Milgamma - what is it and what is it used for? Milgamma is a combination drug that contains B vitamins: B1 (thiamine), vitamin B6 (pyridoxine) and vitamin B12 (cyanocobalamin).
This vitamin complex saturates the body with essential elements, improves the functioning of the nervous system and supporting apparatus, has an effective therapeutic effect, and is a powerful analgesic for attacks of acute pain.
Milgamma has an effective effect on pinching, damage and inflammation of nerve endings. So, it is successfully taken for diseases such as:
- neuropathy;
- neuralgia;
- facial nerve paresis;
- radicular syndromes;
- retrobulbar neuritis.
Due to its unique ability to saturate the human body with essential vitamins, Milgamma is recommended by specialists as an auxiliary drug in the treatment of diseases of internal organs (arthrosis, vertebral hernia, gout, inflammation of the pancreas, etc.)
Due to stressful situations that accompany modern man, natural degenerative processes occurring in the body, possible physical activity and injuries, changes in the structure of the myelin sheaths of nerve endings occur, which leads to pain. The Milgamma vitamin complex helps get rid of pain.
pharmachologic effect
Milgamma compositum tablets are a complex of B vitamins. The active ingredients of the drug - benfotiamine and pyridoxine hydrochloride - alleviate the patient’s condition with inflammatory and degenerative diseases of the nerves, as well as the musculoskeletal system. Milgamma tablets activate blood flow and improve the functions of the nervous system.
Benfotiamine is a substance that plays an important role in carbohydrate metabolism. Pyridoxine is involved in the body's metabolism of protein; it is also partially involved in the metabolism of fats and carbohydrates. Benfotiamine and pyridoxine in high doses act as an analgesic due to the participation of benfotiamine in the synthesis of serotonin . A regenerating effect is also noted: under the influence of the drug, the myelin sheath of the nerves is restored.
Pharmacological group of vitamin Milgamma
Agents that affect tissue metabolic processes. B vitamins (Milgamma) do not contain mineral complexes.
The active ingredients of the drug are B vitamins: B1 (thiamine), vitamin B6 (pyridoxine) and vitamin B12 (cyanocobalamin).
The choice of the form of administration of this medication into the body depends on the individual characteristics of the patient, whether ampoules with a solution or tablets
The active ingredients of Milgamma injections are B vitamins: B1 (thiamine), vitamin B6 (pyridoxine) and vitamin B12 (cyanocobalamin), as well as lidocaine, which has local anesthetic properties.
Milgamma tablets are intended for oral administration. Their composition is identical to the injection solution (B vitamins - active substances benfotiamine 100 mg, pyridoxine hydrochloride 1) and differs in the absence of lidocaine hydrochloride and the presence of excipients.
Pharmacokinetics and pharmacodynamics
Benfotiamine is a fat-soluble derivative of vitamin B1 (thiamine). In the body, this substance is phosphorylated into thiamine diphosphate and thiamine triphosphate, which are biologically active coenzymes. The main part of benfotiamine is absorbed in the duodenum, the rest of it is absorbed in the small intestine.
Pyridoxine is converted into pyridoxal phosphate. This enzyme affects the non-oxidative metabolism of amino acids. It takes part in the production of physiologically active amines. It is mainly absorbed in the upper parts of the digestive tract through the process of passive diffusion.
Both active substances are excreted mainly through the kidneys. The half-life of benfotiamine from the blood is 3.6 hours, the half-life of pyridoxine is 2–5 hours.
Milgamma compositum film-coated tablets 100 mg No. 30
A country
Germany
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Benfotiamine + Pyridoxine
Compound
Active ingredients: benfotiamine 100.0 mg, pyridoxine hydrochloride 100.0 mg. Round, biconvex, white film-coated tablets. Release form: film-coated tablets. 15 film-coated tablets each in a blister pack (blister) made of polyvinyl chloride film and aluminum foil .2 or 4 blisters (15 film-coated tablets each) along with instructions for use in a cardboard box.
pharmachologic effect
Benfotiamine, a fat-soluble derivative of thiamine (vitamin B1), is phosphorylated in the body to the biologically active coenzymes thiamine diphosphate and thiamine triphosphate. Thiamine diphosphate is a coenzyme of pyruvate decarboxylase, 2-oxyglutarate dehydrogenase and transketolase, thus participating in the pentose phosphate cycle of glucose oxidation (in the transfer of the aldehyde group). The phosphorylated form of pyridoxine (vitamin B6) - pyridoxal phosphate - is a coenzyme of a number of enzymes that affect all stages of non-oxidative metabolism amino acids. Pyridoxal phosphate is involved in the process of decarboxylation of amino acids, and, consequently, in the formation of physiologically active amines (for example, adrenaline, serotonin, dopamine, tyramine). Participating in the transamination of amino acids, pyridoxal phosphate is involved in anabolic and catabolic processes (for example, being a coenzyme of transaminases such as glutamate-oxalocetate transaminase, glutamate-pyruvate transaminase, gamma-aminobutyric acid (GABA), β-ketoglutarate transaminase), as well as in various reactions of breakdown and synthesis of amino acids. Vitamin B6 is involved in 4 different stages of tryptophan metabolism.
Indications for use
Neurological diseases with confirmed deficiency of vitamins B1 and B6.
Mode of application
Orally, 1 tablet per day. The tablet should be taken with plenty of liquid. In acute cases, after consulting a doctor, the dose can be increased to 1 tablet 3 times a day. After 4 weeks of treatment, the doctor must decide whether to continue taking the drug at an increased dose. If possible, the dose should be reduced to 1 tablet per day in order to reduce the risk of developing neuropathy associated with the use of vitamin B6.
Interaction
see full instructions for medical use
Side effect
very rarely. See full instructions for medical use
Contraindications
Increased individual sensitivity to thiamine, benfotiamine, pyridoxine or other components of the drug. The period of pregnancy and breastfeeding. Children's age due to missing data. Each tablet contains 92.4 mg of sucrose. Therefore, the drug should not be used by persons with congenital fructose intolerance, glucose-galactose malabsorption syndrome, or glucose-isomaltase deficiency.
Overdose
Given the wide therapeutic range, overdose of benfotiamine when taken orally is unlikely. Taking high doses of pyridoxine (vitamin B6) over a short period of time (more than 1g per day) may result in short-term neurotoxic effects. See full prescribing information
special instructions
When using the drug at a dose of 1 tablet of 100 mg per day for more than 6 months, the development of sensory peripheral neuropathy is possible. Before using the drug, you must read the full instructions for medical use!
Indications for use
The following indications for the use of Milgamma compositum as part of complex treatment are determined:
- neuritis;
- retrobulbar neuritis;
- neuralgia;
- ganglionitis;
- facial nerve paresis;
- plexopathy;
- polyneuropathy;
- neuropathy;
- lumboischialgia;
- radiculopathy.
There are also indications for the use of this drug in people who regularly suffer from night cramps (primarily older people) and muscle-tonic syndromes. For what else the drug is prescribed, the doctor determines individually.
What is it prescribed for?
Milgamma contains B vitamins.
B vitamins are fat-soluble substances that play a major role in the cellular metabolism of the body and are involved in all vital processes. The group of vitamins B includes the main components of the drug Milgamma - vitamin B1 (thiamine), B6 (pyridoxine) and B12 (cyanocobalamin). Each of the components of the Milgamma vitamin complex plays its own important role.
Vitamin B1 (thiamine)
Thiamine (B1) is responsible for normalizing carbohydrate metabolism in internal organs (liver, brain and living tissues). In addition, it is involved in the production of fatty acids and optimizes amino acid metabolism. An important function of thiamine is that it effectively reduces inflammation of the skin and improves the condition of the mucous membranes. Thiamine is involved in hematopoiesis and in the process of cell division, preventing the aging process of the body.
Thiamine is prescribed by specialists in the following cases:
- with liver disease;
- if the endocrine system is disrupted (consequences of obesity, diabetes);
- for eczema, psoriasis, pyoderma;
- in case of malfunction of the kidneys, brain and central nervous system;
- for gastritis, ulcers, pancreatitis and other gastrointestinal diseases.
Vitamin B6 (pyridoxine)
Pyridoxine (B6) is a water-soluble element that regulates metabolic processes and normalizes blood circulation. Pyridoxine is involved in the synthesis of molecules and the breakdown of carbohydrates. In addition, vitamin B6 reduces the risk of obesity, diabetes and the development of cardiovascular diseases. The level of cholesterol in the human body depends on the amount of vitamin B6. The role of vitamin B6 is indispensable in the synthesis of new red blood cells, i.e. this component is actively involved in the restoration of hematopoietic function. Like the other vitamins of the Milgamma complex, vitamin B6 affects the strengthening of the human immune system. In addition, a sufficient amount of pyridoxine protects against depression, relieves anxiety, and ensures calm.
Vitamin B6 is prescribed:
- patients with atherosclerosis, anemia and diabetes;
- pregnant women with toxicosis;
- teenagers with problems with improper functioning of the sebaceous glands.
Vitamin B12 (cyanocobalamin)
Cyanocobalamin (B12) helps accelerate the breakdown of proteins, fats and carbohydrates. Responsible for the synthesis of leukocytes, which are involved in protecting living tissues from foreign elements. Reduces cholesterol levels in the human body. Vitamin B12 helps normalize sleep and optimize the production of melatonin, the sufficient amount of which determines the sleep-wake cycle.
Indications for the use of cyanocobalamin are as follows:
- radiculitis;
- cirrhosis of the liver;
- polyneuritis;
- skin diseases (dermatitis, psoriasis);
- radiation sickness;
- bone injuries;
- acute and chronic hepatitis;
- bone injuries;
- radiculitis and others.
Side effects
Milgamma compositum tablets, like Milgamma injections, can cause some side effects, which, as a rule, appear only in rare cases. The following manifestations are possible:
- urticaria , skin itching , difficulty breathing, angioedema , anaphylactic shock ;
- tachycardia;
- reactions associated with high sensitivity;
- heavy sweating, acne ;
- headache ; _
- nausea.
If any of these side effects occur, you should immediately inform your doctor.
Instructions for use Milgamma compositum (Method and dosage)
When taken orally, tablets should be taken with plenty of liquid.
If the patient is prescribed Milgamma tablets, the instructions for use include taking 1 tablet per day. In acute diseases, the dose may be increased: 1 tablet three times a day. At this dosage, treatment can be carried out for no more than 4 weeks, after which the doctor decides to reduce the dose, since taking vitamin B6 in large quantities increases the likelihood of developing neuropathy. In general, the course of therapy lasts no more than two months.
Overdose
An overdose of vitamin B6 may cause neurotoxic effects. When treated with large doses of this vitamin for more than six months, neuropathy may develop. polyneuropathy may occur , which is accompanied by ataxia. Taking large doses of medication may cause convulsions. An overdose of benfotiamine when taken orally is unlikely.
After taking high doses of pyridoxine, induce vomiting and then take Activated Charcoal . However, such measures are effective only in the first 30 minutes. In more serious cases, you should immediately contact a specialist.
Reviews from patients and doctors about Milgamma
By analyzing the totality of the complex of vitamins that make up Milgamma, you can understand the benefits this drug brings to the human body. It is the B vitamins that have a positive effect on the overall strengthening of the immune system and have a powerful therapeutic effect in the treatment of diseases of the central nervous system and musculoskeletal system. Thanks to the use of Milgamma, specialists achieve quick relief from acute pain; the treatment brings a long-term positive effect. In addition, experts recommend taking Milgamma vitamins for various diseases of internal organs, since this replenishes the elements and nutrients that a weakened body lacks.
Analogues of Milgamma compositum
Level 4 ATX code matches:
Neurobex Forte
Neurobex
Milgamma
Neurorubin
Neurobion
Combilipen
Analogs of Milgamma compositum tablets are medications that contain the same components. Such medicines are:
- Milgamma
- Combilipen
- Neuromultivitis
- Triovit
The price of analogues depends on the number of tablets in the package, the manufacturer and other factors.
Milgamma compositum price, where to buy
Price of Milgamma compositum tablets 30 pcs. is from 700 rubles. Buy dragees in a pack of 60 pieces in Moscow. possible at a price of 1300 - 1400 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Milgamma compositum tab.
p/o 30 pcs. Vervag Pharma/Mauermann-Artsneimittel 679 rub. order
