Overdose
Symptoms: when used in accordance with the instructions, the risk of overdose is minimal. However, in case of accidental exposure to the gastrointestinal tract, the following symptoms of overdose are possible: pupil dilation, nausea, cyanosis, fever, convulsions, tachycardia, cardiac arrhythmia, cardiac arrest, increased blood pressure, pulmonary edema, impaired respiratory function, central nervous system function and coma. The risk of overdose symptoms associated with absorption of the drug is high in newborns and young children, especially if swallowed. Treatment: administration of activated carbon, gastric lavage, oxygen inhalation, administration of antipyretics and anticonvulsants. To lower blood pressure, use phentolamine 5 mg in saline solution (iv, slowly) or 100 mg (orally). Vasopressor agents are contraindicated in patients with low blood pressure. There is no known antidote for tetrizoline hydrochloride. If any symptoms of overdose appear, consult a doctor immediately!
Precautions for use
Contact lenses should be removed before instilling the drug and installed after approximately 15 minutes. It is advisable to use Vizin Classic only for mild eye irritation. If the condition does not improve within 48 hours or if irritation and redness persist or increase, you should discontinue the drug and consult a doctor. If you experience intense eye pain, headache, loss of vision, sudden appearance of floaters in front of your eyes, red eyes, pain when exposed to light, or double vision, you should immediately consult a doctor. You should not use Visin Classic if irritation or redness is associated with serious diseases of the organ of vision: infection, foreign body or chemical injury to the cornea. If the medicine has become unusable or has expired, do not pour it into wastewater or throw it outside. It must be placed in a bag and placed in a trash container. These measures will help protect the environment. Impact on the ability to drive a car and operate machinery. In rare cases, after using Visin Classic eye drops, the pupil may dilate and blurred vision may occur, which may affect the ability to drive a car or operate machinery.
Visine classic eye drops 0.05% 15ml
A country
Belgium
Country of manufacture may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Tetrizoline
Compound
The active ingredient is tetrizoline hydrochloride.
pharmachologic effect
Tetrizoline is an adrenomimetic drug that stimulates alpha-adrenergic receptors of the sympathetic nervous system, but has no or weak effect on beta-adrenergic receptors. Being an adrenomimetic amine, tetrizoline has a vasoconstrictor effect and reduces tissue swelling. The effect begins 60 seconds after instillation and lasts 4-8 hours. When applied topically, systemic absorption is possible in patients with damage to the mucous membrane and epithelium. Detailed pharmacokinetic studies have not been conducted following topical application of eye drops.
Indications for use
To relieve swelling and hyperemia of the conjunctiva (redness of the eyes), caused by exposure to chemical and physical factors (smoke, wind, dust, chlorinated water, light, cosmetics, contact lenses), as well as those arising from allergic reactions such as hay fever.
Mode of application
Locally. Adults and children over 2 years old, 1 drop into the affected eye 2-3 times a day. Use of the drug for more than 4 days should only be done under the supervision of a physician.
Interaction
The drug "Vizin Classic" should not be used simultaneously with MAO inhibitors such as tranylcypromine, tricyclic antidepressants, or drugs that increase blood pressure. Combination therapy with these groups of drugs can lead to increased vasoconstrictor effects and increased blood pressure.
Side effect
Uncommon: reactive hyperemia, burning sensation, dry mucous membranes, systemic disorders (for example, palpitations, headache, tremor, weakness, sweating and increased blood pressure). Blurred vision, conjunctival irritation, or rarely mydriasis may occur. In addition, systemic adrenomimetic effects are infrequently observed. In isolated cases, after long-term use of tetrizoline, keratinization of the epithelium (xerosis) of the conjunctiva with occlusion of the lacrimal openings and epiphora has been reported.
Contraindications
Hypersensitivity to the components of the drug, angle-closure glaucoma, children under 2 years of age.
Overdose
Symptoms: Excessive systemic absorption of alpha-adrenomimetic imidazole derivatives can lead to depression of the central nervous system, which is manifested by drowsiness, low body temperature, bradycardia, shock-like hypotension, apnea and coma. Symptoms of overdose are mydriasis, nausea, cyanosis, fever, convulsions, tachycardia, arrhythmia, cardiac arrest, increased blood pressure, pulmonary edema, respiratory dysfunction, and mental disorders. The risk of overdose symptoms associated with the absorption of the drug is especially high in newborns and small children if swallowed, resulting in possible disturbances in the central nervous system, as well as respiratory depression and collapse. The toxic dose of tetrizoline is 0.01 mg per kilogram of body weight. Treatment : In case of overdose, activated charcoal, gastric lavage, oxygen inhalation, antipyretics and anticonvulsants are prescribed. To lower blood pressure, use phentolamine 5 mg in saline solution slowly intravenously or 100 mg orally. Vasopressor drugs are contraindicated in patients with low blood pressure. In case of symptoms caused by blockade of m-cholinergic receptors, the antidote physostigmine is used. If any symptoms of overdose appear, consult a doctor immediately!
special instructions
Contact lenses should be removed before instilling the drug and installed after 15 minutes. It is necessary to avoid direct contact of the drug with soft contact lenses due to possible disruption of their transparency. The development of reactive hyperemia of the conjunctiva and nasal mucosa (rhinitis medicamentosa) may develop due to improper use of the drug. If you experience intense pain in the eyes, severe acute or unilateral redness of the eyes, headaches, blurred vision, spots before the eyes or double vision, you should immediately consult a doctor. If irritation or redness is associated with serious diseases of the organ of vision: infection, foreign body or chemical injury to the cornea, consultation with an ophthalmologist is necessary. Long-term use and overdose of the drug should be avoided, especially in children. If the medicine has become unusable or has expired, do not pour it into wastewater or throw it outside! Place the medication in a bag and place it in the trash. These measures will help protect the environment! In rare cases, after using Visin Classic eye drops, blurred vision occurs, which can affect the ability to drive a car and operate machinery.
Special instructions for use
Before instilling the drug, it is necessary to remove contact lenses and install them approximately 15 minutes after instillation. It is advisable to use the drug only for mild eye irritation. The patient should be warned that if the condition does not improve within 48 hours or if irritation and hyperemia persist or increase, the drug should be discontinued and consult a doctor. The patient should be informed that if intense pain in the eyes, headache, loss of vision, sudden appearance of “floating” spots in front of the eyes, redness of the eyes, pain when exposed to light or double vision occurs, it is necessary to immediately consult a doctor. The drug should not be used if irritation or hyperemia is associated with serious diseases of the organ of vision, such as infection, foreign body or chemical trauma to the cornea. The patient should be informed that if the medicine has become unusable or has expired, it should not be thrown into wastewater or onto the street. It is necessary to place the medicine in a bag and place it in the trash container. These measures will help protect the environment.
Impact on the ability to drive vehicles and operate machinery In rare cases, after using eye drops, pupil dilation is observed and blurred vision occurs, which may affect the ability to drive a car or operate machinery.
Visine eye drops Classic 0.05%, 15ml
Registration Certificate Holder
JOHNSON & JOHNSON (Russia)
Dosage form
Medicine - Visine® Classic
Description
Eye drops 0.05%
in the form of a clear, colorless solution.
1 ml
tetrizoline hydrochloride 500 mcg
Excipients
: boric acid - 12.3 mg, sodium chloride - 2.23 mg, disodium edetate dihydrate - 1 mg, benzalkonium chloride solution 50% - 0.2 mg (in terms of benzalkonium chloride - 0.1 mg), sodium tetraborate - 0.57 mg, purified water - 989.78 mg .
15 ml - plastic dropper bottles (1) with first opening control - cardboard packs.
Indications
- adults and children over 2 years of age to relieve swelling and hyperemia of the conjunctiva (redness of the eyes) caused by exposure to chemical and physical factors (smoke, wind, dust, chlorinated water, light, cosmetics, contact lenses), as well as those arising from allergic reactions such as like hay fever.
Contraindications for use
- angle-closure glaucoma;
- endothelial-epithelial dystrophy of the cornea;
- children under 2 years of age;
- hypersensitivity to the components of the drug.
Carefully
the drug is prescribed to patients with severe cardiovascular diseases (coronary artery disease, arterial hypertension), pheochromocytoma, prostatic hyperplasia, hyperthyroidism, diabetes mellitus, porphyria, dry rhinitis, keratoconjunctivitis sicca, glaucoma and in patients receiving MAO inhibitors or other drugs that can increase blood pressure .
pharmachologic effect
Tetrizoline is a sympathomimetic drug that stimulates α-adrenergic receptors of the sympathetic nervous system, but has no or weak effect on β-adrenergic receptors. As a sympathomimetic amine, tetrizoline has a vasoconstrictor effect and reduces tissue swelling.
The effect begins 60 seconds after instillation and lasts 4–8 hours.
Drug interactions
The drug Vizin® Classic should not be used simultaneously with MAO inhibitors such as tranylcypromine, tricyclic antidepressants, or drugs that increase blood pressure. Combination therapy with these groups of drugs can lead to increased vasoconstrictor effects and increased blood pressure.
Dosage regimen
The drug is used topically.
Adults and children over 6 years old
Prescribe 1 or 2 drops into the affected eye 2-3 times a day.
Continuous use of the drug for more than 4 days is not recommended. Use of the drug for more than 4 days should only be carried out under the supervision of a physician.
Instructions for using the dropper bottle
The medicinal product is supplied in packaging that is protected from accidental opening by children.
When using the bottle for the first time, you must remove the tamper evident tape from the cap.
Press the top of the bottle cap while turning it counterclockwise. Remove the cap from the dropper bottle and invert the bottle.
Do not touch the tip of the bottle to any surfaces.
After use, screw on the cap of the dropper bottle.
Instructions for using ampoules for single use
Each ampoule of Vizin® Classic is intended for single use only. The drug should be used immediately after opening the ampoule. The amount of the drug in 1 ampoule is sufficient for a single injection into both eyes.
Break off one ampoule from the strip, put the remaining ampoules back into the foil bag.
Open the ampoule by unscrewing the top, unfilled part of the ampoule.
Instill the drug into the conjunctival sac, pressing lightly on the filled part of the ampoule.
Overdose
When used in accordance with the instructions, the risk of overdose is minimal. However, if the drug accidentally gets into the gastrointestinal tract (swallowed), the following symptoms
overdose: pupil dilation, nausea, cyanosis, fever, convulsions, tachycardia, arrhythmia, cardiac arrest, arterial hypotension, pulmonary edema, respiratory depression, including apnea (respiratory arrest), hypothermia, depression of central nervous system function, sedation, lethargy, stupor, drooling, development of drowsiness, coma.
The risk of developing overdose symptoms due to the systemic effects of the drug is high in neonates and young children, especially if swallowed.
Treatment:
specific antidote is unknown. If it enters the gastrointestinal tract, activated charcoal, gastric lavage, oxygen inhalation, antipyretics and anticonvulsants are prescribed. To reduce blood pressure, phentolamine is used slowly intravenously at 5 mg in saline solution or orally at 100 mg. Vasopressor agents are contraindicated in patients with low blood pressure.
If any of the overdose symptoms described above occur, the patient should immediately consult a doctor.
Side effect
Post-marketing data
Very common (>1/10), common (>1/100, <1/10), uncommon (>1/1000, <1/100), rare (>1/10,000, <1/1000), very rare (<1/10,000, including isolated reports), frequency unknown (incidence cannot be estimated from available data).
From the organs of vision:
frequency unknown - increased lacrimation, pupil dilation.
General disorders and administration site disorders:
frequency unknown - injection site reactions (including burning sensation in the eye area, redness, irritation, swelling, pain, itching).
It is assumed that the frequency, type and severity of adverse reactions in children are similar to those observed in adults.
special instructions
Vizin® Classic should be used with caution in elderly patients, in patients with aneurysms, hypertension and/or coronary artery disease, as well as in patients with type 1 diabetes mellitus or hyperthyroidism.
The drug in dropper bottles contains benzalkonium chloride, which can cause eye irritation and discoloration of soft contact lenses. Therefore, before instilling the drug, it is necessary to remove contact lenses and install them after 15 minutes. It is necessary to avoid direct contact of the drug with soft contact lenses due to possible disruption of their transparency.
It is possible to develop reactive hyperemia of the conjunctiva and nasal mucosa (medicinal rhinitis) if the instructions for use are not followed.
If the condition does not improve within 72 hours or if irritation and redness persist or increase, you should stop using the drug and consult a doctor. If you experience intense pain in the eyes, severe acute or unilateral redness of the eyes, headache, blurred vision, spots before the eyes or double vision, you should immediately consult a doctor.
Long-term use of the drug may increase hyperemia or lead to its reappearance.
If irritation or redness is caused by diseases of the organ of vision (infection, foreign body or mechanical, chemical, thermal effects), before using the drug it is necessary to consult a doctor and determine the need for further therapeutic measures.
The use of the drug may cause temporary dilation of the pupil.
Long-term use and overdose of the drug should be avoided, especially in children.
Do not use the drug if its color changes or becomes cloudy.
Local application of sympathomimetic amines into the conjunctival sac, resulting in pupil dilation, can sometimes lead to disturbances in intraocular pressure in susceptible individuals.
If the medicine has become unusable or has expired, do not pour it into wastewater or throw it outside. It is necessary to place the medicine in a bag and place it in the trash container. These measures will help protect the environment.
Use in pediatrics
Safety studies of the drug in children and adolescents have not been conducted.
In children aged 2 to 6 years, the use of the drug is possible after consultation with a medical professional. Effect on the ability to drive vehicles and operate machinery
In rare cases, after using Vizin® Classic eye drops, pupil dilation is observed and blurred vision occurs, which can affect the ability to drive a car and operate machinery.
Storage conditions
The drug should be stored out of the reach of children, bottles - at a temperature not exceeding 30°C, ampoules - at a temperature not exceeding 25°C.
Best before date
Shelf life: 3 years. Do not use the drug after the expiration date indicated on the package.
The contents of an open bottle should be used within 4 weeks.
After a single use of the drug in ampoules, the unused contents of the ampoule must be disposed of.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - Contraindicated. Restrictions when breastfeeding - Contraindicated.
There are no data on the penetration of the drug through the placental barrier and into breast milk.
The drug should not be used during pregnancy and breastfeeding, because Well-controlled studies examining the effects of tetrizoline hydrochloride on the fetus have not been conducted.
Use in elderly patients
Restrictions for elderly patients - Use with caution.
The drug should be used with caution in elderly patients.
Use in children
Restrictions for children - With caution.
The use of the drug in children under 2 years of age is contraindicated.
In children aged 2 to 6 years, the use of the drug is possible after consultation with a medical professional.
Terms of sale
The drug is available without a prescription.
Contacts for inquiries
JOHNSON & JOHNSON LLC (Russia)
"JOHNSON & JOHNSON" LLC group of companies Johnson & Johnson
121614 Moscow st. Krylatskaya, 17, bldg. 2 Tel Fax
