Amoxicillin Express, 1000 mg, dispersible tablets, 20 pcs.

pharmachologic effect

Antibiotic , belongs to the group of aminopenicillins , has a wide spectrum of action. By inhibiting the synthesis of cell walls, it has a bactericidal effect. Active against staphylococci , streptococci , corynebacteria diphtheria , enterococci, Escherichia coli and Haemophilus influenzae , Neisseria gonorrhea and meningitis , Proteus , Salmonella and Shigella; and anaerobes - clostridia , peptostreptococci and peptococci.

When used simultaneously with metronidazole, it is effective against Helicobacter pylori. Microorganisms capable of producing penicillinase are resistant to the drug.

Amoxil is inactive against mycoplasmas , mycobacteria , fungi , rickettsia , plasmodium , amoebas , viruses , as well as Pseudomonas aeruginosa and Proteus.

Side effects

Allergic reaction in the form of itching , urticaria , fever , hyperemia , Stevens syndrome , hyperkeratosis , epidermal necrolysis , eczema , bullous dermatitis , angioedema , vasculitis , serum sickness , anaphylactic shock .

Digestive tract: decreased appetite, nausea, dry mouth, vomiting, diarrhea, flatulence , colitis, upward changes in liver enzymes, hepatitis and jaundice.

Nervous system: insomnia, anxiety, loss of consciousness, dizziness , hyperkinesis , headache. If kidney function is affected, seizures may occur.

Hematopoietic organs: thrombocytopenia , leukopenia , hemolytic anemia , increased prothrombin index.

Urinary system: interstitial nephritis .

Other reactions may include superinfections, candidiasis , general weakness, false-positive reactions to the determination of glucose in the urine and urobilinogen.

Side effects of the drug Amoxil

When using Amoxil, the following are possible: allergic reactions: skin rash, itching, urticaria, hyperemia, fever, very rarely - erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, skin hyperkeratosis, bullous and exfoliative dermatitis, eczema, enanthema, anaphylactic shock and angioedema edema, serum sickness, vasculitis; from the gastrointestinal tract: nausea, vomiting, diarrhea, loss of appetite, dry mouth, taste disturbance, bloating, discomfort and pain in the abdomen, colitis (including pseudomembranous, hemorrhagic), change in tongue color (black “hairy” tongue ); from the urinary system : rarely - interstitial nephritis; from the hematopoietic organs : rarely - hemolytic anemia, reversible thrombocytopenia, eosinophilia, reversible leukopenia (including neutropenia, agranulocytosis), increased prothrombin time; from the liver and biliary system : moderate increase in the level of liver enzymes, very rarely - hepatitis, jaundice; from the central and peripheral nervous system : rarely - anxiety, restlessness, insomnia, loss of consciousness, behavioral disorders, hyperkinesia, dizziness, headache. In patients with impaired renal function, seizures are possible; Other : general weakness, development of superinfection, candidiasis of the mucous membranes, false positive results when determining the level of glucose in the urine using non-enzymatic methods and when conducting tests to determine urobilinogen.

Instructions for use of Amoxil (Method and dosage)

Take the tablets as prescribed by your doctor, regardless of food.

Dosage for diseases of moderate and mild severity:

• adults and children over 10 years old - 500-750 mg 2 times a day;
• children from 3 to 10 years: 750 mg per day in 3 divided doses;
• from 1 to 3 years 250 mg twice a day.

In the case of chronic recurrent diseases and in severe cases, adults take 3 g per day; children - 60 mg/kg body weight, divided into 3 doses.

The daily dose for adults is a maximum of 6 g.

The course of treatment is continued for another 3 days after the cessation of symptoms. Mild to moderate infections require a course of treatment of about 1 week. In case of infection with beta-hemolytic streptococcus, treatment is for at least 10 days.

For the treatment of acute uncomplicated gonorrhea, a single dose of 3 g is prescribed in combination with probenecid in an amount of 1 g.

For peptic ulcers to eradicate Helicobacter pylori, the instructions for Amoxil 500 mg provide regimens that should be prescribed in combination with other drugs:

• Amoxil 2 g per day in two doses in combination with clarithromycin 500 mg twice daily and omeprazole 40 mg per day.
• Amoxil 2 g per day with metronidazole 400 mg three times a day and omeprazole 40 mg per day.

The course of treatment is 1 week.

In case of renal failure, it is prescribed taking into account the level of glomerular filtration and the level of creatinine .

Use of the drug Amoxil

Amoxil is prescribed orally (regardless of food intake). The dosage regimen of the drug is set individually, taking into account the characteristics of the disease. Standard dosage regimen for adults and children over 10 years of age with mild or moderate infections: 500-750 mg 2 times a day, for children aged 3-10 years - 375 mg 2 times a day or 250 mg 3 times per day; at the age of 1–3 years - 250 mg 2 times a day or 125 mg 3 times a day. The daily dose of the drug for children is 30–60 mg/kg body weight, divided into 2–3 doses. For chronic diseases, relapses, and severe diseases, adults are prescribed the drug at 0.75–1 g 3 times a day; children - 60 mg/kg body weight in 2 - 3 doses per day. The maximum daily dose for adults is 6 g. For acute uncomplicated gonorrhea, 3 g of the drug is prescribed per dose in combination with 1 g of probenecid. For the eradication of Helicobacter pylori in stomach or duodenal ulcers, Amoxil is prescribed as part of complex therapy according to approved international regimens: – for 7 days: amoxicillin 1 g 2 times a day + clarithromycin 500 mg 2 times a day + omeprazole 40 mg per day or 2 doses; – for 7 days: amoxicillin 0.75–1 g 2 times a day + metronidazole 400 mg 3 times a day + omeprazole 40 mg in 1 or 2 doses. The maximum daily dose for adults is 6 g.

Children with renal failure (body weight up to 40 kg):

The drug should be continued for 2-3 days after the symptoms of the disease disappear. For mild to moderate infections, the drug is taken for 5–7 days. For infections caused by beta-hemolytic streptococcus, the duration of treatment should be at least 10 days.

Interaction

Amoxil tablets, when taken simultaneously with oral contraceptives, can reduce the effect of contraception and increase the likelihood of bleeding.

of digoxin increases and the toxicity of methotrexate .

When used simultaneously with probenecid, phenylbutazone, sulfinperazone, indomethacin and acetylsalicylic acid, the excretion of Amoxil by the kidneys slows down.

Drugs that have a bacteriostatic effect ( chloramphenicol , macrolides , tetracycline ) neutralize the effect of Amoxil.

Combined use with allopurinol increases the likelihood of allergic skin reactions.

The simultaneous administration of antacids reduces the absorption of Amoxil.

Combination with anticoagulants increases the likelihood of bleeding, so you need to monitor the prothrombin time.

Diarrhea reduces drug absorption.

In pregnant women, the medicine reduces the concentration of estradiol in the urine.

Drug interactions Amoxil

With the simultaneous use of amoxicillin and oral contraceptives, the effectiveness of the latter is reduced, and there is also a risk of bleeding. Increases the absorption of digoxin. Reduces clearance and increases toxicity of methotrexate. The excretion of amoxicillin from the body by the kidneys is reduced when used simultaneously with probenecid, oxyphenbutazone, phenylbutazone, acetylsalicylic acid, indomethacin, sulfinperazone. Drugs with a bacteriostatic effect (tetracyclines, macrolides, chloramphenicol) can neutralize the bactericidal effect of amoxicillin. Forced diuresis leads to a decrease in the concentration of amoxicillin in the blood serum due to increased elimination. When used simultaneously with allopurinol, an increase in the frequency of allergic reactions from the skin is possible. Concomitant use with antacids reduces the absorption of amoxicillin. When taken simultaneously with anticoagulants, monitoring of prothrombin time is necessary, as the likelihood of bleeding increases. The occurrence of diarrhea may reduce the absorption of other drugs and reduce the effectiveness of Amoxil. Amoxil may reduce the concentration of estradiol in the urine of pregnant women.

special instructions

The possibility of developing an allergy to cephalosporin and penicillin antibiotics should be excluded before starting treatment.

Repeated and long-term use leads to the development of resistance and superinfections.

Vomiting and diarrhea reduce the absorption of the drug; in these conditions it should not be prescribed.

Prescribed with caution to patients with asthma and allergic diathesis .

Taking the drug in high doses causes the development of crystalluria , so for prevention it is necessary to take a sufficient amount of fluid.

The drug can change the color of tooth enamel in children, so you need to ensure proper dental and oral hygiene.

In case of anaphylactic shock, artificial ventilation of the lungs is performed, epinephrine , antihistamines , glucocorticoids and oxygen .

AMOXIL-K 1000

Compound:

active ingredients

: amoxicillin and clavulanic acid;

1 tablet contains amoxicillin (in the form of amoxicillin trihydrate) 875 mg, clavulanic acid (in the form of potassium clavulanate) 125 mg;

Excipients

: microcrystalline cellulose, sodium starch glycolate (type A), colloidal anhydrous silica, magnesium stearate, coating mixture (contains: hydroxypropyl methylcellulose, titanium dioxide (E 171), copovidone, polydextrose, polyethylene glycols (macrogols), medium chain triglycerides).

Dosage form.

Film-coated tablets.

Basic physical and chemical properties

: film-coated tablets, white or almost white with a yellowish tint, oval in shape with a biconvex surface, scored on one side.

Pharmacotherapeutic group.

Antimicrobial agents for systemic use. Beta-lactam antibiotics, penicillins. Combinations of penicillins with beta-lactamase inhibitors. Amoxicillin and enzyme inhibitor. ATX code J01C R02.

Pharmacological properties.

Pharmacodynamics.

Amoxicillin is a semisynthetic antibiotic with a wide spectrum of antibacterial activity against many gram-positive and gram-negative microorganisms. Amoxicillin is sensitive to β-lactamase and breaks down under its influence, therefore the spectrum of activity of amoxicillin does not include microorganisms that synthesize this enzyme. Clavulanic acid has a β-lactam structure similar to penicillins, as well as the ability to inactivate β-lactamase enzymes characteristic of microorganisms resistant to penicillins and cephalosporins. In particular, it has pronounced activity against clinically important plasmid β-lactamases, which are often responsible for the emergence of cross-resistance to antibiotics.

The presence of clavulanic acid in the composition of the drug "Amoxil-K 1000" protects amoxicillin from degradation under the action of β-lactamase enzymes and expands the spectrum of antibacterial action of amoxicillin, including many microorganisms resistant to amoxicillin and other penicillins and cephalosporins.

The microorganisms listed below are classified according to in vitro

.

Sensitive microorganisms.

Gram-positive aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroids, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans,

other β-hemolytic species of
Streptococcus, Staphylococcus aureus
(methicillin-sensitive strains),
Staphylococcus saprophyticus
(methicillin-sensitive strains), coagulase-negative staphylococci (methicillin-sensitive strains).

Gram-negative aerobes: Bordetella pertussis, Haemophilus influenza, Haemophilus parainfluenzae, Helicobacter pylori, Moraxella catarrhalis, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholera.

Others: Borrelia burgdorferi, Leptospirosa ictterohaemorrhagiae, Treponema pallidum.

Gram-positive anaerobes: Clostridium species, Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros

,
Peptostreptococcus
.

Gram-negative anaerobes: Bacteroides

(including
Bacteroides fragilis
),
Capnocytophaga spp., Eikenella corrodens
,
Fusobacterium spp
.,
Porphyromonas spp
.,
Prevotella
spp.

Strains that can acquire resistance.

Gram-negative aerobes: Escherichia
coli, Klebsiella oxytoca, Klesiella pneumonia
,
Proteus mirabilis, Proteus vulgaris
,
Proteus
,
Salmonella
.,
Shigella spp
.

Gram-positive aerobes: Corynebacterium species, Enterococcus
faecium
.

Insensitive microorganisms.

Gram-negative aerobes: Acinetobacter species, Citrobacter
freundii
,
Enterobacter species, Hafnia alvei, Legionella pneumophila, Morganella morganii
,
Providencia
species,
Pseudomonas species
,
Serratia species, Stenotrophomas maltophilia, Yesinia enterolitica
.

Others: Chlamydia
pneumonia, Chlamydia psittaci
,
Chlamydia species, Coxiella burnetti
,
Mycoplasma
.

Pharmacokinetics

.

The pharmacokinetic parameters of amoxicillin and clavulanic acid are similar. Peak serum concentrations of both components are achieved 1 hour after taking the drug. The optimal level of absorption is achieved if the drug is taken at the beginning of a meal.

Doubling the dose of Amoxil-K 1000 approximately doubles the drug level in the blood serum.

Both components of the drug, both clavulanate and amoxicillin, have a low level of binding to plasma proteins, approximately 70% of them remain in the blood serum in an unbound state.

Clinical characteristics.

Indications.

Treatment of bacterial infections in adults and children caused by microorganisms sensitive to the drug "Amoxil-K 1000":

- acute bacterial sinusitis;

- acute otitis media;

- confirmed exacerbation of chronic bronchitis;

— community-acquired pneumonia;

- cystitis;

- pyelonephritis;

- infections of the skin and soft tissues, including cellulitis, animal bites, severe dentoalveolar abscesses with widespread cellulitis;

- infections of bones and joints, including osteomyelitis.

Contraindications

.

Hypersensitivity to the components of the drug, to any antibacterial agents of the penicillin group.

A history of severe hypersensitivity reactions (including anaphylaxis) associated with the use of other β-lactam agents (including cephalosporins, carbapenems or monobactams).

History of jaundice or liver dysfunction associated with amoxicillin/clavulanate use.

Interaction with other drugs and other types of interactions.

Concomitant use of probenecid is not recommended. Probenecid reduces renal tubular secretion of amoxicillin. Its simultaneous use with the drug "Amoxil-K 1000" can lead to an increase in the level of the drug in the blood for a long time, but does not affect the level of clavulanic acid.

Concomitant use of allopurinol during treatment with amoxicillin increases the likelihood of allergic reactions. There are no data on the simultaneous use of a combination drug of amoxicillin and clavulanic acid with allopurinol.

Like other antibiotics, Amoxil-K 1000 can affect intestinal flora by reducing the reabsorption of estrogens and the effectiveness of combined oral contraceptives.

There is evidence of an increase in the international normalized ratio (INR) in patients treated with acenocoumarol or warfarin and taking amoxicillin. If such use is necessary, the prothrombin time or international normalized ratio should be carefully monitored and, if necessary, treatment with Amoxil-K 1000 should be discontinued.

In patients treated with mycophenolate mofetil, predose concentrations of the active metabolite of mycophenolic acid may decrease by approximately 50% after initiation of oral amoxicillin with clavulanic acid. This change in predose level may not accurately correspond to the change in total mycophenolic acid exposure.

Penicillins can reduce the elimination of methotrexate, which can lead to increased toxicity of the latter.

Features of application.

Before starting therapy with Amoxil-K 1000, it is necessary to accurately determine whether there is a history of hypersensitivity reactions to penicillins, cephalosporins or other allergens.

Serious and sometimes even fatal cases of hypersensitivity (anaphylactic reactions) have been observed in patients during penicillin therapy. These reactions are more likely in individuals with a history of similar reactions to penicillin (see Contraindications section). If allergic reactions occur, therapy with Amoxil-K 1000 should be discontinued and alternative therapy should be started.

If it is proven that the infection is caused by microorganisms sensitive to amoxicillin, it is necessary to weigh the possibility of switching from the amoxicillin/clavulanic acid combination to amoxicillin according to official recommendations.

This dosage form of Amoxil-K 1000 should not be used if there is a high probability that the pathogens are resistant to β-lactams, and should not be used to treat pneumonia caused by penicillin-resistant strains of S. pneumoniae.

"Amoxil-K 1000" should not be prescribed if infectious mononucleosis is suspected, since cases of measles-like rash have been reported with the use of amoxicillin for this pathology.

Long-term use of the drug can cause excessive growth of microflora that is insensitive to the drug Amoxil-K 1000.

The development of polymorphic erythema associated with pustules at the beginning of treatment may be a symptom of acute generalized exanthematous pustulosis (see section "Adverse reactions"). In this case, it is necessary to stop treatment, and further use of amoxicillin is contraindicated.

"Amoxil-K 1000" should be prescribed with caution to patients with signs of liver failure (see sections "Method of administration and dosage", "Contraindications", "Adverse reactions"). Adverse liver reactions occurred primarily in men and elderly patients and were associated with long-term treatment with the amoxicillin/clavulanic acid combination drug. Such events have been reported very rarely in children. In all patient groups, symptoms usually occurred during or immediately after treatment, but in some cases they appeared several months after stopping treatment.

In general, these phenomena were reversible. Liver side effects can be severe and very rarely fatal. They always occurred in patients with severe concomitant diseases or with simultaneous use of drugs that can adversely affect the liver (see section "Adverse reactions").

Antibiotic-associated colitis, ranging from mild to life-threatening colitis, has been reported with the use of almost all antibacterial drugs (see section "Adverse Reactions"). This is important to keep in mind if patients experience diarrhea during or after antibiotic use. If antibiotic-associated colitis occurs, treatment with Amoxil-K 1000 should be stopped immediately and appropriate treatment initiated.

Rarely, patients taking Amoxil-K 1000 and oral anticoagulants may experience an increase in prothrombin time [increase in the international normalized ratio (INR)]. When taking anticoagulants simultaneously, appropriate monitoring of laboratory parameters is necessary. Dosage adjustment of oral anticoagulants may be required to maintain the required level of coagulation.

For patients with impaired renal function, the dose must be adjusted according to the degree of renal impairment (see section "Dosage and Administration").

In patients with reduced urine excretion, crystalluria can very rarely be observed, mainly with parenteral administration of the drug. Therefore, to reduce the risk of crystalluria during treatment with high doses, it is recommended to ensure fluid balance in the body (see section “Overdose”).

When treating with amoxicillin, enzymatic reactions with glucose oxidase should be used to determine the level of glucose in urine, since other methods may give false-positive results.

The presence of clavulanic acid in the drug may cause nonspecific binding of immunoglobulin G and albumin on red blood cell membranes, which may result in a false positive result when performing the Coombs test.

There have been reports of false positive test results for Aspergillus

in patients treated with amoxicillin/clavulanic acid (using the Bio-Rad Laboratories Platelis Aspergillus EIA test). Therefore, such positive results in patients receiving amoxicillin/clavulanic acid should be interpreted with caution and confirmed by other diagnostic methods.

Use during pregnancy or breastfeeding.

Reproduction studies in animals (at doses 10 times higher than human doses) of oral and parenteral forms of the combination of amoxicillin and clavulanic acid did not reveal any teratogenic effects. One study in women with premature rupture of membranes reported that prophylactic use of amoxicillin and clavulanic acid increased the risk of necrotizing enterocolitis in neonates. The use of the drug should be avoided during pregnancy, especially in the first trimester, unless the benefit of the drug outweighs the potential risk.

Both active components of the drug are excreted into breast milk (there is no information regarding the effect of clavulanic acid on breast-fed children). Accordingly, diarrhea and fungal infections of the mucous membranes may occur in infants, so breastfeeding should be stopped.

The drug "Amoxil-K 1000" can be used during breastfeeding only when, in the opinion of the doctor, the benefits of use will outweigh the risks.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

No studies have been conducted to study the ability of the drug to influence the reaction rate when driving vehicles or other mechanisms. However, adverse reactions may occur (eg, allergic reactions, dizziness, seizures) that may affect your ability to drive or operate machinery.

Method of administration and dose.

The drug should be used in accordance with official recommendations for antibiotic therapy and local antibiotic sensitivity data. Sensitivity to amoxicillin/clavulanate varies between regions and may change over time. Local susceptibility data should be consulted, if available, and microbiological determination and susceptibility testing performed if necessary.

The range of suggested doses depends on the expected pathogens and their sensitivity to antibacterial drugs, the severity of the disease and the location of the infection, the age, body weight and renal function of the patient.

For adults and children weighing ≥ 40 kg, the daily dose is 1750 mg amoxicillin / 250 mg clavulanic acid (2 tablets), divided into 2 doses.

For children with body weight - 2800 mg amoxicillin / 143 - 400 mg clavulanic acid (see below for details).

If large doses of amoxicillin are required for treatment, other forms of the drug should be used to avoid unnecessary high doses of clavulanic acid.

The duration of treatment is determined by the patient's clinical response to treatment. Some infections (such as osteomyelitis) require long-term treatment.

Overweight children

Dose from 25 mg / 3.6 mg/kg/day to 45 mg / 6.4 mg/kg/day, divided into 2 doses.

Elderly patients

No dose adjustment is required for elderly patients. If necessary, the dose is adjusted depending on renal function.

Dosing for liver dysfunction.

Use with caution; liver function must be regularly monitored. There are insufficient data to make dosage recommendations.

Dosing for renal impairment.

The drug "Amoxil-K 1000" is prescribed only for the treatment of patients with creatinine clearance more than 30 ml/minute. In case of renal failure with creatinine clearance less than 30 ml/minute, Amoxil-K 1000 is not used.

The tablet should be swallowed whole without chewing. If necessary, the tablet can be broken in half and swallowed without chewing.

For optimal absorption and to reduce possible gastrointestinal side effects, the drug should be taken at the beginning of a meal.

The duration of treatment is determined individually. Treatment should not be continued for more than 14 days without assessing the patient's condition.

Treatment can be started with parenteral administration and then switched to oral administration.

Children.

The drug in this dosage and dosage form is not recommended for the treatment of children under 12 years of age.

Overdose

.

An overdose may be accompanied by symptoms from the gastrointestinal tract and disturbances in water and electrolyte balance. These phenomena should be treated symptomatically, paying attention to the correction of water and electrolyte balance. Cases of crystalluria have been reported, which sometimes led to renal failure (see section "Peculiarities of application"). The drug "Amoxil-K 1000" can be removed from the bloodstream by hemodialysis.

Adverse reactions.

Side effects were classified according to their frequency of occurrence: very common ≥1/10; often ≥ 1/100 and

Infections and infestations.

Often – candidiasis of the skin and mucous membranes.

Unknown - excessive increase in the number of non-susceptible microorganisms.

Hematopoietic and lymphatic systems.

.

Rarely – reversible leukopenia (including neutropenia) and thrombocytopenia.

Very rarely - reversible agranulocytosis and hemolytic anemia. Increased bleeding time and prothrombin index.

From the immune system.

Very rarely - angioedema, anaphylaxis, serum syndrome, allergic vasculitis.

From the nervous system.

Uncommon: dizziness, headache.

Very rarely - reversible hyperactivity, aseptic meningitis and convulsions. Seizures may occur in patients with impaired renal function or in those receiving high doses of the drug, unknown - aseptic meningitis.

From the gastrointestinal tract.

Adults

Very often - diarrhea.

Often - nausea, vomiting.

Children

Often – diarrhea, nausea, vomiting.

Nausea is more often associated with high doses of the drug. The above mentioned gastrointestinal symptoms can be reduced by taking the drug at the beginning of meals.

Uncommon: indigestion.

Very rarely - antibiotic-associated colitis (including pseudomembranous and hemorrhagic colitis - see section “Peculiarities of use”), black “hairy” tongue.

From the hepatobiliary system.

Uncommon – a moderate increase in the level of aspartate aminotransferase and/or alanine aminotransferase is observed in patients treated with β-lactam antibiotics.

Very rarely - hepatitis and cholestatic jaundice. These phenomena occur with the use of other penicillins and cephalosporins.

Hepatitis occurs mainly in men and elderly patients, and their occurrence may be associated with long-term treatment.

In children, such phenomena occurred very rarely.

Symptoms of the disease occur during or immediately after treatment, but in some cases they may occur several weeks after the end of treatment. These phenomena are usually reversible. Deaths occur very rarely and always occur in patients with severe underlying disease or in patients simultaneously receiving drugs that adversely affect the liver.

From the skin and its derivatives.

Uncommon: skin rash, itching, urticaria.

Rarely – polymorphic erythema.

Very rarely - Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous exfoliative dermatitis, acute generalized exanthematous pustulosis.

If any allergic dermatitis occurs, treatment should be discontinued.

From the kidneys and urinary system.

Very rarely – interstitial nephritis, crystalluria (see section “Overdose”).

Best before date.

1.5 years.

Storage conditions.

Store in original packaging at a temperature not exceeding 25 ºС.

Keep out of the reach of children.

Package.

7 tablets per blister, 2 blisters per pack.

Vacation category.

On prescription.

.

The location of the manufacturer and its address of place of business.

Ukraine, 01032, Kyiv, st. Saksaganskogo, 139.

Amoxil's analogs

Level 4 ATC code matches:
Hiconcil

Ampioks

Ampicillin Trihydrate

Ampicillin

Ospamox

Amoxicar

Penicillin

Flemoxin Solutab

Amoxicillin

Amosin

Ecoball

Ospamox , Flemoxin Solutab , Ampiox , Amoxicillin

Reviews about Amoxil

By studying reviews about Amoxil, you can be sure that it is a fairly affordable and effective drug. There are a lot of good opinions about its use for bronchitis , pneumonia and tonsillitis , both in adults and children. Patients who used the drug noted rapid recovery.

There are also several positive reviews of use for streptoderma and other pustular skin lesions.

The disadvantage is that some patients experience side effects such as skin rashes or gastrointestinal upset.

Another advantage is that, due to its safety, Amoxil tablets are allowed to be used by pregnant and lactating women.

Amoxil price, where to buy

In Ukraine, Amoxil is sold at an average price of 19 UAH. for 20 tablets of 250 mg. The price of Amoxil in a dose of 500 mg ranges from 29 to 34 UAH.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

LuxPharma* special offer

• Amoxil tablet
  No. 20 500 mg 1600 rub. order

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