Kvamatel and Kvamatel-mini: instructions for use, price and reviews. Indications for use

Compound

One coated tablet contains 20 mg of the main substance famotidine and auxiliary components: lactose monohydrate, povidone K90, colloidal silicon dioxide, corn starch, magnesium stearate, talc, sodium carboxymethyl starch.
One bottle of the drug in the form of a lyophilized powder, from which an injection solution is prepared, contains 20 mg of the main substance famotidine . The auxiliary component is a solution of sodium chloride 0.9% in a 5 ml ampoule.

Pharmacodynamics and pharmacokinetics

This drug, acting on the walls of the stomach, helps to effectively reduce the production of gastric juice, reducing its volume. At the same time, the evacuation function of the stomach, blood circulation in the liver, secretory function of the pancreas, and so on do not change.

The dosage form Kvamatel Mini is also used to treat ulcerative lesions of the stomach and duodenum. The main indication for taking tablets is heartburn . This not only eliminates unpleasant symptoms, but also prevents excessive production of hydrochloric acid. Therefore, Kvamatel Mini helps eliminate heartburn and prevents the development of peptic ulcers.

To achieve a therapeutic effect lasting 10-12 hours, a single dose of the drug at a dosage of 20-40 mg may be sufficient. If you take 10 mg, its effect will last about 9 hours. The drug is absorbed in the gastrointestinal tract, metabolized in the liver, excreted by the kidneys, a small part - in the form of metabolites, and mostly unchanged.

Buy Kvamatel film-coated tablets 20 mg No. 28 in pharmacies

Instructions for use Kvamatel

Buy Kvamatel TB 20 mg Dosage forms film -coated tablets 20 mg, film-coated tablets 20 mg Manufacturers Gedeon Richter A.O. (Hungary), Gedeon Richter OJSC (Hungary) Group H2-histamine receptor blockers and similar agents Composition Active ingredient: famotidine. International nonproprietary name Famotidine Synonyms Kvamatel, Ulfamid, Ulceran, Famosan, Famotidine, Famotidine Stada, Famotidine-AKOS, Famotidine-Akri, Famocid, Fudon Pharmacological action Pharmacological action - antiulcer. Blocks histamine H2 receptors, inhibits basal and stimulated secretion of hydrochloric acid; inhibits pepsin activity. It is not completely absorbed from the gastrointestinal tract. Metabolized in the liver and excreted by the kidneys. After oral administration, the effect begins within 1 hour, reaches a maximum within 3 hours and lasts 10-12 hours. Under conditions of intravenous administration, the maximum effect develops after 30 minutes. Indications for use Peptic ulcer of the stomach and duodenum (treatment and prevention of exacerbations), symptomatic ulcers, erosive esophagitis, reflux esophagitis, Zollinger-Ellison syndrome, bleeding from the upper gastrointestinal tract (iv), prevention of erosive and ulcerative lesions of the gastrointestinal tract against the background taking NSAIDs and aspiration of gastric contents during general anesthesia. Contraindications Hypersensitivity, pregnancy, breastfeeding (stop during treatment). Side effects Dry mouth, loss of appetite, nausea, vomiting, abdominal discomfort, increased levels of transaminases in the blood serum, cholestatic jaundice, increased fatigue, tinnitus, headache, hallucinations, fever, arrhythmias, muscle pain, arthralgia, dry skin, allergic reactions: angioedema, itching, urticaria, conjunctivitis, bronchospasm; irritation at the injection site. Interaction Antacids containing magnesium and aluminum reduce absorption (should be administered at least 2 hours apart). Directions for use and dosage : Inside. For exacerbation of gastric and duodenal ulcers, 40 mg at night or 20 mg 2 times a day (morning and evening), course duration - 4-8 weeks; to prevent exacerbations - 20 mg 1 time per day at night for 6 months. For reflux esophagitis - 20 mg 1-2 times/day for 6-12 weeks, Zollinger-Ellison syndrome - 20-40 mg 4 times/day (if necessary, increase the dose of the drug). Overdose Symptoms: increased side effects. Treatment; Gastric lavage, symptomatic or supportive therapy are recommended. Special instructions The drug is not recommended for children. When treating gastric and duodenal ulcers, it is necessary to exclude the presence of a malignant tumor in the patient. Use with caution in case of liver dysfunction. Storage conditions List B. In a dry place, protected from light, at room temperature.

Contraindications for use

lactation, pregnancy;
childhood;
intolerance to the drug and other histamine H2 receptor blockers.

Particular care is required when treating patients with Kvamatel who suffer from renal or liver failure , liver cirrhosis , accompanied by portosystemic encephalopathy .

Using quamatel for cats

Kvamatel is used in the treatment and prevention of gastric (stomach) and intestinal ulcers in cats. Kvamatel promotes the healing of ulcers in animals with ulcers or erosions (shallow depressions in the gastric mucosa). Kvamatel may be useful in treating stomach inflammation caused by kidney failure. Another use is to treat gastric reflux disease, a condition similar to “heartburn” in humans and caused by stomach acid moving up into the lower esophagus. To reduce damage to the esophagus, this drug is prescribed to cats.

Cats with mast cell tumors can be treated with Quamatel or similar drugs, as these tumors can produce large amounts of histamine.

Side effects

Treatment with Kvamatel can lead to the development of various undesirable reactions in the body. Deviations in the functions of the gastrointestinal tract occur especially often: nausea , vomiting , problems with stool, loss of appetite , impaired liver function , dry mouth.

The nervous, hematopoietic and cardiovascular systems often suffer, which is manifested by: headache, dizziness , high fatigue, anxiety, heart rhythm disturbances, leukopenia , thrombocytopenia and so on. Allergic reactions may also develop, body temperature may rise, muscle or joint pain, gynecomastia , and more may occur. If any unwanted effects occur, you should consult a specialist.

Kvamatel, instructions for use (Method and dosage)

Despite the fact that the indications for the use of Kvamatel include various gastrointestinal diseases associated with ulcerative lesions, when starting treatment it is necessary to exclude malignancy of the ulcer .

An injection solution prepared from lyophilized powder is used strictly for intravenous administration in a hospital setting. The medicine is prepared from powder in a bottle, mixed with a solvent from an ampoule. When the powder is completely dissolved, the product is slowly injected into a vein over 2 minutes.

In addition, intravenous infusion of Kvamatel is possible. To do this, the powder is dissolved in 5 ml of sodium chloride 0.9% and mixed with the infusion solution. The period of this type of administration can be 15-30 minutes.

The drug in tablets should be taken without crushing or chewing, with plenty of liquid. The dosage and duration of therapy is determined by the attending physician for each patient.

This also applies to Kvamatel Mini tablets. However, in most cases, adult patients suffering from heartburn caused by high acidity need to take 1 tablet daily. To prevent heartburn and postprandial symptoms, one tablet is also prescribed one hour before meals. You can take no more than 2 tablets per day.

Continuous treatment should not exceed a course of 2 weeks. If after 7 days of therapy the symptoms do not disappear, you should urgently visit your doctor - undergo a re-examination and receive a new treatment prescription.

The therapeutic effect of famotidine is associated primarily with a decrease in the aggressiveness of gastric juice

Famotidine reduces the production of hydrochloric acid and pepsin activity; in a single dose of 40 mg reduces the nighttime secretion of H+ ions by 94%, basal secretion by 92%.

Famotidine has an additional mechanism of action

Stimulates the protective properties of the mucous membrane of the stomach and duodenum by:

increased blood flow in the mucous membrane,
increasing bicarbonate production,
increasing the synthesis of prostaglandins,
enhancing epithelial repair.

The higher effectiveness of QUAMATEL compared to ranitidine was shown in multicenter clinical studies of patients with duodenal ulcer [1, 2]. The results of these tests are shown in the graph, which shows the percentage of cured patients at different periods of treatment.

KVAMATEL® quickly relieves pain in peptic ulcers [1, 3, 4]. When taken orally in a single dose of 40 mg per day, the pain syndrome disappears within 1 week in 66% of patients. With intravenous administration of 20 mg twice a day, pain in most cases disappears on the 3-4th day of treatment [5, 7].

The main differences between KVAMATEL and other N

2-blockers
Less than the average effective therapeutic dose

Kvamatel 40 mg Ranitidine 300 mg Cimetidine 1000 mg

Longer duration of action

Kvamatel 10-12 hours Ranitidine 7-8 hours Cimetidine 5 hours

Does not have side effects characteristic of other H2 blockers.
The probability of side effects does not exceed 1%. Safe for long-term use.

Does not interfere with liver function.

May be recommended for long-term therapy in men:

does not cause impotence, as it does not have an antiandrogenic effect;
Gynecomastia does not develop due to the fact that it does not increase the level of prolactin in the blood.

Does not increase the bioavailability of alcohol, as it does not reduce the activity of liver alcohol dehydrogenase.
It can be successfully used for the treatment of erosive and ulcerative lesions of the esophagus, stomach and duodenum in persons suffering from alcoholism.

The most important advantage of
KVAMATEL is the availability of a dosage form for intravenous administration.
Drug interactions

It does not interact with the cytochrome P450 enzyme system, therefore it does not affect the metabolism of a number of drugs (indirect anticoagulants, diphenine, theophylline, propranolol, metronidazole, etc.). However, it should be taken into account that with an increase in gastric pH, the absorption of simultaneously administered ketoconazole may decrease.

Safety

Does not have carcinogenic or mutagenic effects; does not affect reproductive function.

Indications for the use of KVAMATEL and recommended doses
Peptic ulcer of the stomach and duodenum
during exacerbation - 40 mg 1 time per day in the evening; in remission as anti-relapse maintenance therapy - 20 mg 1 time per day.

Reflux esophagitis

Interaction

Kvamatel does not affect the biotransformation of drugs whose metabolism is related to the cytochrome P450 .

Concomitant use with Ketoconazole may reduce its absorption by changing the pH formula of gastric juice.

A decrease in the absorption of famotidine was noted when the drug was combined with antacid drugs .

Combined use with drugs containing probenecid reduces the excretion of famotidine .

Dosage of injection quamatel for cats (1 bottle of 20 mg diluted in 5 ml of solvent):

1 kg - 0.25 ml
2 kg - 0.5 ml
3 kg - 0.75 ml
4 kg - 1 ml
5 kg - 1.25 ml
10 kg - 2.5 ml

Gastric ulcers and erosions are relatively common complications of renal failure, gastric bloating, steroid treatment, nonsteroidal anti-inflammatory drug (NSAID) administration, and primary gastric disease. Drug therapy is often necessary to treat ulcers and prevent further health problems in cats.

Kvamatel is an antiulcer drug of the histamine receptor-2 (H-2) blocker class. Stimulation of H-2 receptors (targets) located on the cell membranes of stomach cells leads to the secretion of gastric juice and hydrochloric acid, in particular. By blocking these receptors, cats' stomach acid will not be released, allowing the ulcer to heal.

Kvamatel and other H-2 blockers are useful in the treatment and prevention of gastric ulcers

(duodenum) and intestines, as they prevent the activation of this cellular receptor. Other drugs with similar effects include ranitidine (Zantac®), nizatidine (Axid®), and cimetidine (Tagamet®). This drug is not approved for use in animals by the US Food and Drug Administration, but veterinarians legally prescribe it as an off-label drug.

Quamatel is available over the counter but should not be administered to cats except under the supervision and direction of a veterinarian.
Brand names and other names of quamatela
This drug is registered for use in humans only.
Human formulations: Quamatel, famotidine, Pepcid® (Merck) and various generic drugs
Veterinary drugs: no

Analogues of Kvamatela

Level 4 ATC code matches:
Gastrosidine

Gistak

Ranitidine

Acylok

Cimetidine

Zantac

Famotidine

Drugs with similar effects include:

Gasterogen;
Famotidine;
Famotel;
Pepsidin;
Famosan;
Gastrosidin.

Reviews about Kvamatel

Numerous reviews of Kvamatel confirm its effectiveness, since as a result of treatment: pain disappears, the functioning of the digestive system improves, and so on. At the same time, some users are interested in what Kvamatel tablets help best with, and what form should be used for severe disorders. In response, experts advise visiting a gastroenterologist and finding out everything after the examination.

However, there are reports when patients say that treatment with Kvamatel did not help them. Moreover, additional problems appeared in the gastrointestinal tract.

Therefore, it is recommended to take treatment with Kvamatel seriously and not use it without a doctor’s prescription for attacks of heartburn or stomach pain, since taking it requires an accurate diagnosis.

Learn about essential drugs in animals

Vaccination of puppies
Vaccination of cats against rabies
Vaccination of small animals
Vaccination for a kitten
Why vaccinate dogs against rabies?
Vaccinations for kittens
Nobivac triquet trio
Nobivak dhppi
Puppy vaccinations
Vaccinations for cats
Tick vaccination for dogs
What vaccinations for dogs?
Ursofalk for cats
Serenia for animals
Ursofalk suspension for dogs, dosage
Marfloxin for veterinary medicine
How to use serenia in dogs
Graying in cats
Heptor for dogs
Lidocaine for dogs
Heptor for cats
Lidocaine for cats
Heptral for a dog
Can cats use marfloxin?
Marfloxin for cats - instructions
Heptral in cats
Dirofen suspension for cats: instructions
Vetom 1 for cats
multifel for cats
Use of fosprenil in cats

^Top

Kvamatela price, where to buy

In pharmacies in Moscow and some Russian cities, the price of Kvamatel varies between 119-450 rubles.

In Ukraine, this drug can be purchased in a variety of forms at a cost of 39-179 UAH.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Kvamatel tablets p.p.o.
20 mg 28 pcs. JSC Gedeon Richter RUB 141 order
Kvamatel tablets p.p.o. 40 mg 14 pcs. JSC Gedeon Richter
123 RUR order

Pharmacy Dialogue

Kvamatel (tab.p.pl/vol. 20 mg No. 28) Gedeon-Richter
134 RUR order
Kvamatel (flask 20 mg No. 5+sol.)Gedeon-Richter
RUB 252 order
Kvamatel (tab.p.pl/vol. 40 mg No. 14)Gedeon-Richter
114 RUR order

Pharmacy24

Kvamatel 20 mg N5 lyophilisate + solvent 5 ml N5
303 UAH.order
Kvamatel 20 mg No. 28 tablets VAT "Gedeon Richter", Ugorshchina
145 UAH order
Kvamatel 40 mg No. 14 tablets VAT "Gedeon Richter", Ugorshchina
137 UAH order

PaniPharmacy

Kvamatel bottle Kvamatel Liof. por. d/in. 20mg amp. 5ml No. 5 Hungary, Gedeon Richter
304 UAH order
Kvamatel tablets Kvamatel tablets. 20 mg No. 28 Hungary, Gedeon Richter
155 UAH order
Kvamatel tablets Kvamatel tablets. 40 mg No. 14 Hungary, Gedeon Richter
131 UAH order