Treatment of hair loss with medications

Pharmacodynamics and pharmacokinetics

Rogaine solution is a medicine used to treat thinning scalp hair ( baldness , alopecia ). The main effect of minoxidil is aimed at stimulating and activating hair growth in patients suffering from androgenetic alopecia .

When using the drug externally, signs of hair growth were observed after at least 4 months of use. The onset of scalp growth and the degree of its severity are quite variable and depend on the personal response of each patient to the treatment. Rogaine 5% solution has a more significant effect on hair growth than a 2% solution of this drug, which has been proven by the observed increase in the number of vellus hairs .

When treatment with Rogaine is discontinued, the appearance of new hair slows down until the process stops completely and over the course of 3-4 months brings the scalp to the level observed before the onset of problems with hair loss.

The true mechanism of action of minoxidil in the treatment of androgenetic alopecia is still unknown.

When applied externally to intact scalp, absorption of minoxidil remains low. On average, less than 1.5% (with variability - 0.3-4.5%) of the drug from its total used dose enters the systemic circulation. Application of 1 ml of a 5% solution of Regaine (50 mg minoxidil ) leads to the absorption of only 0.70 mg of the drug. The effect of skin pathologies on the absorption process of minoxidil has not been studied.

The profile of metabolic transformations of minoxidil , when applied externally, has not yet been thoroughly studied. It is known that the drug does not bind to plasma proteins and does not penetrate the BBB.

When you stop using Rogaine, about 95% of minoxidil in the systemic circulation is excreted within 4 days, mainly through glomerular filtration in the urine.

Minoxidil

Minoxidil is a hair drug that is a vasodilator that effectively stops hair loss and increases the growth rate of new hair shafts. Minoxidil, for example, is the main component of the drug "Rogaine" or "Regaine", which is actively used to get rid of androgenetic alopecia and treat hair growth. Among the drugs that also include Minoxidil are eucapil, procopil, and alerana. It is used as an additive by many cosmetic lines that produce shampoos to strengthen hair.

Minoxidil directly affects hair follicles, activates cell nutrition by dilating blood vessels and improving blood flow. For ease of use, Rogaine is available in the form of a spray and hair foam.

Minoxidil is actively used to treat hair loss in women. Correctly, a drug with a 2% concentration is used. In turn, “Regaine” for men has a 5% percentage solution concentration. The product is especially effective in the initial stages of hair loss with aggressive processes, and gives less pronounced results with a large area of ​​baldness.

Side effects

Local side effects

Negative side effects observed during clinical studies of the effects of Rogaine were, as a rule, limited to the formation of dermatitis of the scalp. of dermatitis , characterized by peeling , redness and inflammation , was much less common .

Itching of the scalp , allergic contact dermatitis alopecia , folliculitis , seborrhea and unwanted hair growth were occasionally observed

During a comparative clinical study, a comparison of 2% and 5% solutions of minoxidil and placebo showed a more frequent development of dermatological reactions in the group using the 5% drug. The severity and nature of negative side effects in the groups using 2% and 5% minoxidil were almost comparable, although the incidence of side effects was higher in the latter group.

Systemic side effects (less common than local)

• Skin: swelling of the face , nonspecific reactions of allergic etiology (including the formation of a skin rash and the occurrence of urticaria ).
• Respiratory system: allergic rhinitis , shortness of breath .
• Nervous system: vertigo; headaches , neuritis , dizziness .
• Cardiovascular system: fluctuations , chest pain, rapid heartbeat , swelling , changes in heart rate .

A direct cause-and-effect relationship between the use of Rogaine solution and the formation of the above adverse reactions was monitored only for dermatological manifestations .

Composition and analogues

Drugs similar in effect to Rogaine.

Rogaine contains minoxidil in varying concentrations. Its indicator depends on the form of release and purpose. Thus, 2% of the drug is usually recommended for women, and 5% for men or people with increased fat content of the epidermis on the head and advanced stages of baldness.

In addition to the main active ingredient, Rogaine hair product also consists of auxiliary elements:

• distilled water;
• ethanol;
• propylene glycol (only in lotion).

Modern analogues of this dermatotropic drug based on the active substance included in the composition are:

• Alopexy;
• Minoxidil (Minoxidil);
• Kosilon;
• Revasil;
• Generolon;
• Perfect Hair Solution;
• Alerana.

That is, many similar products are now produced by different companies. However, the hair loss drug Rogaine showed the world's first proven clinical effectiveness and to this day remains widely used in the treatment of baldness, as well as for beard growth. But you should know that not every form of alopecia can be treated.

ON A NOTE! This product was registered by the Ministry of Health of the Russian Federation on May 23, 1996. Registration number: P-8-242 No. 007196.

Rogaine, instructions for use

Instructions for use assume exclusively external application of the drug Rogaine to the skin of the scalp. Applying the solution to other areas of the body is not allowed.

A single dosage of the external solution should be 1 ml and applied twice every 24 hours (morning and evening). The process of applying the drug should begin from the center of the problem area and then around the affected area, using your fingers or the nozzles included in the package. A single dose of Rogaine remains the same regardless of the area of ​​the skin surface being treated. The total maximum permissible daily dosage is 2 ml of solution.

Patients using a 2% solution of Rogaine and who have not received a satisfactory hair growth effect , as well as patients with the need for a rapid cosmetic increase in hair growth , can use the drug Rogaine 5%.

The greatest effectiveness of Rogaine for women was observed when it was used in the area of ​​the middle parting , for men - on the crown .

Rules for using the solution

Rogaine solution should be applied exclusively to dry and clean skin of the scalp. The choice of application method is directly related to the bottle attachment used. If you apply the drug with your fingertips, you should wash them thoroughly immediately after treating your head.

Nozzle for rubbing

This nozzle is ideal for applying the solution to small areas without hair.

To use this attachment, you must first remove the outer cap and screw-on inner cap from the solution bottle. Screw the nozzle tightly into place in place of the removed inner cover. Keeping the bottle vertical, squeeze it until the upper chamber of the nozzle (accommodating 1 m) is filled to the black line. Turn the bottle 180 degrees and use the nozzle to massage problem areas of the scalp, covering the entire area of ​​baldness, until the upper chamber is completely emptied. After using the solution, put the outer cap on the bottle.

Spray

This attachment is best suited for treating large areas of the scalp with the solution.

To use this attachment, you must first remove the outer cap and screw-on inner cap from the solution bottle. Screw the nozzle tightly into place in place of the removed inner cover. Remove the transparent cap from the spray bottle, thus freeing the nozzle head. Point the head to the center of the problem area and press the valve of the spray bottle. Using your fingertips, distribute the solution over the entire bald area. Repeat the above operation 6 times in order to apply the full dose of the drug, which is 1 ml. When applying the aerosol, avoid inhalation and contact with the eyes. After using the solution, put the outer cap on the bottle.

Extended Spray Nozzle

This nozzle is most suitable for spraying the solution onto small areas of baldness or applying it to the skin under the remaining hair.

To use this attachment, you must first remove the outer cap and screw-on inner cap from the solution bottle. Screw the nozzle tightly into place in place of the removed inner cover. Remove the small spray head from the spray gun and attach the extended nozzle to the spray gun bushing. Remove the small cap from the tip of the extension nozzle. Orient the nozzle towards the center of the problem area and press the spray gun once. Using your fingertips, distribute the solution over the entire area of ​​baldness and lightly rub into the skin. Repeat the above operation 6 times in order to apply the full dose of the drug, which is 1 ml. When applying the aerosol, avoid inhalation and contact with the eyes. After using the solution, place the cap on the tip of the extended nozzle.

Clinical experience with the use of Rogaine suggests that the first signs of increased hair growth appeared, as a rule, after its twice daily use for 4 months or even more. The beginning of hair growth, the degree of its expression and the quality of the hair depend on the personal response of the patient’s body. In isolated cases, complete restoration of the original appearance of the scalp within 3-4 months.

Rogaine foam for external use 5% 60 g 3 pcs. in Moscow

Latin name

REGAINE

International nonproprietary name

minoxidil

Release form

Solution for external use

Package

60 g - aluminum cylinders (3) with a valve with a spray and a cap with a child protection system - polymer packaging.

Description

Solution for external use 5% transparent, colorless or light yellow.

pharmachologic effect

A drug for the treatment of alopecia (baldness). It has a stimulating effect on hair growth in people with androgenetic alopecia. The appearance of signs of hair growth is observed after 4 months or more of use of the drug. The onset and severity of the effect may vary from patient to patient. A 5% solution of the drug stimulates hair growth more than a 2% solution, which has been shown to increase the growth of vellus hair. After discontinuation of the drug, the growth of new hair stops, and within 3-4 months the original appearance can be restored. The exact mechanism of action of Rogaine® in the treatment of androgenetic alopecia is unknown.

Indications

— androgenetic alopecia in men and women (with the aim of restoring hair growth and stabilizing the process of hair loss).

Directions for use and doses

The drug is intended only for external use on the scalp. Do not apply Rogaine® to other areas of the body. Rogaine® is applied to the affected areas of the scalp in a dose of 1 ml 2 times a day, starting from the center of the affected area. The drug is used in this dose regardless of the size of the treated areas of the scalp. The total daily dose should not exceed 2 ml. Patients who do not experience cosmetically satisfactory hair growth when using a 2% solution, and patients for whom faster hair growth is desired, can use a 5% solution. For men, Rogaine® is most effective for hair loss on the top of the head, for women - for hair loss in the middle parting area. Rules for using Rogaine® are applied only to dry scalp. The application method depends on the applicator used, as described below. If the drug is applied using your fingertips, hands should be washed thoroughly after treating the head. A. Sprayer This nozzle is suitable for applying the drug to large areas of the scalp. 1. Remove the large outer cap and inner screw cap from the bottle. 2. Place the spray nozzle on the bottle and screw it tightly. 3. Remove the transparent cap. 4. Direct the spray head to the center of the affected area, press the valve and use your fingertips to distribute the product over the entire bald area. To apply a dose of 1 ml of solution, repeat this operation a total of 6 times. 5. Avoid inhalation of aerosol. After use, place the transparent cap and large outer cap on the bottle. B. Extended Spray Nozzle This nozzle is suitable for applying the product to small areas of baldness or for treating the skin under remaining hair. 1. To use the extended nozzle, a spray bottle must be installed on the bottle. Complete steps A1 and A3 (see above). 2. Remove the small spray head from the spray gun, attach the extended spray nozzle to the spray gun bushing. Remove the small cap from the end of the extension nozzle. 3. Pointing the nozzle at the center of the bald area, press the spray bottle once, then distribute the product with your fingertips over the entire area, lightly rubbing into the skin. To apply a dose of 1 ml of solution, repeat this operation a total of 6 times. 4. Avoid inhalation of aerosol. After use, you can place the cap on the end of the extension nozzle. C. Rub-in attachment This attachment is suitable for applying the product to small areas of baldness. 1. Remove the large outer cap and inner screw cap from the bottle. 2. Place the rubbing attachment on the bottle and screw tightly. 3. Holding the bottle vertically, squeeze the bottle so as to fill the upper chamber to the black line. The chamber holds one full dose (1 ml of solution). 4. Turning the bottle over, massage the scalp with the nozzle in such a way as to treat the entire bald area until the chamber is empty. After use, place the large outer cap on the bottle. Clinical experience with the drug shows that the first signs of hair growth stimulation may appear after using the drug 2 times a day for 4 months or more. The onset and severity of hair growth, as well as the quality of hair, may vary from patient to patient. According to isolated reports, restoration of the original appearance can be expected within 3-4 months after cessation of treatment.

Compound

1 ml contains: minoxidil 50 mg Excipients: ethanol, propylene glycol, purified water.

Contraindications

- children and adolescents up to 18 years of age; — age over 65 years; — violation of the integrity of the scalp; - dermatoses of the scalp; - hypersensitivity to minoxidil and other components of the drug.

Use during pregnancy and breastfeeding

The effect of Rogaine® on pregnancy is unknown. When absorbed systemically, minoxidil is excreted in breast milk. Rogaine® should not be used during pregnancy and lactation.

special instructions

Before starting treatment with Rogaine®, patients should undergo a general examination, including the collection and study of a medical history. The doctor must make sure that the scalp is healthy. Although the effects listed below have not been observed when Rogaine® is applied to the skin, minoxidil is absorbed through the skin in small quantities and there is a risk of systemic side effects such as water and salt retention, generalized and local edema, pericardial effusion, pericarditis, pericardial tamponade, tachycardia, angina pectoris, increased orthostatic hypotension caused by certain antihypertensive drugs, for example, guanethidine and its derivatives. Prescribing Rogaine® to patients with arterial hypertension receiving treatment with guanethidine or guanethidine derivatives, or minoxidil, is possible only under medical supervision. Patients should undergo periodic examinations to identify possible signs of systemic side effects of minoxidil. If systemic side effects occur, treatment should be discontinued. To treat edema and fluid retention in the body, diuretics can be prescribed if necessary. To eliminate tachycardia and angina pectoris, beta-blockers can be prescribed. Patients with a history of cardiovascular disease should be warned that treatment with Rogaine may cause an exacerbation of these diseases. If systemic side effects or severe skin reactions occur, patients should discontinue the drug and consult a doctor. The effect of Rogaine® in patients with impaired skin integrity and dermatoses of the scalp at the site of application of the drug is unknown. The safety and effectiveness of Rogaine® for patients under 18 years of age and over 65 years of age has not been established. Rogaine® contains ethyl alcohol, which can cause inflammation and irritation of the eyes. If the drug gets on sensitive surfaces (eyes, irritated skin, mucous membranes), it is necessary to rinse the affected area with plenty of cold water. Accidental ingestion of the solution can lead to serious consequences. The symptoms observed in this case mainly affect the cardiovascular system and include fluid retention, decreased blood pressure or tachycardia. Patients should be warned about the need to store Rogaine® (like other medicines) out of the reach of children. If the drug has become unusable or has expired, then it should not be poured into wastewater or thrown into the street; The drug should be placed in a bag and placed in a trash container. These measures will help protect the environment.

Side effects

Local side effects Side effects observed in clinical studies of Rogaine® were mostly dermatitis of the scalp. More severe cases of dermatitis, manifested by redness, peeling and inflammation, have been observed less frequently. In rare cases, scalp itching, allergic contact dermatitis, folliculitis, alopecia, unwanted hair growth and seborrhea have been reported. In a comparative clinical study examining the use of minoxidil solution 5%, 2% and placebo, dermatological reactions were observed most often in the group receiving minoxidil 5%. The nature and severity of side effects were comparable in the minoxidil 5% and 2% groups; The incidence of side effects was higher in the minoxidil 5% treatment group. Systemic Side Effects Less common side effects are grouped by organ system. Dermatological reactions: nonspecific allergic reactions (skin rash, urticaria), facial swelling. From the respiratory system: shortness of breath, allergic rhinitis. From the side of the central nervous system: headache, dizziness, vertigo, neuritis. From the cardiovascular system: chest pain, blood pressure fluctuations, rapid heartbeat, changes in heart rate, edema. A clear causal relationship between the use of Rogaine® and the occurrence of the side effects listed above has been established only in the case of dermatological reactions.

Drug interactions

There is a theoretical possibility of increased orthostatic hypotension in patients receiving concomitant treatment with peripheral vasodilators, which, however, has not received clinical confirmation. A very slight increase in minoxidil blood levels in patients with arterial hypertension and taking minoxidil orally cannot be ruled out when using Rogaine® simultaneously, although relevant clinical studies have not been conducted. It has been found that topical minoxidil may interact with some other topical medications. The simultaneous use of minoxidil solution for external use and a cream containing betamethasone (0.05%) leads to a decrease in the systemic absorption of minoxidil. Simultaneous use of a cream containing tretinoin (0.05%) leads to increased absorption of minoxidil. Simultaneous application of minoxidil to the skin and topical drugs such as tretinoin and dithranol, which cause changes in the protective functions of the skin, may lead to increased absorption of minoxidil.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25°C.

Overdose

, systemic side effects may occur due to the vasodilating effect of the active ingredient of the drug - minoxidil . It should be remembered that 5 ml of a 2% solution of Rogaine includes 100 mg of minoxidil , which corresponds to the maximum recommended daily dosage of the drug for the treatment of arterial hypertension , and 5 ml of a 5% solution includes 250 mg of minoxidil , which is 2.5 times higher than this dose. Symptoms of oral administration of large doses of minoxidil may include decreased blood pressure , fluid retention , and tachycardia .

In order to eliminate the observed fluid retention diuretics (diuretics) can be prescribed tachycardia can be treated with beta-blockers , and arterial hypotension with intravenous sodium chloride (0.9%). In this situation, the use of sympathomimetic drugs such as Epinephrine or Norepinephrine is inappropriate due to their excessive cardiac stimulating effects.

How does Rogaine (Rogaine) work?

The active ingredient in Rogaine is minoxidil. First of all, as a result of the effects of minoxidil, the growth phase (anagen) of hair is prolonged. In addition, minoxidil has a pronounced vasodilating effect, which significantly improves blood supply to the hair follicles. Minoxidil is a white or whitish crystalline substance. When applied topically, minoxidil has been noted to have a stimulating effect on hair growth in individuals with androgenetic alopecia (hair thinning, baldness).

Interaction

Theoretically, with the parallel use of Rogaine solution and peripheral vasodilators, it is possible to intensify existing orthostatic hypotension , but at this time there is no clinical confirmation of this interaction.

In the case of using Rogaine and parallel oral administration of minoxidil for the treatment of arterial hypertension , a slight increase in its serum content is theoretically possible, although relevant clinical studies in this direction have not been carried out.

Prescribing Rogaine solution to patients suffering from arterial hypertension and taking guanethidine or its derivatives is possible only under constant medical supervision.

It has been proven that the solution interacts with some other external (local) drugs. Thus, the combined use of Rogaine and 0.05% cream containing betamethasone led to a decrease in the absorption of minoxidil , and the parallel use of external agents with dithranol and tretinoin , which cause changes in the skin's protective functions, can cause an increase in the absorption of minoxidil .

Stop the painful process

Androgenic and androgenetic alopecia are treated! It is important to start using medications containing Rogaine on time. Penetrating through the pores of the skin, the active substance suppresses pathological processes in the follicles. With systematic use of Rogaine, the production of dihydrotestosterone is reduced. The bulbs are starting to come to life. Their transition from the sleep stage to the growth stage becomes noticeable after just a couple of months of use. Soft hairs appear first. They usually have a lighter tone than what the person previously had. At this stage, the main thing is not to stop! After 6 months of use, hairiness increases and the effect becomes pronounced. The optimal result can be achieved after 1 year of treatment. It is important to know exactly how to apply Rogaine. Compliance with instructions and systematic use are the main factors for successful treatment of alopecia.

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special instructions

Before starting therapy with Regaine, potential patients should be given a general examination with the collection and study of a medical history . In case of a positive assessment of the patient’s general condition, it is necessary to examine the scalp and ensure its integrity.

Until now, with external use of Regaine, the following effects have not been observed, however, due to the penetration of a small amount of minoxidil into the systemic circulation, the following negative manifestations are potentially possible: salt and water retention, tachycardia , local and generalized edema , angina pectoris , pericarditis , pericardial effusion and tamponade, increased hypotension caused by taking certain antihypertensive drugs .

Throughout Regaine therapy, patients are required to undergo periodic examinations in order to identify possible negative systemic side effects of minoxidil . If such phenomena are detected, therapy is suspended until their causes are clarified.

Patients with a history of pathologies of the cardiovascular system, when using Rogaine, must be warned about the potential for exacerbation of their observed diseases.

If systemic side effects or severe skin reactions occur, patients should discontinue the drug and consult a doctor.

The safety and effectiveness of using Rogaine for the treatment of persons under 18 and after 65 years of age, as well as for the treatment of patients with dermatoses and disorders of the scalp, is unknown.

Ethyl alcohol included in the solution , if it gets on the mucous membranes of the eyes, can cause irritation and inflammation . In such a situation, you should immediately rinse your eyes with plenty of cold water.

When taking the solution orally, there is a high probability of serious negative manifestations, mainly from the cardiovascular system (including tachycardia , fluid retention , drop in blood pressure ). In this regard, storage of the drug requires a place inaccessible to children.

Composition of Rogaine for hair

Different manufacturers produce the drug with different concentrations. The degree of influence of Rogaine on the hair follicles is determined by the content of the active substance: from 2% to 5%. Ethanol and ordinary distilled water are used as auxiliary components in the preparations. The lotions also contain:

• propylene glycol;
• butylated hydroxytoluene;
• lactic and citric acid;
• glycerol;
• cetyl and steal alcohol;
• polysorbate 60.

The beneficial effects of Rogaine are manifested in the fact that the product opens pores and activates blood flow. Once the damaged bulb receives enough nutrients, it begins to generate new hair.

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Analogs

Level 4 ATX code matches:
Badyaga Forte

Badyaga

Capsiol

Vulnuzan

Skin cap

Petrolatum

Generolon

Alerana

Apilak

Tsinocap

Silocast

Analogues of Rogaine in terms of active ingredient and main action are represented by the following drugs:

• Kosilon;
• Alerana;
• Revasil;
• Alopexy;
• Generolon.

Rogaine for hair for men video

Now that you know all the important facts about using Rogaine to treat a receding hairline, use it with caution and don't expect too much from it!

Post Views: 151

coolka4k

• Hair products

Reviews of Rogaine

Opinions about this drug, used to treat alopecia (baldness), are divided approximately equally and, in the vast majority of cases, the assessment of this drug comes from representatives of the fair half of humanity. Women's reviews of Rogaine are quite varied. For some, this solution simply became a “savior”, for others it helped stop hair loss , and for others it brought nothing but loss of time and money. Reviews from men about the drug Rogaine are generally no different from the opinions of women and indicate a rather selective effect of this drug.

Advantages of Finasteride in the treatment of hair loss

• Reviews about Finasteride are positive. The drug leads to a quick stop of hair loss. This has been proven by millions of men who have used the drug to treat alopecia for several years.
• The product is suitable for monotherapy and for use in combination with other drugs. Finasteride is most active in the initial stages of hair loss, and produces less pronounced results as alopecia progresses. A good effect is achieved if you use the product after hair transplantation.
• Finasteride, reviews of which indicate its maximum effectiveness, leads to a reduction in testosterone activity in the hair.

Rogaine price, where to buy

The price of Rogaine depends on the mass content of the active ingredient in the solution. You can buy Rogaine 2% solution, 60 ml each, for about 1200-1500 rubles, and a 5% solution, 60 ml each, for 1600-1700 rubles.

• Online pharmacies in RussiaRussia

ZdravCity

• Rogaine foam for external use 5%, 60g, 3pcsASM Aerosol-Service AG/Dr.Falk Pharma GmbH RUB
  3,113 order
• Rogaine foam for external use 5% 60g 1pcASM Aerosol-Service AG/Dr.Falk Pharma GmbH

  RUB 1,561 order

What types of Rogaine are there?

When purchasing the drug Rogaine, buyers are interested in which of the proposed options to choose? Pharmacies offer this product in three varieties:

Rogaine lotion 2%

Rogaine lotion 2%

A colorless and transparent (sometimes yellowish) solution of Rogaine 2% contains 20 mg of the active substance Minoxidil. It also contains auxiliary components - ethanol, distilled water and propylene glycol.

The drug Rogaine 2 is intended for external use, packaged in a dense polyethylene bottle and equipped with three functional attachments (a spray bottle, an extended spray attachment and a rubbing attachment). The volume of each bottle is 60 ml. Rogaine 2% is more often prescribed to women for baldness in the middle parting area.

Rogaine lotion 5%

Rogaine lotion 5%

Rogaine 5 – lotion for external use, volume 60 ml. The main component of this medicinal solution is minoxidil. The colorless drug, sometimes with a light yellow tint, is packaged in a bottle made of dense polyethylene and, in addition to the main active substance, contains several auxiliary components: purified water, propylene glycol and ethanol.

Regaine 5% is recommended for use by men with baldness in the crown area and by those patients who want to accelerate hair growth.

Foam Rogaine 5%

Foam Rogaine 5%
Foam Rogaine is an innovative drug that appeared on the anti-baldness market relatively recently and has already won the trust of many buyers. Thanks to its foam form, the product leaves no traces when applied to the hair and is absorbed into the scalp much faster. The drug Rogaine in the form of foam gives an even greater treatment effect than solutions of the same series. The product is packaged in a plastic box of 3 bottles. The capacity of each bottle is 60 ml (this volume is enough for a month of treatment).

The visible effect of treatment with Rogaine foam occurs after 4 months of regular use.

This drug provides good results for hereditary baldness. But for alopecia caused by taking hormonal drugs and poor diet, Rogaine foam will help little.

Use of the drug Rogaine

The drug is intended for external use only. Rogaine is applied to thoroughly dried scalp in a dose of 1 ml 2 times a day, starting from the center of the affected area. The drug is used in the indicated dose regardless of the size of the affected skin areas. The total daily dose should not exceed 2 ml. Depending on the length of the hair, different applicators are used. In order for the dose of the solution to be 1 ml, you need to press the applicator pump 6 times, aimed at the center of the affected area.