Instructions for use
pharmachologic effect
The therapeutic effect of Tribux is explained by the beneficial properties of its active component - trimebutine. This substance binds to opioid receptors and normalizes the motility of the digestive system. Trimebutine acts on the smooth muscles of the gastrointestinal tract, but has no effect on the central nervous system.
It is noteworthy that Tribux compares favorably with medications containing codeine and morphine. Unlike them, it affects muscles in two directions: it simultaneously stimulates and inhibits the peristalsis of the gastrointestinal tract. The product begins to act quite quickly: the effect becomes noticeable after 30 minutes. after taking the pill.
Indications for use
Before use, consult your doctor. In therapeutic practice, Tribux is prescribed quite often. The following problems may be the basis for prescribing this drug:
- irritable bowel syndrome, characterized by impaired gastrointestinal motility (the standard symptom is the appearance of pain before and during bowel movements);
- gastroesophageal reflux or, more simply, heartburn;
- various functional gastrointestinal disorders, such as constipation, diarrhea, stabbing pain in the intestines or stomach, etc.
Despite the listed indications, doctors recommend not taking the drug without consulting a doctor. Especially if the pain in the intestines or stomach is not one-time, but systematic. This symptom may indicate the presence of serious diseases of the gastrointestinal tract.
Mode of application
The drug Tribux is recommended for use in adult patients and children over the age of twelve. As for the dosage, it is determined by the age of the patient:
- Adults are recommended to take 1 tablet of Tribux (equivalent to 100 mg trimebutine) three times a day. In special cases, patients are transferred to taking 4-6 tablets per day at regular intervals (with the doctor’s permission).
- For children over 12, the dose is selected based on body weight. It is recommended to give no more than 6 mg of the drug per 1 kilogram of weight.
Tribux tablets are intended for oral use. They are swallowed whole, without chewing, and washed down with boiled water. The manufacturer of the drug emphasizes that before taking Tribux you should consult your doctor regarding the dose and duration of treatment. If you have any doubts, you should contact your doctor again.
Release form, composition
A drug intended to regulate the functioning of the muscles of the gastrointestinal tract, Tribux is supplied to pharmacies in the form of hard tablets of 100 mg. The manufacturer packages the tablets in blisters and cartons. One pack may contain 60, 30 or 20 tablets.
The active component of Tribux is trimebutine maleate. In addition to the active ingredient, the drug contains several auxiliary ingredients, namely: modified starch, microcrystalline cellulose, lactose monohydrate, magnesium stearate.
Interaction with other drugs
Tribux can actively interact with most medications, so before taking the pills, you must tell your doctor about all the medications you are currently taking (even those sold in pharmacies without a prescription).
Thus, parallel use of Zotepine may provoke an increase in anticholinergic effect. In turn, trimebutine is able to prolong the effect of d-tubocurarine.
All gastroenterology clinics and medical centers in your city. Tests and ultrasound. Consultation with a gastroenterologist. Diseases of the digestive system. Find out more: - In Kiev (Hertz, Ilaya, Euromed) - In St. Petersburg (SM-Clinic, Longevity, Allergomed, Doctor +, BaltZdrav, Professor) - In Moscow (SM-Clinic, Medlux, Onmed) - In Kharkov ( TsMEI, Olympic, Victoria, Fortis, Ecomed) - In Minsk (Belgirudo, Art-Med-Company, Sinlab, Mikosha, GrandMedica, MedClinic) - in Odessa (Medea, On Clinic, Into Sano, Venus) - In Razyan (Trust + , Polyclinic-Pesochnya, Evrikas +) - in Nizhny Novgorod (Only Clinic, Alpha Center, EuroClinic, SOLO, Altea) - gastroenterological clinics of Tyumen (Doctor A+, Clinic "Vera", Avicenna, Medis, Sibirina, Your Doctor)
Tribux tablets 100 mg packaging No. 30
General characteristics Round, biconvex tablets, white or almost white, with acceptable inclusions.
Composition Active ingredient: One tablet contains 100 mg of trimebutine maleate. Excipients: lactose monohydrate, microcrystalline cellulose, lovidone, crospovidone, magnesium stearate.
Pharmacotherapeutic group Pharmacological group: drugs used for intestinal dysfunction. ATC code: A 03 AA 05 Indications for use - Disorders of gastrointestinal motility, defined as irritable bowel syndrome. — Functional disorders of the gastrointestinal tract and biliary tract: diarrhea, constipation, abdominal pain, spastic intestinal conditions.
Contraindications Allergies to trimebutine or any component of the medication. Phenylketonuria.
Use of the drug TRIBUX with food and drink. The tablets should be taken before meals with a glass of boiled water.
Drug interactions and other interactions - Zotepine taken concomitantly with trimebutine may increase the anticholinergic effects. — Trimebutine prolongs the action of d-tubocurarine. — Trimebutine weakens the effect of cisapride. - The simultaneous use of trimebutine and procainamide may enhance the inhibitory effect of the vagus nerve on conduction in the heart muscle, which may manifest itself in an excessive increase in heart rate. - The simultaneous use of trimebutine and drugs that affect the calcium channel (for example, calcium antagonists, captoprgot, reserpine, midazolam) reduces the precellular influx of calcium ions, which can lead to inhibition of intestinal smooth muscle contraction. It is important to tell your doctor or pharmacist about all medications you are currently taking and those you have recently taken, especially those without a prescription.
Pregnancy and breastfeeding Before using the medicine, you should consult your doctor or pharmacist. Due to the lack of sufficient data on the use of trimebutia during pregnancy, it is not recommended to take TRIBUX in the first trimester of pregnancy. Only in case of emergency, the medicine can be taken in the second and third trimesters of pregnancy. Animal studies have not shown trimebutine to be teratogenic, mutagenic or embryotoxic. Due to the lack of data regarding the effect of trimebutium on lactation, breastfeeding women should take TRIBUX only if absolutely necessary. If a woman is pregnant or planning pregnancy or breastfeeding, she should inform the doctor about this.
Effect on the ability to drive vehicles and control moving mechanisms The drug TRIBUX taken in accordance with the recommended dosage does not affect the ability to drive vehicles, maintain machines and does not reduce psychophysical activity.
Directions for use and dosage Adults: 100 mg trimebutine maleate (1 tablet) 3 times a day. In exceptional cases, you can take up to 6 100 mg tablets per day, dividing them into doses. Children: trimebutine maleate can be taken by children over 12 years of age at a dose not exceeding 6 mg/kg body weight per day. The tablets should be swallowed without chewing, with a glass of boiled water. The doctor determines the course of treatment individually.
Overdose In case of overdose, consult a doctor. TRIBUX taken in large doses (exceeding the recommended dosage) may lead to increased side effects. In case of drug overdose, gastric lavage and symptomatic treatment are recommended.
If you miss the next dose of the TRIBUX drug, you must take the missed dose as quickly as possible, and then adhere to the specified dosage method for the TRIBUX drug. Do not take a double dose to make up for a missed dose. Treatment should be continued following the doctor's recommendations.
Side effects When taking TRIBUX medication in recommended doses, the following side effects rarely appear: From the digestive system: dry mouth, taste disturbance, diarrhea, indigestion, stomach pain, numbness of the lips, nausea, vomiting, constipation, thirst; liver dysfunction, including increased activity of the liver enzymes AlAT and AspAT in the blood. From the nervous system; drowsiness, lethargy, feeling tired, apathy, dizziness, headaches, feeling warm/cold. From the cardiovascular system: heart rhythm disturbances. Allergic reactions: skin rash. Very rarely appeared: menstruation disorder, painful breast enlargement, pain in the chest area, anxiety, decreased hearing, urinary retention, hepatitis, skin changes (itching, urticaria, redness, blisters, papules, exudation, erythema multiforme).
Conditions and shelf life of the drug TRIBUX Do not take the drug after the expiration date. Keep the drug out of the reach of children. Store at a temperature of 15C - 25C. Shelf life is three years from the date of production. Dispensing conditions The drug is dispensed by prescription. Packaging Cardboard pack containing 2, 3 or 6 blisters of 10 tablets, along with an insert.
Side effects
Among the side effects observed during treatment with Tribux are the following adverse reactions:
- Digestive system: poor taste discrimination, indigestion, nausea, dry mouth, stomach pain, constipation, diarrhea.
- Nervous system: dizziness, drowsiness, fever or chills, headaches.
- Allergic reactions: skin rashes.
Problems associated with urination (delay), menstrual irregularities, temporary hearing impairment, anxiety, swelling and tenderness of the breasts in women were extremely rarely observed.
Overdose
As for an overdose, the same side effects appear, but more pronounced. Patients who notice symptoms of overdose should immediately contact their doctor or pharmacist. Therapy in this case is aimed at removing the drug from the stomach (using lavage), as well as eliminating the side effects that appear (symptomatic therapy).
To avoid an accidental overdose, it is worth understanding one important thing: making up for a missed dose with a double dose is strictly prohibited. You can take the pill only if there is enough time left before the next dose.
If you take more than the recommended dose of the medicine, you should immediately consult your doctor or pharmacist, or go to the nearest hospital
Contraindications
There are practically no contraindications to taking Tribux. Like other drugs, it is prohibited for people with intolerance to certain components of the drug (especially trimebutine), as well as a predisposition to allergic reactions.
Due to the lack of sufficient data on the use of trimebutine during pregnancy, it is not recommended to take the drug
During pregnancy
Independent use of Tribux (without consulting a doctor) during pregnancy is contraindicated, because this may negatively affect the child's health. In the first trimester, the drug is completely prohibited for use.
It is sometimes prescribed in the third and second trimesters, but in small doses and in cases of extreme need. These recommendations should be followed despite the fact that animal studies have not revealed embryotoxic, teratogenic or mutagenic effects of Tribux on the embryo.
As for nursing mothers, they also try to protect them from taking Tribux, because the effect of the drug on nursing patients and their children has not been fully studied. It follows from this that during lactation the drug is prescribed in cases of extreme necessity.
Reviews
Most Tribux reviews found on medical forums are positive. Patients claim that the effect of the drug is felt almost immediately, and there are no side effects when using the medication. According to doctors who prescribed Tribux to their patients, taking the drug led to the rapid elimination of symptoms of impaired gastrointestinal motility. The only drawback of the drug is its rather high price. In addition, many people complain that finding medicine in Russian and Ukrainian pharmacies is quite problematic.
Real reviews of Tribux are at the end of the article. Add your own to the existing reviews if you have ever taken this product. Believe me: the readers of our resource will thank you for this.
Tribux tablets: instructions and description
Tribux are tablets produced in solid form.
The active substance in the drug is 100 mg of trimebutine maleate.
As excipients - modified starch, lactose monohydrate, microcrystalline cellulose and magnesium stearate.
Conditions of release and storage
The drug is available only with a prescription.
Tribux should be stored away from children in a dry and dark place at an air temperature of no more than 25 degrees.
Package
The drug is produced in the form of tablets of 100 mg in blisters, in packages No. 20, No. 30 and No. 60.
Pharmacology
Tribux contains trimebutine, which stimulates intestinal motility. Trimebutine binds to the m, d and k opioid receptors. According to the mechanism of action, the following occurs: the drug acts on the smooth muscles of the gastrointestinal tract and regulates motor function disorders, without affecting the central nervous system. When withdrawn from other opioids, morphine and codeine, trimebutine does not show selectivity towards opioid receptors, due to which it is an stimulant for gastrointestinal motility. Normalization of motor activity begins half an hour after taking the drug.
