Tadalafil-sz 20 mg 4 pcs. film-coated tablets

Tadalafil

pharmachologic effect

The drug for the treatment of erectile dysfunction is a reversible selective inhibitor of the specific PDE5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by tadalafil results in increased cGMP levels in the corpus cavernosum of the penis. The consequence of this is relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Tadalafil is ineffective in the absence of sexual stimulation.

In vitro studies have shown that tadalafil is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the corpus cavernosum, in the smooth muscles of the vessels of internal organs, in skeletal muscles, platelets, kidneys, lungs, and cerebellum.

The effect of tadalafil on PDE5 is more active than on other phosphodiesterases. Tadalafil is 10,000 times more active against PDE5 than against PDE1, PDE2, PDE4, which are localized in the heart, brain, blood vessels, liver and other organs. Tadalafil is 10,000 times more potent at blocking PDE5 than PDE3, an enzyme found in the heart and blood vessels. This selectivity for PDE5 over PDE3 is important because PDE3 is an enzyme involved in cardiac muscle contraction. In addition, tadalafil is approximately 700 times more active against PDE5 than against PDE6, which is found in the retina and is responsible for phototransmission. Tadalafil is also 10,000 times more active against PDE5 compared to its effect on PDE7-PDE10.

Effective for 36 hours. The effect appears within 16 minutes after ingestion in the presence of sexual arousal.

Tadalafil in healthy individuals does not cause significant changes in systolic and diastolic blood pressure, compared with placebo, in the supine position (average maximum decrease is 1.6/0.8 mmHg, respectively) and standing (average maximum decrease is 0.2/4.6 mmHg. respectively). Tadalafil does not cause a significant change in heart rate.

Tadalafil does not cause changes in color recognition (blue/green), which is explained by its low affinity for PDE6. In addition, there was no effect of tadalafil on visual acuity, electroretinogram, intraocular pressure and pupil size.

There were no clinically significant effects on sperm characteristics in men taking tadalafil in daily doses for 6 months.

Release forms and composition of the drug

The product is produced in capsule form, the main substance of which is the component of the same name, tadalafil.

Additional composition:

• lactose monohydrate;
• MCC;
• povidone K30;
• micellar water;
• additive E551;
• sodium lauryl sulfate;
• magnesium stearate;
• additive E

  
  Tadalafil for women

Capsules are packaged in plastic blisters and placed in cardboard containers.

Contraindications

The product has numerous restrictions on its use.

Contraindications:

• joint use of medications containing organic nitrates;
• rehabilitation period after a heart attack (at least 3 months);
• repeated episodes of angina, including the development of pathology during sexual intercourse,
• chronic form of heart failure from group 2 and above;
• arrhythmias;
• high blood pressure;
• minor age;
• loss of visual function;
• chronic renal failure;
• glucose-galactose malabsorption syndrome.

Taking capsules in old age does not require dosage adjustment.

Drug interactions

Drugs related to CYP3A4 inhibitors may increase the effect of the capsules. When using this group of drugs together, it is recommended to use capsules no more than once every 3 days. The level of absorption decreases with the simultaneous administration of tablets and drugs belonging to the class of antacids.

When using the drug and alcohol together, a decrease in blood pressure may occur. At high doses of alcohol, the drug can lead to the development of dizziness and tachycardia.

A decrease in blood pressure occurs with the simultaneous use of tablets and the following drugs:

• Alpha adrenergic blockers.
• Amlodipine.

• Metoprolol.
• Bendrofluazide.
• Enalapril.
• Drugs that block angiotensin 2 receptors.

The combined use of the drug and acetylsalicylic acid does not affect the time to stop bleeding.

Price

The cost of the drug depends on the dosage of the drug being dispensed, as well as the retail pharmacy chain that sells and dispenses medications.

Before using the tablets, you should consult with a urology specialist and read the official instructions for use of Tadalafil. Additionally, it is recommended to study the reviews of women who took capsules as a libido-increasing agent.

Analogs

Tadalafil for women (patient reviews warn of possible allergic reactions) can be replaced with other drugs if it is poorly tolerated.

Analogues:

• Viagra. This medication is available in the form of tablets for oral administration. Its active ingredient is sildenafil, a substance that has a high stimulating effect on erectile function (excitement). For the treatment of erectile dysfunction, 50 or 100 mg of the drug is prescribed immediately before sexual intercourse. Take the capsule 1 hour before the intended sexual contact. Use the product once a day. If necessary, the dosage can be reduced to 25 mg once every 2 days. The following disorders and pathologies are contraindications to the use of Viagra: heart attack or stroke, severe renal and cardiovascular disorders, visual impairment, minor age, ischemic neuropathy. This drug is available with a prescription and requires ongoing consultation with a specialist. The price depends on the dosage and varies from 135 to 800 rubles.
• Cialis. This drug is produced by a UK pharmaceutical plant in the form of capsules for oral use. The main component of the product is tadalafil, an ingredient that helps enhance erectile function. The drug is used to enhance erectile function and is taken immediately half an hour to an hour before sexual intercourse. The daily dosage is calculated based on the physiological characteristics of the patient and according to the indications. However, it can be adjusted as treatment progresses. Contraindications to taking tablets: the patient is a minor, has a high sensitivity to the active ingredient, as well as simultaneous use with drugs that contain organic nitrates. You can purchase the medicine at any pharmacy with a prescription from a specialist. Its cost ranges from 1175 to 7724 rubles. depending on the dosage and number of capsules.

• Levtyra. This medical product is manufactured at a pharmaceutical plant in Germany. The drug has one dosage form and is produced in the form of oral tablets based on vardenafil, the main component. The medicine is prescribed for erectile disorders, including erectile dysfunction caused by the development of benign prostatic hyperplasia. The dosage regimen is determined by the treating specialist. Capsules must be taken 20-30 minutes before. before the start of sexual intercourse. Restrictions on the prescription of tablets: simultaneous use of nitric oxide donors, allergic reactions, combined use of capsules with HIV protease inhibitors. The method of dispensing from pharmacies is by doctor's prescription. You can purchase capsules for a price starting from 990 rubles.

Tadalafil for women (reviews from patients warn about the possible development of adverse reactions) should be replaced by other means only with the permission of a specialist.

Indications for use

Tadalafil for women (reviews of the tablets allow their use in this group of patients) are allowed to be taken only after prior consultation with a specialist. The main indication for taking capsules is a violation of eretkyle function.

Additional indications:

• negative signs caused by the development of benign prostatic hyperplasia;
• erectile dysfunction caused by benign prostatic hyperplasia.

The medicine must be used strictly according to the indications of a specialist.

Instructions for use, dosage

Patients who have sexual activity more than 2 times a week are prescribed 1 capsule (or 5 mg) per day. Take the tablet at the same time. Eating does not affect the effect of the drug. If necessary, the dosage can be reduced by 2 times.

Patients who are sexually active less than 2 times a week are prescribed 20 mg of the drug half an hour before the start of sexual intercourse.

For patients with signs of mild to moderate renal failure, no dosage adjustment is required. In the presence of severe forms of renal failure, treatment with the drug is prohibited.

Side effects

Tadalafil for women (reviews about the product are mostly positive) is prescribed by a specialist in extremely rare cases. According to studies, the use of pills occasionally leads to the development of negative effects. However, therapy had to be interrupted in 3.1% of all patients.

Side effects:

• Throughout the body: pain, general malaise, asthenic condition.
• Cardiovascular disorders: high or low blood pressure, chest pain, angina pectoris, heart attack, rapid heartbeat or pulse, fainting.

• Gastrointestinal disorders: dry mouth, diarrhea, changes in liver test results, vomiting and nausea, pain in the upper abdomen. In extremely rare cases, the development of esophagitis, gastritis, and GERD is possible.
• Musculoskeletal system: pain in the neck or joints (arthralgia).
• Central nervous system: insomnia, decreased sensitivity to external stimuli, increased drowsiness, dizziness, development of parasthesia.
• Respiratory organs: pharyngitis, nosebleeds, shortness of breath.
• Skin manifestations: increased sweating, rashes, itching.
• Visual organs: disturbances in color sensitivity, pain in the eye area, conjunctivitis, lacrimation, swelling in the eyelid area.
• Genitourinary disorders: uncontrolled erection.

If negative reactions develop, you should immediately contact a specialist.

special instructions

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Tadalafil is intended for oral administration. Before carrying out drug therapy, it is necessary to undergo all studies to identify the cause of the pathology. Women are additionally recommended to consult a gynecologist and study reviews of other patients.

Before prescribing the drug, it is necessary to take into account that it can have a negative effect on patients who have cardiovascular diseases.

The medicine may cause attacks of priapism. Therefore, if this condition occurs and lasts more than 4 hours, it is necessary to contact a treating specialist, since untimely solution to this problem can lead to complete impotence.

It is not recommended to use the medication together with drugs belonging to the same pharmacological group, since such a combination has not been studied.

The capsules have vasodilating properties, which may lead to a decrease in blood pressure . Therefore, when prescribing the drug to patients with cardiovascular diseases, the potential risks should be carefully weighed.

According to clinical data, several cases of complete or partial loss of vision have been recorded while taking the pills. However, at the moment, a direct relationship between the development of pathology and medication has not been established. If visual function is suppressed during the period of use of the medication, it is recommended to stop taking it further and seek medical help.

Before taking capsules, patients with signs of benign prostatic hyperplasia are recommended to undergo examinations confirming the absence of malignant forms of the disease.

The effect of the components of the drug on patients who have undergone surgery in the pelvic area is unknown.

A high degree of caution should be exercised when driving vehicles or performing work that requires increased psychomotor functions.