Pharmacological properties of the drug Tamsulosin
A selective and competitive blocker of postsynaptic α1A-adrenergic receptors located in the smooth muscles of the prostate gland, bladder neck and prostatic urethra, reduces their tone and improves urine outflow. At the same time, it reduces the severity of symptoms of obstruction and irritation caused by benign prostatic hyperplasia. As a rule, the therapeutic effect develops 2 weeks after starting tamsulosin. The selectivity of tamsulosin for α1A-adrenergic receptors is 20 times greater than that for α1B-adrenergic receptors located in vascular smooth muscle. Due to its high selectivity, tamsulosin does not cause any clinically significant reduction in systemic blood pressure in both patients with hypertension (arterial hypertension) and in patients with normal baseline blood pressure. After oral administration, tamsulosin is quickly and almost completely absorbed from the digestive tract. Bioavailability is about 100%. After a single oral dose of 400 mcg, the maximum concentration in the blood plasma is achieved after 6 hours. At steady state (5 days after the start of treatment), the maximum concentration of the active substance in the blood plasma is 60–70% higher than after a single dose . 99% of tamsulosin binds to plasma proteins. The volume of distribution is insignificant and amounts to 0.2 l/kg. Slowly metabolized in the liver to form pharmacologically active metabolites that retain high selectivity for α1A-adrenergic receptors. Most tamsulosin is found in the blood unchanged. Excreted by the kidneys, 9% unchanged. The half-life for a single dose is 10 hours, the terminal half-life is 22 hours.
Tamsulosin
As with the use of other alpha1-blockers, during treatment with tamsulosin, in some cases a decrease in blood pressure may be observed, which can sometimes lead to fainting. At the first signs of orthostatic hypotension (dizziness, weakness), the patient should sit or lie down and remain in this position until the signs disappear.
Before prescribing tamsulosin therapy, it is necessary to exclude the presence of other diseases in the patient that can cause the same symptoms as benign prostatic hyperplasia.
Before starting treatment and regularly during therapy, a digital rectal examination and, if necessary, determination of prostate specific antigen (PSA) should be performed.
Treatment with tamsulosin in patients with severe renal failure (creatine clearance less than 10 ml/min) requires caution, because No studies have been conducted in this category of patients.
In some patients taking or previously taking tamsulosin. During surgery for cataracts or glaucoma, it is possible to develop intraoperative instability syndrome of the iris (narrow pupil syndrome), which can lead to complications during surgery or in the postoperative period. The advisability of discontinuing tamsulosin therapy 1-2 weeks before surgery for cataracts or glaucoma has not been proven. Cases of intraoperative instability of the iris occurred in patients who stopped taking the drug earlier before surgery. It is not recommended to initiate tamsulosin therapy in patients scheduled for cataract or glaucoma surgery. During the preoperative examination of patients, the surgeon and ophthalmologist should consider whether the patient is taking or has taken tamsulosin. This is necessary to prepare for the possibility of developing intraoperative iris instability syndrome during surgery. If angioedema develops, drug therapy should be discontinued immediately. Repeated administration of tamsulosin is contraindicated.
In case of renal failure, as well as in case of mild and moderate liver failure, no dosage adjustment is required.
There are reports of cases of the development of prolonged erection and priapism during therapy with alpha1-blockers. If an erection persists for 4 hours, you should immediately seek medical help. If priapism therapy is not carried out immediately, it can lead to damage to the tissue of the penis and irreversible loss of potency.
Tamsulosin overdose, symptoms and treatment
Acute overdose of tamsulosin has not been described. Theoretically, after an overdose, there is a risk of developing acute arterial hypotension, which may require additional cardiotropic therapy. If the symptoms are not eliminated, you should replenish the blood volume by prescribing electrolyte solutions, or administer vasoconstrictor drugs. To prevent further absorption of tamsulosin, gastric lavage should be performed, activated charcoal and an osmotic laxative should be prescribed.
List of pharmacies where you can buy Tamsulosin:
- Moscow
- Saint Petersburg
Side effects
When using the medicine, the following unwanted side effects are likely:
- CNS: headache , dizziness , asthenia , sleep disturbance , drowsiness ;
- gastrointestinal tract: nausea, constipation , vomiting, diarrhea ;
- allergies: rash, urticaria , itching , angioedema ;
- CVS: orthostatic hypotension , palpitations , chest pain, fainting , tachycardia ;
- genitourinary system: priapism , retrograde ejaculation , decreased libido.
In addition, back pain and rhinitis .
Tamsulosin analogs
Level 4 ATX code matches:
Dalfaz
Sonirid Duo
Setegis
Terazosin
Sonizin
Omnik Okas
Omnic
Proflosin
Urorek
Adenorm
Omics
Focusin
The following Tamsulosin analogues are available:
- Adenorm;
- Omics;
- Omnimax;
- Tamex;
- Tamsonic;
- Tulosin;
- Flosin;
- Bazetam;
- Omnic;
- Ranoprost;
- Tamsol;
- Taniz;
- Urofrin;
- Focusin.
All drugs have their own nuances of use. Tamsulosin analogues are not recommended to be taken without consulting a specialist.
Interaction
in the antihypertensive effect and the appearance of orthostatic hypotension is likely when combined with Amlodipine and Perindopril . This combination requires caution.
Antihypertensive effect is possible in interaction with Ramipril and Amlodipine . The combination of these drugs should be prescribed with caution.
The rate of elimination of the active substance of the drug increases when interacting with Warfarin and Diclofenac .
The hypotensive effect increases with the use of Doxazosin , Terazosin and Prazosin . This combination is not recommended.
The maximum concentration of the active substance of the drug increases when taking Ketoconazole and Paroxetine , and also decreases when combined with Furosemide .
Interaction with cimetidine leads to a decrease in clearance and an increase in the AUC of the active component of the described drug.
Tamsulosin price, where to buy
The price of Tamsulosin is on average from 400 to 500 rubles. This remedy is rarely found in pharmacies. The price of Tamsulosin is considered very high among analogues.
- Online pharmacies in RussiaRussia
ZdravCity
- Tamsulosin Canon caps.
intestinal with prolong. vysv. 0.4 mg No. 30 ZAO Kanonpharma Production RUR 364 order - Tamsulosin-OBL capsules with modification. release 0.4 mg 30 pcs. JSC Obolenskoe farm. company
RUR 554 order
- Tamsulosin Retard tablets p.p.o. prolonged action 0.4 mg 30 pcs. JSC Obolenskoe farm. company
RUR 565 order
- Tamsulosin -vertex caps.prolong.release. 0.4 mg 90 pcs. Vertex AO
RUR 927 order
- Tamsulosin Canon tablets with p.v.p.p.o. 0.4 mg 30 pcs. Canonpharma Production CJSC
RUB 383 order
Is it possible to combine Fokusin (Proflosin) and analogues with alcohol?
Fokusin (Proflosin, Tamsulosin, Sonizin, Omsulosin) - drugs for the treatment of prostate hyperplasia. Manufacturers do not recommend combining medications with alcohol.
All of these drugs are alpha-adrenergic receptor blockers and are used as part of complex therapy for the treatment of prostate diseases. The drugs are market analogues with the same active ingredient - tamsulosin .
The manufacturer, dosage, release form and additional components in the composition may differ. The decision to prescribe a specific drug is made by the attending physician.
Compatibility of tamsulosin with alcohol
All drugs containing tamsulosin (Fokusin, Proflosin, Omsulosin, Sonisin and other analogues) are not recommended to be consumed simultaneously with alcohol. Diseases of the prostate gland, for which these drugs are prescribed, are themselves a serious contraindication for drinking.
Alcohol reduces immunity and increases inflammatory processes, stresses the liver and kidneys. Because of this:
- The prognosis for the course of the disease becomes less favorable;
- The likelihood of exacerbation of chronic diseases increases;
- The effectiveness of drug treatment decreases;
- The chance of side effects from medications increases.
In addition, in the presence of inflammatory processes in the body, antibiotics are often prescribed. These drugs always put a huge burden on the liver and kidneys. Alcohol abuse while taking medications can lead to serious consequences, including hepatitis and kidney failure. You should definitely consult with your doctor about the possibility of drinking alcohol with any medications you are taking.
Side effects
Tamsulosin-based drugs are well accepted by most patients and rarely cause complications or side effects, especially if you follow your doctor's recommendations and do not abuse alcohol.
If the rules of administration are violated, side effects may develop:
- Bowel dysfunction, diarrhea or constipation;
- Nausea and vomiting, pain in the epigastric region;
- From the cardiovascular system, orthostatic hypotension is possible;
- Headache;
- Loss of sleep;
- Dizziness;
- Rarely - loss of orientation in space and consciousness;
You should also remember about the possibility of individual reactions of the body to the components of the drug, intolerance and allergic reactions. Drug manufacturers indicate all possible consequences in the annotations, but practically nothing is written there about alcohol.
How soon can you start drinking?
You can drink alcohol if you space your intake with Focusin (Proflosin, Tamsulosin and analogues) for a period of 6 to 12 hours. To make it easier to understand, below is an approximate minimum period that you should focus on when planning a feast.
It is forbidden:
- Drink alcohol together with medication;
- Abuse alcohol during the course of treatment.
Can:
- Take medications 8 hours before drinking alcohol for men and 12 hours for women.
- Take the medicine 6 hours after drinking alcohol for men and 9 hours for women.
Important: Even if you take all precautions, you should remember that taking alcoholic beverages simultaneously with medications and without a doctor’s permission is a risk for which the responsibility falls entirely on the drinker. Chronic alcoholism and regular alcohol abuse are almost guaranteed to lead to the development of side effects from most medications.
