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Manufacturers: Aventis Pharma (UK)
Active ingredients
- Artikain
- Epinephrine
Disease class
- Surgical practice
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Local anesthetic
Pharmacological group
- Local anesthetics in combinations
Pharmacodynamics and pharmacokinetics
This drug is a local anesthetic , which is actively used in dentistry for conduction and infiltration anesthesia. Its use makes it possible to block the depolarization of the nerve ending membrane, which significantly reduces the perception of irritation and the conduction of nerve impulses. The effect of the drug is quite fast and usually lasts 1-3 minutes. The duration of anesthesia lasts on average 45 minutes.
The low content of epinephrine in this drug indicates that the possible effect on the activity of the cardiovascular system is very insignificant, with virtually no increase in blood pressure and heart rate.
In the body, the active components of the drug, namely articaine , bind to plasma proteins by 95%. The maximum concentration as a result of injection under the oral mucosa is achieved within 25 minutes. It has been established that a minimal amount of the drug penetrates the placental barrier and is almost not excreted in breast milk. Articaine eliminated from the body primarily through the kidneys.
Precautionary measures
Do not administer intravenously or inject into the area of inflammation. In patients with cholinesterase deficiency, it should be used only for urgent indications. For diseases of the cardiovascular system (chronic heart failure, pathology of the coronary vessels, angina pectoris, rhythm disturbances, history of myocardial infarction, arterial hypertension), cerebrovascular disorders with a history of paralysis, chronic bronchitis, emphysema, diabetes mellitus, hyperthyroidism, severe anxiety, it is advisable use of a drug containing a smaller amount of adrenaline. It is not recommended to combine with non-selective beta-blockers.
Contraindications for use
This drug is not used for patients suffering from allergies to articaine, epinephrine or its other components. In addition, Ultracaine is contraindicated for:
- tachyarrhythmias and tachycardia;
- angle-closure glaucoma;
- pheochromocytoma;
- hyperthyroidism;
- bronchial asthma;
- acute cardiovascular failure;
- severe form of arterial hypertension and so on.
Ultracaine DS during pregnancy and lactation
It is believed that the use of this local anesthesia has a non-stressful effect, providing adequate pain relief during various operations, including dentistry. of articaine penetrates the blood-placental barrier , so it can be used during pregnancy .
Once in the body, atricaine hydrochloride undergoes rapid disintegration and is then rapidly excreted, which ensures rapid elimination and does not allow large amounts to pass into breast milk. The use of this drug during lactation does not require even a temporary cessation of breastfeeding .
Side effects
When treated with Ultracaine, various side effects may occur that affect the activity of the central nervous, digestive and immune systems, and organs of vision. Some patients experience headaches and abnormalities in the normal functioning of the cardiovascular system, such as arrhythmia , increased blood pressure and palpitations .
The development of undesirable reactions in patients with bronchial asthma is possible, for example: disturbances of consciousness, vomiting, diarrhea, an attack of bronchial asthma, shock and wheezing.
Side effects
Impaired consciousness (up to loss), respiratory arrest, muscle tremors, convulsions, nausea, vomiting, drop or increase in blood pressure, tachycardia or bradycardia, arrhythmia; blurred vision, transient blindness, diplopia; headaches, allergic reactions (redness of the skin, itching, conjunctivitis, rhinitis, angioedema of varying severity, including swelling of the upper and/or lower lip and/or cheeks, glottis with difficulty swallowing, urticaria, difficulty breathing); all these phenomena can progress to the development of anaphylactic shock; local reactions - swelling or inflammation at the injection site, in some cases - accidental intravascular injection can lead to the development of ischemic zones at the injection site, sometimes progressing to tissue necrosis. Side effects caused by the action of adrenaline (tachycardia, arrhythmia, increased blood pressure) occur extremely rarely at low concentrations of adrenaline - 1:200000 (0.5 mg/100 ml) and 1:100000 (1 mg/100 ml). Nerve damage (up to the development of facial nerve paralysis) occurs only when the injection technique is violated.
Instructions for Ultracaine D-S (Method and dosage)
The administration of Ultracaine D-S requires special attention and professionalism to avoid getting inside the vessel. Test aspiration before injection also helps prevent intravascular injection. The use of the drug on inflamed areas of tissue is not recommended. Uniject K injection syringe and cartridges. In this case, the drug is administered so that its pressure corresponds to the sensitivity of the tissue at the injection site.
For each use according to indications, the specialist sets a certain dosage of the drug. For example, when preparing a tooth for a crown or a dental cavity for treatment, use 0.5-1.7 ml of Ultracaine for a vestibular injection, without interfering with the lower premolars. The accuracy of the drug dose depends on the duration of the intervention and the desired depth of anesthesia. On average, one dental intervention requires 7 mg of articaine hydrochloride per 1 kg of patient weight.
Indications of the drug Ultracain® D-S
Infiltration and conduction anesthesia in dentistry during the following manipulations: uncomplicated removal of one or more teeth, preparation of carious cavities and teeth for a crown (Ultracaine D-S); operations on mucous membranes or bones requiring a more pronounced ischemic effect, operations on the dental pulp (amputation and pulp extirpation), removal of a broken tooth (osteotomy), removal of a tooth affected by apical periodontitis, Caldwell-Luc surgery, percutaneous osteosynthesis, cystectomy, mucogingival operations , resection of the apex of the tooth root, preparation of carious cavities and teeth for a crown in patients with increased tooth sensitivity (Ultracain D-S forte).
Overdose
The use of this drug in high doses can cause cases of overdose, signs of which may include: unexpected dizziness , impaired consciousness and motor restlessness . In this case, it is necessary to urgently stop administering the medication, place the patient in a horizontal position, and immediately monitor all hemodynamic parameters - pulse, blood pressure and airway patency. Further therapy is performed depending on the symptoms that appear and the severity of the disorders.
Interaction
The simultaneous use of monoamine oxidase inhibitors and tricyclic antidepressants with Ultracaine D-S can cause a significant vasoconstrictor effect. In addition, the active components of this drug, when entering the human body, inhibit the secretion of insulin by the pancreas, which helps reduce the effect of oral hypoglycemic agents.
It is also not recommended to use Ultracain D-S simultaneously with beta-adrenergic receptor blockers .
The combination of Ultracaine with Heparin, Acetylsalicylic acid and other antithrombotic agents increases the likelihood of bleeding. Accidental puncture of the vessel wall can lead to particularly serious bleeding.
Halothane and a number of other drugs for inhalation use increase the sensitivity of the heart muscle to certain catecholamines that cause arrhythmia .
Analogs
Level 4 ATX code matches:
Markain
Scandonest
Emla
Naropin
Versatis
Lidocaine
Ubistezin
Ultracaine D-S Forte
Ultracaine
Artikain
The main analogues of this drug, also included in the “local anesthetics” group, are: Ultracain D-S Forte, Ultracain D and Trimecain .
Similar drugs:
- Menovasin Topical solution
- Dimexid Solution for local and external use
- Dimexid Concentrate for external use
- Lidocaine Gel for external use
- Tantum Verde Solution for topical use
- Lidocaine Solution for injection
- Falimint Dragee
- Maraslavin Solution for topical use
- Heparin ointment Ointment for external use
- Septolete plus Lozenges
** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Ultracain D-S forte, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Ultracain D-S forte is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Reviews of Ultracaine D-S
As a rule, there are many positive reviews about Ultracaine on the Internet. All patients who were prescribed this drug as an anesthetic during dental procedures recommend it to other users. They claim that this is the most effective drug without causing side effects.
In addition, there are many reports when this anesthetic is used in cosmetology, for example, during lip tattooing. At the same time, some clients of beauty salons note severe swelling after such a procedure. Others say that the effect of this drug did not particularly affect them in any way, except for good pain relief.
In any case, before using such drugs, it is necessary to find out how well it is tolerated. The fact is that it is easier to prevent the development of unwanted reactions than to treat negative symptoms later.
Difference between Ultracain D-S and Ultracain D-S Forte
The French company produces three possible variations of Ultracaine, which differ in the presence or absence of epinephrine in its composition and its concentration.
Thus, Ultracaine D-S Forte has an epinephrine concentration of 1:100,000, Ultracaine D-S has an epinephrine concentration of 1:200,000, and Ultracaine D does not contain epinephrine or preservatives.
Price of Ultracain D-S, where to buy
Injection solution Ultracain D-S 40 mg+5 mcg/ml, 10 pcs. can be purchased at almost any pharmacy in Russia. Moreover, the cost of this drug varies between 464-610 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Ultracaine D-S solution d/in.
(with epinephrine) 40 mg+0.005 mg/ml amp. 2ml No. 10Sanofi-Winthrop Industrie/Delpharm Dijon RUB 1,379 order - Ultracaine D-S solution d/in. (with epinephrine) 40 mg+0.005 mg/ml cartridges 1.7 ml No. 100 Sanofi-Aventis Deutschland GmbH / Sanofi Winthrop Industry
6400 rub. order
- Ultracaine D-S forte solution for injection. 1.7 ml 100 pcs. Sanofi-Aventis Deutschland GmbH / Sanofi Winthrop Industry
RUR 6,443 order
- Ultracaine D-S forte solution for injection. 2ml 10 pcs. Sanofi-Aventis Deutschland GmbH/Delpharm Dijon France
RUB 1,450 order
Pharmacy Dialogue
- Ultracaine D-S Forte ampoules 2ml No. 10Sanofi-Winthrop Industrie
RUB 1,355 order
- Ultracaine D-S ampoules 2ml No. 10Sanofi-Winthrop Industrie
RUB 1,318 order
- Ultracain D-S (cart. 1.7 ml No. 100)Sanofi-Aventis
RUR 6,286 order
- Ultracaine D-S (amp. 2 ml No. 10) Delpharm Dijon
RUB 1,326 order
show more
Pharmacy24
- Ultracaine D-S forte cartridge 1.7 ml No. 100 solution Sanofi-Aventis Deutschland GmbH, Germany/Sanofi Winthrop Industries, France
2214 UAH.order
Directions for use and doses
The dose of the drug is set individually, taking into account the severity and duration of the surgical intervention. For uncomplicated extraction of teeth in the upper jaw (no inflammation), infiltration anesthesia with Ultracaine is performed in a dose of 1.7 ml (for each tooth); in some cases, additional administration of 1 to 1.7 ml of the drug may be required to achieve complete anesthesia. In most cases, there is no need to perform anesthesia using a palatal approach; For anesthesia on palatal incisions and suturing to create a palatal depot, about 0.1 ml of anesthetic per injection is required. When removing several adjacent teeth, the number of injections can usually be limited. In the case of removal of mandibular premolars (in the absence of inflammation), mandibular anesthesia can be dispensed with (infiltration anesthesia provided by an injection of 1.7 ml per tooth is usually sufficient; if necessary, an additional injection of 1–1.7 ml of anesthetic is possible, and in the absence effect - blockade of the mandibular nerve). To prepare a cavity or prepare a crown for any tooth (except for lower molars), a dose of 0.5 to 1.7 ml is administered for each tooth using the type of infiltration anesthesia from the vestibular side. When performing one treatment procedure, adults can be administered up to 7 mg/kg body weight. A dose of up to 500 mg (12.5 ml of injection solution) is well tolerated if an aspiration test is performed before injection to exclude the possibility of intravascular administration (the Unidget K syringe for carpules is most suitable for this purpose).
