Compound
Drops for oral use 0.75% contain the active component: sodium picosulfate - 7.5 mg/ml and additional substances: sorbitol, hydrochloric acid, sodium methylhydroxybenzoate and purified water.
One tablet contains the active substance: sodium picosulfate in terms of 100% anhydrous substance, 5 mg or 7.5 mg, as well as auxiliary components: lactose monohydrate, corn starch and pregelatinized 1500, magnesium stearate, colloidal anhydrous silicon dioxide.
PICOLAX 7.5MG TAB No. 10
Trade name of the drug:
Picolax
Active ingredient (INN):
sodium picosulfate
Dosage form:
pills
Compound:
1 tablet contains:
active substance: sodium picosulfate in terms of 100% anhydrous substance 5 mg or 7.5 mg;
excipients: lactose monohydrate, corn starch, pregelatinized starch 1500, colloidal anhydrous silicon dioxide, magnesium stearate.
Description:
tablets are white or almost white, flat-cylindrical, scored and chamfered.
Pharmacotherapeutic group:
laxatives.
ATX code : A06A B08.
Pharmacological properties
A laxative of the triarylmethane group, activated in the colon under the action of bacterial sulfatases; the substance that is released in this case stimulates the sensitive nerve endings of the intestinal mucosa, enhances its motility, and promotes the accumulation of water and electrolytes in the lumen of the colon. The result of this is stimulation of defecation, reduction of transit time and softening of stool. The use of the drug is not accompanied by tenesmus and intestinal spasms. After oral administration, it reaches the large intestine without significant absorption, so there is no intrahepatic circulation. Under the influence of bacterial flora, it breaks down to form the active form (free diphenol). The laxative effect develops 6-12 hours after administration; the severity of the laxative effect does not correlate with the level of active diphenol in the blood plasma. During a course of treatment, Picolax stimulates the growth and metabolic activity of normal intestinal microflora.
Indications for use
Constipation or cases requiring relief of bowel movements.
Directions for use and doses
Prescribed orally, preferably at night.
Adults and children over 10 years old – 5-10 mg 1 time per day. For severe and persistent constipation, adults are recommended to take 15 mg once.
Children from 4 to 10 years old – 2.5-5 mg 1 time per day.
For children, a single dose of the drug can be effective. If necessary, the course of treatment for the child can be extended, but it is preferable to limit it to three days. The duration of treatment is determined individually, usually it does not exceed 10 days.
Side effects
With short-term use of the drug, side effects are rare.
With long-term use of the drug in significantly increased doses, the following violations are possible:
from the water-electrolyte balance: loss of potassium, sodium and other electrolytes, possible development of dehydration;
from the digestive system: rarely - dyspeptic symptoms, vomiting, nausea, cramps and abdominal pain, diarrhea, flatulence, pain in the stomach and anus, increased intestinal motility, which disappear when the dose of the drug is reduced;
from the immune system: hypersensitivity reactions, including angioedema, urticaria, skin rashes, itching;
from the central nervous system: very rarely - headache, increased fatigue, drowsiness, convulsions, dizziness, fainting.
Contraindications
Hypersensitivity to the components of the drug; intestinal obstruction; acute inflammatory bowel diseases and acute diseases of the abdominal organs (including acute appendicitis, ulcerative colitis, peritonitis); abdominal pain, nausea and vomiting of unknown origin; condition after surgery on the gastrointestinal tract; severe dehydration.
In the case of rare hereditary conditions that may result in hypersensitivity to the excipients of the drug (see section “Special instructions”), taking the drug is contraindicated.
Appropriate safety precautions for use.
Like other laxatives, Picolax should not be used daily or for an extended period without identifying the cause of constipation. Long-term and excessive use can lead to fluid or electrolyte imbalance and hypokalemia. Dizziness and/or syncope have occurred in patients taking sodium picosulfate. Available evidence from these cases suggests that the events are consistent with defecatory syncope (or syncope associated with attempting to defecate) or a vasovagal response to abdominal pain associated with constipation and not necessarily sodium picosulfate ingestion.
Drug interactions
Electrolyte imbalance can lead to decreased tolerance to cardiac glycosides. Diuretics or glucocorticosteroids may increase the severity of hypokalemia caused by the use of Picolax in high doses. Simultaneous treatment with antibiotics may reduce the laxative effect of the drug.
special instructions
Use with caution in case of hypokalemia, high levels of magnesium in the blood, and in patients with a weakened body.
The drug contains lactose, which should be kept in mind by patients with hereditary lactose intolerance.
Use during pregnancy and lactation
Long-term experience has not revealed any unwanted or harmful side effects of Picolax when taken during pregnancy.
There is no evidence regarding the penetration of Picolax into breast milk.
Despite this, Picolax, like all other medicines, can be used during pregnancy or breastfeeding only if, in the opinion of the doctor, the benefits of using the drug outweigh the potential risk to the fetus/child.
Particular caution should be taken if there is a threat of miscarriage.
Children
Do not use the drug in children without consulting a doctor. 7.5 mg tablets should not be used in children under 10 years of age. 5 mg tablets should not be used in children under 4 years of age.
Impact on the ability to drive a car and operate complex machinery
Patients should be aware that due to the possibility of a vasovagal reaction (abdominal cramp), dizziness and/or fainting, potentially hazardous activities such as driving or operating machinery should be avoided.
The drug should not be used after the expiration date and should be stored out of the reach of children.
Overdose
Symptoms High doses of Picolax may cause loose stools, abdominal cramps (colic) and clinically significant fluid and electrolyte imbalances (hypokalemia, loss of other electrolytes and fluids). There are reports of ischemia of the colon mucosa with the use of higher doses of Picolax, significantly higher than those usually recommended for constipation. Long-term overdose leads to the development of chronic diarrhea and abdominal pain, hypokalemia, secondary hyperaldosteronism, possible kidney damage and the development of nephrolithiasis, metabolic alkalosis and muscle weakness as a result of hypokalemia.
Treatment. Discontinuation of the drug, inducing vomiting, gastric lavage, taking enterosorbents (activated carbon), symptomatic treatment (correction of water and electrolyte balance, which is especially important for elderly patients and children, use of antispasmodics).
Release form
10 tablets in a blister.
Tablets 5 mg. 1 blister per pack.
Tablets 7.5 mg. 1 or 3 blisters per pack.
Storage conditions
Store in a place protected from light at a temperature not exceeding 25oC.
Best before date
2 years.
Conditions for dispensing from pharmacies
Over the counter.
Pharmacodynamics and pharmacokinetics
When treated with Picolax inside the body, its active component sodium picosulfate has a beneficial effect on the large intestine. Under the influence of bacterial flora, the drug is broken down, resulting in the formation of the active form - free diphenol.
Then the sensitive nerve endings of the intestinal mucosa are stimulated, enhancing its motility. Taking this drug does not lead to tenesmus and intestinal spasms. The development of the laxative effect occurs 6-12 hours after using one dose.
During the treatment of infants, insufficient effectiveness of the drug was noted, since they have a small amount of bacterial flora that produces sulfatases .
Picolax 0.75% 15 ml drops for oral administration
Instructions for medical use of the drug PICOLAX Trade name Picolax International nonproprietary name Sodium picosulfate Dosage form Oral drops 0.75% Composition 1 ml of the drug contains the active substance: sodium picosulfate in terms of 100% substance - 7.5 mg (20 drops); excipients: sorbitol (E 420), sodium methyl parahydroxy benzoate (E 219), 1 M hydrochloric acid solution to pH 6.0 to 7.0, water for injection. Description Transparent colorless or yellowish liquid Pharmacotherapeutic group Contact laxatives. Sodium picosulfate. ATX code A06A B08 Pharmacological properties Pharmacokinetics After oral administration, it reaches the large intestine without significant absorption, where, under the influence of bacterial flora, it is broken down to form the active form (free diphenol). The laxative effect develops 6-12 hours after administration; the severity of the laxative effect does not correlate with the level of active diphenol in the blood plasma. During a course of treatment, Picolax stimulates the growth and metabolic activity of normal intestinal microflora. Pharmacodynamics Contact laxative of the triarylmethane group, activated in the large intestine under the influence of bacterial sulfatases; the substance that is released stimulates the sensitive nerve endings of the intestinal mucosa and enhances its motility. The use of the drug is not accompanied by tenesmus and intestinal spasms. Indications for use - constipation - cases requiring relief of bowel movements. Method of administration and dosage. The drug is dosed using the manufacturer's dispenser. Adults and children over 10 years old: 13-27 drops (5-10 mg); children from 4 to 10 years old: 7-13 drops (2.5-5 mg). For children under 4 years of age, a dosage of 250 mcg/kg body weight or 2 drops per 3 kg of child weight is recommended. For children, the drug can be added to food. In children, a single dose of the drug can be effective. If necessary, the course of treatment for a child can be extended, but it is preferable to limit it to three days. Picolax should be taken at night in order to have stool the next morning. To relieve constipation in cancer patients receiving large doses of opioids, it is used as prescribed by a doctor. Side effects - skin rash - urticaria - itching - loss of potassium, sodium and other electrolytes - possible development of dehydration - dyspeptic symptoms - vomiting - nausea - cramps and abdominal pain - diarrhea - flatulence - pain in the stomach and anus - increased motility intestines - allergic reactions - angioedema - headache - fatigue - drowsiness - convulsions Contraindications - intestinal obstruction - acute inflammatory bowel diseases - acute diseases of the abdominal organs (including acute appendicitis, ulcerative colitis, peritonitis) - acute abdominal pain accompanied by nausea and vomiting, which may indicate acute inflammatory diseases mentioned above - abdominal pain of unknown nature - severe dehydration - hypersensitivity to sodium picosulfate and other components of the drug. Drug interactions Electrolyte imbalance may lead to decreased tolerance to cardiac glycosides. Diuretics or glucocorticosteroids may increase the severity of hypokalemia caused by the use of Picolax in high doses. Simultaneous treatment with antibiotics may reduce the laxative effect of the drug. Special instructions Like other laxatives, Picolax should not be taken daily for a long time. If you need to take laxatives every day, you should find out the cause of constipation. Long-term use of laxatives can lead to electrolyte imbalance and hypokalemia, as well as cause addiction and constipation due to the rebound effect. Use with caution in elderly people, with hypokalemia, high levels of magnesium in the blood, and in patients with a weakened body. Picolax is effective in relieving constipation in cancer patients receiving large doses of opioids. The drug contains sorbitol, so patients with rare hereditary fructose intolerance are not recommended to take it. Pregnancy and lactation No negative effect of sodium picosulfate on the course of pregnancy and fetal development has been identified, however, the drug can be used during pregnancy only if the expected benefit to the mother outweighs the possible risk for the fetus. Sodium picosulfate is not excreted in breast milk, but if it is necessary to use the drug Picolax during lactation, breastfeeding should be stopped. Application in pediatrics. Children should not use Picolax without consulting a doctor. Features of the drug's influence on the ability to drive vehicles and potentially dangerous mechanisms. In therapeutic doses, the drug does not affect the ability to drive vehicles or operate other machinery. Overdose Symptoms. High doses of Picolax can cause loose stools, abdominal cramps (colic) and clinically significant disturbances in water and electrolyte balance (hypokalemia, loss of other electrolytes and fluids), ischemia of the colon mucosa. Long-term overdose leads to the development of chronic diarrhea and abdominal pain, hypokalemia, secondary hyperaldosteronism, possible kidney damage and the development of nephrolithiasis, metabolic alkalosis, hypokalemia and muscle weakness as a result of hypokalemia. Treatment. Gastric lavage, intake of enterosorbents (activated carbon), symptomatic treatment (correction of water and electrolyte balance, use of antispasmodics). Release form and packaging 15 ml or 30 ml in transparent or opaque polyethylene bottles with dispensers, sealed with caps with seals (first opening control) or in polyethylene bottles, sealed with dropper stoppers and caps. Self-adhesive labels are placed on the bottles. Each bottle, along with instructions for medical use in the state and Russian languages, is placed in a cardboard pack. Storage conditions Store in a place protected from light at a temperature of 15 0C to 25 0C. Keep out of the reach of children! Shelf life: 3 years The drug should not be used after the expiration date indicated on the package. Conditions for dispensing from pharmacies Without a prescription. Manufacturer PJSC “Farmak”, Ukraine, 04080, Kyiv, st. Frunze, 63. Owner of the registration certificate PJSC “Farmak”, Ukraine Address of the organization that accepts claims from consumers regarding the quality of products (products) in the territory of the Republic of Kazakhstan Republic of Kazakhstan, 050009 Almaty, st. Abaya 157, office 5 Tel/fax, email address
Indications for use
Picolax is prescribed to patients in the following cases:
- atonic constipation caused by changes in diet, prolonged immobilization, severe general condition, fever , metabolic disorders and diseases of the cardiovascular system;
- preparation for surgical and gynecological operations, as well as instrumental studies;
- stool adjustments for hemorrhoids and fissures in the anus .
Contraindications for use
It is not recommended to use the medicine in any form if:
- increased individual sensitivity to the drug;
- obstructive intestinal obstruction , nausea , vomiting , abdominal pain of unknown etiology and complicated dehydration;
- acute surgical pathologies of the abdominal organs and after surgical interventions on the gastrointestinal tract.
- lactation, pregnancy.
Picolax drops are not prescribed for:
- fructose intolerance.
Tablets are contraindicated in patients suffering from:
- lactase deficiency, galactosemia and glucose-galactose malabsorption ;
- under the age of 10 years.
Caution must be exercised when treating patients suffering from hypokalemia , hypermagnesemia and elderly patients.
Side effects
As clinical practice shows, Picolax is well tolerated by patients of various age groups. However, one should not exclude the development of such side effects as: indigestion, diarrhea , vomiting , nausea , intestinal colic , flatulence, pain in the anal area.
Also possible: headaches, sleep problems, cramps, severe fatigue, tremors, various allergic manifestations , and so on.
Long-term use of the drug contributes to addiction and the development of constipation , which causes a “ricochet” effect. To avoid the development of unwanted symptoms, it is recommended to take this drug once or for a short time.
Instructions for Picolax (Method and dosage)
It should be noted that Picolax drops, instructions for use recommend taking them in the evening. For young patients, this form of the drug can be added to food. For precise dosing of the drug there is a special dispenser on the bottle. The duration of treatment and dosage are determined by the attending physician for each patient, taking into account his individual characteristics. As a rule, for adult patients and adolescents from 10 years of age, a daily dose of 13-27 drops is prescribed. Children aged 4-10 years are prescribed an average daily dosage of 7-13 drops of the drug. When treating children under 4 years of age, the dosage of the drug is calculated according to a special formula of 250 µg/kg per total weight of the child, that is, 2 drops of Picolax for every 3 kg of body weight - once a day.
For patients with cancer who are receiving treatment with opioid analgesics, the dosage of the drug is also calculated by the attending physician. In any case, it is not recommended to take the drops for more than 3 days in a row.
It is recommended to swallow Picolax tablets whole with liquid. The drug is prescribed for use in the morning or evening. The duration of the course of therapy and the dose of the drug are determined by the attending physician for each individual patient. For adult patients and adolescents over 10 years of age, the average daily dosage is 1 tablet. If necessary, the dose is increased to 2 pieces per day. The therapeutic course can last no more than 10 days.
Note!
Description of the drug Picolax cap. yelled 0.75% fl. 30ml on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Overdose
In case of an overdose of Picolax, patients may develop: diarrhea, pain in the abdomen, a decrease in the level of potassium in the blood and other disturbances in water and electrolyte balance.
Ischemia of the mucous membranes of the large intestine is also possible. If the drug is used in high dosages for a long time, patients may experience: chronic diarrhea, intestinal colic, hypokalemia , renal dysfunction, secondary hyperaldosteronism , urolithiasis and metabolic acidosis . Hypokalemia can lead to muscle weakness.
In such cases, gastric lavage, enterosorbents are usually prescribed, and further symptomatic therapy is carried out.
Pharmacological properties
Pharmacodynamics.
sodium picosulfate, the active ingredient of the drug picolax, is a local laxative of the triarylmethane group. sodium picosulfate, after bacterial breakdown in the colon, stimulates its mucous membrane, accelerating peristalsis, and promotes the accumulation of water and electrolytes in the lumen of the colon. the result is stimulation of defecation, reduction of transit time and softening of the feces. Pharmacokinetics. Following oral administration, sodium picosulfate reaches the large intestine without significant absorption. The active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane is formed after bacterial breakdown in the colon; the onset of action of Picolax usually occurs 6–12 hours after dosing, depending on the release of the active metabolite. After oral administration, a small amount of the drug can be detected in the organs and systems of the body.
The laxative effect of the drug does not correlate with the level of the active metabolite in the blood plasma.
Reviews of Picolax
This drug is very popular among patients of various age groups. Therefore, reviews of Picolax can be found on medical forums where problems of digestion and gastrointestinal tract are discussed. In addition, users often say that they use this medicine to treat children. It is successfully used in the treatment of constipation during dysbacteriosis and other problems. Many people note its high effectiveness, which relieves intestines in a short time.
Quite often, this drug is used by patients suffering from chronic digestive disorders . Unfortunately, they often experiment with dosage or introduce additional agents. As a result, they develop side effects, mainly in the form of diarrhea. Therefore, experts recommend abandoning self-medication and strictly adhering to doctor’s prescriptions.
Picolax® (drops)
Features of application
Patients suffering from chronic constipation should undergo a complete diagnosis and determine the cause of constipation.
Prolonged and excessive use of the drug can lead to fluid and electrolyte imbalances and hypokalemia.
Discontinuation of Picolax may result in a return of symptoms. If Picolax has been used for chronic constipation for a long time, any return of symptoms may be more severe.
Cases of dizziness and/or syncope have been reported concurrently with the use of sodium picosulfate. Available information suggests that these phenomena are consistent with syncope during defecation (associated with the Valsalva maneuver) or are associated with a vasovagal response to abdominal pain.
Patients with rare hereditary fructose intolerance should not take this medicine because it contains sorbitol.
This medicinal product contains less than 1 mmol/dose sodium, which means it is practically sodium-free.
This medicinal product contains 2 mg sodium benzoate per 1 ml (30 mg sodium benzoate per 15 ml bottle, 60 mg sodium benzoate per 30 ml bottle).
Use during pregnancy or breastfeeding.
Pregnancy
No adequate clinical studies have been conducted in pregnant women. Animal studies have demonstrated reproductive toxicity of the drug when used in daily doses of 10 mg/kg and above. For safety reasons, Picolax should not be used during pregnancy if possible.
Breastfeeding period
Clinical data show that neither the active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM) nor its glucuronides are excreted in breast milk. Thus, Picolax can be used during breastfeeding.
Fertility
Clinical studies to evaluate the effect of the drug on fertility in humans have not been conducted.
Animal studies have shown no effect of the drug on fertility.
The ability to influence the reaction rate when driving vehicles or other mechanisms.
Studies of the effect on the ability to drive a car and operate other mechanisms have not been conducted. However, patients should be warned about the possibility of developing adverse reactions such as dizziness and/or syncope as a result of a vasovagal reaction (in particular abdominal spasm). If abdominal spasm occurs, the patient should avoid potentially hazardous activities such as driving or operating other machinery.
Picolax price, where to buy
In Moscow, the price of Picolax tablets starts from 49 rubles.
The drug in drops can be purchased at a price of 185 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
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