Trigan-D is a drug that has an antipyretic, analgesic, antispasmodic effect, the main use of which is to eliminate pain due to intestinal, renal or hepatic colic. The drug is a non-narcotic substance, but causes severe dependence and numerous side effects. The composition of the drug includes - Dicycloverine and Paracetamol. The release form is round white or flat smooth tablets with beveled edges and a score on one side, or in ampoules.
Pharmacodynamics and pharmacokinetics
There is no information about Trigan-D on Wikipedia, and the interested category of people have questions “Trigan-D, what is it?” or “What is Trigan-D?”
The first component is paracetamol : it has an antipyretic, analgesic and weak anti-inflammatory effect. Inhibits cyclooxygenase of the first and second types in the nervous system and other tissues, as a result, the synthesis of prostaglandins - mediators of pain, regulation of body temperature and inflammation - stops.
The second component is dicycloverine hydrochloride : it has a small non-selective m-anticholinergic and myotropic antispasmodic effect on the smooth muscle cells of internal organs. In therapeutic doses, it has a relaxing effect on smooth muscles, not accompanied by atropine-like side effects.
The combined use of these two components allows for relaxation of the smooth muscle tissue of internal organs and relief of pain.
Pharmacokinetics
Well absorbed from the intestines. The maximum concentration in the blood is recorded after one hour. Paracetamol is transformed in the liver to form a number of metabolites, one of them N-acetyl-benzoquinomine can have a damaging effect on the kidneys and liver. 80% of the drug is excreted by the kidneys and in small amounts with feces.
How is the mephedrone test performed?
Medical examination for mephedrone is carried out in two stages.
- First, rapid tests based on the immunochromatography method are carried out. They give a qualitative result: either positive or negative. The accuracy of such analyzes is not very high, but they are time- and labor-efficient, which makes it possible to examine large groups of people. Thanks to test strips, diagnostics can be carried out outside the laboratory.
- If the preliminary analysis gives a positive result, then the person is sent for a confirmatory study. It is carried out in laboratories, and the biological material can be not only urine, but also blood. The methods used are thin layer chromatography, gas-liquid chromatography and chromatography-mass spectrometry. The results show the concentration of mephedrone in the biomaterial sample.
Indications for use
Indications for use (for which Trigan-D tablets are usually used):
- spasm of smooth muscle internal organs;
- algomenorrhea;
- hepatic, intestinal or renal colic ;
- neuralgia;
- toothache or headache ;
- myalgia;
- fever in infectious and inflammatory diseases .
Contraindications
- Sensitization to paracetamol or dicycloverine .
- Stomach or duodenal ulcer.
- Intestinal diseases complicated by obstruction.
- Hypovolemic shock.
- Reflux esophagitis.
- Myasthenia gravis.
- Lactation and pregnancy .
- Age less than 15 years.
The components of the drug in patients with liver or kidney disorders, glucose-6-phosphate dehydrogenase , glaucoma , blood diseases, hyperbilirubinemia, viral hepatitis, alcoholism and in old age can worsen the course of these diseases, from which Trigan-D tablets should be used in this category of people with extreme caution.
Treatment of mephedrone addiction
Treatment of drug addicts who use mephedrone is carried out only in closed institutions. The craving for the drug is so strong that even after a full course of treatment, only 2-3 people out of ten return to normal life.
How to quit mephedrone on your own
Dependence on mefa is formed at all levels: psychological, physical and spiritual. It is almost impossible to cope with an irresistible desire on your own. Therefore, it is important to seek help from a drug treatment center as soon as possible.
Get rid of mephedrone addiction in the clinic
If you suspect that a loved one has started taking this drug, it is important to immediately contact a specialist. By calling the rehabilitation center, the doctor will immediately come to you to conduct an initial examination.
Side effects
- Reactions from the digestive system: distortion of taste, stomach pain, decreased appetite, increased levels of liver enzymes , constipation, hepatonecrosis.
- Reactions from the nervous system: dizziness , drowsiness , agitation and disorientation.
- Allergic reactions: Quincke's edema , rash , urticaria , Stevens-Johnson syndrome, itching , Lyell's syndrome.
- Reactions from the hormonal system: hypoglycemia.
- Reactions from the excretory system: interstitial nephritis, urinary retention, pyuria , papillary necrosis , decreased potency.
- Reactions from the hematopoietic system: methemoglobinemia, hemolytic anemia.
- Reactions from the vision: mydriasis, paralysis of accommodation, blurred vision, increased intraocular pressure.
Trigan-D tablets, instructions for use (Method and dosage)
Instructions for use on Trigan-D recommend taking the drug orally, 1 tablet up to three times a day. The largest single dose is two tablets, the daily dose is four tablets. Duration of administration is no more than five days when used as an analgesic and three days when used as an antipyretic.
It is not recommended to exceed the daily dose, since an overdose of the drug causes liver failure, for which Trigan-D (if it is necessary to increase the dose or increase the standard duration of treatment) must be used under the supervision of a physician.
Symptoms of a mephedrone addict
Signs of using mephedrone are the following symptoms:
- facial redness;
- huge icons that almost cover the iris of the eye;
- very cold and sweaty hands;
- slight trembling;
- fast pulse;
- refusal of food.
Doctors also note that within 3-5 days after taking it, a syndrome of a specific odor of sweat and urine occurs.
Leave a request for a free consultation with a specialist
we will contact you as soon as possible
- Anonymously
- For free
- Around the clock
Submit your application
Or call: +7 (495) 127-02-03
At the beginning of using mephedrone, the addict manages to successfully hide his new addiction, but very quickly the behavior and appearance of the addict begins to raise suspicions for the following reasons:
- Under the influence of mephedrone, the addict does not want to sleep or eat. If he uses the drug for several days, his relatives will clearly suspect something is wrong.
- The addict becomes very active and talkative. He expresses deep interest in each topic, jumping sharply from one to another.
- There are also external signs: shiny eyes, crazy eyes and dilated pupils. Muscle spasms may begin on the face. Behavior is overly emotional and fussy.
Overdose
Overdose of Trigan-D, symptoms: tachypnea, tachycardia, fever, convulsions, agitation, pain in the stomach, decreased appetite, thrombocytopenia, anemia, nephrotoxicity, hemolytic or aplastic anemia, pancytopenia, methemoglobinemia, hepatonecrosis.
Therapy: stop using the drug, perform gastric lavage, take adsorbents , agents that stimulate the formation of glutathione (for example, acetylcysteine ) and activate conjugation ( methionine ).
Intensive
150,000 months
- Accompanying a psychiatrist-narcologist
- Individual plan and diagnostics
- Accommodation 1-2 people per room
- 4 meals a day
- Individual support
- Personal therapy with an intensive psychologist
- Group classes and seminars
- Leisure time organized
- Sports events
- Yoga, sauna, swimming pool
- Massotherapy
- Intensive program for relatives
Order service
Treatment usually takes place in the following stages:
- Motivational conversation,
- Detoxification (5-7 days),
- Treatment in a drug treatment or psychiatric clinic (1-3 months),
- Rehabilitation in a center for drug addicts (3-6 months),
- Social adaptation.
Treatment of mephedrone addiction is a complex and lengthy process. But only comprehensive treatment with the involvement of various medical specialists can give a drug addict the opportunity to return to normal life and give up drug use forever.
Interaction
The effects of dicycloverine are stimulated by first class antiarrhythmic drugs benzodiazepines, narcotic painkillers, MAO inhibitors, sympathomimetics, nitrates, nitrites, tricyclic antidepressants.
Dicycloverine increases the level of dioxin in the blood.
Enhancers of microsomal oxidation ( ethanol, barbiturates, rifampicin, tricyclic antidepressants ) stimulate the synthesis of hydroxylated metabolites in the liver, this can lead to the development of severe intoxication even with mild overdoses of paracetamol .
Inhibitors of microsomal oxidation reduce the possibility of hepatotoxicity .
Adrenergic stimulants and anticholinergic drugs increase the risk of unwanted effects.
Paracetamol activates the action of indirect anticoagulants.
Consequences of using mephedrone: harm to the body
Negative effects from using mephedrone include:
- Changes in heart rate (palpitations).
- Sleep disorder (insomnia).
- Short-term amnesia.
- Spasms in the muscles of the jaw and legs.
- Narrowing of capillaries and blood vessels.
- Pain, swelling, bleeding from the throat and nose.
- Severe rhinitis (runny nose), sinusitis.
Due to the constantly changing formulas of mephedrone, it is difficult to test it and find out what kind of toxic effects the drug has.
Analogs
Level 4 ATC code matches:
Phenacetin
Combiflu
Chlorphenamine
Coldflu
Calpol
Fervex
Panadol Extra
Panadol for children
Panadol
Solpadeine
Efferalgan
Milistan
Coldrex Maxgripp
Coldrex Hotrem
Coldrex
AntiGrippin
Unispaz
Pentalgin Plus
Rapidol
Maxicold
Duspatalin, Mebsin Retard, Moreaze SR, Trimpa.
Reviews about Trigan-D
According to reviews, the product helps to effectively relieve spasms and pain in the vast majority of cases.
paracetamol are also known . As a result, after consuming the resulting substance, side effects occur on the psyche and nervous system, called “highs.” You should know that this is an extremely harmful effect that can lead to irreparable consequences. On specialized forums, you often encounter questions like “how to remove paracetamol from Trigan to get the drug?” We strongly advise you not to engage in such experiments with medications and your body.
Types of mephedrone
Myofedrine is most often distributed as a fine powder called flour or crystals. But you can also find the following release forms:
- In the form of tablets or capsules in a variety of colors (to attract the interest of young people),
- Solutions that are administered intravenously or intramuscularly.
Drug Flour
The most common form in which mephedrone is sold is small packets of fine-grained off-white, grayish or yellow powder. When compressed, the powder can be collected into lumps. Powdered mef is usually called flour due to its similar shape. In this form, it is used for inhalation, dissolved in liquids or rubbed into the gums.
Drug Meow
Meow is a slang name that combines all types of the drug Mephedrone. The full name of the chemical composition - methylmethcathinone in the language of drug addicts took the form "meow-meow cat" or abbreviated - "meow". This word is used to avoid arousing suspicion among others, including when speaking within earshot of family members or in the company of others. This is where the slang word “meow” comes from, meaning “to take a dose of mephedrone.”
Drug Myth
Mephedrone sachets may also contain a powder with large grains, similar to washing powder. For this comparison, this form received its name “Myth”.
Drug Battery
The figurative name “Battery” was given to tablets with mephedrone, since after their use there is a sharp surge of energy and good mood. To enhance the effect or obtain new sensations, other narcotic drugs, for example, amphetamines, are added to the composition. Mephedrone tablets are often sold in nightclubs and other places where young people have fun. To increase interest, they are made multi-colored and given the most unusual shapes.
Drug Crystal
Mephedrone can be sold in the form of small clear or cloudy crystals, similar to sugar grains.
Trigan-D price, where to buy
The average price of Trigan D No. 100 in Ukraine is 302 hryvnia, and in Russia – 316 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Trigan-D tablets 500 mg 100 pcs. Cadila Pharmaceuticals Ltd.
RUB 341 order - Trigan-D tablets 500 mg 20 pcs. Cadila Pharmaceuticals Ltd.
121 rub. order
- Trigan-D tab. No.10Cadila Pharmaceuticals Ltd.
68 RUR order
show more
