosive and ulcerative lesions of the gastrointestinal tract;
• hemophilia and other bleeding ;
• pregnancy;
• under 12 years of age;
• breastfeeding;
• history of a negative reaction to acetylsalicylic acid and other NSAIDs ;
• aspirin asthma;
• bleeding;
• deficiency of glucose-6-phosphate dehydrogenase ;
• diseases of the optic nerve.

The medicine should be used with caution in the elderly, as well as in cases of arterial hypertension , liver or kidney failure , hyperbilirubinemia , gastritis , colitis , heart failure , liver cirrhosis with portal hypertension , nephrotic syndrome , gastric and duodenal ulcers (including a history ), enteritis , blood diseases.

Instructions

Registration number: LS-002211-021121

Trade name: MIG® 400

International nonproprietary name: ibuprofen

Dosage form: film-coated tablets

Composition per 1 tablet:

Core:

Active ingredient: ibuprofen - 400.00 mg.

Excipients: corn starch, anhydrous colloidal silicon dioxide, sodium carboxymethyl starch (type A), magnesium stearate.

Film coating : hypromellose (viscosity 6 mPas), macrogol 4000, povidone (K value = 30), titanium dioxide (E 171).

Description

Oval, film-coated tablets, white or almost white, with a double-sided scoring line and embossed on one side with an “E” and an “E” on either side of the scoring line.

Pharmacotherapeutic group: Non-steroidal anti-inflammatory drug (NSAID)

ATX code: M01AE01

Pharmacological properties

Pharmacodynamics

The mechanism of action of ibuprofen, a derivative of propionic acid from the group of non-steroidal anti-inflammatory drugs (NSAIDs), is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction. Indiscriminately blocks cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), as a result of which it inhibits the synthesis of prostaglandins. It has a rapid, targeted effect against pain (analgesic), antipyretic and anti-inflammatory effects. In addition, ibuprofen reversibly inhibits platelet aggregation. The analgesic effect of the drug lasts up to 8 hours.

Pharmacokinetics

Absorption is high, quickly and almost completely absorbed from the gastrointestinal tract (GIT). After taking the drug on an empty stomach, the maximum concentration (Cmax) of ibuprofen in the blood plasma is reached after 45 minutes.

Taking the drug with food may increase the time to reach maximum concentration (TCmax) by up to 1-2 hours. Communication with blood plasma proteins - 90%. Slowly penetrates into the cavities of the joints, lingers in the synovial fluid, creating higher concentrations in it than in the blood plasma. Lower concentrations of ibuprofen are found in cerebrospinal fluid compared to blood plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. Metabolized in the liver. The half-life (T1/2) is 2 hours. It is excreted by the kidneys (no more than 1% unchanged) and, to a lesser extent, with bile.

In limited studies, ibuprofen has been found in breast milk at very low concentrations.

Indications for use

The drug MIG® 400 is used for headaches and toothaches, migraines, painful menstruation, neuralgia, back pain, joint pain, muscle and rheumatic pain, as well as fever due to influenza and colds.

Contraindications

• hypersensitivity to ibuprofen or any of the components included in the drug;
• complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history);
• erosive and ulcerative diseases of the gastrointestinal tract (including gastric and duodenal ulcers, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or ulcerative bleeding);
• a history of bleeding or perforation of a gastrointestinal ulcer caused by the use of NSAIDs;
• severe heart failure (class IV according to the New York Heart Association (NYHA) classification);
• severe liver failure or active liver disease;
• severe renal failure (creatinine clearance <30 ml/min); confirmed hyperkalemia;
• decompensated heart failure; period after coronary artery bypass surgery;
• cerebrovascular or other bleeding;
• hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis;
• pregnancy more than 20 weeks;
• children under 6 years of age.

Carefully

If you have the conditions listed in this section, you should consult your doctor before using the drug.

Concomitant use of other NSAIDs, a history of a single episode of gastric ulcer or ulcerative bleeding of the gastrointestinal tract, gastritis, enteritis, colitis, the presence of Helicobacter pylori infection, allergic diseases in the acute stage or a history - the development of bronchospasm, systemic lupus erythematosus or mixed connective tissue disease is possible (Sharpe's syndrome) - increased risk of aseptic meningitis, chickenpox, renal failure, including dehydration (creatinine clearance 30-60 ml/min), nephrotic syndrome, liver failure, liver cirrhosis with portal hypertension, hyperbilirubinemia, arterial hypertension and/ or heart failure, cerebrovascular diseases, blood diseases of unknown etiology (leukopenia and anemia), severe somatic diseases, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol consumption, phenylketonuria or phenylalanine intolerance, simultaneous use of drugs that may increase the risk of ulceration or bleeding, in particular oral corticosteroids (including prednisolone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel), pregnancy up to 20 weeks, breastfeeding, old age, children under 12 years of age.

Use during pregnancy and breastfeeding

NSAIDs should not be used by women from the 20th week of pregnancy due to the possible development of oligohydramnios and/or kidney pathology in newborns (neonatal renal dysfunction). You should avoid using the drug before 20 weeks of pregnancy; if you need to use the drug, you should consult your doctor.

There is evidence that ibuprofen can pass into breast milk in small quantities without any adverse effects on the health of the nursing infant, so there is usually no need to stop breastfeeding when taken for a short period of time. If long-term use of the drug is necessary, you should consult a doctor to decide whether to stop breastfeeding for the period of use of the drug.

Directions for use and doses

To relieve symptoms, the lowest effective dose should be used for the shortest time (see section "Special Instructions").

For oral administration. Patients with hypersensitivity of the stomach are recommended to take the drug with meals. For short term use only. The tablets should be taken with water. Read the instructions carefully before taking the drug.

Adults and children over 12 years old

200 mg (1/2 tablet) 3-4 times a day.

To achieve a rapid therapeutic effect in adults, the single dose can be increased to 1 tablet (400 mg) 3 times a day. When taking 400 mg (1 tablet), the interval between doses of the drug should be at least 6 hours.

Children aged 6 to 12 years (weighing more than 20 kg)

200 mg (1/2 tablet) 3-4 times a day. The drug can only be used if the child’s body weight is more than 20 kg.

The interval between taking tablets should be at least 6 hours.

Taking the drug in a single dose of 400 mg is not approved for use in children under 12 years of age. The maximum daily dose for adults is 1200 mg.

The maximum daily dose for children from 6 to 18 years of age is 800 mg.

If symptoms persist or worsen after taking the drug for 2-3 days, you should stop treatment and consult a doctor.

Side effect

The risk of adverse reactions can be minimized if the drug is taken in a short course, at the minimum effective dose required to eliminate symptoms.

Elderly people experience an increased incidence of adverse reactions due to the use of NSAIDs, especially gastrointestinal bleeding and perforation, in some cases fatal.

Adverse reactions are predominantly dose-dependent. In particular, the risk of gastrointestinal bleeding depends on the dose range and duration of treatment.

The following adverse reactions were observed with short-term use of ibuprofen in doses not exceeding 1200 mg/day (3 tablets). When treating chronic conditions and with long-term use, other adverse reactions may occur.

The frequency of occurrence of adverse reactions was assessed based on the following criteria: very often (≥ 1/10), often (from ≥ 1/100 to < 1/10), infrequently (from ≥ 1/1000 to < 1/100), rarely ( from ≥ 1/10,000 to < 1/1000), very rare (< 1/10,000), frequency unknown (insufficient data to estimate frequency).

Blood and lymphatic system disorders

Very rare: hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial ulcers in the mouth, “flu-like” symptoms, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology.

Immune system disorders

Uncommon: hypersensitivity reactions - nonspecific allergic reactions and anaphylactic reactions, reactions from the respiratory tract (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura, Quincke's edema, exfoliative and bullous dermatoses , including toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, erythema multiforme), allergic rhinitis, eosinophilia.

Very rare: severe general hypersensitivity reactions, including swelling of the face, tongue and larynx, shortness of breath, tachycardia, hypotension (anaphylaxis, Quincke's edema or severe anaphylactic shock).

Skin and subcutaneous tissue disorders

Frequency unknown: acute generalized exanthematous pustulosis (AGEP), photosensitivity reactions.

Gastrointestinal disorders

Uncommon: abdominal pain, nausea, dyspepsia (including heartburn, bloating).

Rarely: diarrhea, flatulence, constipation, vomiting.

Very rare: peptic ulcer, perforation or gastrointestinal bleeding, melena, hematemesis, in some cases fatal, especially in elderly patients, ulcerative stomatitis, gastritis.

Frequency unknown: exacerbation of colitis and Crohn's disease.

Disorders of the liver and biliary tract

Very rare: liver dysfunction, increased activity of liver transaminases, hepatitis and jaundice.

Renal and urinary tract disorders

Very rare: acute renal failure (compensated and decompensated), especially with long-term use, in combination with an increase in the concentration of urea in the blood plasma and the appearance of edema, hematuria and proteinuria, nephritic syndrome, nephrotic syndrome, papillary necrosis, interstitial nephritis, cystitis.

Nervous system disorders

Uncommon: headache.

Very rare: aseptic meningitis.

Cardiovascular disorders

Frequency unknown: heart failure, peripheral edema, with long-term use there is an increased risk of thrombotic complications (for example, myocardial infarction), increased blood pressure.

Disorders of the respiratory system and mediastinal organs

Frequency unknown: bronchial asthma, bronchospasm, shortness of breath.

Laboratory indicators

• hematocrit or hemoglobin (may decrease);
• bleeding time (may increase);
• plasma glucose concentration (may decrease);
• creatinine clearance (may decrease);
• plasma creatinine concentration (may increase);
• activity of “liver” transaminases (may increase).

If adverse reactions occur, you should stop taking the drug and consult a doctor.

Overdose

In children, overdose symptoms may occur after taking a dose exceeding 400 mg/kg body weight. In adults, the dose-dependent effect of overdose is less pronounced. The half-life of the drug in case of overdose is 1.5-3 hours.

Symptoms: nausea, vomiting, epigastric pain or, less commonly, diarrhea, tinnitus, headache and gastrointestinal bleeding. In more severe cases, manifestations from the central nervous system are observed: drowsiness, rarely - agitation, convulsions, disorientation, coma. In cases of severe poisoning, metabolic acidosis and increased prothrombin time, renal failure, liver tissue damage, decreased blood pressure, respiratory depression and cyanosis may develop. In patients with bronchial asthma, exacerbation of this disease is possible.

Treatment: symptomatic, with mandatory maintenance of airway patency, monitoring of ECG and vital signs until the patient’s condition is normalized. Oral use of activated charcoal or gastric lavage is recommended within 1 hour after taking a potentially toxic dose of ibuprofen. If ibuprofen has already been absorbed, an alkaline drink may be prescribed in order to eliminate the acidic derivative of ibuprofen by the kidneys, forced diuresis. Frequent or prolonged seizures should be treated with intravenous diazepam or lorazepam. In case of exacerbation of bronchial asthma, the use of bronchodilators is recommended.

Interaction with other drugs

The simultaneous use of ibuprofen with the following drugs should be avoided:

Acetylsalicylic acid: with the exception of low doses of acetylsalicylic acid (no more than 75 mg per day) prescribed by a doctor, since simultaneous use may increase the risk of adverse reactions. With simultaneous use, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (after starting ibuprofen in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent, the incidence of acute coronary insufficiency may increase).

Other NSAIDs, in particular selective COX-2 inhibitors: the simultaneous use of two or more drugs from the NSAID group should be avoided due to a possible increased risk of adverse reactions.

Use with caution simultaneously with the following medications:

Anticoagulants and thrombolytic drugs: NSAIDs may enhance the effect of anticoagulants, in particular warfarin and thrombolytic drugs.

Antihypertensives (ACE inhibitors and angiotensin II antagonists) and diuretics: NSAIDs may reduce the effectiveness of drugs in these groups. In some patients with impaired renal function (eg, dehydrated patients or elderly patients with impaired renal function), concomitant use of ACE inhibitors or angiotensin II antagonists and cyclooxygenase inhibitors may lead to a deterioration of renal function, including the development of acute renal failure. (usually reversible). These interactions should be considered in patients taking coxibs concomitantly with ACE inhibitors or angiotensin II antagonists. In this regard, the simultaneous use of the above drugs should be prescribed with caution, especially in the elderly. Patients should be prevented from dehydration and consideration should be given to monitoring renal function upon initiation of this combination treatment and periodically thereafter. Diuretics and ACE inhibitors may increase the nephrotoxicity of NSAIDs.

Glucocorticosteroids: increased risk of gastrointestinal ulceration and gastrointestinal bleeding.

Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding.

Cardiac glycosides: simultaneous use of NSAIDs and cardiac glycosides can lead to worsening heart failure, a decrease in glomerular filtration rate and an increase in the concentration of cardiac glycosides in the blood plasma.

Lithium preparations: there is evidence of the likelihood of an increase in the concentration of lithium in the blood plasma during the use of NSAIDs.

Methotrexate: there is evidence of the likelihood of an increase in the concentration of methotrexate in the blood plasma during the use of NSAIDs.

Cyclosporine: Increased risk of nephrotoxicity with concomitant use of NSAIDs and cyclosporine.

Mifepristone: NSAIDs should be started no earlier than 8 to 12 days after taking mifepristone, as NSAIDs may reduce the effectiveness of mifepristone.

Tacrolimus: Concomitant use of NSAIDs and tacrolimus may increase the risk of nephrotoxicity.

Zidovudine: Concomitant use of NSAIDs and zidovudine may result in increased hematotoxicity. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received concomitant treatment with zidovudine and ibuprofen.

Quinolone antibiotics: Patients receiving concomitant treatment with NSAIDs and quinolone antibiotics may have an increased risk of seizures.

Myelotoxic drugs: enhance the manifestations of hematotoxicity of the drug.

Caffeine: enhances the analgesic effect.

special instructions

To relieve symptoms, the lowest effective dose should be used for the shortest time.

In patients with bronchial asthma or an allergic disease in the acute stage, as well as in patients with a history of bronchial asthma/allergic disease, the drug may provoke bronchospasm. Use of the drug in patients with systemic lupus erythematosus or mixed connective tissue disease is associated with an increased risk of developing aseptic meningitis.

During long-term treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a complete blood count (hemoglobin determination), and a stool test for occult blood. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study. During the treatment period, ethanol intake is not recommended.

Patients with renal failure should consult a doctor before using the drug, as there is a risk of deterioration in the functional state of the kidneys.

Patients with hypertension, including a history of hypertension and/or chronic heart failure, should consult a physician before using the drug, as the drug may cause fluid retention, increased blood pressure, and edema.

In patients with uncontrolled hypertension, NYHA class II-III congestive heart failure, coronary artery disease, peripheral arterial disease and/or cerebrovascular disease, ibuprofen should be prescribed only after a careful benefit-risk assessment, and high doses of ibuprofen should be avoided (≥ 2400 mg/day).

In rare cases, serious skin reactions (some of which have been fatal), including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, have been observed with the use of NSAIDs. Apparently, patients are at greatest risk at the beginning of treatment, because In most patients, these reactions developed in the first month of therapy. There have been reports of cases of acute generalized exanthematous pustulosis (AGEP) associated with the use of drugs containing ibuprofen. At the first appearance of a skin rash, damage to the mucous membranes or any other signs of hypersensitivity, the use of MIG® 400 should be discontinued.

The use of NSAIDs in patients with chickenpox may be associated with an increased risk of developing severe purulent complications of infectious and inflammatory diseases of the skin and subcutaneous fat (for example, necrotizing fasciitis). In this regard, it is recommended to avoid using the drug for chickenpox.

Masking the symptoms of infectious diseases

MIG® 400 may mask important symptoms of infectious diseases, which may lead to delayed initiation of appropriate treatment and thereby worsen the outcome of the infectious disease. This has been observed in bacterial community-acquired pneumonia and in a bacterial complication of chickenpox. When MIG® 400 is used to relieve fever and pain caused by an infectious disease, monitoring the patient's condition is recommended. In an outpatient setting (outside the hospital), the patient should consult a doctor if symptoms persist or worsen.

Information for women planning pregnancy: such drugs suppress cyclooxygenase and prostaglandin synthesis, affect ovulation, disrupting female reproductive function (reversible after discontinuation of treatment).

The drug contains less than 1 mmol (23 mg) of sodium in 1 film-coated tablet, that is, it actually does not contain sodium.

Impact on the ability to drive vehicles and machinery

Patients who experience dizziness, drowsiness, lethargy, or blurred vision while taking ibuprofen should avoid driving or operating machinery.

Release form

Film-coated tablets, 400 mg. 10 tablets each in a blister pack (blister) made of PVC/aluminum foil. 1 or 2 blisters with instructions for use of the drug in a cardboard box.

Storage conditions

Store at a temperature not exceeding 25°C. Keep the medicine out of the reach of children!

Best before date

3 years. Do not use after the expiration date of the drug indicated on the package.

Vacation conditions

Available without a prescription.

Registration Certificate Holder

Berlin-Chemie AG, Germany

Manufacturer

Berlin - Chemie AG Tempelhofer Weg 83 12347, Berlin Germany or Menarini-Von Heiden GmbH Leipziger Strasse, 7-13 01097, Dresden Germany or Novartis Neva LLC Road to Kamenka, 40, bldg. 3 lit. Ah, lit. B St. Petersburg Russia

Organization receiving complaints from consumers:

LLC "Berlin-Chemie/A. Menarini", Russia 123112, Moscow, Presnenskaya embankment 10, Business Center "Tower on Naberezhnaya", Block B, tel., fax.

Side effects

The use of Mig 400 can lead to the following adverse reactions:

• Gastrointestinal tract: vomiting, pain in the abdomen, loss of appetite , nausea, flatulence , heartburn , diarrhea , constipation ;
• sensory organs: dry or irritated eyes, decreased hearing, toxic damage to the optic nerve, ringing or noise in the ears, blurred or double vision, swelling of the conjunctiva and eyelids;
• CVS: heart failure , high blood pressure , tachycardia ;
• allergies : rash, Quincke's edema , dyspnea , anaphylactic shock , erythema multiforme , eosinophilia , itching , anaphylactoid reactions , bronchospasm , fever , Lyell's syndrome , rhinitis ;
• changes in laboratory parameters: increased serum creatinine concentration , increased bleeding time, decreased hemoglobin , decreased creatinine clearance liver transaminase activity serum glucose , decreased hematocrit ;
• respiratory organs: shortness of breath , bronchospasm ;
• CNS: insomnia , headache , nervousness, psychomotor agitation , depression , hallucinations , dizziness , anxiety, irritability, drowsiness , impaired consciousness ;
• urinary system: allergic nephritis , acute renal failure , cystitis , nephrotic syndrome , polyuria ;
• hematopoietic system: thrombocytopenic purpura , anemia , leukopenia , thrombocytopenia , agranulocytosis .

In rare cases, ulceration of the gastrointestinal mucosa, pain in the mouth, aphthous stomatitis , hepatitis , irritation or dryness of the oral mucosa, ulceration of the gum mucosa, pancreatitis , and aseptic meningitis .

With prolonged use of the drug in high doses, the likelihood of ulceration of the gastrointestinal mucosa, visual impairment, and bleeding increases.

Using the drug for a hangover

The reason for the hangover syndrome is that when drinking alcoholic beverages, the body is poisoned by toxins and alcohol, the water-salt balance is disturbed, which results in swelling and severe thirst. A person suffers from a lack of fluid.

Using the drug for a hangover is strictly prohibited, since the reaction may be unexpected. Ibuprofen, which is included in the composition, when combined with alcohol, will lead to irritation of the gastrointestinal tract and disruption of the liver.

As a result, neurotoxic complications due to ethanol will occur. The patient may also experience visual hallucinations.

To treat a hangover, it is recommended to drink mineral water, sweet tea, and pickled cucumber brine. Simple liquids will help replenish micronutrient deficiencies and improve liver detoxification. A contrast shower with a combination of hot and cold water will improve the condition of blood vessels.

Adsorbent is taken from hangover tablets. It absorbs liquid and removes harmful components. Activated carbon is the most effective. It is taken at the rate of 2 tablets per 10 kg of weight.

Instructions for use Mig 400 (Method and dosage)

The medicine is used internally. For those who take Mig 400 tablets, the instructions for use indicate that dosages are set individually depending on the indications.

Usually start taking the medicine with 200 mg every day 3-4 times. If necessary, the dosage can be increased to 400 mg, which are taken 3 times a day. When the therapeutic effect is achieved, the daily dosage is reduced to 600-800 mg.

The instructions for use of Mig 400 advise that this product should not be taken for more than a week or in higher dosages without consulting a specialist.

In case of , heart or liver dysfunction, the dose is reduced.

Composition and release form

The active substance in Mig is ibuprofen. One tablet contains 400 mg of it. The auxiliary elements are:

• magnesium stearate;
• corn starch;
• silica;
• sodium carboxymethyl starch.

The drug is available in tablets. Each has an elongated oval shape. It is convex on both sides and has a score in the middle, which can be used to divide a single dose in half. The tablets are packaged in blisters. A cardboard box may contain 1 or 2 blisters.

Overdose

When using the drug in doses above normal, abdominal pain , vomiting, drowsiness , headaches, metabolic acidosis , acute renal failure , bradycardia , atrial fibrillation , nausea, lethargy, depression , tinnitus, coma , marked decrease in blood pressure, tachycardia , respiratory arrest are possible. .

If less than 60 minutes have passed since the overdose, gastric lavage . In addition, alkaline drinking, taking Activated Carbon , and forced diuresis . Treatment is symptomatic.

Top 10 drugs incompatible with alcohol

Why paracetamol, ibuprofen and antigrippin require an exclusively sober lifestyle

It has long been known that alcoholic beverages are not friendly with many medications. But information about which drugs should not be combined with alcohol “in the same glass” is often contradictory and confusing. As part of self-education and preparation for the “generous” Russian holidays - New Year and Christmas - we will fill the gaps in knowledge and determine the list of the most common medications that require an exclusively sober lifestyle.

Let’s say right away that “combining” does not mean washing down the drug with a glass of champagne or wine. The half-life of drugs can reach 10–12 hours, so when you take the medicine in the morning and “on the chest” in the evening, you also combine it with alcohol.

Paracetamol

Few people know that one of the most popular antipyretic and painkillers can be dangerous if combined with alcoholic beverages. In the presence of alcohol, paracetamol is metabolized in the body to form toxic substances that can cause liver damage. The danger is greatest if you combine long-term alcohol intake (for example, 90 ml of vodka or more per day for several days) with high doses of paracetamol (3000 mg or more).

Antiallergic and anti-cold medications

Alcohol consumed on the same day with some antihistamines, including the popular cetirizine and loratadine, increases the effects of the drugs on the central nervous system. This is manifested by increased drowsiness, lethargy and decreased motor activity. It should be borne in mind that many combined anti-cold medications include antiallergic components and, by the way, paracetamol.

Read also: Antibiotics and alcohol: consequences

Be sure to give up alcohol if you are taking Antigrippin (paracetamol + chlorphenamine + ascorbic acid), AntiFlu or Coldact Flu Plus (paracetamol + phenylephrine + chlorphenamine).

Nonsteroidal anti-inflammatory drugs

They are popular and sometimes almost irreplaceable. Ibuprofen, ketoprofen, naproxen, diclofenac and other NSAIDs are taken for toothaches, headaches, severe arthritis or muscle inflammation. And often consumers do not suspect that alcohol taken during treatment with NSAIDs greatly increases the risk of gastrointestinal bleeding. Let me remind you that drugs in this group are already not very friendly to the digestive tract and can cause gastropathy - stomach diseases. Alcohol can turn NSAIDs into aggressive substances that threaten real disaster.

Antitussives

Treatment with widely used medications for dry cough, including dextromethorphan, which is part of complex antitussives (Terasil-D), as well as drugs with codeine (Terpinkod) in combination with alcohol can lead to drowsiness, dizziness and weakness.

Interaction

When taking Mig 400, the effect of Furosemide and thiazide diuretics , which can be caused by sodium retention due to inhibition of prostaglandin .

In addition, the active ingredient of the drug may enhance the effect of oral anticoagulants . Taking them together is not advisable.

Ibuprofen also reduces the antiplatelet effect of acetylsalicylic acid and reduces the effectiveness of antihypertensive drugs.

Mig 400 should be used with caution in combination with NSAIDs and corticosteroids , as this can lead to adverse reactions from the gastrointestinal tract.

The drug also provokes an increase in the level of Methotrexate in the blood plasma .

In HIV-infected patients with hemophilia, the combination of ibuprofen with zidovudine increases the risk of hemarthrosis .

Combination with Tacrolimus increases the likelihood of nephrotoxicity due to inhibition of prostaglandin .

Under the influence of the drug Mig 400, the hypoglycemic properties of oral hypoglycemic drugs and Insulin are enhanced. Dosage adjustments may be necessary.

Compatibility of Mig and alcohol

? NSAIDs are taken for diseases of the musculoskeletal system, as an analgesic and antipyretic. The compatibility of the drug and alcohol leads to various negative consequences.

Mig is absolutely incompatible with alcoholic drinks. When present, the drug is converted into toxic substances that can cause enormous damage to the liver. The risk increases if you combine about 90 ml of vodka and 3000 mg of the drug for a long time.

Alcohol, which has a negative effect on the medication:

• beer;
• vodka;
• wine;
• cocktails;
• champagne;
• cognac.

Even one dose of alcohol affects the medication. Alcohol and painkillers are classified as antidepressants that depress the central nervous system. The double effect inhibits the processes of the nervous system and reduces the supply of oxygen to the body.

Alcohol and drugs are broken down in the liver, so the simultaneous intake of both components forces the nephrons to function at an increased rate. Their decay negatively affects the excretory system.