Lindinet 20, 63 pcs., 20 mcg+75 mcg, film-coated tablets


Compound

Composition of Lindinet 20 (1 tablet):

  • ethinyl estradiol – 0.02 mg;
  • gestodene – 0.075 mg;
  • sodium calcium edetate – 0.065 mg;
  • Magnesium stearate – 0.2 mg;
  • colloidal silicon dioxide – 0.275 mg;
  • povidone – 1.7 mg;
  • corn starch – 15.5 mg;
  • lactose monohydrate – 37.165 mg.

Composition of Lindinet 30 (1 tablet):

  • ethinyl estradiol – 0.03 mg;
  • gestodene – 0.075 mg;
  • sodium calcium edetate – 0.065 mg;
  • Magnesium stearate – 0.2 mg;
  • colloidal silicon dioxide – 0.275 mg;
  • povidone – 1.7 mg;
  • corn starch – 15.5 mg;
  • lactose monohydrate – 37.165 mg.

Both pharmaceutical forms are supplied in the form of tablets, the shell of which has the following components:

  • sucrose – 19.66 mg;
  • calcium carbonate – 8.231 mg;
  • macrogol 6000 – 2.23 mg;
  • titanium dioxide – 0.46465 mg;
  • povidone – 0.171 mg;
  • yellow quinoline dye (D+S yellow No. 10 – E 104) – 0.00135 mg.

pharmachologic effect

Lindinet belongs to the group of monophasic combined oral contraceptive drugs based on sex hormones , and accordingly is used primarily for the purpose of contraception. The main therapeutic effect of the drug is associated with several mechanisms of action, including a decrease in the secretion of pituitary , active inhibition of ovulatory processes and inhibition of follicle maturation in the ovaries.

First of all, it should be noted that ethinyl estradiol , one of the biological active components, is a synthetic analogue of the follicular hormone estradiol , which, together with the hormones of the corpus luteum, is involved in the regulation of a woman’s menstrual cycle, significantly inhibiting it at certain stages.

Another active component, gestodene , is a gestagenic derivative of 19-nortestosterone and is a stronger and more selective version of natural progesterone secreted by the corpus luteum. This component is used in ultra-low quantities, due to which it does not realize its androgenic potential (the chemical basis for gestodene is a variation of the male sex hormone) and has the weakest effect on the carbohydrate and lipid metabolism of the body.

In addition to the central mechanisms of action directly on sex hormones, the drug exerts contraceptive properties indirectly through peripheral components. Under the influence of the pharmaceutical drug, the susceptibility of the endometrium to the blastocyst is reduced, which makes the process of implantation of the initial forms of the fetus almost impossible. The density and viscosity of the mucus localized in the cervix also increases, which becomes largely impenetrable for sperm making active movements towards the female egg.

Lindinet not only has contraceptive effects, the pharmaceutical drug promotes the active prevention of certain gynecological diseases and more. In particular, the possibility of functional ovarian cysts and ectopic pregnancies . The risk of fibroadenomas in the mammary glands is reduced, and congestive inflammatory processes practically disappear. The beneficial properties of the drug also apply to the skin , as their general condition improves and the severity of acne (with regular use, dermatological defects disappear completely).

Pharmacodynamics and pharmacokinetics

Pharmacokinetic abilities of gestodene

After oral administration, the active component is absorbed quite quickly and almost completely from the gastrointestinal tract, because its bioavailability is about 99%, and the maximum concentration of 2-4 ng/ml is observed after 1 hour.

In the bloodstream, gestodene binds to albumin and specific globulin SHBG , only 1-2% of the amount of the active component remains in free form. The pharmacokinetics of gestodene largely depends on the level of SHBG and the concentration of estradiol, because the amount of the selective transporter increases 3 times under the influence of the sex hormone. Constant use of oral contraceptives also contributes to the active saturation of gestodene; with daily use, the concentration increases by 3-4 times.

The active component undergoes the main stages of biochemical transformation in the liver, after which only in the form of metabolites is excreted in the urine (60%) and feces (40%). The half-life of the active component is biphasic and takes about 1 day, since the average plasma clearance ranges from 0.8 to 1 ml/million/kg.

Pharmacokinetic properties of ethinyl estradiol

The second active component has slightly lower absorption rates - due to presystemic conjugation and primary metabolism, the absolute bioavailability of the pharmacological component from the digestive tube is only 60%, and the maximum concentration of 30-80 pg/ml is achieved after 1-2 hours.

On the distribution side, ethinyl estradiol, on the contrary, outperforms gestodene, because 98.5% of the active substance binds to nonspecific albumin. Also, the active component induces an increase in SHBG levels, which has a beneficial effect on the overall effectiveness of the oral contraceptive. A constant average level of ethinyl estradiol is established by 3-4 days after the start of the therapeutic course, and it is 20% higher than after a single dose of Lindinet tablet.

Biotransformation of the active substance occurs in the liver and is aromatic hydroxylation with the formation of methylated and hydroxylated metabolic products in free form or in the form of conjugates with sulfates or glucuronides. Metabolic clearance from blood plasma ranges from 5-13 ml.

Ethinyl estradiol is excreted only in the form of metabolic products with urine and bile in a ratio of 2:3. The half-life, like that of gestodene, is biphasic and is about 1 day.

Pregnancy and lactation

If a woman is pregnant, then taking the medicine is prohibited - this poses a risk of harm to the fetus. Before starting to take the pills, it is necessary to exclude possible pregnancy.

Comment! Contraceptive pills can be used during lactation only as prescribed by a gynecologist.

When breastfeeding a baby, part of the consumed active substance is excreted in milk, which deteriorates its quality and taste. Therefore, while taking the drug, the gynecologist insists on transferring the child to artificial feeding.

Contraindications

  • individual hypersensitivity to the pharmaceutical drug or its components;
  • risk factors for arterial or venous thrombosis;
  • moderate to severe arterial hypertension
  • transient ischemic attack or angina pectoris as precursors of thrombosis;
  • surgery with prolonged immobilization;
  • diabetes;
  • pancreatitis with a pronounced increase in blood triglycerides;
  • dyslipidemia;
  • severe liver diseases ( hepatitis , cholestatic jaundice , etc.);
  • cholelithiasis;
  • Gilbert , Dubin-Johnson, Rotor syndrome;
  • neoplasm localized in the liver;
  • otosclerosis or a history of it in a previous pregnancy or after taking glucocorticosteroids;
  • smoking over the age of 35;
  • hormone-dependent malignant tumors of the genital organs and mammary glands;
  • vaginal bleeding of unknown origin;
  • period of lactation and childbearing.

LINDINET 20 TAB N21

Before starting to use the drug, it is recommended to collect a detailed family and personal history and subsequently undergo a general medical and gynecological examination every 6 months (examination by a gynecologist, examination of a cytological smear, examination of the mammary glands and liver function, monitoring of blood pressure, cholesterol concentrations in the blood, urine analysis). These studies must be repeated periodically due to the need for timely identification of risk factors or contraindications that have arisen.

The drug is a reliable contraceptive drug - the Pearl index (an indicator of the number of pregnancies occurring during the use of a contraceptive method in 100 women over 1 year) when used correctly is about 0.05. Due to the fact that the contraceptive effect of the drug from the start of administration is fully manifested by the 14th day, it is recommended to additionally use non-hormonal methods of contraception in the first 2 weeks of taking the drug.

In each case, before prescribing hormonal contraceptives, the benefits or possible negative effects of their use are individually assessed. This issue must be discussed with the patient, who, after receiving the necessary information, will make the final decision on the preference for hormonal or any other method of contraception. The woman's health condition must be carefully monitored.

If any of the following conditions/diseases appear or worsen while taking the drug, you must stop taking the drug and switch to another, non-hormonal method of contraception:

— diseases of the hemostasis system;

— conditions/diseases predisposing to the development of cardiovascular and renal failure;

- epilepsy;

- migraine;

- the risk of developing an estrogen-dependent tumor or estrogen-dependent gynecological diseases;

- diabetes mellitus, not complicated by vascular disorders;

- severe depression (if depression is associated with impaired tryptophan metabolism, then vitamin B6 can be used for correction);

- sickle cell anemia, because in some cases (for example, infections, hypoxia), estrogen-containing drugs for this pathology can provoke thromboembolism;

- the appearance of abnormalities in laboratory tests assessing liver function.

Thromboembolic diseases

Epidemiological studies have shown that there is an association between taking oral hormonal contraceptives and an increased risk of arterial and venous thromboembolic diseases (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism). An increased risk of venous thromboembolic diseases has been proven, but it is significantly less than during pregnancy (60 cases per 100 thousand pregnancies). When using oral contraceptives, arterial or venous thromboembolism of the hepatic, mesenteric, renal or retinal vessels is very rarely observed.

The risk of arterial or venous thromboembolic disease increases:

- with age;

- when smoking (heavy smoking and age over 35 years are risk factors);

- if there is a family history of thromboembolic diseases (for example, parents, brother or sister). If you suspect a genetic predisposition, you should consult a specialist before using the drug;

— for obesity (body mass index above 30);

- for dislipoproteinemia;

- for arterial hypertension;

— for diseases of the heart valves complicated by hemodynamic disorders;

- with atrial fibrillation;

- with diabetes mellitus complicated by vascular lesions;

- with prolonged immobilization, after major surgery, surgery on the lower extremities, severe trauma.

In these cases, temporary cessation of use of the drug is assumed. It is advisable to stop no later than 4 weeks before surgery, and resume no earlier than 2 weeks after remobilization.

The risk of venous thromboembolic diseases increases in women after childbirth.

Diseases such as diabetes mellitus, SLE, hemolytic uremic syndrome, Crohn's disease, ulcerative colitis, and sickle cell anemia increase the risk of developing venous thromboembolic diseases.

Biochemical abnormalities such as resistance to activated protein C, hyperhomocysteinemia, protein C and S deficiency, antithrombin III deficiency, and the presence of antiphospholipid antibodies increase the risk of arterial or venous thromboembolic diseases.

When assessing the benefit/risk ratio of taking the drug, it must be borne in mind that targeted treatment of this condition reduces the risk of thromboembolism.

Signs of thromboembolism are:

- sudden chest pain that radiates to the left arm;

- sudden shortness of breath;

- any unusually severe headache that continues for a long time or appears for the first time, especially when combined with sudden complete or partial loss of vision or diplopia, aphasia, dizziness, collapse, focal epilepsy, weakness or severe numbness of half the body, movement disorders, severe unilateral pain in the calf muscle, acute abdomen.

Tumor diseases

Some studies have reported an increased incidence of cervical cancer in women who took hormonal contraceptives for a long time, but the results of the studies are inconsistent. Sexual behavior, infection with the human papillomavirus and other factors play a significant role in the development of cervical cancer.

A meta-analysis of 54 epidemiological studies found that there was a relative increase in the risk of breast cancer among women taking oral hormonal contraceptives, but the higher detection rate of breast cancer may have been associated with more regular medical screening. Breast cancer is rare among women under 40, whether they are taking hormonal birth control or not, and increases with age. Taking pills can be considered one of many risk factors. However, women should be made aware of the possible risk of developing breast cancer based on a benefit-risk assessment (protection against ovarian, endometrial and colon cancer).

There are few reports of the development of benign or malignant liver tumors in women taking hormonal contraceptives for a long time. This should be kept in mind when diagnosing abdominal pain, which may be associated with an increase in liver size or intra-abdominal bleeding.

The woman should be warned that the drug does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

The effectiveness of the drug may decrease in the following cases:

missed pills, vomiting and diarrhea, simultaneous use of other drugs that reduce the effectiveness of birth control pills.

If the patient is concomitantly taking another drug that may reduce the effectiveness of birth control pills, additional methods of contraception should be used.

The effectiveness of the drug may decrease if, after several months of their use, irregular, spotting or breakthrough bleeding appears, in such cases it is advisable to continue taking the tablets until they run out in the next package. If at the end of the 2nd cycle menstrual-like bleeding does not begin or acyclic bleeding does not stop, you should stop taking the pills and resume it only after pregnancy has been ruled out.

Chloasma

Chloasma can occasionally occur in women who have a history of it during pregnancy. Those women who are at risk of developing chloasma should avoid contact with sunlight or UV rays while taking the pills.

Changes in laboratory parameters

Under the influence of oral contraceptive pills, due to the estrogen component, the level of some laboratory parameters (functional indicators of the liver, kidneys, adrenal glands, thyroid gland, hemostasis indicators, levels of lipoproteins and transport proteins) may change.

After acute viral hepatitis, it should be taken after normalization of liver function (no earlier than 6 months). In case of diarrhea or intestinal disorders, vomiting, the contraceptive effect may decrease (without stopping the drug, it is necessary to use additional non-hormonal methods of contraception). Women who smoke have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk depends on age (especially in women over 35 years of age) and the number of cigarettes smoked. During lactation, milk secretion may decrease; in small quantities, the components of the drug are excreted in breast milk.

The effect of the drug on the ability to drive a car and operate machinery.

Studies have not been conducted to study the possible effect of Lindinet 20 on the ability to drive a car or other machines.

Side effects

Adverse effects of treatment requiring immediate discontinuation of pharmaceutical therapy:

  • From the cardiovascular system: arterial hypertension, myocardial infarction , stroke , deep vein thrombosis of the lower extremities, pulmonary embolism , venous or arterial thromboembolism of the hepatic, mesenteric, retinal or renal vessels.
  • From the senses: hearing loss caused by otosclerosis .
  • Other: porphyria , hemolytic-uremic syndrome, exacerbations of reactive systemic lupus erythematosus , Sydenham's chorea .

Side effects, after the appearance of which the advisability of further use of the drug is decided on an individual basis:

  • From the reproductive system: acyclic bleeding from the vagina of unknown etiology, amenorrhea , colpocytological changes in vaginal mucus, inflammatory diseases, vaginal candidiasis , pain, enlarged mammary glands, galactorrhea .
  • From the central nervous system: hearing loss, depression , migraines , mood lability.
  • Dermatological reactions: nodular or exudative erythema , unclear rash, chloasma, increased alopecia .
  • From the digestive system: epigastric pain, nausea and vomiting, Crohn's disease , ulcerative colitis , jaundice and the itching that is caused by it, cholelithiasis , liver adenoma, hepatitis.
  • From the side of metabolic processes: fluid retention in the body, decreased tolerance to carbohydrates, increased levels of triglycerides or blood glucose, increased body weight.
  • Other allergic reactions.

Lindinet 20, 63 pcs., 20 mcg+75 mcg, film-coated tablets

Before starting to use the drug, it is recommended to collect a detailed family and personal history and subsequently undergo a general medical and gynecological examination every 6 months (examination by a gynecologist, examination of a cytological smear, examination of the mammary glands and liver function, monitoring of blood pressure, cholesterol concentrations in the blood, urine analysis). These studies must be repeated periodically due to the need for timely identification of risk factors or contraindications that have arisen.

The drug is a reliable contraceptive drug - the Pearl index (an indicator of the number of pregnancies occurring during the use of a contraceptive method in 100 women over 1 year) when used correctly is about 0.05. Due to the fact that the contraceptive effect of the drug from the start of administration is fully manifested by the 14th day, it is recommended to additionally use non-hormonal methods of contraception in the first 2 weeks of taking the drug.

In each case, before prescribing hormonal contraceptives, the benefits or possible negative effects of their use are individually assessed. This issue must be discussed with the patient, who, after receiving the necessary information, will make the final decision on the preference for hormonal or any other method of contraception. The woman's health condition must be carefully monitored.

If any of the following conditions/diseases appear or worsen while taking the drug, you must stop taking the drug and switch to another, non-hormonal method of contraception:

— diseases of the hemostasis system;

— conditions/diseases predisposing to the development of cardiovascular and renal failure;

- epilepsy;

- migraine;

- the risk of developing an estrogen-dependent tumor or estrogen-dependent gynecological diseases;

- diabetes mellitus, not complicated by vascular disorders;

- severe depression (if depression is associated with impaired tryptophan metabolism, then vitamin B6 can be used for correction);

- sickle cell anemia, because in some cases (for example, infections, hypoxia), estrogen-containing drugs for this pathology can provoke thromboembolism;

- the appearance of abnormalities in laboratory tests assessing liver function.

Thromboembolic diseases

Epidemiological studies have shown that there is an association between taking oral hormonal contraceptives and an increased risk of arterial and venous thromboembolic diseases (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism). An increased risk of venous thromboembolic diseases has been proven, but it is significantly less than during pregnancy (60 cases per 100 thousand pregnancies). When using oral contraceptives, arterial or venous thromboembolism of the hepatic, mesenteric, renal or retinal vessels is very rarely observed.

The risk of arterial or venous thromboembolic disease increases:

- with age;

- when smoking (heavy smoking and age over 35 years are risk factors);

- if there is a family history of thromboembolic diseases (for example, parents, brother or sister). If you suspect a genetic predisposition, you should consult a specialist before using the drug;

— for obesity (body mass index above 30);

- for dislipoproteinemia;

- for arterial hypertension;

— for diseases of the heart valves complicated by hemodynamic disorders;

- with atrial fibrillation;

- with diabetes mellitus complicated by vascular lesions;

- with prolonged immobilization, after major surgery, surgery on the lower extremities, severe trauma.

In these cases, temporary cessation of use of the drug is assumed. It is advisable to stop no later than 4 weeks before surgery, and resume no earlier than 2 weeks after remobilization.

The risk of venous thromboembolic diseases increases in women after childbirth.

Diseases such as diabetes mellitus, SLE, hemolytic uremic syndrome, Crohn's disease, ulcerative colitis, and sickle cell anemia increase the risk of developing venous thromboembolic diseases.

Biochemical abnormalities such as resistance to activated protein C, hyperhomocysteinemia, protein C and S deficiency, antithrombin III deficiency, and the presence of antiphospholipid antibodies increase the risk of arterial or venous thromboembolic diseases.

When assessing the benefit/risk ratio of taking the drug, it must be borne in mind that targeted treatment of this condition reduces the risk of thromboembolism.

Signs of thromboembolism are:

- sudden chest pain that radiates to the left arm;

- sudden shortness of breath;

- any unusually severe headache that continues for a long time or appears for the first time, especially when combined with sudden complete or partial loss of vision or diplopia, aphasia, dizziness, collapse, focal epilepsy, weakness or severe numbness of half the body, movement disorders, severe unilateral pain in the calf muscle, acute abdomen.

Tumor diseases

Some studies have reported an increased incidence of cervical cancer in women who took hormonal contraceptives for a long time, but the results of the studies are inconsistent. Sexual behavior, infection with the human papillomavirus and other factors play a significant role in the development of cervical cancer.

A meta-analysis of 54 epidemiological studies found that there was a relative increase in the risk of breast cancer among women taking oral hormonal contraceptives, but the higher detection rate of breast cancer may have been associated with more regular medical screening. Breast cancer is rare among women under 40, whether they are taking hormonal birth control or not, and increases with age. Taking pills can be considered one of many risk factors. However, women should be made aware of the possible risk of developing breast cancer based on a benefit-risk assessment (protection against ovarian, endometrial and colon cancer).

There are few reports of the development of benign or malignant liver tumors in women taking hormonal contraceptives for a long time. This should be kept in mind when diagnosing abdominal pain, which may be associated with an increase in liver size or intra-abdominal bleeding.

The woman should be warned that the drug does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

The effectiveness of the drug may decrease in the following cases:

missed pills, vomiting and diarrhea, simultaneous use of other drugs that reduce the effectiveness of birth control pills.

If the patient is concomitantly taking another drug that may reduce the effectiveness of birth control pills, additional methods of contraception should be used.

The effectiveness of the drug may decrease if, after several months of their use, irregular, spotting or breakthrough bleeding appears, in such cases it is advisable to continue taking the tablets until they run out in the next package. If at the end of the 2nd cycle menstrual-like bleeding does not begin or acyclic bleeding does not stop, you should stop taking the pills and resume it only after pregnancy has been ruled out.

Chloasma

Chloasma can occasionally occur in women who have a history of it during pregnancy. Those women who are at risk of developing chloasma should avoid contact with sunlight or UV rays while taking the pills.

Changes in laboratory parameters

Under the influence of oral contraceptive pills, due to the estrogen component, the level of some laboratory parameters (functional indicators of the liver, kidneys, adrenal glands, thyroid gland, hemostasis indicators, levels of lipoproteins and transport proteins) may change.

After acute viral hepatitis, it should be taken after normalization of liver function (no earlier than 6 months). In case of diarrhea or intestinal disorders, vomiting, the contraceptive effect may decrease (without stopping the drug, it is necessary to use additional non-hormonal methods of contraception). Women who smoke have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk depends on age (especially in women over 35 years of age) and the number of cigarettes smoked. During lactation, milk secretion may decrease; in small quantities, the components of the drug are excreted in breast milk.

The effect of the drug on the ability to drive a car and operate machinery.

Studies have not been conducted to study the possible effect of Lindinet 20 on the ability to drive a car or other machines.

Instructions for use of Lindinet (Method and dosage)

Lindinet 20, instructions for use

Birth control pills are used orally once a day, without chewing and with a sufficient amount of water, regardless of meals. If possible, you should take the pills at the same time of day for 21 days, then take a break for 7 days, and then resume using contraceptives. That is, the next tablet should be used 4 weeks from the start of the course on the same day of the week. During the break, uterine bleeding will be observed, which corresponds to menstruation in a normal cycle.

A course of conservative contraception should be started from the 1st to the 5th day of the menstrual cycle, if other oral contraceptives have not been used before. Otherwise, the 1st tablet must be taken after taking the last dose of the previous pharmaceutical preparation containing hormones, on the 1st day of bleeding after discontinuation.

Switching from progestogen-containing drugs to Lindinet requires the use of an additional method of contraception in the first week. The date of first use of a new contraceptive should be consistent with the pharmaceutical form of the previous drug:

  • in the form of mini-tablets - on any day of the menstrual cycle;
  • in case of injections - on the eve of the last injection;
  • implant - the day after its removal.

Lindinet 30, instructions for use

Since this pharmaceutical form is an enhanced version of Lindinet 20 with a higher concentration of ethinyl estradiol, it is recommended to prescribe it after an abortion so that the restoration of physiological hormonal levels occurs much faster and less painfully.

If the abortion was performed in the 1st trimester of pregnancy , then there is nothing to worry about. Taking oral contraceptives can be started immediately after gynecological manipulation and there is no need to use additional methods of contraception.

If abortion or childbirth occurred in the 2nd trimester of pregnancy , then taking the pharmaceutical drug can only be started on the 21st-28th day after the obstetric surgery. If the course of conservative protection is started later, a barrier method of contraception should be used in the first week. If full sexual intercourse took place before starting to take the drug, then before taking birth control you need to make sure that there is no new pregnancy.

Missing an oral contraceptive pill

If the next dose of the tablet was missed, then the missing amount of the pharmaceutical drug in the bloodstream must be replenished as quickly as possible. With a delay that does not exceed 12 hours , the clinical effects of the contraceptive are not reduced and the need for additional protection by other methods of contraception automatically disappears. Subsequent tablets are taken according to the usual regimen.

If a woman misses a pill and does not replace it within 12 hours , then the pharmacological effectiveness of the drug is reduced, which requires special measures and precautions. First of all, you should resume taking the drug as soon as possible and continue to take it as usual. It is recommended to use any other methods of contraception for a week after the missed period.

This situation may become more complicated if there are less than 7 tablets left in the package . How to take it in this case - start the next pack without observing the required one-week break, which is carried out only after the end of the 2nd pack of contraceptives. It should be noted that while using the 2nd pack, spotting or even breakthrough bleeding may be observed, which can indirectly indicate the presence of pregnancy. If hemorrhages have not stopped after the end of the 2nd pack, then before continuing to take birth control you should consult a doctor and rule out the presence of a developing fetus in the womb.

Comparison of ease of use of Lindineta 20 and Lindineta 30

This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.

The ease of use of Lindinet 20 is approximately the same as Lindinet 30. However, they are not convenient enough to use.

The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.

Last update date: 2020-12-04 13:43:31

Interaction

The contraceptive properties of the pharmaceutical drug are reduced when used with drugs such as Ampicillin , Tetracycline , Rifampicin , barbiturates, Primidone , Carbamazepine , Phenylbutazone , Phenytoin , Griseofulvin , Topiramate , Oxcarbazepine .

Therefore, if it is necessary to use these drugs together with Lindinet, it is necessary to use additional non-hormonal contraceptives for 7 days (it is recommended to visit an additional consultation with your doctor and clarify the period for certain). You may also experience spotting or breakthrough bleeding, menstrual irregularities, or some other side effects.

In conditions of increased peristalsis or diarrhea , the residence time of the contraceptive drug in the lumen of the gastrointestinal tract is reduced, which significantly reduces the absorption properties of the hormonal contraceptive. Any drug that shortens the stay of Lindinet in the digestive tube leads to a decrease in the concentration of active components in the blood, and accordingly to a decrease in their beneficial effect.

Drug interactions at the absorption stage are modeled using the combined use of a contraceptive with ascorbic acid , since biologically active substances are equally subject to sulfation in the intestinal wall, which inhibits metabolic chains and increases the bioavailability of ethinyl estradiol.

Comparison of the effectiveness of Lindinet 20 and Lindinet 30

The effectiveness of Lindinet 20 is quite similar to Lindinet 30 - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Lindinet 20 is more pronounced, then using Lindinet 30 even in large doses will not achieve this effect.

Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Lindinet 20 and Lindinet 30. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.

special instructions

Pregnancy after using hormonal contraceptives

Oral hormonal contraceptives are a group of pharmaceuticals based on synthetic analogs of female sex hormones (estrogen and progesterone) that prevent the onset of ovulation, preventing the very possibility of fertilization. Of course, a large audience of women is convinced that using them for contraception is harmful, since a normal, physiological pregnancy will most likely not occur after drug changes in hormonal levels. However, this is one of the myths about this group of drugs.

After stopping taking hormonal contraceptives and completing a course of conservative contraception, the effects of the drugs gradually disappear. The only peculiarity is that when planning a pregnancy , you should find out the exact timing of the optimal moment for fertilization in the antenatal clinic or from your personal gynecologist. After all, every time a woman takes a pill for a headache, she does not worry about the health of her unconceived child; in this case, the situation is almost identical.

When can you not use barrier methods of contraception?

Lindinet is a reliable hormonal contraceptive drug, which can be determined from a special indicator of the number of pregnancies that occurred during a course of oral contraception in 100 women for 1 year. For this pharmaceutical product, it is only 0.05, if you use the contraceptive correctly and only according to the application plan. However, the pharmacological effects of Lindinet do not fully develop immediately, but only by the 14th day from the start of taking the pills, therefore, in the first 2 weeks it is recommended to use barrier methods of contraception.

Lindinet 20 and Lindinet 30 - what's the difference?

A large number of visitors to pharmaceutical forums for women ask the following series of questions: “Lindynet 20 and 30 - what is the difference?”, as well as whether the drugs are interchangeable and, finally, which is better of the two forms of the contraceptive drug. The difference in the forms of the same contraceptive lies in the concentration of one of the active components - ethinyl estradiol. In oral tablets, the level can be 0.02 mg and 0.03 mg, respectively, which in biochemical terms does place them in different categories.

Lindinet 20 has a milder pharmacological effect and contributes to a lesser extent to increasing the selective SHBG transporter, which makes it possible to use it for contraception, however, for therapeutic needs , as a rule, a stronger form of the drug is required, which is why Lindinet 30 is used. What is different from weaker tablets, a more concentrated form of the drug is not advertised, since sometimes, for individual indications, even as a contraceptive, it is necessary to use Lindinet 30, which can be perceived by a woman as an unfair load with a hormonal drug.

It is strictly contraindicated to replace pharmaceutical forms of a drug on your own, because a qualified specialist who prescribes contraceptives or therapeutic agents relies on the results of clinical studies, their interpretation and many years of experience in his field, and not on an approximate idea of ​​the biomechanism of the female body. If any side effects or other adverse effects occur, you should seek advice and resolve the issue on an individual basis.

Reviews of birth control pills Lindinet 30

Gorbunova Marina Viktorovna, 32 years old, Izhevsk

I switched to Lindinet 30 immediately after taking Lindinet 20 for 2 years. The transition was smooth and I did not notice any side effects. The gynecologist insisted on the transition due to reaching a certain age, arguing that after 30 years a different content of hormones in the tablets is necessary.

Romancheva Olga Andreevna, 35 years old, Krasnoyarsk

Last month, the doctor prescribed Lindinet 30 birth control pills, the reviews and price of the drug suited me, so I immediately purchased it. I had not previously taken oral contraception, so I was wary of the decision, but in vain. The drug suited me completely. I’m already finishing the first pack and thinking about buying the next one, since I haven’t noticed any side effects.

Andreeva Anastasia Olegovna, 30 years old, Tolyatti

I like Lindinet 30 because it does not suppress libido, as many other contraceptives do. For 2 years of taking the pills, I did not notice any weight gain, headaches or other side effects. During the adaptation period, minor pain was felt in the mammary glands, but after the 3rd month of use it went away.

Analogs

Level 4 ATC code matches:
Ovidon

Rigevidon

Non-Ovlon

Mercilon

Yarina Plus

Yarina

Miniziston 20 fem

Novinet

Microgynon

Janine

Cyclo-Proginova

Regulon

Logest

Midiana

Belara

Femoden

Jess Plus

Jess

Zoely

Among pharmaceutical drugs similar to Lindinet, several groups of contraceptives should be distinguished:

  • Lindinet 20 analogues with identical ATX code and composition of active ingredients: Logest , Model Tin , Femoden ;
  • analogues with the same level 4 ATX code: Angeleta , Vidora , Dayla , Naadin , Novinet .

Lindinet 20 or Logest - which is better?

Like Lindinet, Logest belongs to the group of combined oral hormonal contraceptives. The pharmaceutical preparation contains the same active ingredients in identical quantities, that is, 1 contraceptive tablet contains 0.02 mg ethinyl estradiol and 0.075 mg gestodene. The only significant difference between medicines is the country of production, and, accordingly, the price indicator.

Since Lindinet is produced in Hungary, its cost in pharmacy kiosks is much lower than that of the drug produced jointly by French and German pharmacists, but this in no way indicates the effectiveness of the former, therefore the choice of a contraceptive should be entrusted to a qualified specialist, because he is based on individual indicators of hormonal balance and some other medical aspects.

Which is better: Novinet or Lindinet 20?

Novinet is a monophasic oral contraceptive, which, in addition to ethinyl estradiol, contains the synthetic progestogen desogestrel , which somewhat changes the mechanism of action of the contraceptive drug. Like all artificial pharmaceutical components of this nature, desogestrel has a high affinity for progesterone receptors located in the hypothalamic-pituitary region, on which its effects are based. In sufficiently small quantities, it is able to “turn on” the negative feedback mechanism, which results in a sharp inhibition of the release and production of gonadotropins and a complete blocking of ovulation.

Since Novinet includes such a potent pharmaceutical component as one of the active ingredients, its price is accordingly almost twice as high as that of Lindinet. However, with certain individual indications or contraindications, a woman does not have the opportunity to use a cheaper contraceptive, which makes it possible to include Novinet in a conservative course of contraception.

Reviews about Lindinet

Reviews about Lindinet 20 can be found in antenatal clinics, on pharmaceutical or other thematic forums, and almost everywhere hormonal contraceptive pills receive good responses, because oral contraceptives really effectively help solve this issue. Of course, some women complain that weight increases unreasonably when following the dosage regimen and correct dosages of the contraceptive, but side effects are not common, especially since hormonal levels are one of the most unstable balances in the body.

Birth control pills, in addition to their main purpose, are also used as a therapeutic agent for functional disorders of the menstrual cycle and some other gynecological pathologies, and even cope with this task perfectly. Reviews about Lindinet 30 on forums fully confirm the advisability of conservative treatment with this form of pharmaceutical drug, because the dosage of active components in it is slightly higher.

Reviews from doctors on Lindinet 20, as well as for the more concentrated form of the drug, have a positive advantage, because thanks to the carefully developed pharmaceutical formula and regimen for taking the oral contraceptive, you can easily achieve the desired effects for a long time. Of course, qualified specialists are overshadowed by the fact that women allow themselves to independently change the forms, and sometimes dosages, of the drug based on the fact that side effects are observed, but this does not always lead to catastrophic consequences.

However, experienced pharmacists and gynecologists recommend seeking additional advice in advance if side effects begin to bother you during a conservative course of taking Lindinet 20 or 30 or any other types of discomfort that arise during drug treatment.

What is the difference between Lindinet 20 and 30

The drug "Lindinet 20" or 30 is produced by a world-famous pharmaceutical company located in Hungary. Contraceptive pills from this company have always had a mild effect on the female body. To understand the difference between Lindinet 20 and Lindinet 30, you need to refer to detailed information about contraceptives.

Lindinet 20 or 30: which is better?

There is no point in talking about which of the two contraceptive pills is better. Each of them is aimed at a different audience of girls. The difference between the tablets is that Lindinet 20 contains a lower dosage of the active substance than Lindinet 30 tablets. Therefore:

  1. "Lindynet 20" is prescribed to young nulliparous girls aged 20 to 30 years, and also when a small amount of hormonal exposure is required.
  2. A dosage of 30 mcg is prescribed to women over 30 years of age.

The smaller amount of hormones in Lindinet 20 has a mild effect on the body of a nulliparous girl. The drug should not cause side effects; it gently corrects the menstrual cycle, protecting the girl from unwanted pregnancy.

Transition from Lindinet 20 to Lindinet 30

Switching from one contraceptive pill to another is carried out only according to the indications of the treating gynecologist who was prescribed these drugs. Often a transition is prescribed due to changes in age, as well as when there is a need to increase the dosage of the active substance.

Warning! As the dosage increases, women may experience chest pain - this is due to increased estrogen levels.

The transition is carried out smoothly, according to the doctor’s recommendations or instructions. Usually, girls are advised to finish a pack of Lindinet 20, take a 7-day break and start a new pack of Lindinet 30. During this break, menstruation should occur.

Lindineta price, where to buy

The price of Lindinet 20 in pharmacies in the Russian Federation averages 300-350 rubles. How much a stronger form of a pharmaceutical drug costs should be found out individually, since it is prescribed much less frequently.

The cost of Lindinet 20 in Ukrainian pharmacies ranges from 150 to 200 hryvnia, and the price of Lindinet 30 starts at 170 hryvnia.

  • Online pharmacies in RussiaRussia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in KazakhstanKazakhstan

ZdravCity

  • Lindinet 20 tablets p.p.o.
    63 pcs. JSC Gedeon Richter RUB 1,397 order
  • Lindinet 30 tablets p.p.o. 21pcs JSC Gedeon Richter

    RUR 607 order

  • Lindinet 20 tablets p.p.o. 21 pcs. JSC Gedeon Richter

    600 rub. order

Pharmacy Dialogue

  • Lindinet 20 (tab. No. 21x3) Gedeon-Richter

    RUB 1,368 order

  • Lindinet 20 (tab. No. 21) Gedeon-Richter

    RUB 593 order

  • Lindinet 30 (tab. No. 21)Gedeon-Richter

    RUB 593 order

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Pharmacy24

  • Lindinet 20 mg No. 63 tablets VAT "Gedeon Richter", Ugorshchina
    452 UAH. order

PaniPharmacy

  • Lindinet 20 tablets Lindinet 20 tablets. p/o No. 63 Hungary, Gedeon Richter

    540 UAH. order

  • Lindinet 20 tablets Lindinet 20 tablets. p/o No. 21 Hungary, Gedeon Richter

    164 UAH order

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