Inexpensive substitutes for Macmiror®: TOP 6 analogues in suppositories and tablets

There are restrictions during pregnancy

Possible while breastfeeding

Not suitable for children

Has restrictions for older people

Has limitations for liver problems

Has limitations for kidney problems

Macmiror is a broad-spectrum antibacterial agent. Macmiror is used to treat both adults and children over 6 years of age. Its use is indicated for diagnosed:

• diseases of the genitourinary system of an infectious nature, such as urethritis, cystitis and others;
• chronic inflammatory (associated with Helicobacter pylori) pathologies of the upper gastrointestinal tract (ulcerative gastrointestinal tract, GERD, chronic gastritis);
• intestinal amebiasis and giardiasis;
• vulvovaginal infections.

  Vulvovaginitis

The drug is contraindicated in cases of hypersensitivity to the substances that make up its composition, or to one of the components. The prescription of Macmiror to pregnant patients should be approached with the utmost caution, since in case of an overdose there is a possibility of its penetration through the hematoplacental barrier.

During the lactation period, breastfeeding is recommended to be suspended, as Macmiror is excreted in breast milk. If you need to buy a drug cheaper than the original, you can select effective structural analogues and substitutes for Macmiror with a similar effect.

pharmachologic effect

Manufacturer: Doppel Pharmaceuticals, Polikem, Italy
Release form: film-coated tablets

Active ingredient: Nifuratel

Synonyms: Nifuratel-SZ

Macmiror contains an active substance that has antibacterial, antifungal and antiprotozoal effects. The drug exhibits high activity against various microorganisms:

• papillobacteria, Helicobacter pylori;
• enterococci and staphylococci;
• Escherichia, Shigella, Salmonella;
• amoeba, lamblia;
• Trichomonas;
• mushrooms of the genus Candida.

Macmiror Complex also contains Nystatin (an antifungal component) and is used externally for vaginal infections.

Macmiror is not an antibiotic, although it is classified as an antibacterial drug, the drug does not have a toxic effect on the body and does not disturb the natural microflora. The drug has minimal side effects and practically no contraindications, except for individual intolerance, as indicated in the instructions for use of Macmiror.

Forms of release of the drug and structural analogues

Macmiror is produced in several forms, namely tablets, vaginal suppositories and ointments. This medication belongs to the antimicrobial and antiseptic agents used in gynecology.

The main active component is nifuratel, which affects enzymes that are involved in the development of microorganisms. The influence is exerted by its metabolites. Through research, the high effectiveness of nifuratel against gram-positive and gram-negative flora was revealed.

Activity spectrum of nifuratel

When taken orally, nifuratel is rapidly absorbed from the gastrointestinal tract. Excretion from the body is carried out by the kidneys, and therefore produces a significant antibacterial effect in the urinary tract. It should be noted that from 30 to 50% of nifuratel is excreted in its original form. Important features include passage through the blood-brain and hematoplacental barriers. As the closest analogue in composition and action, Nifuratel is indicated for use in suppositories or tablets.

See also:

Instructions and indications for use of the drug Dilasid

Macmiror - instructions for use

For vaginal diseases, Macmiror is taken one tablet three times a day for a week. Moreover, the medicine is prescribed to both partners. During treatment, sexual relations should be excluded.

Macmiror Complex is used at night, 1 suppository or 2.5 g of cream using an applicator deep into the upper part of the vagina for 8 days in a row.

To eradicate Helicobacter pylori and various intestinal infections, the drug is used 2 tablets 2-3 times a day. The course of treatment is usually one or two weeks.

For urinary tract infections, twice the dose is prescribed.

For children, the dose is calculated based on body weight. Usually it is 10–15 mg per kg of weight twice a day for 7–10 days.

How to take Macmiror - before or after meals

The drug is used after meals, so the drug is better absorbed.

Macmiror's analogues

Substitutes for the drug should be divided into analogues of Macmiror tablets and analogues of suppositories and cream Macmiror Complex.

Depending on the pathogen and localization of the disease, Macmiror tablets can be replaced with Pimafucin, Nemozol, Enterofuril, Tiberal, Metronidazole, Furadonin or Furamag.

Analogs of Macmiror Complex cream and suppositories are Hexicon, Betadine, Polygynax, Neo Penotran, Terzhinan.

Prices for cheap analogues of Macmiror can be found in the table:

Hexicon

Manufacturer: Nizhpharm, Russia
Release form: suppositories and vaginal tablets

Active ingredient: Chlorhexidine

The Hexicon analog contains Chlorhexidine, an antiseptic that has a bactericidal effect against many bacteria, Trichomonas and Treponema. Doesn't work only on viruses.

The product is used to treat inflammatory diseases of the genital area, one suppository or vaginal tablet, pre-moistened with water, twice a day for a week.

Hexicon suppositories can be used to prevent sexually transmitted diseases. To do this, a suppository or tablet is administered no later than two hours after sexual intercourse.

Pimafucin

Manufacturer: LEO Pharma, Denmark/Astellas, Netherlands
Release form: enteric tablets, cream for external use, vaginal suppositories

Active ingredient: Natamycin

Synonyms: Primafungin, Ecofucin

The Pimafucin analogue contains a macrolide antibiotic, which is effective against yeast and mold fungi, including Candida, Aspergillus, and Trichomonas.

This analogue is used for diseases caused by agents sensitive to it, in the form of internal tablets, and external forms - cream and suppositories.

Pimafucin can be used during pregnancy and lactation.

Domestic substitutes

Today there are many analogues of Macmiror, both in the form of tablets and in the form of suppositories. Let's look at each separately.

In tablets

Before starting treatment, you must be sure to familiarize yourself with the contraindications for each of the similar drugs. The most popular Russian-made medicines are:

1. Furazolidone . Has the same indications for use. It can also be used for external treatment of wounds on the skin (to do this, you need to dilute the tablet in water and apply it to the affected area using cotton wool). It is prohibited for use in cases of liver dysfunction, sensitivity to the components of the drug, in children under 5 years of age, during pregnancy and breastfeeding, and disorders of the nervous system. Adverse reactions such as abdominal pain, nausea or vomiting are common. To reduce the risk of their development, it is recommended to take the tablets with a sufficient amount of water and at the same time take antihistamines. The price starts from 60 rubles.
2. Metronidazole . The drug has a wide spectrum of action, shows its effectiveness in the treatment of giardiasis, pathologies of the stomach and intestines, etc. It has several release forms. It has a number of contraindications (early pregnancy, lactation, disorders of the nervous system) and can cause side symptoms. The price ranges from 20-150 rubles depending on the form of release.
3. Nifuratel . This is a direct analogue of Macmiror and has an identical active ingredient. It is used to treat diseases of the genitourinary tract (cystitis, pyelonephritis, pyelitis, etc.), disorders of the gastrointestinal tract, giardiasis, enterocolitis, etc. Has an antifungal and antibacterial effect. Not for use in pregnant and lactating women. May cause allergies or intestinal upset during therapy. The price is within 500 rubles per package.

In the form of candles

A replacement for McMirror can also be found in the form of candles; let’s look at the most popular ones:

1. Clomegel . Available in the form of a vaginal gel. Contains clotrimazone and metronidazole. Has a powerful antifungal and antibacterial effect. Sold for 50-150 rubles per package.
2. Povidone-iodine . Used for the treatment and prevention of genitourinary diseases. The main contraindications are intolerance to the components of the drug, thyroid problems, pregnancy, breastfeeding, and the patient's age before puberty. Sold in pharmacies at a price of 250 rubles.
3. Vagiferon . It contains fluconazole, metronidazole and natural interferon. It is considered one of the most effective in the treatment of genitourinary diseases. Price 400-435 rubles.

Macmiror candles or Terzhinan – which is better?

Manufacturer: Bouchara Recordati, France
Release form: vaginal tablets

Active ingredient: Ternidazole + Neomycin sulfate + Nystatin + Prednisolone sodium metasulfobenzoate

Terzhinan is a complex drug, an analogue of Macmiror suppositories, containing several active ingredients: antifungal, antibacterial and anti-inflammatory.

The drug is used for bacterial, fungal and trichomonas vaginitis, as well as when it is impossible to establish a diagnosis. It is optimal to combine Terzhinan vaginally and Macmiror orally.

Terzhinan is approved for use in pregnant women.

Reviews from doctors

Doctors speak positively about many drugs with similar effects to Macmiror. Here are the main expert opinions.

Due to the high demand, Macmiror is difficult to find in pharmacies. I prescribe Macmiror Complex to my patients. Its action is much more effective, the price is not much higher than the main drug.

Obukhovsky V.A., urologist

Among the cheap analogues, I think Fupacilin is effective. It is available in almost all forms; you can choose the optimal one for each patient. In this case, there is a risk of developing side symptoms if the treatment regimen is not followed.

Fedyunina T.V., therapist

I consider Vilprafen to be the safest analogue for children. It has many forms of release and shows effectiveness in the treatment of many diseases caused by bacterial microflora. In this case, it is very important to choose the correct dosage and take the drug according to a strict regimen.

Narvina L.S., pediatrician

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Macmiror or Polygynax - which is better?

Manufacturer: Innotera, France
Release form: vaginal capsules

Active ingredient: Neomycin + Nystatin + Polymyxin B

Polygynax is a combination medicine containing antifungal substances and antibiotics. This analogue of Macmiror suppositories is used for bacterial and other vaginitis with an unspecified diagnosis, including thrush.

In addition, the Polygynax analogue is prescribed in gynecology before operations to prevent the development of infection.

The drug can be used during pregnancy. During menstruation, treatment should not be interrupted. The preventive course is 6 vaginal capsules, for treatment 12 capsules are needed.

Foreign analogues

The most effective analogues of foreign-made McMirror are:

1. Vilprafen . Available in tablet form, it is effective in treating bacterial infections of the genitourinary system, respiratory system, dermatology, etc. Among the main contraindications it is worth highlighting renal failure. Does not cause side symptoms. The price in pharmacies is from 500 to 700 rubles per package.
2. Ketodin . Available in the form of vaginal suppositories and cream for external use. Among the contraindications, it is worth highlighting the age of patients under 12 years, pregnancy and breastfeeding. Shows high effectiveness in the treatment of fungal infections of the genitourinary tract. The price is 100-150 rubles.
3. McMirror Complex . A complete analogue of the main Italian-made drug. It contains nystatin, which enhances the antifungal property. Available in different forms, it is allowed to be prescribed to pregnant and lactating women, the cost is in the range of 250-900 rubles (depending on the form of release).
4. Gravagin . The drug is made in Ukraine and is available in the form of vaginal suppositories. It contains metronidazole and is highly effective in the treatment of diseases of the urinary system, vaginitis and other gynecological pathologies. May cause slight irritation to the vaginal mucosa during treatment. The average price is 90-100 rubles per package.

It is important to remember that the selection of an analogue is carried out by the attending physician. Self-medication causes the development of serious complications.