Omeprazole-acriquine 20 mg 30 pcs. enteric capsules

Release form

Omeprazole-Akrikhin

is a trade brand that reflects in its name the main component of the drug and the name of a chemical and pharmaceutical plant located in the Moscow region. Omeprazole is a compound with the formula C17H19N3O3S.

JSC "Akrikhin"

produces it in capsules of 20 mg, which are packaged in a cell blister of 10 pieces. At the pharmacy you can purchase a cardboard pack of medicine with one, two or three blisters and mandatory instructions.

Composition of the medicine

Yellow-green capsules made from titanium dioxide, delatin, iron oxide, indigotine, in addition to the active substance, contain:

• mannitol;
• sodium lauryl sulfate;
• lactose;
• diethyl phthalate;
• methacrylic acid copolymer;
• povidone;
• calcium carbonate;
• propylene glycol;

• polysorbate;
• sodium hydrogen phosphate;
• hypromellose;
• sucrose;
• sodium hydroxide;
• cetyl alcohol;
• titanium dioxide

The complex composition inside the capsules is represented by white or yellowish granules.

Capsules should not be opened because their shell protects the contents from the acidic gastric environment.

Medicinal substances need to “get” the medicinal substances to the alkaline environment of the intestine. Here they are safely absorbed into the blood.

Characteristics of Omeprazole

The main active ingredient is omeprazole. Excipients: sodium lauryl sulfate, disodium hydrogen orthophosphate, calcium carbonate, mannitol, sugar, hydroxypropyl methylcellulose E5, diethyl phthalate, methacrylic acid copolymer, talc, titanium dioxide, gelatin, nipagin, glycerin, nipazole, purified water, sodium lauryl sulfate, titanium dioxide.

The medication is prescribed for the following pathologies:

• reflux disease;
• hypersecretory conditions;
• acute pancreatitis;
• peptic ulcer of the stomach and duodenum.

The drug inhibits both nighttime and daytime acid production. In addition, it has a bactericidal effect on Helicobacter pylori, increasing the susceptibility of bacteria to antibacterial agents and eradication therapy.

The drug is prescribed for oral administration. The capsule is swallowed without damaging its integrity, washed down with plenty of water.

Therapeutic effect

Omeprazole-Akrikhin treats such serious ailments as:

• reflux of acidic stomach contents into the esophagus, called reflux esophagitis;

• gastric ulcer, duodenal ulcer;
• gastrointestinal ulcers acquired due to stress;
• tumors in the endocrine glands;
• gastropathy that occurs after treatment with non-steroidal anti-inflammatory drugs;
• pancreatic adenoma and gastrinoma;
• destruction of Helicobacter pylori in patients with complex forms;
• thermal or chemical burns of the esophagus;
• systemic mastocytosis.

All indications for the drug are united by excessive acidity in the gastrointestinal tract, manifested by heartburn, belching, and severe pain.

In the instructions for the drug you can read that Omeprazole-Akrikhin is a proton pump inhibitor. For the average person, a mysterious combination of words means that the active component of the drug reduces the production of hydrochloric acid in the stomach by blocking the functional protein in the mucosa responsible for the movement of protons through the cell membranes.

Due to this action, the occurrence of hydrochloric acid is reduced, regardless of what causes it. After taking even an Omeprazole tablet, acidity normalizes within 0.5-3.5 hours and the patient’s well-being becomes significantly better.

Omeprazole is taken once a day, since the effect of 1 capsule lasts for 23 hours.

Pharmacists guarantee that after 4 days the drug will reach its maximum effect, which is lost just as quickly after stopping use.

The chemical compound easily penetrates the cells of the stomach and is just as easily excreted - with bile or kidneys within an hour, after being broken down in the liver. If the functioning of the liver and kidneys is impaired, then the excretion of the drug’s components and breakdown products is significantly reduced.

Omeprazole-acriquine 20 mg 30 pcs. enteric capsules

Composition and release form Omeprazole-akrikhin 20 mg 30 pcs. enteric capsules

Composition of omeprazole pellets: pellets - 235 mg:

• Active substance: omeprazole - 8.5%;
• Excipients: mannitol - 17%, sucrose - 27.33%, sodium hydrogen phosphate (disubstituted sodium phosphate) - 1.27%, sodium lauryl sulfate - 0.34%, lactose monohydrate - 3.4%, sodium carbonate - 3.4%, hypromellose (hydroxypropyl methylcellulose) - 8.75%, copolymer of methacrylic acid and ethyl acrylate (1:1) - 25%, propylene glycol - 0.81%, diethyl phthalate - 2.5%, cetyl alcohol - 0.75%, sodium hydroxide - 0.15%, polysorbate 80 (Tween 80) - 0.3%, povidone (polyvinylpyrrolidone) - 0.26%, titanium dioxide - 0.18%, talc - 0.06%);
• Composition of the hard gelatin capsule body: titanium dioxide - 2%, yellow iron oxide - 0.25%, gelatin - up to 100%;
• Composition of the hard gelatin capsule cap: titanium dioxide - 0.5%, yellow iron oxide - 0.65%, black iron oxide - 0.41%, indigotine - 0.2086%, gelatin - up to 100%;

Description of the dosage form

Hard gelatin capsules, No. 1, two-color: yellowish-cream body with dark green cap; the contents of the capsules are pellets from almost white to creamy white or yellowish white.

Directions for use and doses

Inside, do not chew. Capsules are usually taken in the morning with a small amount of water (immediately before or during meals).

For exacerbation of peptic ulcer, reflux esophagitis and NSAID gastropathy - 20 mg 1 time per day. For patients with severe reflux esophagitis, the dose of Omeprazole-Akrikhin is increased to 40 mg once a day. The course of treatment for duodenal ulcer is 2-3 weeks, if necessary - 4-5 weeks; for gastric ulcers and esophagitis - 4-8 weeks.

For patients resistant to treatment with other antiulcer drugs, Omeprazole-Akrikhin is prescribed 40 mg/day. The course of treatment for duodenal ulcer is 4 weeks, for gastric ulcer and reflux esophagitis - 8 weeks.

For Zollinger-Ellison syndrome - 60 mg/day; if necessary, the dose is increased to 80-120 mg/day (in this case it is prescribed in 2-3 doses).

To prevent relapses of peptic ulcer - 10 mg 1 time per day.

To eradicate Helicobacter pylori, “triple” therapy is used (within 1 week: Omeprazole-Akrikhin 20 mg, amoxicillin 1 g, clarithromycin 500 mg - 2 times a day; or Omeprazole-Akrikhin 20 mg, clarithromycin 250 mg, metronidazole 400 mg - 2 times a day; either Omeprazole-Akrikhin 40 mg once a day, amoxicillin 500 mg and metronidazole 400 mg - 3 times a day) or “double” therapy (within 2 weeks: Omeprazole-Akrikhin 20-40 mg and amoxicillin 750 mg - 2 times a day or Omeprazole-Akrikhin 40 mg - 1 time a day and clarithromycin 500 mg - 3 times a day or amoxicillin 0.75-1.5 g - 2 times a day).

Pharmacodynamics

Proton pump inhibitor, reduces acid production - inhibits the activity of H+/K+-ATPase in the parietal cells of the stomach and thereby blocks the final stage of hydrochloric acid secretion. The drug is a prodrug and is activated in the acidic environment of the secretory tubules of parietal cells. Reduces basal and stimulated secretion regardless of the nature of the stimulus. The antisecretory effect after taking 20 mg occurs within the first hour, maximum after 2 hours. Inhibition of 50% of maximum secretion lasts 24 hours.

A single dose per day provides rapid and effective suppression of daytime and nighttime gastric secretion, reaching its maximum after 4 days of treatment and disappearing by the end of 3-4 days after the end of administration. In patients with duodenal ulcer, 20 mg omeprazole maintains intragastric pH at 3.0 for 17 hours.

Pharmacokinetics

Absorption is high, the maximum concentration in the blood plasma is achieved within 0.5-3.5 hours, bioavailability is 30-40% (with liver failure it increases to almost 100%); Having high lipophilicity, the drug easily penetrates the parietal cells of the stomach, the connection with plasma proteins is 90-95% (albumin and acidic alpha1-glycoprotein).

The half-life is 0.5-1 hour (in case of liver failure - 3 hours), clearance - 500-600 ml/min. Almost completely metabolized in the liver with the participation of the CYP2C19 enzyme system, with the formation of several metabolites (hydroxyomeprazole, sulfide and sulfone derivatives, etc.), pharmacologically inactive. It is an inhibitor of the CYP2C19 isoenzyme. Excretion by the kidneys (70-80%) and bile (20-30%).

In chronic renal failure, excretion decreases in proportion to the decrease in creatinine clearance. In elderly patients, excretion decreases and bioavailability increases.

Indications for use Omeprazole-acriquin 20 mg 30 pcs. enteric capsules

• peptic ulcer of the stomach and duodenum (including prevention of relapses);
• reflux esophagitis;
• Zollinger-Ellison syndrome;
• stress ulcers of the gastrointestinal tract (GIT);
• polyendocrine adenomatosis;
• systemic mastocytosis;
• gastropathy caused by taking nonsteroidal anti-inflammatory drugs (NSAID gastropathy);
• eradication of Helicobacter pylori in infected patients with gastric and duodenal ulcers (as part of combination therapy).

Contraindications

• hypersensitivity;
• childhood;
• pregnancy;
• lactation period.

With caution: renal and/or liver failure.

special instructions

Before starting therapy, it is necessary to exclude the presence of a malignant process (especially with a stomach ulcer), because Treatment, masking symptoms, can delay the correct diagnosis.

Overdose

Symptoms: confusion, blurred vision, drowsiness, dry mouth, headache, nausea, tachycardia, arrhythmia.

Treatment: symptomatic. Hemodialysis is not effective enough.

Side effects Omeprazole-acriquin 20 mg 30 pcs. enteric capsules

From the digestive system: diarrhea or constipation, abdominal pain, nausea, vomiting, flatulence; in rare cases - increased activity of liver enzymes, taste disturbances; in some cases - dry mouth, stomatitis, in patients with previous severe liver disease - hepatitis (including jaundice), impaired liver function.

From the hematopoietic organs: in some cases - leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.

From the nervous system: in patients with severe concomitant somatic diseases - dizziness, headache, agitation, depression, in patients with previous severe liver disease - encephalopathy.

From the musculoskeletal system: in some cases - arthralgia, myasthenia, myalgia.

From the skin: rarely - skin rash and/or itching, in some cases - photosensitivity, exudative erythema multiforme, alopecia.

Allergic reactions: urticaria, angioedema, fever, bronchospasm, interstitial nephritis and anaphylactic shock.

Other: rarely - gynecomastia, malaise, visual disturbances, peripheral edema, increased sweating, formation of gastric glandular cysts during long-term treatment (a consequence of inhibition of HCI secretion, is benign, reversible).

Drug interactions

May reduce the absorption of ampicillin esters, iron salts, itraconazole and ketoconazole (omeprazole increases gastric pH).

Being an inhibitor of cytochrome P450, Omeprazole-Akrikhin can increase the concentration and reduce the excretion of diazepam, indirect anticoagulants, phenytoin (drugs that are metabolized in the liver via cytochrome CYP2C19), which in some cases may require a reduction in the doses of these drugs.

At the same time, long-term use of Omeprazole-Akrikhin at a dose of 20 mg 1 time per day in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol did not lead to a change in their concentration in plasma.

There was no interaction with concomitantly taken antacids.

Mode of application

Taking the drug is usually associated with breakfast

- before or after.
Omeprazole-Akrikhin is taken orally, swallowing the capsules whole and washing down with water. The correct dosage helps to get rid of the disease faster. It differs depending on the diagnosis:

With the correct dosage, which is determined and prescribed by a specialist, the medicine treats painful symptoms in a short time. If the recommendations of the doctor and the manufacturer were not followed, then in the near future you will have to find out what the signs of an overdose are.

These are dry mouth, drowsiness, nausea, headache, blurred vision, tachycardia. Treatment of the consequences of exceeding the dose is prescribed in accordance with the symptoms. The instructions comment: hemodialysis in this case is not effective.

Contraindications for use

You should not take medications with the following clinical pictures:

• rare hereditary diseases: lactose intolerance, lactase deficiency, sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption;
• use simultaneously with certain antifungal agents, protease inhibitors, drugs for the treatment of non-small cell lung cancer, St. John's wort preparations;
• use simultaneously with Clarithromycin for liver failure;
• children under 2 years of age weighing less than 20 kg during the treatment of reflux esophagitis and the treatment of unpleasant symptoms that arise due to the reflux of hydrogen chloride into the esophagus;
• children under 4 years of age weighing less than 31 kg during treatment of duodenal ulcer caused by Helicobacter pylori;
• children under 18 years of age for all indications except those indicated above;
• allergic reactions to omeprazole or any other component of the drug.

Medications should be prescribed with caution to women during intrauterine pregnancy, to persons with impaired renal/liver function, and to those with a deficiency of vitamin B12 in the body.

In what cases is the drug contraindicated?

Despite all the effectiveness of Omeprazole-Akrikhin, which provides symptomatic relief and recovery, it is not approved for everyone. The reasons for the ban are clearly stated:

1. Individual sensitivity
   to the components of the drug. An allergic reaction can include a rash, hives, swelling, fever, and even anaphylactic shock.
2. Carrying a child
   . Studies of the effect of omeprazole on pregnant women have identified the risk of complications both in the mothers themselves and in the children born to them. Treatment is prescribed only when the benefit outweighs the threat to health.

3. Feeding period
   . Nursing mothers who have been prescribed appropriate treatment are advised to temporarily stop feeding for the same reasons as during pregnancy.
4. Childhood
   . The drug is prohibited, despite studies and permission to use it in the treatment of children in other countries.
5. Kidney
   and
   liver failure
   , especially in chronic form.

The manufacturer warns that the drug is contraindicated after the expiration date, which is 2 years.

Side effects

Does the patient have any restrictions on the use of the medicine? Then treatment can begin, but keep in mind: one thing is treated, another is crippled. Omeprazole-Akrikhin has a rather large list of side effects, which you should also familiarize yourself with before using it. After therapy you may experience:

• diarrhea or constipation;
• nausea;
• stomatitis;
• abdominal pain;
• liver dysfunction;
• decrease in the number of leukocytes, platelets, red blood cells in the blood;
• dizziness;

• depression;
• hallucinations;
• sleep disorder;
• encephalopathy;
• joint pain;
• muscle fatigue with pain;
• dermatitis with severe itching;
• increased sweating;
• formation of benign cysts in the stomach.

The longer the treatment, the more persistent the side effects become. Omeprazole is not life-threatening, but it can cause discomfort. Although the fact that a beneficial effect is simultaneously achieved should reassure patients.

Combination with other medications

The result of treatment is influenced by a complex of drugs, and their chemical components influence each other. What can Omeprazole-Akrikhin be taken with at the same time, and what shouldn’t it be taken with it?

Research data is shown in the table:

Omeprazole alters the effectiveness of drugs whose action is dependent on pH

. Moreover, it can both reduce the therapeutic result and enhance it.

It is not recommended to combine Omeprazole-Akrikhin simultaneously with alcoholic drinks that neutralize its effect.

During its use, the drug has earned positive reviews.

Another advantage is low cost

facilities. The difference in price in pharmacies is small - a package with 30 capsules of Omeprazole-Akrikhin can be purchased for less than 100 rubles. A good reason to prefer this particular medicine, given its time-proven effectiveness.

Comparison of Omeprazole and Omeprazole Akrikhin

Both medicines contain the same active ingredient - omeprazole. For this reason, medications have more similarities than differences.

Similarities

The medications have the same healing properties; the prescriptions and contraindications are also the same.

Differences

The difference lies in the auxiliary components. Moreover, the amount of active substance in both drugs is the same.

Which is cheaper?

Both drugs are inexpensive, but Omeprazole is 2 times cheaper than Omeprazole Akrikhin. The average cost of the first is 28.5 rubles. (30 tablets), the second - 69.3 rubles. (30 tablets).

Omeprazole is 2 times cheaper than Omeprazole Akrikhin. The average cost of the first is 28.5 rubles. (30 tablets).

What's better?

Both drugs show good results in practice, but only a doctor can determine which is better in each individual case.