Haloperidol-ratiopharm Drops, 30 ml, 2 mg/ml
Side effect
When treating with Haloperidol-ratiopharm-drops, many patients experience side effects such as early dyskinesia (spasms of masticatory muscles, oculogyric crises, back muscle tension, convulsive tongue protrusion, dystonic phenomena), Parkinson's syndrome (tremor, stiffness) and akathisia (motor restlessness) . It should be borne in mind that in children, extrapyramidal syndrome often develops at low dosages. If early dyskinesia or Parkinson's syndrome occurs, it is necessary to reduce the dosage or begin treatment with antiparkinsonian drugs (anticholinergics, for example, cyclodol). Treatment of akathisia is more complex. At the beginning of treatment, they try to reduce the dosage. If there is no success, they try to treat with sedatives and hypnotics and beta blockers. Sometimes, especially at the beginning of treatment, hypotension or orthostatic dysregulation and reflex tachycardia occur. At the beginning of treatment, you may experience a feeling of fatigue, and later - anxiety, tension, depressive mood disorders (especially with long-term treatment), insomnia, dizziness, and headaches. in rare cases, delirious symptoms and seizures. When using high doses, symptoms of autonomic dysregulation such as impaired accommodation, dry mouth, feeling of nasal congestion, increased intraocular pressure, constipation, nausea, retching, diarrhea, loss of appetite can sometimes be observed. In some cases, blood picture disorders such as leukopenia, thrombocytopenia, eosinophilia, and pancytopenia are detected. in very rare cases - agranulocytosis. In some cases, galactorrhea, gynecomastia, sexual dysfunction, increased body weight may appear, and thrombosis of the veins of the lower extremities may also rarely occur. In very rare cases, allergic reactions can be observed. In extremely rare cases, life-threatening neuroleptic malignant syndrome develops. SPECIAL INSTRUCTIONS With long-term treatment in large doses, tardive dyskinesia (prolonged hyperkinetic syndrome with involuntary movements mainly in the area of the maxillofacial muscles) may occur. There is currently no effective therapy for this syndrome. When using haloperidol, it is necessary to regularly monitor the blood count (every 2-4 weeks). If the white blood cell count decreases to or below 3000/mm3 or other abnormalities, treatment with haloperidol is discontinued. It is also necessary to regularly check the functional state of the kidneys, liver and cardiovascular system (by comparing initial and current ECG data). Patients should be informed that if, during the first 3 months after starting treatment with haloperidol, fever, inflammation of the gums or stomatitis, sore throat, signs of sore throat or inflammation of the throat occur, they should not begin self-medication, but immediately contact their doctor. doctor When high fever and muscle tension occur, you should always remember the possibility of neuroleptic malignant syndrome, which is often mistakenly confused with catatonia. Treatment of this syndrome is very difficult and includes the following measures: withdrawal of haloperidol. - treatment of hyperthermia with cooling, because antipyretics are often ineffective. - treatment of water and electrolyte imbalances, cardiovascular disorders, infections, respiratory and renal complications. - specific treatment with dantrolene infusions (3-10 mg/day) in combination with bromocriptine (7.5-30 mg/day) orally. Treatment of drug addicts with cocaine intoxication may increase extrapyramidal disorders. Warning While taking haloperidol, driving vehicles and servicing machinery, as well as other types of work that require increased concentration and quick motor reactions, are prohibited.
Haloperidol
Haloperidol increases the severity of the depressant effect on the central nervous system of opioid analgesics, hypnotics, tricyclic antidepressants, general anesthesia, and alcohol.
When used simultaneously with antiparkinsonian drugs (levodopa, etc.), the therapeutic effect of these drugs may be reduced due to the antagonistic effect on dopaminergic structures.
When used with methyldopa, disorientation, difficulty and slowdown in thinking processes may develop.
Haloperidol can reduce the intensity of the action of adrenaline (epinephrine) and other sympathomimetics, causing a “paradoxical” decrease in blood pressure and tachycardia when used together.
Enhances the effect of peripheral M-anticholinergic drugs and most antihypertensive drugs (reduces the effect of guanethidine due to its displacement from α-adrenergic neurons and suppression of its uptake by these neurons).
When combined with anticonvulsants (including barbiturates and other inducers of microsomal oxidation), the doses of the latter should be increased, because haloperidol lowers the threshold for seizure activity; Serum concentrations of haloperidol may also be reduced. In particular, with simultaneous consumption of tea or coffee, the effect of haloperidol may be reduced.
Haloperidol may reduce the effect of indirect anticoagulants, so when taken together, the dose of the latter should be adjusted.
Haloperidol slows down the metabolism of tricyclic antidepressants and MAO inhibitors, resulting in an increase in their plasma levels and increased toxicity.
When used simultaneously with bupropion, it reduces the epileptic threshold and increases the risk of epileptic seizures.
When taking haloperidol concomitantly with fluoxetine, the risk of side effects on the central nervous system, especially extrapyramidal reactions, increases.
When haloperidol is administered simultaneously with lithium, especially in high doses, it can cause irreversible neurointoxication and also increase extrapyramidal symptoms.
When taken simultaneously with amphetamines, the antipsychotic effect of haloperidol and the psychostimulating effect of amphetamines are reduced due to the blockade of α-adrenergic receptors by haloperidol.
Haloperidol may decrease the effect of bromocriptine.
Anticholinergic, antihistamine (1st generation), antidyskinetic agents may increase anticholinergic side effects and reduce the antipsychotic effect of haloperidol.
Haloperidol price, where to buy
The price of Haloperidol tablets 1.5 mg 50 pieces is 45-50 rubles.
10 ampoules of 5 mg/ml cost approximately 75 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Haloperidol tablets 1.5 mg 50 pcs. Ozon LLC
41 rub. order - Haloperidol Welfarm solution for intravenous and intramuscular injection. 5mg/ml 1ml 10pcs Velpharm LLC
102 RUR order
- Haloperidol solution for intravenous and intramuscular injection. 5mg/ml 1ml 10pcsOzon LLC
92 rub. order
- Haloperidol-Ratiopharm drops for internal use. approx. 2mg/ml 30ml Merckle GmbH.
53 RUR order
- Haloperidol tablets 5 mg 50 pcs. Ozone LLC
64 RUR order
special instructions
Regular monitoring of liver test levels, ECG dynamics, and blood parameters are required. Parenteral administration of the drug is carried out only under the supervision of the attending physician. After achieving a therapeutic effect, they switch to taking tablet forms of the drug. If tardive dyskinesia during treatment, a gradual reduction in dosage is required until complete cessation. When taking a hot bath, heat stroke due to the suppression of peripheral, central thermoregulation located in the hypothalamus. Caution is required when performing strenuous physical work. It is not recommended to use over-the-counter “anti-cold” medications during the entire treatment period due to the risk of heat stroke and increased anticholinergic effects. Due to the risk of photosensitivity, patients must protect exposed skin from exposure to sunlight. Haloperidol is discontinued gradually due to the risk of developing withdrawal syndrome. Often, the antiemetic effect of the drug masks signs of drug toxicity , and also complicates the diagnosis of conditions that are accompanied by nausea. Haloperidol may precipitate when mixing its solution with tea or coffee. Before prescribing long-acting forms of the drug, the patient is transferred to Haloperidol from other antipsychotics to prevent sudden hypersensitivity to the drug. The medication affects driving.
The medicine is described in Wikipedia.
INN: haloperidol.
OKPD: 24.42.13.693
Instructions for use of Haloperidol (Method and dosage)
Haloperidol tablets, instructions for use
Take orally with a full glass of milk and water. The initial dosage is 0.5-5 mg three times a day. No more than 100 mg per day. The duration of therapy is 2-3 months. The drug is discontinued gradually, the dosage is reduced slowly, and maintenance doses are switched to - 5-10 mg per day.
Tourette's disease, non-psychotic behavioral disorders: 2-3 times a day 0.05 mg/kg/day, with a gradual increase in dose by 0.5 mg once a week to a maximum of 0.075 mg/kg/day.
Using the solution
The average single dosage for intramuscular administration of Haloperidol is 2-5 mg, the interval between injections is 48 hours. Acute alcoholic psychosis: intravenously 5-10 mg.
Instructions for Haloperidol Ratiopharm drops
Typically consumed up to three times a day with food.
Adults are usually prescribed 0.5-1.5 mg 3 times a day. Further, the dose of the drug can be increased to an average of 10-15 mg per day. For acute symptoms, it is allowed to take 15 mg per day or more. The maximum dose is 100 mg per day.
The initial dose for children from three years of age is 0.025-0.05 mg per kg of body weight, taken 3 times. The maximum can be increased to 0.2 mg per kg of body weight.
Indications for use of Haloperidol
Indications for use are as follows. The drug is prescribed for hallucinations , delusions, acute psychosis, paranoid states , psychomotor agitation, “steroid” psychosis, alcoholic and drug psychosis, agitated depression, mental retardation, Tourette’s disease , psychoses of various origins, Huntington’s chorea , psychosomatic disorders, stuttering, childhood autism , hyperactivity in children.
