For joint pain, bruises, and various hematomas, doctors recommend using external remedies. One of these drugs is the drug “Indovazin”. The medicine has anti-inflammatory, analgesic, anti-edematous properties. Analogues of Indovazin (gel) are no less effective. Let's consider the original product and its best substitutes.
pharmachologic effect
Indovazin gel contains 2 active substances, the complex action of which provides a pronounced therapeutic effect of the drug.
Indomethacin has several effects:
- anesthetic;
- anti-inflammatory;
- decongestant.
The active substance allows you to quickly reduce the severity of pain , relieve swelling, and shorten the recovery period of affected and damaged tissues. The main principle of action is based on suppressing the processes of synthesizing active substances of prostaglandins by reversibly blocking cyclooxygenases of the first and second types.
Troxerutin is a bioflavonoid . Trihydroxyethylrutinoside is an angioprotector . The venotonic effect is manifested due to the ability of the active substance to reduce capillary permeability . Troxerutin is able to block the venodilating effect of bradykinin , histamine and acetylcholine . An anti-inflammatory effect is manifested in relation to perivenous tissue . The component has an antiplatelet (inhibiting aggregation) effect , reduces the severity of swelling, reduces capillary fragility, and has a positive effect on trophism in pathology.
Indovazin gel, when applied externally, suppresses the severity of pain, reduces the temperature in the inflammatory focus, and reduces inflammatory swelling. The drug is characterized by capillary protective (protective) and venotonic effects.
Pharmacodynamics and pharmacokinetics
The ointment base used for the preparation of the medication ensures maximum solubility and release of the active components troxerutin and indomethacin. The dosage form in the form of a gel provides the best therapeutic effect due to the good absorption of active substances from the surface of the skin. Application to the skin allows you to create therapeutic concentrations of active substances in the periarticular tissues and subcutaneous fat. A small amount of active substances enters the systemic circulation.
Indovazin 45g gel for external use
pharmachologic effect
Indovazin® gel is a combination drug that contains indomethacin and troxerutin.
Indomethacin has a pronounced anti-inflammatory, analgesic and anti-edematous effect. This leads to pain relief, reduced swelling and reduced recovery time for damaged tissue. The main mechanism of action is associated with the suppression of prostaglandin synthesis through reversible blockade of COX-1 and COX-2.
Troxerutin (trihydroxyethylrutinoside) is a bioflavonoid. It belongs to angioprotective agents. Reduces capillary permeability and has a venotonic effect. Blocks the venodilating effect of histamine, bradykinin and acetylcholine. It has an anti-inflammatory effect on perivenous tissue, reduces capillary fragility and has some antiplatelet effect. Reduces swelling, improves trophism in pathological changes associated with venous insufficiency.
When applied to the skin, Indovazin® gel suppresses the inflammatory edematous reaction, relieves pain and temperature in areas of inflammation located on the surface and in the depths, reaching the blood vessels located there. Shows venotonic and capillary protective effects.
Composition and release form Indovazin 45g gel for external use
Gel – 1 g:
- Active ingredients: indomethacin 30 mg, troxerutin 20 mg.
- Excipients: carbomer - 23 mg, macrogol 400 - 524.5 mg, sodium benzoate - 2.5 mg, propylene glycol - 100 mg, ethanol 96% - 300 mg.
45 g - aluminum tubes (1) - cardboard packs.
Description of the dosage form
Gel for external use is yellow to yellow-brown in color, with slight opalescence.
Directions for use and doses
The drug is intended for external use.
4-5 cm of gel is applied 3-4 times a day in a thin layer to the affected area with light rubbing movements. The total daily amount should not exceed 20 cm. The duration of treatment should not exceed 10 days.
Pharmacokinetics
The ointment base used ensures the solubility and release of indomethacin and troxerutin.
The gel dosage form, which includes indomethacin and troxerutin, is well absorbed from the skin surface and provides the therapeutic effect of the drug.
When applied to the skin, concentrations close to therapeutic are created in the subcutaneous tissue and periarticular tissues. The penetration of the active components of the drug into the systemic circulation is clinically insignificant.
Indications for use Indovazin 45g gel for external use
- In complex therapy of chronic venous insufficiency of the lower extremities (varicose veins) - to relieve swelling, a feeling of heaviness and pain in the legs;
- superficial thrombophlebitis, phlebitis, post-phlebitis conditions;
- rheumatic lesions of soft tissues: tendovaginitis, bursitis, fibrositis, periarthritis;
- for swelling after surgery, contusions, dislocations, sprains.
Contraindications
- Violation of the integrity of the skin;
- III trimester of pregnancy;
- lactation period (breastfeeding);
- children under 14 years of age (no clinical experience of use);
- hypersensitivity to the components of the drug and NSAIDs.
With caution: simultaneous use of the drug with other NSAIDs, bronchial asthma, allergic rhinitis, polyps of the nasal mucosa.
Application of Indovazin 45g gel for external use during pregnancy and breastfeeding
There is no clinical experience proving the safety of the drug when used during pregnancy and lactation. Its use is possible only if the expected benefit outweighs the potential risk to the fetus.
Use in children
Contraindicated in children under 14 years of age.
special instructions
Do not apply to open wounds, mucous membranes, oral cavity, or eyes.
In case of contact with the eyes, mucous membranes or open wound surfaces, local irritation is observed - tearing, redness, burning, pain.
The necessary measures are to wash the affected area with copious amounts of distilled water or saline until the complaints disappear or decrease.
Indovazin® gel contains sodium benzoate and propylene glycol as excipients that may be irritating to the skin.
Impact on the ability to drive vehicles and operate machinery
Does not affect the speed of psychomotor reactions when driving and working with machinery.
Overdose
There are no reports of cases of overdose with topical use. If large quantities are accidentally ingested, a burning sensation in the mouth, salivation, nausea, and vomiting may occur.
Treatment: lavage of the oral cavity and stomach, symptomatic treatment if necessary.
Side effects Indovazin 45g gel for external use
The drug is usually well tolerated.
Local reactions: symptoms of hypersensitivity on the skin may occur - contact dermatitis, itching, redness, rash, feeling of warmth and burning at the site of application.
Drug interactions
The ointment may enhance the effect of drugs that cause photosensitivity.
Clinically significant interactions with other drugs have not been described.
Indications for use of Indovazin (what is the ointment for)
- superficial thrombophlebitis;
- postphlebitic conditions;
- superficial phlebitis;
- soft tissue lesions of a rheumatic nature : bursitis, tendovaginitis, periatritis, fibrositis .
Why Indovazin ointment is used in surgery and traumatology:
- dislocations, contusions, sprains, swelling after surgery;
- for the relief of pain, swelling in the complex therapy of venous insufficiency in the lower extremities (chronic course).
Gel "Indovenol"
This is one of the few drugs that has the same active ingredients as the drug "Indovazin" (ointment). Analogs, similar in composition, are very similar to the original medicine. The drug "Indovenol" is no exception.
Since the main components of the gel are indomethacin (an excellent NSAID) and troxerutin, it is quite clear what effect the medication has on the body. The drug is able to reduce the severity of inflammatory reactions and perfectly eliminate pain. In addition, the gel has an anti-edematous effect.
The medicine is recommended for use in:
- swelling and pain syndromes;
- venous insufficiency of the lower extremities (in the acute or chronic stage);
- thrombophlebitis;
- injuries (bruises, sprains);
- chronic lymphostasis;
- postthrombophlebitic syndromes;
- synovitis;
- acute thrombosis of hemorrhoids;
- bursitis, tendovaginitis;
- myositis.
Contraindications
Indovazin is not used in pediatric practice (age limit is 14 years due to lack of experience in clinical practice).
Absolute contraindications:
- breast-feeding;
- individual hypersensitivity to NSAIDs;
- damaged skin, violation of their integrity at the site of application of the ointment;
- third trimester of pregnancy .
Relative contraindications:
- allergic rhinitis;
- taking other medications containing NSAID components;
- polyps in the mucous membranes of the nasal cavity;
- bronchial asthma.
special instructions
Indovazin ointment is not intended for application to mucous membranes, eyes, open wound surfaces, or the oral cavity. Otherwise, severe redness, tearing, pain, and burning are observed, which requires rinsing with copious amounts of liquid (distilled water/saline).
The gel contains auxiliary components such as propylene glycol and Na benzoate, which can cause skin irritation. The medication does not have any effect on the patient’s ability to drive vehicles or perform various activities that require increased concentration.
Gel "Valusal"
When considering the drug “Indovazin” (gel) analogues, which are cheaper, it is necessary to focus on this medication. On average, Valusal gel costs patients 225 rubles.
The main component of the drug is the non-steroidal anti-inflammatory substance – ketoprofen. It is this that gives the gel the ability to eliminate pain, effectively reduce swelling and provide an anti-inflammatory effect.
The main indications for prescribing the drug are the following pathologies:
- various bruises, dislocations;
- myalgia;
- pain in the back;
- sciatica;
- traumatic sprains;
- radiculitis.
Analogs
Level 4 ATX code matches:
Rutin
Venosmin
Venoruton
Troxevasin Neo
Troxevasin
Detralex
Ginkor Gel
Ginkor fort
Vasocket
Anavenol
Troxerutin
Askorutin
Antistax
Venarus
A structural analogue (a medicine with an identical composition) is Troximethacin . Pharmacological analogues (medicines with a similar therapeutic effect):
- Voltaren;
- Valusal;
- Dicloran.
Which is better - Troxevasin or Indovasin?
The latter contains two active components, one of which is Troxerutin - the main active ingredient of Troxevasin . Indovazin additionally contains Indomethacin, which has a pronounced anti-edematous, analgesic and anti-inflammatory effect. Thus, in the treatment of certain diseases (for example, varicose veins of the lower extremities), Indovazin has a stronger, more complex effect in comparison with the drug Troxevasin.
Analogues of "Indovazin"
What can replace an effective remedy? There are many drugs that have a similar mechanism of action on the human body. However, patients should remember that only a doctor can recommend the most suitable medicine from a wide range of pharmacological agents.
So, effective analogues of Indovazin:
- "Artrosilene".
- "Artrum".
- "Bioran."
- "Butadion".
- "Bystrumgel".
- "Valusal."
- "Voltaren."
- "Diklak."
- "Diclobene."
- "Diclogen".
- "Dicloran."
- "Diclofenac".
- "Diclofenacol."
- "Longit."
- "Dorosan."
- "Ibalgin".
- "Ibuprofen."
- "Indobene."
- "Indovenol".
- "Indotrosine."
- "Ketonal".
- "Nise."
- "Nimulid".
- "Nurofen".
- "Ortofen".
- "Piroxicam".
- "Revmonn."
- "Sulaideen."
- "Febrofeed".
- "Finalgel".
- "Flexen".
Let's look at some of the drugs that can be a good alternative to medication.
Reviews about Indovazine
Thanks to the combined composition, the ointment has a complex effect, which allows the medication to be used in several areas of medicine (surgery, traumatology, phlebology) for a wide variety of pathologies (bruises, injuries, varicose veins, bursitis, etc.). The gel has a pleasant consistency, is easy to apply and is quickly absorbed into the subcutaneous tissue, without requiring the use of various dressings. The drug is available in tubes that are convenient to take with you. Reviews about the Indovazin gel are mostly positive, because the drug allows you to quickly relieve pain - exactly what all patients with bruises and traumatic injuries to the musculoskeletal system expect. In case of varicose veins of the lower extremities, swelling quickly disappears. Among the side effects, patients note mild itching , sometimes even redness in the area of application, which go away on their own after stopping the medication and do not require medical intervention.
Gel "Dicloran Plus"
The cost of this drug is slightly lower than the drug Indovazin. The cheap analogue "Dicloran Plus" costs patients 207 rubles, while the cost of the original medicine is 250 rubles.
The gel is created on the basis of 4 active ingredients:
- diclofenac diethylamine;
- methyl salicylate;
- menthol;
- linseed oil.
The combined agent, like the drug Indovazin, has anti-inflammatory, anti-edematous and analgesic effects.
Dicloran Plus gel is prescribed for:
- rheumatoid arthritis;
- myalgia of various origins;
- psoriatic arthritis;
- rheumatic lesions of soft tissues;
- ankylosing spondylitis;
- traumatic injuries of soft tissues;
- osteoarthritis of the spine or peripheral joints.
Indovazin price, where to buy
The average cost of a medicine in Russia is 250 rubles. The price of Indovazin gel depends on the region and pharmacy. The price of Indovazin ointment in Ukraine is 45 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Indovazin gel 45gBalkanpharma
RUB 285 order
Pharmacy Dialogue
- Indovazin gel 45gBalkanpharma
RUB 284 order
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Pharmacy24
- Indovazin 45 g gel Balkanfarma-Troyan AT, Bulgaria
58 UAH.order
PaniPharmacy
- Indovazin gel Indovazin gel 45g Bulgaria, Balkanpharma-Troyan
67 UAH order
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