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Manufacturers: Synthesis, Biochemist, Shandong Keyuan Pharmaceutical Co. ltd., ShanDong Weifang Pharmaceutical Factory
Active ingredients
- Benzylpenicillin
Disease class
- Bacterial meningitis, not elsewhere classified
- Corneal ulcer
- Acute and subacute infective endocarditis
- Bronchopneumonia, unspecified
- Bronchitis, not specified as acute or chronic
- Pyothorax
- Impetigo
- Acute peritonitis
- Local infection of skin and subcutaneous tissue, unspecified
- Cholangitis
- Soft tissue disease, unspecified
- Osteomyelitis, unspecified
- Lesion of the skin and subcutaneous tissue, unspecified
- Urinary tract infections during pregnancy
- Pleurisy
- anthrax
- Leptospirosis icteric-hemorrhagic
- Leptospirosis, unspecified
- Diphtheria, unspecified
- Scarlet fever
- Septicemia, unspecified
- Pulmonary actinomycosis
- Erysipelas
- Gas gangrene
- Syphilis, unspecified
- Gonococcal eye infection
- Gonococcal infection, unspecified
- Post-traumatic wound infection, not elsewhere classified
- Acute tonsillitis, unspecified
- Urinary tract infection without established localization
- Inflammatory diseases of the female pelvic organs, unspecified
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Antibacterial
- Bactericidal
Pharmacological group
- Penicillins
Pharmacodynamics and pharmacokinetics
Benzylpenicillin is a biosynthetic antibiotic and belongs to the group of penicillins . The bactericidal effectiveness of the drug is manifested due to its ability to inhibit the synthesis of bacterial cell .
The effect of the drug is detrimental to gram-positive microorganisms: staphylococci , causative agents of diphtheria and anthrax , streptococci ; gram-negative bacteria: pathogens of gonorrhea and meningococcal infection ; spore-forming anaerobic rods; as well as spirochetes and actinomycetes .
Strains of staphylococci that produce penicillinase are not sensitive to the effects of benzylpenicillin .
When the drug is administered intramuscularly, TCmax in plasma is observed after 20-30 minutes. Binding to plasma proteins occurs by 60%. The antibiotic has good penetration into tissues, biological fluids and organs of the human body, with the exception of cerebrospinal fluid , prostate gland and eye tissues, and passes through the BBB . Excretion is carried out in unchanged form by the kidneys. T1/2 fluctuates between 30-60 minutes, with kidney pathologies it can increase to 4-10 hours or even more.
Benzylpenicillin sodium
Benzylpenicillin sodium salt is administered intramuscularly, intravenously, subcutaneously, endolumbarally, intratracheally.
For moderate disease (infections of the upper and lower respiratory tract, urinary and biliary tract, soft tissue infection, etc.) - 4-6 million units/day for 4 administrations. For severe infections (sepsis, septic endocarditis, meningitis, etc.) - 10-20 million units/day; with gas gangrene - up to 40-60 million units/day.
The daily dose for children under 1 year of age is 50-100 thousand units/kg, over 1 year of age – 50 thousand units/kg; if necessary - 200-300 thousand units/kg, for “vital” indications - increase to 500 thousand units/kg. Frequency of administration - 4-6 times a day, intravenous - 1-2 times a day in combination with intramuscular injections.
It is administered endolumbarally for purulent diseases of the brain, spinal cord and meninges. Depending on the disease and the severity of its course: adults - 5-10 thousand units, children - 2-5 thousand units once a day for 2-3 days intravenously, then prescribed intramuscularly.
For intravenous jet administration, a single dose (1-2 million units) is dissolved in 5-10 ml of sterile water for injection or 0.9% NaCl solution and administered slowly over 3-5 minutes. For intravenous drip administration, 2-5 million units are diluted with 100-200 ml of 0.9% NaCl solution or 5-10% dextrose solution and administered at a rate of 60-80 drops/min. When administered dropwise to children, a 5-10% dextrose solution (30-100 ml depending on the dose and age) is used as a solvent.
Solutions are used immediately after preparation, without allowing other drugs to be added to them.
Endolumbar. The drug is diluted in sterile water for injection or in 0.9% NaCl solution at the rate of 1 thousand units/ml. Before injection (depending on the level of intracranial pressure), 5-10 ml of CSF is removed and added to the antibiotic solution in equal proportions.
Inject slowly (1 ml/min), usually once a day for 2-3 days, then proceed to intravenous or intramuscular injections.
In case of suppurative processes in the lungs, a solution of the drug is administered intratracheally (after thorough anesthesia of the pharynx, larynx and trachea). Usually 100 thousand units are used in 10 ml of 0.9% NaCl solution.
For eye diseases (acute conjunctivitis, corneal ulcer, gonoblennorrhea, etc.), eye drops containing 20-100 thousand units in 1 ml of 0.9% NaCl solution or distilled water are sometimes prescribed. Inject 1-2 drops 6-8 times a day.
For ear drops or nasal drops, solutions containing 10-100 thousand units/ml are used.
Benzylpenicillin potassium salt is administered only intramuscularly and subcutaneously, in the same doses as benzylpenicillin sodium salt.
Benzylpenicillin procaine salt is administered only intramuscularly. Average therapeutic dose for adults: single - 300 thousand units, daily - 600 thousand units. The highest daily dose for adults is 1.2 million units. Children under the age of 1 year are prescribed 50-100 thousand units/kg/day, over 1 year - 50 thousand units/kg/day. The frequency of administration is 1-2 times a day.
The duration of treatment with benzylpenicillin, depending on the form and severity of the disease, is 7-10 days.
Indications for use
Benzylpenicillin is indicated for the treatment of diseases that were caused by microorganisms sensitive to its effects:
- focal/lobar pneumonia ;
- syphilis;
- pleural empyema;
- scarlet fever;
- sepsis;
- diphtheria;
- septicemia;
- erysipelas;
- pyemia;
- anthrax;
- septic endocarditis (subacute and acute);
- actinomycosis;
- meningitis;
- ENT infections;
- osteomyelitis;
- gonorrhea;
- biliary and urinary tract infections;
- blenorrhea;
- angina;
- infections of mucous membranes and soft tissues;
- purulent skin infections;
- purulent-inflammatory infections in gynecologists.
Benzylpenicillin sodium salt 1 million units 50 pcs. powder for solution for injection
pharmachologic effect
Antibiotic of the group of biosynthetic penicillins.
It has a bactericidal effect by inhibiting the synthesis of the cell wall of microorganisms. Active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis; anaerobic spore-forming rods; as well as Actinomyces spp., Spirochaetaceae.
Strains of Staphylococcus spp. that produce penicillinase are resistant to the action of benzylpenicillin. Destroys in an acidic environment.
The novocaine salt of benzylpenicillin, compared to the potassium and sodium salts, is characterized by a longer duration of action.
Composition and release form Benzylpenicillin sodium salt 1 million units 50 pcs. powder for solution for injection
Powder - 1 vial: benzylpenicillin sodium salt 1 million units.
1 million units - bottles (50) - cardboard packs.
Description of the dosage form
Powder for the preparation of solution for injection is white, with a slight characteristic odor.
Directions for use and doses
Individual. Injected intramuscularly, intravenously, subcutaneously, endolumbarally.
When administered intramuscularly and intravenously to adults, the daily dose varies from 250,000 to 60 million units. The daily dose for children under 1 year of age is 50,000-100,000 units/kg, over 1 year of age - 50,000 units/kg; if necessary, the daily dose can be increased to 200,000-300,000 units/kg, for health reasons - up to 500,000 units/kg. Frequency of administration 4-6 times/day.
Depending on the disease and severity, adults are administered endolumbarally - 5000-10,000 units, children - 2000-5000 units. The drug is diluted in sterile water for injection or in 0.9% sodium chloride solution at the rate of 1 thousand units/ml. Before injection (depending on the level of intracranial pressure), 5-10 ml of CSF is removed and added to the antibiotic solution in equal proportions.
Subcutaneous benzylpenicillin is used to inject infiltrates (100,000-200,000 units in 1 ml of 0.25%-0.5% novocaine solution).
Benzylpenicillin potassium salt is used only intramuscularly and subcutaneously, in the same doses as benzylpenicillin sodium salt.
Benzylpenicillin novocaine salt is used only intramuscularly. Average therapeutic dose for adults: single - 300,000 units, daily - 600,000 units. Children under 1 year of age - 50,000-100,000 units/kg/day, over 1 year of age - 50,000 units/kg/day. Frequency of administration 3-4 times/day.
The duration of treatment with benzylpenicillin, depending on the form and severity of the disease, can range from 7-10 days to 2 months or more.
Pharmacokinetics
After intramuscular administration, it is quickly absorbed from the injection site. Widely distributed in tissues and body fluids. Benzylpenicillin penetrates well through the placental barrier and the blood-brain barrier during inflammation of the meninges.
T1/2 - 30 min. Excreted in urine.
Indications for use: Benzylpenicillin sodium salt 1 million units 50 pcs. powder for solution for injection
Treatment of diseases caused by microorganisms sensitive to benzylpenicillin: lobar and focal pneumonia, pleural empyema, sepsis, septicemia, pyaemia, acute and subacute septic endocarditis, meningitis, acute and chronic osteomyelitis, urinary and biliary tract infections, tonsillitis, purulent infections of the skin, soft tissues and mucous membranes, erysipelas, diphtheria, scarlet fever, anthrax, actinomycosis, treatment of purulent-inflammatory diseases in obstetric and gynecological practice, ENT diseases, eye diseases, gonorrhea, blenorrhea, syphilis.
Contraindications
Hypersensitivity to benzylpenicillin and other drugs from the group of penicillins and cephalosporins. Endolumbar administration is contraindicated in patients with epilepsy.
Application of Benzylpenicillin sodium salt 1 million units 50 pcs. powder for the preparation of solution for injection during pregnancy and lactation
Use during pregnancy is possible only if the expected benefit of therapy for the mother outweighs the potential risk to the fetus.
If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.
special instructions
Use with caution in patients with impaired renal function, heart failure, predisposition to allergic reactions (especially drug allergies), and hypersensitivity to cephalosporins (due to the possibility of developing cross-allergy).
If no effect is observed 3-5 days after the start of use, you should move on to the use of other antibiotics or combination therapy.
Due to the possibility of developing fungal superinfection, it is advisable to prescribe antifungal drugs when treating with benzylpenicillin.
It must be taken into account that the use of benzylpenicillin in subtherapeutic doses or early cessation of treatment often leads to the emergence of resistant strains of pathogens.
Side effects of Benzylpenicillin sodium salt 1 million units 50 pcs. powder for solution for injection
From the digestive system: diarrhea, nausea, vomiting.
Effects caused by chemotherapy: vaginal candidiasis, oral candidiasis.
From the side of the central nervous system: when benzylpenicillin is used in high doses, especially with endolumbar administration, neurotoxic reactions may develop: nausea, vomiting, increased reflex excitability, symptoms of meningism, convulsions, coma.
Allergic reactions: fever, urticaria, skin rash, rash on mucous membranes, joint pain, eosinophilia, angioedema. Cases of anaphylactic shock with fatal outcome have been described.
Drug interactions
Probenecid reduces the tubular secretion of benzylpenicillin, as a result of which the concentration of the latter in the blood plasma increases and the half-life increases.
When used simultaneously with antibiotics that have a bacteriostatic effect (tetracycline), the bactericidal effect of benzylpenicillin is reduced.
Side effects
candidiasis of the oral cavity and/or vagina , may occur .
From the gastrointestinal tract, a feeling of nausea , diarrhea , and sometimes vomiting .
On the part of the central nervous system, especially when using high doses of the drug or when performing endolumbar injections, the formation of neurotoxic phenomena , such as an increase in reflex excitability, convulsions , nausea, symptoms of meningism , vomiting, coma .
The observed allergic manifestations included fever , skin rash and/or rash on mucous membranes, urticaria , joint pain, angioedema , eosinophilia anaphylactic shock , which can be fatal is also possible .
Benzylpenicillin sodium salt, instructions for use
The dosage regimen of benzylpenicillin is determined individually. Intramuscular (IM), subcutaneous (SC), intravenous (IV) and endolumbar administration of the drug is practiced.
In the case of intramuscular and intravenous injections, the daily dosage for adult patients varies between 250,000-60,000,000 units. As a rule, benzylpenicillin sodium salt 1,000,000 units is used.
The daily pediatric dose is calculated based on the child's weight and is 50,000-100,000 units per kilogram of weight for the age of up to 1 year and 50,000 units per kilogram of weight for the age after the 1st year. According to indications, it is possible to increase the daily dosage to 300,000 units per kilogram of weight, for vital indications - up to 500,000 units per kilogram of weight. The drug is administered 4-6 times every 24 hours.
Basically, for intravenous and intramuscular injections, the powder is diluted in water d/in . Also, for intramuscular use, it can be dissolved in novocaine (0.5%), with a preliminary test to determine the patient’s sensitivity to it. Before diluting benzylpenicillin sodium salt, you should visually check the powder for the content of foreign inclusions. The prepared solution can be stored for no more than 24 hours.
Subcutaneous administration of an antibiotic is practiced to puncture infiltrates . In this case, dissolve 100,000-200,000 units of powder in 1 ml of novocaine (0.25-0.5%).
Endolumbar injections are performed based on the disease and its severity. Adult doses are 5000-10000 units, children's doses are 2000-5000 units. In this case, the powder is diluted with water d/in . or sodium chloride (0.9%) at the rate of 1000 units per 1 ml of solvent. Before administration, depending on intracranial pressure , 5-10 ml of CSF and added to the prepared drug solution in a 1:1 ratio.
The minimum duration of treatment is limited to 7 days, the maximum can last up to 2 months or even longer.
Publications in the media
Benzylpenicillin (Benzylpenicillin sodium salt, Benzylpenicillin potassium salt, Penicillin G sodium salt sterile), powder for preparing a solution for intravenous and intramuscular administration, powder for preparing a solution for intramuscular administration, powder for preparing a solution for intramuscular and subcutaneous administration, powder for preparing a suspension for intramuscular injection
Pharmaceutical group - biosynthetic antibiotic penicillin.
Pharmaceutical action. Bactericidal antibiotic from the group of biosynthetic (“natural”) penicillins. Suppresses the synthesis of the cell wall of microorganisms. Active against gram-positive pathogens: staphylococci (non-penicillinase-forming), streptococci, pneumococci, corynebacteria diphtheria, anaerobic spore-forming bacilli, anthrax bacilli, Actinomyces spp.; gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, as well as against Treponema spp., gonococci, meningococci and spirochetes. Inactive against most gram-negative bacteria, rickettsia, viruses, and protozoa. Penicillinase-forming strains of microorganisms are resistant to the action of the drug. Destroys in an acidic environment. The procaine salt of benzylpenicillin, in comparison with the potassium and sodium salts, is characterized by a longer duration of action.
Pharmacokinetics. TCmax with intramuscular administration - 20-30 minutes. T1/2 30-60 minutes, in case of renal failure - 4-10 hours or more. Communication with plasma proteins - 60%. Penetrates into organs, tissues and biological fluids, except for cerebrospinal fluid, eye and prostate tissues, during inflammation of the meningeal membranes it penetrates the BBB. It is excreted unchanged by the kidneys. Indications. Bacterial infections caused by sensitive pathogens: lobar and focal pneumonia, pleural empyema, bronchitis; sepsis, septic endocarditis (acute and subacute), peritonitis; meningitis; osteomyelitis; infections of the genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, blenorrhea, syphilis, cervicitis), biliary tract (cholangitis, cholecystitis); wound infection, skin and soft tissue infections: erysipelas, impetigo, secondary infected dermatoses; diphtheria; scarlet fever; anthrax; actinomycosis; infections of the ENT organs and infections of the eyeball.
Contraindications. Hypersensitivity; epilepsy (for endolumbar administration), hyperkalemia, arrhythmias (for potassium salt). Carefully . Pregnancy, lactation period.
Dosing. Benzylpenicillin sodium salt is administered intramuscularly, intravenously, subcutaneously, endolumbarally, intratracheally. For moderate disease (infections of the lower respiratory tract, urinary and biliary tract, infection of soft tissues, etc.) - 4-6 million units/day for 4 administrations. For severe infections (sepsis, septic endocarditis, meningitis, etc.) - 10-20 million units/day; with gas gangrene - up to 40-60 million units/day. The daily dose for children under 1 year of age is 50-100 thousand units/kg, over 1 year of age – 50 thousand units/kg; if necessary - 200-300 thousand units/kg, for “vital” indications - increase to 500 thousand units/kg. Frequency of administration - 4-6 times a day, intravenous - 1-2 times a day in combination with intramuscular injections. It is administered endolumbarally for purulent diseases of the brain, spinal cord and meninges. Depending on the disease and the severity of its course: adults - 5-10 thousand units, children - 2-5 thousand units once a day for 2-3 days intravenously, then prescribed intramuscularly. For intravenous jet administration, a single dose (1-2 million units) is dissolved in 5-10 ml of sterile water for injection or 0.9% NaCl solution and administered slowly over 3-5 minutes. For intravenous drip administration, 2-5 million units are diluted with 100-200 ml of 0.9% NaCl solution or 5-10% dextrose solution and administered at a rate of 60-80 drops/min. When administered dropwise to children, a 5-10% dextrose solution (30-100 ml depending on the dose and age) is used as a solvent. Solutions are used immediately after preparation, without allowing other drugs to be added to them. Endolumbar. The drug is diluted in sterile water for injection or in 0.9% NaCl solution at the rate of 1 thousand units/ml. Before injection (depending on the level of intracranial pressure), 5-10 ml of CSF is removed and added to the antibiotic solution in equal proportions. Inject slowly (1 ml/min), usually once a day for 2-3 days, then proceed to intravenous or intramuscular injections. In case of suppurative processes in the lungs, a solution of the drug is administered intratracheally (after thorough anesthesia of the pharynx, larynx and trachea). Usually 100 thousand units are used in 10 ml of 0.9% NaCl solution. For eye diseases (acute conjunctivitis, corneal ulcer, gonoblennorrhea, etc.), eye drops containing 20-100 thousand units in 1 ml of 0.9% NaCl solution or distilled water are sometimes prescribed. Inject 1-2 drops 6-8 times a day. For ear drops or nasal drops, solutions containing 10-100 thousand units/ml are used. Benzylpenicillin potassium salt is administered only intramuscularly and subcutaneously, in the same doses as benzylpenicillin sodium salt. Benzylpenicillin procaine salt is administered only intramuscularly. Average therapeutic dose for adults: single - 300 thousand units, daily - 600 thousand units. The highest daily dose for adults is 1.2 million units. Children under the age of 1 year are prescribed 50-100 thousand units/kg/day, over 1 year - 50 thousand units/kg/day. The frequency of administration is 1-2 times a day. The duration of treatment with benzylpenicillin, depending on the form and severity of the disease, is 7-10 days.
Side effect . Allergic reactions (hyperthermia, urticaria, skin rash, rash on mucous membranes, arthralgia, eosinophilia, angioedema, interstitial nephritis, bronchospasm); rarely - anaphylactic shock. At the beginning of the course of treatment (especially when treating congenital syphilis), rarely - fever, chills, increased sweating, exacerbation of the disease, Jarisch-Herxheimer reaction. For sodium salt - decreased pumping function of the myocardium; for potassium salt - arrhythmias, cardiac arrest, hyperkalemia. With endolumbar administration - neurotoxic reactions: nausea, vomiting, increased reflex excitability, meningeal symptoms, convulsions, coma. Local reactions: pain and hardness at the site of intramuscular injection. With long-term use: dysbacteriosis, development of superinfection. Interaction. Bactericidal antibiotics (including cephalosporins, vancomycin, rifampicin, aminoglycosides) have a synergistic effect; bacteriostatic (including macrolides, chloramphenicol, lincosamides, tetracyclines) - antagonistic. Increases the effectiveness of indirect anticoagulants (suppressing intestinal microflora, reduces the prothrombin index); reduces the effectiveness of oral contraceptives, drugs, during the metabolism of which PABA is formed, ethinyl estradiol - the risk of developing breakthrough bleeding. Diuretics, allopurinol, tubular secretion blockers, phenylbutazone, NSAIDs, reducing tubular secretion, increase the concentration of benzylpenicillin. Allopurinol increases the risk of allergic reactions (skin rash).
Special instructions. Solutions of the drug for intramuscular administration are prepared ex tempore. If no effect is observed 2-3 days (maximum 5 days) after starting to use the drug, you should proceed to the use of other antibiotics or combination therapy. Due to the possibility of developing fungal infections, it is advisable to prescribe B vitamins and vitamin C during long-term treatment with benzylpenicillin, and, if necessary, nystatin and levorin. It must be taken into account that the use of insufficient doses of the drug or stopping treatment too early often leads to the emergence of resistant strains of pathogens.
Overdose
In case of overdose of benzylpenicillin, its toxic effect on the central nervous system was noted (mainly when administered endolumbarally). The observed symptoms were manifested by reflex agitation , nausea, headaches , myalgia , vomiting, convulsions , meningism , arthralgia, coma .
In this situation, further injections are stopped and symptomatic treatment is prescribed, including hemodialysis . In this case, special attention is paid to the water-electrolyte state.
special instructions
Benzylpenicillin is prescribed with extreme caution to patients with kidney pathologies , heart failure , allergies (especially drug allergies ), as well as hypersensitivity to cephalosporins (due to the possible formation of cross-reactions).
In case of zero effect of therapy carried out over 3-5 days, the possibility of combination with other drugs or the prescription of other antibiotics .
During treatment fungal superinfections , and therefore it is advisable to use antifungal agents .
It should be remembered that early interruption of treatment with benzylpenicillin or its use in subtherapeutic doses contributes to the formation of resistant bacterial strains .
Analogs
Level 4 ATC code matches:
Bicillin
Phenoxymethylpenicillin
Extensillin
Retarpen
Benzylpenicillin
Sulacillin
- Bicillin;
- Phenoxymethylpenicillin;
- Benzicillin;
- Ospen;
- Moldamin;
- Retarpen;
- Star Pen.
Reviews
On various Internet resources you can find both negative and positive reviews about benzylpenicillin sodium salt . When the drug is used against microorganisms , the treatment almost always shows good results and, on the contrary, when using Benzylpenicillin to destroy strains of bacteria , at best, it is wasted. In this regard, for any bacterial infection causative agent before starting therapy and only then prescribe an antibiotic .
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Benzylpenicillin sodium salt, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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Price, where to buy
The price for benzylpenicillin sodium salt, 1,000,000 units, is 6-7 rubles per bottle.
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
PaniPharmacy
- Benzylpenicillin bottle Benzylpenicillin sodium salt powder for injection 1000000IU Ukraine, Kievmedpreparat OJSC
11 UAH.order
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Benzylpenicillin sodium salt
Benzylpenicillin sodium salt is administered intramuscularly, intravenously, subcutaneously, locally.
Intravenous and intramuscular: for moderate disease (infections of the upper and lower respiratory tract, urinary and biliary tract, soft tissue infection, etc.) - 4-6 million units/day for 4 administrations. For severe infections (sepsis, septic endocarditis, meningitis, etc.) - 10-20 million units/day; with gas gangrene - up to 40-60 million units/day.
The daily dose for children under 1 year of age is 50-100 thousand units/kg, over 1 year of age – 50 thousand units/kg; if necessary - 200-300 thousand units/kg, for “vital” indications - increase to 500 thousand units/kg. Frequency of administration: intramuscularly - 4-6 times a day, intravenously - 1-2 times a day in combination with intramuscular injections.
Subcutaneously to inject infiltrates at a concentration of 100-200 thousand units in 1 ml of 0.25-0.5% procaine solution.
In the cavity (abdominal, pleural, etc.), a solution of benzylpenicillin sodium salt is administered to adults at a concentration of 10-20 thousand units per 1 ml, for children - 2-5 thousand units per 1 ml. Water for injection or 0.9% sodium chloride solution is used as a solvent. The duration of treatment is 5-7 days, followed by switching to intramuscular administration.
For eye diseases, eye drops are prescribed containing 20-100 thousand units in 1 ml of a sterile 0.9% sodium chloride solution or distilled water. Inject 1-2 drops 6-8 times a day. The solution is used freshly prepared.
For ear drops or nasal drops, solutions containing 10-100 thousand units in 1 ml of sterile 0.9% sodium chloride solution or distilled water are used. Administer 1-2 drops 6-8 times a day.
The duration of treatment with benzylpenicillin, depending on the form and severity of the disease, is 7-10 days.
Solutions are used immediately after preparation, avoiding the addition of other medications to them.
For intramuscular administration, add 1-3 ml of water for injection, 0.9% sodium chloride solution or 0.5% procaine (novocaine) solution to the contents of the bottle. The resulting solution is injected deep into the muscle.
When benzylpenicillin is diluted in a procaine solution, cloudiness of the solution may be observed due to the formation of benzylpenicillin procaine crystals, which is not an obstacle to intramuscular and subcutaneous administration of the drug.
For intravenous jet administration, a single dose (1-2 million units) is dissolved in 5-10 ml of sterile water for injection or 0.9% sodium chloride solution and administered slowly over 3-5 minutes.
For intravenous drip administration, 2-5 million units are diluted in 100-200 ml of 0.9% sodium chloride solution or 5-10% dextrose solution and administered at a rate of 60-80 drops/min. When administered dropwise to children, a 5-10% dextrose solution (30-100 ml depending on the dose and age) is used as a solvent.
For subcutaneous administration, the contents of the bottle are diluted in 0.25-0.5% procaine solution: 500 thousand units in 2.5-5 ml, 1 million units in 5-10 ml, respectively.
For intracavitary administration, the contents of the bottle are diluted in 0.9% sodium chloride solution or water for injection: adults - 500 thousand units in 25-50 ml, 1 million units in 50-100 ml, respectively; children - 500 thousand units in 100-250 ml, 1 million units in 200-500 ml, respectively.
Eye drops should be prepared ex tempore: the contents of the bottle are diluted in a 0.9% solution of sodium chloride or distilled water: 500 thousand units in 5-25 ml, 1 million units in 10-50 ml, respectively.
Ear drops and nasal drops: the contents of the bottle are diluted in a 0.9% solution of sodium chloride or distilled water: 500 thousand units in 5-50 ml, 1 million units in 10-100 ml, respectively.
