Compound
The drug Ferlatum Fol contains the active substances: iron protein succinylate and calcium folinate pentahydrate .
As well as auxiliary components: sorbitol, sodium methyl parahydroxybenzoate, propylene glycol, sodium propyl parahydroxybenzoate, sodium saccharinate, cherry flavor, mannitol and purified water. Ferlatum also contains the protein iron succinylate . Auxiliary components: sorbitol, propylene glycol, sodium propyl parahydroxybenzoate, sodium saccharin, sodium methyl parahydroxybenzoate, flavoring and water.
Ferlatum Fol solution for oral administration 15 ml box x10
Trade name: Ferlatum Fol International name: not specified
Country of origin: Spain
Manufacturer: CSC Ltd (registered from Italfarmaco SA)
Release form: oral solution (polyethylene bottles with a container cap) 15 ml /container cap contains 100 mg of powder for preparing an oral solution/
Ingredients: Powder: calcium folinate pentahydrate 235 mcg [eq. 200 mcg calcium folinate or equivalent. 185 mcg folinic acid] - 100 mg, solution: iron protein succinylate 800 mg [eq. 40 mg iron] – 15 ml
Pharmacological group: iron preparation
Pharmacological group according to ATK: B03AB09 Iron protein succinylate
Pharmacological action: hematopoietic, iron preparation
Drug registration number: LSR-004031/07
Dates of registration, re-registration: 11/21/2007
RF HS codes: 3004 90 190 9
Indications: Treatment of latent and clinically significant iron deficiency anemia and folate deficiency, prevention of Fe and folate deficiency during pregnancy, lactation, active growth, after prolonged bleeding, against the background of inadequate and unbalanced nutrition. Contraindications: Hypersensitivity, hemochromatosis, impaired Fe utilization (lead, sideroachristic anemia), non-iron deficiency anemia (hemolytic, megaloblastic, B12-deficient), chronic pancreatitis, liver cirrhosis. Caution. Peptic ulcer of the stomach and duodenum, malabsorption due to pathology of the small intestine (enteritis, malabsorption syndrome, resection of the small intestine, gastric resection according to Billroth II with the inclusion of the duodenum), lactose intolerance, fructose (the drug contains sorbitol). Dosage regimen: Inside, before or after meals. 1 bottle contains 800 mg Fe protein succinylate (equivalent to 40 mg Fe) and 0.235 mg calcium folinate pentahydrate (equivalent to 0.185 mg folinic acid). Adults: 1-2 bottles per day in 2 divided doses. Children: 1.5 ml/kg/day in 2 divided doses (equivalent to 4 mg/kg/day Fe3+ and 0.0235 mg/kg/day calcium folinate). Pregnant women: for the prevention of iron deficiency anemia - 1 bottle per day, for the treatment of latent and clinically significant iron deficiency anemia - 1-2 bottles per day in 2 doses. After normalization of serum Fe and Hb concentrations, the drug is continued for 8-12 weeks at a maintenance dose. Side effects: Gastrointestinal dysfunction (disappears when the dose is reduced and the drug is discontinued). Interaction: Fe absorption increases with simultaneous intake of more than 200 mg of ascorbic acid and decreases with antacids. Chloramphenicol causes a delayed response to Fe therapy. Some antitumor and antileukemic drugs (aminopterin, methotrexate and other pterin derivatives) act as folate antagonists. Special instructions: The continuous period of use should not exceed 6 months, with the exception of cases of chronic blood loss (menorrhagia, hemorrhoids, etc.) and pregnancy.
Pharmacodynamics and pharmacokinetics
The drug Ferlatum Fol includes iron and calcium folinate . Therefore, when taking it, the lack of iron and folate in the human body is compensated.
The main function of iron in these preparations is to transport oxygen to tissues. This component is one of the components of hemoglobin, myoglobin and iron-containing enzymes-cytochromes . It also carries out electron transfer and functions as a catalyst for oxidation reactions, hydroxylation and other metabolic processes.
The active component, iron-protein succinylate , is a complex compound in which ferric iron atoms surround semi-synthetic protein carriers, which helps prevent damage to the mucous membranes of the gastrointestinal tract. The protein carrier can dissolve in the duodenum, optimally releasing iron.
The entry of ferric iron into the blood from the gastrointestinal tract occurs through active absorption, preventing the possibility of overdose or poisoning.
Ferlatum Foul
Ferlatum Fol (iron protein succinylate + calcium folinate pentahydrate) is an antianemic drug, a stimulator of hematopoiesis. Compensates for deficiency of iron and folic acid salts. The main task of iron is to transport oxygen to tissues and cells. This trace element is a component of hemoglobin, myoglobin (oxygen-binding protein of striated muscles and myocardium), and cytochrome enzymes. Iron works as a carrier of electrons to places where they are in demand, stimulates the occurrence of redox reactions, hydroxylation reactions and other metabolic processes. The protein succinylate contained in the drug ferlatum fol is a complex compound in which a semi-synthetic protein carrier is “encrusted” with ferric iron atoms. The protein carrier is hydrolyzed in the duodenum, releasing iron in the place most convenient for its absorption. In addition, it prevents possible damage to the gastric mucosa. The entry of ferric iron from the intestines into the blood is carried out through active absorption, which virtually eliminates the risk of overdose and poisoning. The second component of ferlatum foul - calcium folinate - replenishes folate deficiency in the body. This is a calcium salt of folinic acid, which is two orders of magnitude more active than folic acid.
Ferlatum foul has a combined release form: an oral solution containing iron protein succinylate, and a powder for preparing an oral solution containing calcium folinate pentahydrate. It is recommended to take the drug before or after meals. The daily dose for adults is 1-2 bottles in 2 doses, for children (including newborns) - 1.5 ml per 1 kg of body weight in the same 2 doses. The doctor may recommend other doses of the drug. To prevent the development of iron deficiency, pregnant women are recommended to take 1 bottle per day. For the treatment of latent or clinically pronounced iron deficiency anemia, they are prescribed 1-2 bottles per day for 2 doses.
After normalization of iron and hemoglobin levels, maintenance therapy is continued for at least another 2-3 months. A solution of ferlatum foul for oral administration is prepared as follows: press the perforator of the dispenser cap (for this you need to apply a certain force) so that the powder pours into the solution in the bottle, then vigorously shake the resulting suspension until the contents are homogenized. Then remove the dispenser cap and drink the resulting solution. The maximum duration of continuous use of ferlatum foul is 6 months. In case of chronic blood loss (for example, hemorrhoids, menorrhagia) and pregnancy, the duration of the pharmacotherapeutic course may be increased. Due to the risk of developing allergic reactions in persons with milk protein intolerance, such patients should be especially careful when using the drug. Ferlatum foul contains sorbitol, which excludes the possibility of its use by persons with genetically determined fructose intolerance. To date, the medical literature and periodicals have not described a single case of poisoning from excessive intake of ferlatum foul into the body. There have also been no descriptions of adverse drug interactions between this drug and other drugs when used together. The absorption of iron in the digestive tract increases when ferlatum foul is combined with vitamin C at a dose of over 200 mg. The opposite situation is observed when taking the drug together with drugs that reduce gastric acidity. Some cytotoxic and antileukemic drugs exhibit folate antagonism.
The effectiveness of ferlatum foul in the correction of iron deficiency conditions in pregnant women compared to traditional iron monotherapy was confirmed in a multicenter randomized clinical trial, the results of which concluded that the combination drug was superior.
Contraindications for use
It is not recommended to take any iron supplement if:
- hypersensitivity;
- hemosiderosis;
- anemia caused by impaired iron utilization, for example, lead and sideroblastic, as well as non-iron deficiency - hemolytic and B12 deficiency;
- chronic pancreatitis;
- liver cirrhosis.
Instructions for Ferlatum (Method and dosage)
Iron preparations are intended for internal use before or after eating. The dosage is determined by the attending physician, taking into account the age, characteristics of the patient and the severity of the disorder.
When normal hemoglobin and serum iron are achieved, it is recommended to continue therapy at a maintenance dose for another 8-12 weeks.
Ferlatum is offered in a ready-to-use form. To prepare a solution for oral administration, using the instructions for Ferlatum Fol, it is necessary to press with some force on the perforator of the dispenser cap - this will allow the powder to pour out into the solution placed in the bottle. The contents of the bottle should be shaken vigorously, the dispenser cap should be removed and the resulting solution should be drunk.
Ferlatum Fol solution for oral administration 15 mg fl PE 100 mg powder N10
Registration Certificate Holder
ITALFARMACO (Italy)
Dosage form
Medicine - Ferlatum FOL (Ferlatum FOL)
Description
Oral solution.
The solution for oral administration is transparent, brownish in color, with a pleasant characteristic cherry odor.
1 fl.
iron protein succinylate 800 mg, which corresponds to Fe3+ content 40 mg
Excipients
: sorbitol, propylene glycol, sodium methyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, cherry flavor (concentrated wild black cherry flavor, vanillin, amyl acetate, small amounts of other esters, benzaldehyde, clove bud oil, propylene glycol, diethylene glycol monoethyl ether, water), sodium saccharinate, purified water .
Powder for the preparation of oral solution is white with a yellowish tint, odorless (in a sealed dispenser cap [container cap]).
100 mg
calcium folinate pentahydrate 235 mcg, which corresponds to the content of calcium folinate 200 mcg or equivalent to the content of folinic acid 185 mcg
Excipients
: mannitol.
15 ml - polyethylene bottles (10) with a container cap containing 100 mg of powder - cardboard packs. 15 ml - polyethylene bottles (20) with a container cap containing 100 mg of powder - cardboard packs.
Indications
- treatment of latent and clinically significant iron deficiency (iron deficiency anemia) and folate;
- prevention of iron and folate deficiency during pregnancy, lactation, active growth, after prolonged bleeding, against the background of inadequate and unbalanced nutrition.
Contraindications for use
- hemochromatosis;
- violation of iron utilization (including lead anemia, sideroachrestic anemia);
- non-iron deficiency anemia (including hemolytic anemia, megaloblastic anemia caused by a lack of vitamin B12);
- chronic pancreatitis;
- cirrhosis of the liver;
- hypersensitivity to the components of the drug.
Carefully _
the drug should be used for peptic ulcers of the stomach and duodenum, malabsorption in pathologies of the small intestine (including enteritis, malabsorption syndrome, resection of the small intestine, gastric resection according to Billroth II with the inclusion of the duodenum).
pharmachologic effect
Antianemic drug. Contains iron and calcium folinate. Replenishes the lack of iron and folate in the body.
The main function of iron is to transport oxygen to tissues. Iron is part of hemoglobin, myoglobin, iron-containing cytochrome enzymes, transfers electrons and works as a catalyst for oxidation reactions, hydroxylation and other metabolic processes.
Ferlatum Fol contains iron-protein succinylate, which is a complex compound where ferric iron atoms are surrounded by a semi-synthetic protein carrier that prevents damage to the gastric mucosa. The protein carrier dissolves in the duodenum, releasing iron at the site of optimal absorption.
Ferric iron enters the blood from the intestines through active absorption, which explains the impossibility of overdose and poisoning.
Calcium folinate is the calcium salt of folinic acid, which replenishes the lack of folate in the body.
Drug interactions
With simultaneous use, there was no interaction of the drug Ferlatum Fol with other drugs.
Iron absorption can be increased with simultaneous use of Ferlatum Fol with ascorbic acid in a dose of >200 mg.
Iron absorption may be reduced when Ferlatum Fol is used concomitantly with antacids.
Chloramphenicol causes a delayed response to iron therapy.
There is no pharmacological interaction with the simultaneous use of Forlatum Fol with histamine H2 receptor antagonists.
Some antitumor and antileukemic drugs (including aminopterin, methotrexate and other pterin derivatives) exhibit folate antagonist properties.
Dosage regimen
Ferlatum Fol should be taken orally before or after meals.
For adults
1-2 bottles/day in 2 doses (in an amount equivalent to 40-80 mg of ferric iron and 0.235-0.470 mg of calcium folinate pentahydrate) or as recommended by a doctor.
Children (from the neonatal period)
1.5 ml/kg/day (in an amount equivalent to 4 mg/kg/day ferric iron and 0.0235 mg/kg/day calcium folinate) in 2 divided doses or as recommended by a physician.
1 bottle (15 ml) contains: iron protein succinylate - 800 mg (equivalent to 40 mg ferric iron) and 0.235 mg calcium folinate pentahydrate (equivalent to 0.185 mg folinic acid).
Pregnant
for
the prevention of iron deficiency anemia
- 1 bottle/day.
For the treatment of latent or clinically pronounced iron deficiency
- 1-2 bottles/day in 2 divided doses.
After achieving normal levels of serum iron and hemoglobin, treatment is continued at a maintenance dose for at least 8-12 weeks.
Rules for preparing the solution
To prepare the solution for oral administration, press firmly on the perforator of the dispenser cap so that the powder pours into the solution in the bottle. Then you should vigorously shake the contents of the bottle, remove the dispenser cap and drink the solution from the bottle.
Overdose
To date, no signs of intoxication or excessive intake of the drug Ferlatum Fol into the body have been described.
Side effect
Rarely:
the appearance of gastrointestinal disorders that disappear when the dose is reduced or the drug is discontinued.
special instructions
The continuous period of use of the drug Ferlatum Fol should not exceed 6 months, with the exception of cases of chronic blood loss (including menorrhagia, hemorrhoids) and pregnancy.
Due to the possible development of allergic reactions, the drug should be prescribed with caution to patients with milk protein intolerance.
Ferlatum Fol contains sorbitol, so the drug should not be used in patients with hereditary fructose intolerance.
Effect on the ability to drive vehicles and operate machinery
The drug does not affect the performance of potentially hazardous activities that require increased concentration and speed of psychomotor reactions (including driving vehicles).
Storage conditions
The drug should be stored out of the reach of children at a temperature not exceeding 25°C.
Best before date
Shelf life: 2 years.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - No restrictions. Restrictions when breastfeeding - No restrictions.
The use of Ferlatum Fol is especially recommended for the prevention and treatment of iron and folate deficiency that develops during pregnancy and breastfeeding.
Use for liver dysfunction
Restrictions for liver dysfunction - Contraindicated.
The use of the drug is contraindicated for liver cirrhosis.
Use in children
Restrictions for children - No restrictions.
Children (from the neonatal period)
1.5 ml/kg/day (in an amount equivalent to 4 mg/kg/day ferric iron and 0.0235 mg/kg/day calcium folinate) in 2 divided doses or as recommended by a physician.
Terms of sale
The drug is available with a prescription.
Contacts for inquiries
ITALFARMACO S.p.A. (Italy)
ITALFARMACO SpA
Representative office in Russia ITF LLC 115432 Moscow Andropov Avenue, 18, bldg. 6, off. 4-01 Tel. Fax
Overdose
Ferlatum Fol is well tolerated by patients and its use does not lead to overdose.
Cases of Ferlatum overdose are characterized by the development of epigastric pain , nausea, vomiting, diarrhea, drowsiness, pallor, shock and coma.
In this case, treatment is carried out using emetics, gastric lavage, and adequate supportive therapy.
Interaction
The simultaneous use of iron-containing drugs with ascorbic acid can significantly increase the absorption of iron; antacids, on the contrary, reduce it.
Chloramphenicol may cause a delayed response to iron treatment.
Combination with certain antitumor and antileukemic drugs , for example, Aminopterin, Methotrexate and other pterin derivatives, can cause symptoms characteristic of folate antagonists. It is also possible that the absorption of tetracyclines in the gastrointestinal tract may be impaired.
Ferlatum, 20 pcs., 15 ml, 800 mg/15 ml, oral solution
INSTRUCTIONS FOR MEDICAL USE OF THE DRUG FERLATUM (FERLATUM)
APPROVED BY THE PHARMACOLOGICAL COMMITTEE OF THE RUSSIAN MINISTRY OF HEALTH ON APRIL 12, 2001. PROTOCOL No. 6
Registration number: p No. 013855/01–2002
Trade name of the drug: Ferlatum
International nonproprietary name: Protein iron succinylate
Dosage form: Oral solution
COMPOUND
1 bottle (15 ml) contains:
Active substance
: protein iron succinylate - 800 mg (equivalent to 40 mg Fe3+).
Excipients
: sorbitol; propylene glycol; sodium methyl p-hydroxybenzoate; sodium propyl parahydroxybenzoate; Morella flavoring agent; sodium saccharin; purified water.
Pharmacotherapeutic group
Antianemic drug. Iron supplement.
pharmachologic effect
The ferric iron contained in the drug replenishes the lack of iron in the body, in particular in case of iron deficiency anemia.
INDICATIONS FOR USE
— Treatment of latent and clinically pronounced iron deficiency (iron deficiency anemia).
— Preventive therapy for iron deficiency during pregnancy.
CONTRAINDICATIONS
- Hypersensitivity to the drug.
— Excess iron in the body (hemosiderosis).
— Impaired iron utilization (lead anemia, sideroachrestic anemia).
- Non-iron deficiency anemia (hemolytic anemia or megaloblastic anemia caused by vitamin B12 deficiency).
- Chronic pancreatitis.
- Cirrhosis of the liver.
METHOD OF APPLICATION AND DOSES
Ferlatum is taken orally, preferably before meals.
Adults: 1–2 bottles per day (equivalent to 40–80 mg Fe3+), or as recommended by a physician, in two divided doses.
Children: 1.5 ml/kg/day (equivalent to 4 mg/kg/day Fe3+), in two divided doses or as recommended by a physician.
SIDE EFFECT
Gastrointestinal disorders (including diarrhea, constipation, nausea and epigastric pain) may occur when using increased doses of Ferlatum, which disappear when the dose is reduced or the drug is discontinued.
If side effects associated with taking the drug occur, you should inform your doctor.
OVERDOSE
The first 6–8 hours after using an excessive dose of the drug are characterized by the appearance of epigastric pain, nausea, vomiting (sometimes mixed with blood), diarrhea, in some cases accompanied by drowsiness, pallor of the skin, shock, even coma. Emergency treatment measures before qualified medical care are provided include gastric lavage.
INTERACTIONS WITH OTHER MEDICINES
Iron derivatives contribute to disruption of the absorption processes of tetracyclines in the gastrointestinal tract; therefore, their simultaneous use should be avoided.
Iron absorption can be increased with simultaneous administration of more than 200 mg of ascorbic acid and reduced with the use of antacids. Chloramphenicol causes a delayed response to iron therapy.
There was a lack of pharmacological interaction with concomitant treatment with H2 receptor antagonists.
USE IN PREGNANT AND NURSING WOMEN
Ferlatum is indicated for iron deficiency conditions that develop during pregnancy and lactation.
INFLUENCE ON THE ABILITY TO DRIVE VEHICLES AND WORK WITH MECHANISMS
No decrease in patient reactions was noted during the use of the drug (including driving vehicles and working with mechanical equipment).
SPECIAL INSTRUCTIONS
The total period of use of Ferlatum should not exceed 6 months, with the exception of cases of chronic blood loss (menorrhagia, hemorrhoids, etc.) and pregnancy.
RELEASE FORM
An oral solution containing 800 mg of protein ferrous succinylate is packaged in 15 ml plastic bottles.
The cardboard box contains 10 plastic bottles of 15 ml each.
STORAGE CONDITIONS
Store at a temperature not exceeding 25°C out of the reach of children.
BEST BEFORE DATE
2 years. Do not use a drug that has expired.
CONDITIONS OF VACATION FROM PHARMACIES
By doctor's prescription.
Reviews about Ferlatum
It should be noted that iron-containing preparations are especially often discussed by parents of young children and women during pregnancy . This is not surprising, since it is during these periods that the body requires additional components and blood composition indicators are regularly monitored. Moreover, almost everyone who has used this drug leaves positive reviews about Ferlatum Fol. With its help, it is possible to quickly and reliably increase hemoglobin and normalize the general condition of the body.
Numerous reviews of pregnant women about Ferlatum report that this is one of the most effective remedies and put it in first place among similar drugs.
However, some women note that taking such drugs, on the contrary, worsens their well-being. This was manifested by the development of general ailments - fatigue, drowsiness, and external disorders - redness around the eyes, dulling of the complexion.
In any case, problems such as iron deficiency in the body or the development of suspected side effects should be addressed with your doctor. Timely prescribing or discontinuation of therapy will allow you to avoid complications and properly maintain your health.
FERLATUM (solution)
when they brought me not a pack of pills, but such a decent weighty box:
It contains 20 bottles of 15 ml each. And for me it’s only for 10 days. And it takes quite a long time to treat anemia, so the format seemed strange. Even a monthly course, even if taken once a day, is not included in the package. But these are minor things.
It says on the box that it is available with a prescription:
Nothing like this. Sold without restrictions. There were no problems with the purchase either. I bought it at different pharmacies and they always offered me a choice of just Ferlatum and Ferlatum Fol with folic acid.
I was also surprised by the cost. I didn't expect such a difference in price. And it’s not about how much you had to pay for one box.
We count. Ferlatum 20 bottles costs approximately 1000 rubles. I was prescribed to drink twice a day. In total, the box lasts only 10 days, we get 100 rubles per day for Ferlatum.
Ferrum Lek for 50 tablets costs approximately 500 rubles. Total 20 rubles per day with two doses.
That's the difference. As much as 5 times.
Inside the box there are 20 bottles of the drug:
And instructions:
The side effects also indicate possible problems with the gastrointestinal tract, which is what tormented me with the drug Ferrum Lek.
The bottle is made of white translucent plastic with a red ribbed cap:
The expiration date is again duplicated on the bottle:
Incomprehensible numbers below:
The top cover is perforated and it is along this perforation that it opens:
It opens easily, insert your nail into the groove on the side and pull it to the side:
The plastic breaks and the bottle is opened:
Sometimes when I remove the lid, drops of medicine fly off it, so be careful not to stain anything.
There is a dark liquid inside that resembles syrup:
The taste is not very pleasant for me. It somewhat reminds me of cherry, but it’s so sweet that I wash it down with a whole glass of water. I don't even like the aftertaste. Moreover, at first it seemed not disgusting, but after a couple of uses the taste became disgusting, and somehow cloying - ugh.
But this is medicine, so taste comes second. Much more important is its action and the absence of side effects.
The second one especially worried me, because the side effects from Ferrum Lek were enough for me and I didn’t want any more. After all, as I already said, that’s why they changed my drug and recommended Ferlatum.
So, I can say, after two months of taking it: I didn’t notice any side effects. It was such a joy, honestly.
Regarding anemia. They gave me grade 1 (the mildest), and while taking Ferlatum, my hemoglobin level rose above the minimum acceptable level. But for prevention, the doctor still recommended continuing to drink Ferlatum. But not twice a day, but once.
But here I must confess that I often forgot to take the drug for the second time in a day. The first one is stable, the second one is every other time.
From personal experience I can say that the drug definitely works and helped me, despite my irresponsible approach to the dosage schedule. And the best part for me: no side effects.
Therefore I can recommend it.
And, of course, don’t get sick 
Ferlatum during pregnancy
As a rule, iron supplements are often prescribed to pregnant women. Ferlatum Fol is usually used, since with the help of this remedy it is possible to compensate for the deficiency of iron and B vitamins, known as folates, which are involved in the production of red blood cells. A similar state of the body can be observed in young mothers.
In the majority, reviews during pregnancy are positive. The drug is characterized as quite effective and fast-acting, fully restoring hemoglobin . Moreover, the body absorbs this product better than other iron-containing products .
Ferlatum price, where to buy
Price Ferlatum Fol in oral solution for 10 pcs. varies between 493-652 rubles.
You can buy Ferlatum for a price starting from 414 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Ferlatum solution for internal
approx. 800 mg 15 ml 20 pcs Italfarmako S.A. RUB 892 order - Ferlatum foul solution internal 15ml 10pcsItalfarmako S.A./Dobrolek LLC
625 rub. order
Pharmacy Dialogue
- Ferlatum Fol solution 15ml No. 10Italfarmaco
RUB 619 order
- Ferlatum solution 800 mg 15 ml No. 20Italfarmaco
RUB 873 order
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