Compound
100 ml spray for topical use contains:
- glycyrrhizic acid – 0.1 g (the amount of the active component is equivalent to ammonium glycyrrhizinate);
- malic acid;
- fumaric acid;
- ascorbic acid;
- folic acid;
- propylene glycol;
- Tween 80 (polysorbate 80);
- purified water.
Composition of Epigen Labial (corresponds to gel for external use):
- ammonium glycyrrhizinate – 100 mg per 100 ml (active component concentration – 0.1%);
- Apple acid;
- fumaric acid;
- ascorbic acid;
- Polavax GP 200 (cetearyl alcohol-Peg-20 stearate);
- phenonip;
- butylated hydroxytoluene;
- flavor 195 AG;
- distilled water.
Release form
- Epigen intimate spray is presented in the form of a medicinal solution from light yellow to light brown in color, which has a characteristic odor. In pharmacy kiosks, the pharmaceutical drug can be found in 15 or 60 ml spray bottles with a nozzle for vaginal administration and an annotation.
- Epigen Intim gel (sometimes called cream in pharmacy kiosks or on thematic resources) with a concentration of the active component of 0.1%. Sold in a 250 ml container with a special dispenser for rational use.
- Epigen Labial is a cream for external local use (used primarily as a lip cream). A plastic tube with a medicine in an amount of 5 g or a sachet (a bag or pad with dry flavorings) weighing 2.5 g is placed in a cardboard package.
pharmachologic effect
Epigen Intim is an antiviral and immunostimulating pharmaceutical preparation based on a natural plant component - glycyrrhizic acid , which is obtained by extraction from licorice root. The active component of the drug has a complex therapeutic effect, however, first of all, its pharmacological effects on the immune system should be noted. Glycyrrhizic acid increases the number and activity of T-lymphocytes when applied topically, induces the formation of interferon , increases the concentration of immunoglobulins A and M , but reduces the concentration of IgG.
The mechanism of antiviral action is based on inhibition of replication processes in the early stages, which causes the release of the viral virion from the capsid, preventing its penetration into the cellular structures of the body. In clinical studies, it has been proven that glycyrrhizic acid inactivates herpes simplex virus types 1 and 2, herpes zoster virus (Varicella Zoster), cytomegalovirus and some other oncogenic viruses. Its effectiveness has also been confirmed against mutant strains of viruses that, during their life, have developed resistance to Acyclovir and Iodouridine .
Gel for intimate hygiene Epigen has antiviral properties, which are realized through stimulating effects on the cellular and humoral factors of the immune system. The active biological component significantly inhibits the release of kinins and the formation of prostaglandins by connective tissue cells in the pathological focus of inflammation. This is the basis for the regenerating effects of the pharmaceutical drug, manifested in improved repair of the skin and mucous membranes.
Expert opinion
Lyudmila Sheveleva, pharmacist
Epigen is an effective remedy for the treatment of infectious pathologies of the skin and mucous membranes. It is easy to use, safe, and ideal for long-term therapy. During treatment of the genitals, the required pH level is maintained. This acidity level is favorable for beneficial lactic acid bacteria in the vagina. They begin to actively grow and reproduce, stimulating the strengthening of local immunity. And this becomes an excellent prevention of relapses of bacterial and fungal vaginitis.
Indications for use
- comprehensive prevention of gynecological diseases of viral etiology, sexually transmitted diseases;
- infectious diseases caused by the human papillomavirus ;
- erosions and other pathologies of the cervix;
- treatment and prevention of genital warts ;
- as part of complex therapy in the treatment of herpes simplex virus infections types 1 and 2;
- itching, burning, dryness and other unpleasant sensations in the genital area;
- bacterial vaginosis;
- herpes zoster and infection with the Varicella Zoster virus ;
- nonspecific vulvovaginitis;
- nosological units in which the etiological factor is cytomegalovirus ;
- insufficiency of ovarian function.
Nosological classification (ICD-10)
- A60 Anogenital herpetic viral infection [herpes simplex]
- A63.0 Anogenital (venereal) warts
- B00 Infections caused by herpes simplex virus
- B02 Herpes zoster
- B25.9 Cytomegalovirus disease, unspecified
- B37.3 Candidiasis of the vulva and vagina (N77.1*)
- B97.7 Papillomaviruses
- L29.2 Itching of the vulva
- L29.3 Anogenital itching, unspecified
- N76 Other inflammatory diseases of the vagina and vulva
Instructions for use (Method and dosage)
Instructions for Epigen intimate spray
The intimate spray is intended for external, intraurethral and intravaginal use. Before use, be sure to shake the container so that the medicinal solution is evenly distributed inside the container. Directly during use, the cylinder must be kept in an upright position. For external treatment of the skin and genitals, the pharmaceutical drug is applied to the entire pathological focus from a distance of 4-5 cm in 1-2 presses, which corresponds to the optimal dosage.
To administer the drug intravaginally (this is how a spray is used for cervical erosion, for example), a special nozzle with a sprayer is used, which is included in the kit. After placing the atomizer on the balloon instead of the original valve, insert it into the vagina and spray the pharmaceutical drug with 1-2 presses.
Intraurethral use of the spray by men also involves the use of a spray bottle. The drug is injected directly into the external opening of the urethra with 1-2 presses. If external treatment of the genital organs is performed, then the use of a sprayer is not necessary.
Frequency and duration of use of Epigen Intim spray
For herpesvirus infection type 1 and herpes zoster , the drug is used 6 times a day by applying directly to the pathological focus. The duration of drug treatment is usually 5 days, however, if the disease persists, therapy should be continued until all symptoms disappear completely.
For infection with herpes virus type 2 and cytomegalovirus infection, the drug is used 5 times a day for 14 days. It is recommended to combine external and intravaginal use of the drug. After the elimination of acute symptoms, active prevention of a recurrent course should be carried out by external and intravaginal use of the spray 3 times a day for 10 days.
In case of papillomavirus infection, treatment with a pharmaceutical drug is carried out through surgical procedures. Before removing condylomas, etiotropic therapy involves applying the spray three times throughout the day. Against the background of destruction (the method of surgical intervention is not taken into account), the drug is used five times for 10 days or more. The criterion for completing medicinal sanitation is complete healing of the pathological focus. In order to prevent immediate relapses, the spray is applied 3 times a day for 1 month.
In the long-term prevention of human papillomavirus infection, the use of a pharmaceutical drug is determined by the appearance of various provoking factors, which can be stress, respiratory viral diseases, taking antibiotics or cytostatics, microflora disturbances, and prolonged fatigue. The drug is used before and after sexual intercourse or 3 times a day during the entire period of influence of external factors of aggression.
Epigen spray for thrush , vulvovaginal candidiasis, nonspecific vulvovaginitis or its bacterial etiology is used intravaginally 3-4 times a day for 7-10 days. The therapeutic course should be repeated after 10 days, since the causative agents of these pathological conditions are able to avoid the influence of the pharmaceutical drug due to individual characteristics.
If any provoking factors appear (see above), then the thrush spray is applied 3 times a day externally and intravaginally until the harmful factors cease their effect.
The spray during pregnancy and breastfeeding should be used according to standard conservative therapy regimens, since the pharmaceutical drug is intended for local action on pathological microflora and enters the systemic bloodstream only in trace concentrations, which does not have an adverse effect on the body of the child or mother.
Instructions for Epigen gel
As a rule, the cream is used for intimate hygiene , and not for therapeutic purposes. The method of using it is to apply it externally to the genitals, after which it should be foamed and rinsed thoroughly with warm running water. The natural ingredients in the base of the cosmetic product allow you to repeat the procedure several times a day.
The gel can also be used for prevention against thrush , since glycyrrhizic acid normalizes the acidity of the intimate areas, cleanses the skin and maintains the natural microflora of the mucous membranes of the genital organs. Daily use of intimate hygiene gel helps prevent damage by fungal cultures and avoid the very unpleasant discomfort associated with the problem of thrush.
Epigen intimate gel for intimate hygiene 250ml
Composition and release form Epigen intimate gel for intimate hygiene 250ml
Spray for external and local use – 1 fl. activated glycyrrhizic acid - 0.1% excipients: malic acid; fumaric acid; ascorbic acid; folic acid; propylene glycol; Tween (polysorbate); purified water in plastic bottles of 15 or 60 ml, complete with a spray nozzle for intravaginal use; 1 set in a cardboard box.
Description of the dosage form
The solution is light yellow to light brown in color and has a characteristic odor.
Characteristic
Maintains the necessary physiological pH level of the intimate area, cleanses the skin, and supports the natural microflora of the mucous membranes of the genital organs.
Directions for use and doses
Intravaginal, external and intraurethral. The container must be shaken before use and kept in an upright position when using. For external use, the drug is applied to the entire affected surface from a distance of 4-5 cm by 1-2 valve presses, which is the optimal therapeutic dose. For intravaginal use of the drug, a special nozzle is included. It is a hollow tube 7 cm long, at one end of which there is a sprayer, and at the other end there is a valve. Remove the valve from the spray bottle and put on the nozzle valve. Then the nozzle is inserted into the vagina with the patient lying on her back. The drug is injected intravaginally by 1-2 presses of the nozzle, which is the optimal therapeutic dose. After use, you must remain in the “lying” position for 5-10 minutes. When used by men, in addition to external application, the drug is injected into the external opening of the urethra with 1-2 presses of the spray valve. For papillomavirus infection: before removal of condylomas - 3 times a day for the entire period of etiotropic therapy; against the background of destruction - 5 times a day for 10 days or more until healing; to prevent immediate relapses - 3 times a day for 1 month. To prevent the progression of human papillomavirus infection: before and after sexual intercourse, as well as in the event of provoking factors - stress, fatigue, ARVI, microflora disturbance, taking antibiotics, cytostatics - 3 times a day intravaginally and externally for the entire period of exposure to provoking factors. For skin infections caused by the herpes simplex virus (including herpes zoster): 6 times a day on the affected area for 5 days. If the infectious process persists, the treatment period is extended until the symptoms of the disease completely disappear. For genital herpes and cytomegalovirus infection: 5 times a day for 14 days externally and intravaginally, after stopping the relapse - externally and intravaginally 3 times a day for 10 days. In order to prevent relapses of genital herpes and cytomegalovirus infection: externally and intravaginally from 18-20 days of the menstrual cycle until the end of menstruation, 2 times a day in the morning and evening. For nonspecific colpitis, bacterial vaginosis and vulvovaginal candidiasis: intravaginally 3-4 times a day for 7-10 days. If necessary, the course of treatment is repeated after 10 days. If provoking factors occur - ARVI, take antibiotics, cytostatics - 3 times a day intravaginally and externally for the entire period of exposure to provoking factors. In cases of discomfort in the genital area, accompanied by itching, burning and dryness, incl. for insufficiency of ovarian function and after sexual intercourse: 2 times a day (morning and evening) for 2-3 weeks. To prevent discomfort, use regularly after sexual intercourse. As a prophylactic antiviral agent, the drug is recommended to be used before and after sexual intercourse.
Pharmacodynamics
The active ingredient of Epigen Intim is activated glycyrrhizic acid, obtained by extraction from plant materials (licorice root). The immunostimulating effect is manifested by an increase in the number and activity of T-lymphocytes, a decrease in the concentration of Ig G and an increase in the concentration of Ig A and M. Activated glycyrrhizic acid significantly inhibits the release of kinins and the synthesis of PG by connective tissue cells in the area of inflammation. The regenerating effect is due to improved repair of the skin and mucous membranes. The anti-inflammatory activity of activated glycyrrhizic acid is combined with a stimulating effect on humoral and cellular immunity factors. Activated glycyrrhizic acid induces the formation of interferon, which is one of the components of its antiviral action. Activated glycyrrhizic acid has an antiviral effect on various types of DNA and RNA viruses in vitro and in vivo (Varicella Zoster; herpes simplex virus types 1 and 2; cytomegalovirus, various types of human papillomavirus, including oncogenic ones). Activated glycyrrhizic acid interrupts the replication of viruses in the early stages, causes the virion to exit the capsid, thereby preventing its penetration into cells. Activated glycyrrhizic acid inactivates these viruses in concentrations that are non-toxic for normally functioning cells. Mutant strains of viruses resistant to acyclovir and iodouridine are also highly sensitive to glycyrrhizic acid, like non-mutant strains.
Pharmacokinetics
When applied externally and locally, activated glycyrrhizic acid is deposited in the lesions. Systemic absorption occurs slowly. The drug is found in the blood in trace amounts.
Indications for use Epigen intimate gel for intimate hygiene 250ml
treatment of a viral infection caused by the human papillomavirus, incl. asymptomatic isolation of human papillomavirus of high oncogenic risk as part of combination and complex therapy; treatment of viral infection caused by herpes simplex virus types I and II as part of complex therapy; treatment of a viral infection caused by the Varicella Zoster virus (shingles) as part of complex therapy; treatment of viral infection caused by cytomegalovirus as part of complex therapy; prevention of relapses of viral infections caused by herpes simplex virus types I and II, Varicella Zoster virus, human papillomavirus, cytomegalovirus; prevention and treatment of genital warts and cervical pathology caused by human papillomavirus, cytomegalovirus; prevention and treatment of conditions accompanied by a decrease in local immunity, incl. nonspecific vulvovaginitis, candidal vulvovaginitis and bacterial vaginosis as part of complex therapy; phenomena of discomfort in the genital area, accompanied by itching, burning and dryness, incl. after sexual intercourse; phenomena of discomfort in the genital area, accompanied by itching, burning and dryness of the mucous membranes with insufficient ovarian function.
Contraindications
Individual intolerance to product components.
Application of Epigen intimate gel for intimate hygiene 250ml during pregnancy and breastfeeding
The drug is approved for use during the entire period of pregnancy and breastfeeding.
special instructions
Intimate hygiene procedures must be performed delicately and according to certain rules, use only special intimate hygiene products, avoiding ordinary alkaline soap, warm water, cleanly washed hands, at least 2 times a day, movements in the direction from the pubis to the anus (to avoid getting infections from the rectum), without a washcloth!, the gel can only be used to wash the skin around the entrance to the vagina, the towel must be strictly individual, clean, soft, blotting movements, on menstruation days you should not take a bath, it is better to wash in the shower, you should not swim in in swimming pools, ponds, pads should be changed at least 4-5 times a day, the tampon should not be left in the vagina for more than 4 hours, during menstruation it is better to avoid sexual intercourse and pay special attention to intimate hygiene.
Side effects Epigen intimate gel for intimate hygiene 250ml
In rare cases, local allergic reactions are possible, sometimes in the form of contact dermatitis.
Drug interactions
No interaction was detected with the main groups of drugs used for additional treatment for these diseases (antibiotics and antiseptics; anti-inflammatory and painkillers). At the same time, synergism was discovered with the simultaneous use of glycyrrhizic acid and other antiviral substances, in particular derivatives of acyclovir, iodouridine, interferon and other immunomodulators.
Interaction
Glycyrrhizic acid has synergistic pharmacological effects with other pharmaceutical antiviral drugs , in particular with derivatives of Acyclovir , Iodouridine , Interferon and some immunomodulators.
Drug interactions with basic medications used to treat these pathological conditions and nosological units (for example, antibiotics , antiseptics or painkillers) were not identified during clinical studies.
Epigen analogs
Level 4 ATX code matches:
Aldara
Viru-Merz Serol
Zovirax Duo-Active
Acyclovir
Fenistil Pencivir
Bonafton
Zovirax
Atsik
Alpizarin
Herpferon
Lysozyme
Gerpevir
Kondilin
Virolex
Gevisosh
Analogs of Epigen Intim spray are presented in various pharmaceutical forms from tablets for oral use to granules for preparing a medicinal solution. If there are contraindications to Epigen spray, Glyciram , Glycyrrhizic acid or Epigen Labial are prescribed. The price of analogues of the Epigen intimate spray at licensed points of sale is, as a rule, lower, but the effectiveness of such therapeutic agents is relative, because they realize their beneficial properties indirectly, unlike a spray that acts directly on the pathological focus of the disease.
Epigen intimate gel also has its analogues on the pharmaceutical market, but the proven therapeutic properties of the licorice root extract and effects such as normalizing acidity and maintaining the physiological level of microflora of the genital organs predispose you to choose Epigen gel.
Analogs
In the assortment of pharmacies there are no analogues of Epigen identical in composition. Sometimes patients exhibit hypersensitivity to its ingredients. In such cases, they are usually prescribed any cheaper hygiene product with lactic acid. Treatment can be supplemented with ointments with antiviral activity, for example, Acyclovir or Zovirax.
There are no similar means
Reviews about Epigen
Reviews of Epigen Intim spray characterize the pharmaceutical drug on the positive side. Patients with various infectious diseases of viral etiology recommend the drug on thematic forums and Internet resources, because the spray allows you to eliminate the pathological focus of the nosological unit and normalize the functioning of the genital organs and skin. For thrush, the medicine allows you not only to get rid of unpleasant discomfort and odor, but also to avoid this problem in the future, since the intimate gel effectively prevents this disease.
The anti-condylomas spray, in combination with surgical treatment, completely neutralizes the human papillomavirus, which ensures rapid healing of the skin defect and the fight against further relapses. The spray for HPV activates the humoral and cellular immunity, allowing you to further recognize the structure of the pathological agent and eliminate possible re-infection.
The pharmaceutical drug also helps with bacterial and nonspecific inflammatory diseases of the genital organs. An intimate spray allows you to maintain a physiological level of acidity, providing a feeling of cleanliness and freshness. Thanks to the drug Epigen intimate, the genital area of both partners is protected from unpleasant consequences in the form of irritation, redness or other natural reactions.
Reviews from doctors are based primarily on the pharmacological effects and duration of the course of conservative therapy. Both indicators of a drug in the form of a spray allow us to give professional and qualified preference, based on reliable clinical studies, to this drug. On thematic resources, some medical professionals even openly admit about the independent use of Epigen Intim, which cannot but tip the scales in favor of the medicinal spray.
Separately, it should be noted reviews of Epigen Intim gel, which is often used incorrectly. The cream is designed to keep the genitals clean during daily intimate hygiene, unlike a spray. Of course, both pharmaceutical forms of the drug are based on licorice root extract, but the gel has a milder effect. The absence of soap and some other auxiliary components allows the gel to be used exclusively for cosmetic purposes.
This dosage form receives good recommendations from women who are carrying a child. Gel during pregnancy allows you to avoid a large number of aesthetic consequences of this physiological process, caused by changes in hormonal levels and some other features of the female body. The chemical formula of Epigen cream is specially designed for daily care, which in practice is manifested by the absence of dryness and various types of irritation after its use.
The price of the intimate gel is indicated below, but it is worth noting that among hygiene products it is the best, because it contains a plant with therapeutic properties. Licorice root has long been used for medicinal and cosmetic purposes, which creates a certain level of trust in this pharmaceutical drug, which is why women tend to choose an experienced method of daily intimate hygiene.
Pharmacological properties
Ammonium glycyrrhizinate, isolated from licorice, determines the high therapeutic effectiveness of Epigen. After it penetrates the mucous membranes and skin, it comes into contact with the outer shell of the virus. Such an effect leads to inhibition of the replication of infectious pathogens in the early stages. The virion loses its ability to penetrate the cells of the human body with their further destruction.
Ammonium glycyrrhizinate exhibits antiviral activity against the following infectious agents:
- herpes simplex viruses;
- papillomaviruses;
- cytomegaloviruses;
- Varicella Zoster viruses;
- mutated viruses resistant to other antiviral drugs;
- certain strains of gram-positive and gram-negative bacteria;
- yeast-like fungi.
Bacteria, viruses and fungi that the drug fights.
The active ingredient of Epigen stimulates the production of lymphocytes to destroy viruses, bacteria, and fungi. It helps strengthen local immunity and increase the body's defenses against negative factors. During the treatment, there is also an acceleration of regeneration due to improved blood circulation.
Epigen Intim price, where to buy
The pharmaceutical drug cannot be classified as cheap, but the evidence of therapeutic effects and production in Spain is really worth the money. In the Russian Federation, the price of Epigen Intim spray starts at 600 rubles - for such a minimum price a 15 ml bottle is purchased. You can buy a spray in a 60 ml bottle for between 1100 and 1500 rubles - this form of the drug may be required, for example, for thrush due to a decrease in the body’s own immune parameters. In St. Petersburg, the drug is distributed by the Ozerki Pharmacy - intimate hygiene gel can be purchased from the distributor for an average of 650 rubles.
The price of Epigen intimate spray in other post-Soviet countries may vary not only from the form and quantity of the drug, but also from the place of purchase, since some pharmacy chains enter into individual contracts with foreign suppliers. Ukraine demonstrates this situation: in first place is Dnepropetrovsk, where a 60 ml cylinder can be purchased for 400 hryvnia. Next comes Kharkov - the price of a spray for intimate hygiene is 460-480 hryvnia, and you can buy a spray in Kyiv for 500 hryvnia. The price of Epigen Intim gel is the same throughout almost the entire country and is about 300-350 hryvnia.
In Belarus, a medicinal spray with a capacity of 15 ml can be purchased for 370,000 BYN. rubles The price of intimate hygiene gel is almost 2 times less and in Minsk is about 170,000 BYN. rubles Such a large difference in the cost of various pharmaceutical forms of Epigen Intim is justified by the scope of application, because the gel is used mainly for everyday hygiene procedures, and the spray is prescribed for therapeutic purposes by qualified medical specialists.
You should find out how much a medicine costs in Kazakhstan yourself, since there is no reliable data provided by licensed points of sale.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Epigen Intim spray for local use.
and outside approx. 0.1% 60ml Cheminova/B.Brown Medical S.A RUR 2,676 order - Epigen intimate spray 0.1% 15mlCheminova/B.Brown Medical S.A.
RUB 1,329 order
- Epigen intimate gel 250mlCHEMIGROUP FRANCE
RUB 1,189 order
Pharmacy Dialogue
- Epigen Intim (spray 0.1% 15ml) Cheminova/B.Braun
RUB 1,390 order
- Epigen Intim spray 0.1% 15mlB.Braun
RUB 1,375 order
- Epigen Intim spray 60mlB.Braun
RUB 2,771 order
- Epigen Intim gel for intimate hygiene 250ml Cheminova
RUB 1,495 order
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PaniPharmacy
- Epigen intimate gel 250ml Ukraine, Heminova
404 UAH. order
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