Mizo is a drug intended for the treatment of chronic alcoholism. Medicinal drops are an analogue of Colma, and you can buy them only with a doctor's prescription in pharmacies.
If a person decides to drink strong drinks while taking Mizo, he will develop a serious condition in the form of shortness of breath, chest pain, nausea, redness of the skin and fear. This reaction will be deposited in the patient’s mind after drinking alcohol (“if I drink, it will be very bad”). Gradually, a reflex reaction arises in the form of giving up alcohol.
Release form and composition
The drug is available in the form of drops for oral administration, which are a colorless transparent solution with a slight odor of acetic acid (15 ml in brown glass bottles, equipped with a dropper and a screw cap; 4 bottles in a cardboard box and instructions for use).
A drop of Mizo in 1 ml contains:
Active ingredient: cyanamide - 60 mg; auxiliary ingredients: acetic acid - 0.47 mg, sorbic acid - 0.2 mg, sodium acetate trihydrate - 0.47 mg, purified water - up to 1.0 ml.
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Pharmacological properties
Mizo drops are a drug for the treatment of chronic alcoholism, and can also be prescribed for the prevention of relapse. The mechanism of action is due to the blockade of aldehydrogenase, which is involved in ethanol metabolism. Blocking this enzyme leads to an increase in the concentration of ethanol metabolite - acetaldehyde, which causes negative sensations (for example, flushing, nausea, tachycardia, shortness of breath), which make drinking alcohol after taking cyanamide extremely unpleasant. This leads to a conditioned reflex of aversion to the taste and smell of alcoholic beverages.
The sensitizing effect of cyanamide to alcohol appears earlier (after about 45-60 minutes) and lasts shorter (about 12 hours) than disulfiram.
Unlike disulfiram, cyanamide does not have a hypotensive effect and has less intrinsic toxicity. In addition, cyanamide has greater specificity of action: unlike disulfiram, it only blocks aldehydrogenase and does not affect other enzymes, in particular dopamine β-hydroxylase.
Mizo (drops internally, 60 mg/ml, 15 ml flask, no. 4)
A country
Italy
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Compound
Bottle 15 ml
Cyanamide 60 mg per 1 ml. Excipients: sorbic acid - 0.2 mg, acetic acid - 0.47 mg, sodium acetate trihydrate - 0.47 mg, purified water - up to 1 ml. Drops for oral administration in the form of a clear, colorless solution with a faint odor of acetic acid.
pharmachologic effect
The action of cyanamide is based on the blockade of acetaldehyde dehydrogenase, which is involved in the metabolism of ethyl alcohol. This leads to an increase in the concentration of ethyl alcohol metabolite - acetaldehyde, which causes negative sensations (flushing, nausea, tachycardia, shortness of breath, etc.), which make drinking alcohol extremely unpleasant after taking the drug. This leads to a conditioned reflex aversion to the taste and smell of alcoholic beverages.
Indications for use
It is used to treat patients with chronic alcoholism and prevent relapse.
Side effects
As a rule, the drug is well tolerated if alcohol is not consumed. Sometimes fatigue, drowsiness, skin rashes, tinnitus, and transient leukocytosis are possible.
Contraindications
Severe heart disease, respiratory and kidney diseases with decreased function, severe liver disease, pregnancy, breastfeeding, increased individual sensitivity to the drug. Pregnancy and lactation: The use of the drug during pregnancy and breastfeeding is contraindicated.
Mode of application
Treatment is prescribed after a thorough examination of the patient and warning about the consequences and complications. The drug is prescribed orally, 12-25 drops (36-75 mg of cyanamide) 2 times a day with an interval of 12 hours according to an individual regimen.
special instructions
MIDO should only be used under the supervision of a physician and with the knowledge of the patient. You may have a reaction to the alcohol contained in some medications and foods. Treatment for MIZO can only begin after 12 hours have passed since the last time you took alcohol. Cyanamide should be used with caution in cases where a reaction to simultaneous use with alcohol may entail a risk to the patient's health: hyperthyroidism, diabetes, epilepsy, cardiovascular diseases, kidney diseases. With long-term use, it is recommended to monitor thyroid function at least once every six months. Reaction to alcohol When taking the drug simultaneously with alcohol, the following symptoms appear: severe hyperemia of the skin, “pulsation” in the head and neck, nausea, tachycardia, difficulty breathing, weakness, blurred vision, profuse sweating, chest pain. In the most severe cases - vomiting, decreased blood pressure, respiratory depression, collapsing state. The nature and severity of symptoms depend on the amount of alcohol and drug taken. In severe cases, it is necessary to carry out symptomatic therapy aimed at maintaining the functions of the respiratory and cardiovascular systems, and intravenous infusion of antihistamines.
Overdose
Symptoms of overdose are not described, increased side effects are possible. If too large doses of the drug are taken, gastric lavage and symptomatic treatment aimed at maintaining the functions of the liver, respiratory and cardiovascular system are recommended; monitoring of the hematocrit and, if necessary, blood transfusions are also necessary.
Interaction with other drugs
MIDOZO is not prescribed together with metronidazole, isoniazid, phenotoin and other aldehyde dehydrogenase inhibitors, which may increase the reaction with alcohol. After taking disulfiram, before prescribing MIZO. there must be a break of at least 10 days. MIZO is not compatible with drugs of the aldehyde group (paraldehyde and chloral products).
Dispensing conditions in pharmacies
On prescription
Contraindications for use
- respiratory diseases accompanied by decreased functionality;
- severe diseases of the cardiovascular system;
- serious liver disease;
- kidney disease with reduced kidney function;
- During pregnancy and breastfeeding;
- hypersensitivity to the main or auxiliary components of the drug.
Use during pregnancy and breastfeeding
Contraindicated for use during pregnancy and breastfeeding.
Use for liver dysfunction
Contraindicated in severe liver diseases.
Use for renal impairment
Contraindicated in kidney diseases accompanied by impaired function.
Mizo drops for oral administration 60 mg/ml 15 ml No. 4
Indications
Treatment of patients with chronic alcoholism; prevention of relapse of chronic alcoholism after treatment.
pharmachologic effect
A remedy for the treatment of chronic alcoholism. The mechanism of action is due to the blockade of aldehyde dehydrogenase involved in ethanol metabolism. Blockade of this enzyme leads to an increase in the concentration of ethanol metabolite - acetaldehyde, which causes negative sensations (including flushing, nausea, tachycardia, shortness of breath), which make drinking alcohol extremely unpleasant after taking cyanamide. This leads to a conditioned reflex aversion to the taste and smell of alcoholic beverages.
The sensitizing effect of cyanamide on alcohol appears earlier (after about 45-60 minutes) and lasts shorter (about 12 hours) than the effect of disulfiram.
Unlike disulfiram, cyanamide does not have a hypotensive effect and has lower intrinsic toxicity. In addition, cyanamide has greater specificity of action: unlike disulfiram, it blocks only aldehyde dehydrogenase and does not affect other enzymes, in particular dopamine beta-hydroxylase.
Drug interactions
Cyanamide should not be used simultaneously with metronidazole, isoniazid, phenytoin and other aldehyde dehydrogenase inhibitors - this may increase the reaction to alcohol consumption.
There should be a break of at least 10 days between the use of disulfiram and the prescription of cyanamide.
Cyanamide is not compatible with drugs of the aldehyde group (paraldehyde and chloral products).
Dosage regimen
Cyanamide is prescribed after a thorough examination of the patient. The patient must be warned about possible complications and consequences of the therapy.
Prescribed orally 2 times a day according to an individual regimen.
Contraindications for use
Severe diseases of the cardiovascular system; diseases of the respiratory system; kidney diseases accompanied by dysfunction; severe liver disease; pregnancy, breastfeeding; hypersensitivity to cyanamide.
Use for liver dysfunction
Contraindicated in severe liver diseases.
Restrictions for liver dysfunction
Use with caution
Use during pregnancy and breastfeeding
Contraindicated for use during pregnancy and breastfeeding.
Restrictions when breastfeeding
Contraindicated
Restrictions during pregnancy
Contraindicated
Use for renal impairment
Contraindicated in kidney diseases accompanied by impaired function.
Restrictions for impaired renal function
Use with caution
special instructions
Cyanamide should be used only under the supervision of a physician and with the patient's consent to the therapy. Be aware of the possibility of a reaction to ethanol contained in some medications and foods.
Treatment with cyanamide should be started only after 12 hours from the last time you drank alcohol.
When taking alcohol at the same time, severe hyperemia of the skin, a feeling of pulsation in the head and neck, nausea, tachycardia, difficulty breathing, weakness, blurred vision, increased sweating, and chest pain are possible. In the most severe cases: vomiting, decreased blood pressure, respiratory depression, collaptoid state. Manifestations and their severity depend on the dose of cyanamide and the amount of alcohol taken. In severe cases, symptomatic therapy is carried out aimed at maintaining the functions of the respiratory and cardiovascular systems, and intravenous administration of antihistamines.
Cyanamide is used with caution in cases where the patient's reaction to simultaneous alcohol consumption can lead to a risk to the patient's health: with hyperthyroidism, diabetes, epilepsy, diseases of the cardiovascular system, kidney diseases.
With long-term use of cyanamide, it is recommended to monitor thyroid function at least once every 6 months.
Side effect
Sometimes:
feeling of fatigue, drowsiness, skin rash, tinnitus, transient leukocytosis.
Cyanamide is generally well tolerated if the patient does not drink alcohol.
Instructions for use
Before taking Mizo, the patient must undergo a thorough examination. The patient should be warned about possible complications and consequences of treatment.
With the help of Mizo drops, wives try to “heal” their husbands. Mothers are trying to cure their children. To do this, without the knowledge of the patient, they mix the medicine into food. This should absolutely not be done!
The drug is taken orally 2 times a day, 12-25 drops (which corresponds to 36-75 mg of cyanamide). The dosage interval is 12 hours. The duration of treatment is individual and is prescribed by a narcologist.
Mizo should not be added to hot food because it is “destroyed” in it.
Precautionary measures
Mizo (Cyanamide) should only be used under medical supervision and with the consent of the patient. The possibility of a reaction to ethanol contained in some medications and foods should be considered.
Treatment with cyanamide should only begin 12 hours after the last drink.
Simultaneous consumption of alcohol can cause severe skin flushing, a sensation of pulsation in the head and neck, nausea, tachycardia, difficulty breathing, weakness, blurred vision, increased sweating, and chest pain. In the most severe cases: vomiting, low blood pressure, difficulty breathing, collapse. Manifestations and their severity depend on the dose of cyanamide and the amount of alcohol consumed. In severe cases, symptomatic therapy is carried out to maintain the functions of the respiratory and cardiovascular systems with the use of antihistamines.
Cyanamide should not be used together with metronidazole, isoniazid, phenytoin and other aldehydrogenase inhibitors - this may increase the reaction to alcohol consumption.
There should be an interval of at least 10 days between taking disulfiram and taking cyanamide.
Cyanamide is incompatible with drugs from the aldehyde group (paraldehyde and chlorine products).
Cyanamide is used with caution in cases where the patient's reaction to the simultaneous use of alcohol may jeopardize his health: with hyperthyroidism, diabetes, epilepsy, cardiovascular diseases, kidney diseases.
If cyanamide is used for a long time, it is recommended to check your thyroid function at least once every 6 months.
Mizo drops for internal use 60 mg/ml ampoule 15 ml No. 4
Compound
Active substance: cyanamide 60 mg.
Excipients: sorbic acid - 0.2 mg, acetic acid - 0.47 mg, sodium acetate trihydrate - 0.47 mg, purified water - up to 1 ml.
Pharmacokinetics
The sensitizing effect of cyanamide on alcohol appears earlier (after about 45-60 minutes) and lasts shorter (about 12 hours) than the effect of disulfiram.
Indications for use
- Treatment of patients with chronic alcoholism;
- prevention of relapse of chronic alcoholism after treatment.
Contraindications
- Severe diseases of the cardiovascular system;
- diseases of the respiratory system;
- kidney diseases accompanied by dysfunction;
- severe liver disease; pregnancy, breastfeeding;
- hypersensitivity to cyanamide.
Directions for use and doses
Treatment is prescribed after a thorough examination of the patient and warning about the consequences and complications.
The drug is prescribed orally, 12-25 drops (36-75 mg of cyanamide) 2 times a day with an interval of 12 hours according to an individual regimen.
Storage conditions
In a place protected from light at a temperature not exceeding 25°C. Keep out of the reach of children.
Best before date
2 years. Do not use the drug after the expiration date indicated on the package.
special instructions
Cyanamide should be used only under the supervision of a physician and with the patient's consent to the therapy. Be aware of the possibility of a reaction to ethanol contained in some medications and foods.
Treatment with cyanamide should be started only after 12 hours from the last time you drank alcohol.
When taking alcohol at the same time, severe hyperemia of the skin, a feeling of pulsation in the head and neck, nausea, tachycardia, difficulty breathing, weakness, blurred vision, increased sweating, and chest pain are possible. In the most severe cases: vomiting, decreased blood pressure, respiratory depression, collaptoid state. Manifestations and their severity depend on the dose of cyanamide and the amount of alcohol taken. In severe cases, symptomatic therapy is carried out aimed at maintaining the functions of the respiratory and cardiovascular systems, and intravenous administration of antihistamines.
Cyanamide is used with caution in cases where the patient's reaction to simultaneous alcohol consumption can lead to a risk to the patient's health: with hyperthyroidism, diabetes, epilepsy, diseases of the cardiovascular system, kidney diseases.
With long-term use of cyanamide, it is recommended to monitor thyroid function at least once every 6 months.
Description
A remedy for the treatment of chronic alcoholism.
Pharmacodynamics
The action of cyanamide is based on the blockade of acetaldehyde dehydrogenase, which is involved in the metabolism of ethyl alcohol. This leads to an increase in the concentration of ethyl alcohol metabolite - acetaldehyde, which causes negative sensations (flushing, nausea, tachycardia, shortness of breath, etc.), which make drinking alcohol extremely unpleasant after taking the drug. This leads to a conditioned reflex aversion to the taste and smell of alcoholic beverages.
Side effects
As a rule, the drug is well tolerated if alcohol is not consumed. Sometimes fatigue, drowsiness, skin rashes, tinnitus, and transient leukocytosis are possible.
Use during pregnancy and breastfeeding
The use of the drug during pregnancy and breastfeeding is contraindicated.
Interaction
Cyanamide should not be used simultaneously with metronidazole, isoniazid, phenytoin and other aldehyde dehydrogenase inhibitors - this may increase the reaction to alcohol consumption.
There should be a break of at least 10 days between the use of disulfiram and the prescription of cyanamide.
Cyanamide is not compatible with drugs of the aldehyde group (paraldehyde and chloral products).
Overdose
Symptoms of overdose are not described, increased side effects are possible. If too large doses of the drug are taken, gastric lavage and symptomatic treatment aimed at maintaining the functions of the liver, respiratory and cardiovascular system are recommended; monitoring of the hematocrit and, if necessary, blood transfusions are also necessary.
