pharmachologic effect
The substance acetylcysteine is a derivative of the amino acid cysteine . There is a mucolytic effect of this substance on the body. Under its influence, the process of sputum discharge is facilitated, since acetylcysteine directly affects sputum, in particular, its rheological properties. As a result, the viscosity of sputum decreases. The drug also provides an antioxidant effect, protecting cells from free radical oxidation that occurs during severe inflammatory reactions. It is active if the patient produces purulent sputum.
of glutathione , which is an important component of chemical detoxification, as well as the antioxidant system, improves
If acetylcysteine is used for the purpose of prevention, then in people suffering from cystic fibrosis and chronic bronchitis, the severity and frequency of exacerbations of bacterial origin are reduced.
ACC®
A mucolytic agent that thins sputum, increases its volume, and facilitates the separation of sputum. The action is associated with the ability of free sulfhydryl groups of acetylcysteine to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolymerization of mucoproteins and a decrease in sputum viscosity.
In addition, it reduces induced hyperplasia of mucoid cells, enhances the production of surfactants by stimulating type II pneumocytes, and stimulates mucociliary activity, which leads to improved mucociliary clearance.
Remains active against purulent sputum, mucopurulent and mucous sputum.
Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretion formed during inflammatory diseases of the ENT organs. It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins.
Acetylcysteine easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant, cytoprotector that traps endogenous and exogenous free radicals and toxins.
Acetylcysteine prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, thus promoting the detoxification of harmful substances. This explains the effect of acetylcysteine as an antidote for paracetamol poisoning.
Paracetamol exerts its cytotoxic effect through the progressive depletion of glutathione.
The main role of acetylcysteine is to maintain proper levels of glutathione concentration, thereby providing protection to cells. Protects alpha1-antitrypsin (elastase inhibitor) from the inactivating effects of HOCl, an oxidizing agent produced by myeloperoxidase of active phagocytes.
It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).
Indications for use
The use of ACC 100 is indicated in the following cases:
- diseases of the respiratory system in which viscous sputum is formed, which is difficult to separate ( acute, chronic and obstructive bronchitis bronchial asthma, laryngotracheitis , tracheitis , lung abscess , pneumonia, bronchiectasis, bronchiolitis );
- cystic fibrosis;
- acute and chronic sinusitis
- COPD;
- otitis media.
Contraindications
ACC 100 is prescribed in the following cases:
- hypersensitivity to acetylcysteine or to any other ingredients of the medicine;
- hemoptysis;
- pulmonary bleeding;
- exacerbation of peptic ulcer ;
- pregnancy and breastfeeding ;
- glucose-galactose malabsorption;
- lactase deficiency, lactose intolerance;
- child's age up to 2 years.
It is necessary to use ACC 100 carefully if there is a history of duodenal or gastric ulcers, in case of histamine intolerance, bronchial asthma, varicose veins of the esophagus, adrenal disease, obstructive bronchitis kidney failure , arterial hypertension .
ACC 100 (for children) - is it acceptable for a child 1.6 years old? Or did the same thing happen as with Sinecode?
Hello everyone and have a nice evening ❄️
Brief history. About a month ago, my daughter suddenly began to sniffle. The snot flowed not even like a stream, but like a waterfall. Clear liquid water without fever or any other symptoms. After a week and a half, the snot began to thicken, and for another week and a half the thick snot lasted, also without any other symptoms. About a week ago, my daughter started coughing (the snot gradually began to go away). The first few days, day 2, it was in the form of a completely light cough 3-4 times in just a day. But she certainly noted that something similar to a cough was emerging. Then suddenly the cough became full-blown, quite strong. Also, for the first 3 days the cough was dry and quite frequent. They soldered it generously. She didn't give any medications at all. For the last 2 days, the cough has become wet (when my daughter coughed, she heard a distinct gurgling sound in her chest). I called a doctor to the house, they listened to my daughter, she said what she hoped for at first - a post-snot cough, there was snot, now what had accumulated inside is coming out. There are no wheezes or anything like that.
But with the advent of this very wet cough, my daughter’s general course changed. During the day, while awake and during daytime sleep, the daughter may not cough from a word at all, or slightly a couple of times throughout the day. At night, 2-3 hours after falling asleep, she apparently begins to tear at her throat, gets really upset, and comes to the point of vomiting. Tonight, around 5 am, I even burped a little (I ate the formula half an hour before). It’s also worth noting that she doesn’t cough all night long, it’s like a fit of coughing, she sleeps and sleeps without making a single sound at all, and a sore throat begins, she goes into a coughing fit.
I went to the pharmacy and asked if the child turned 1.6 yesterday, if there was anything that would help with a coughing attack, just make it easier to clear sputum, so that the intensity of the cough would not lead the child to the point of vomiting. For which they gave me ACC100 for children.
I clarified that the child is 1.6! Fits?
The young pharmacist told me that yes, according to the instructions it is allowed.
I bought 2 bags. I didn’t take much (packaging), because there was a story with Sinekod, which was recommended “for a severe sore throat,” and when I came home, read the instructions, wrote a post here about buying the drug, to put it mildly, I was shocked that I bought it.
I went online (the bags were given without instructions). And there one site says one information, another - another.
Some resources clearly state that it is only for children over 2 years old. On others - what is possible from the 10th day after birth, just not 100 mg, but 50....
So who's right? Has anyone taken this remedy for children under one year old? My daughter is 1.6, so I think I can give it to her, or put it on the shelf for Sinekod?
Side effects
A number of side effects are likely to occur when using this drug:
- manifestations of allergies: rash, skin itching , urticaria , exanthema, angioedema , tachycardia , low blood pressure ; in very rare cases - Stevens-Johnson syndrome, anaphylactic manifestations, toxic epidermal necrolysis;
- respiratory system: in rare cases – bronchospasm, shortness of breath ;
- gastrointestinal system: abdominal pain, heartburn , diarrhea , vomiting, nausea, stomatitis , dyspepsia;
- sense organs: tinnitus;
- other manifestations: fever , headache ; in isolated cases - bleeding.
Effervescent tablets ACC 100, instructions for use (Method and dosage)
The instructions for use of ACC 100 stipulate that the drug 100 mg should be taken orally after meals.
Patients over 14 years old - 2 tablets. 2-3 times a day.
Children and adolescents from 6 to 14 years old are recommended to take 1 tablet. 3 times a day or 2 tablets. 2 times a day.
The instructions for ACC 100 for children from 2 to 6 years old include taking 1 tablet. 2-3 times a day.
For patients with cystic fibrosis whose weight is more than 30 kg, if necessary, the dose is increased to 800 mg of acetylcysteine per day.
100 mg tablets are dissolved in 1 glass of liquid; the solution should be taken immediately.
Buy ACC 100 powder for preparing a solution for oral administration Orange for children 3g No. 20 in pharmacies
ACC Buy ACC in pharmacies DOSAGE FORMS granules for the preparation of solution for oral administration orange 100 mg
MANUFACTURERS Salutas Pharma GmbH (Germany)
GROUP Mucolytic agents
COMPOSITION The active substance is acetylcysteine.
INTERNATIONAL NON-PROPENTED NAME Acetylcysteine
SYNONYMS Acetylcysteine, Acetylcysteine Sediko effervescent instant, Acetylcysteine Stada International, Acetylcysteine-Hemofarm, ACC 100, ACC 200, ACC injection, ACC Long, Vicks Active ExpectoMed, Muco Sanigen, Mukobene, Mukonex, Tussicom, Fluimucil
PHARMACOLOGICAL ACTION Mucolytic agent. Pharmacodynamics. The presence of sulfhydryl groups in the structure of acetylcysteine promotes the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum. With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.
INDICATIONS FOR USE Diseases of the respiratory system, accompanied by the formation of viscous, difficult to separate sputum: acute and chronic bronchitis, obstructive bronchitis, laryngotracheitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis. Acute and chronic sinusitis, inflammation of the middle ear (otitis media).
CONTRAINDICATIONS Hypersensitivity to acetylcysteine or other components of the drug, pregnancy, breastfeeding, children under 2 years of age.
SIDE EFFECTS In rare cases, headaches, inflammation of the oral mucosa (stomatitis) and tinnitus are observed. Extremely rare - diarrhea, vomiting, heartburn and nausea, drop in blood pressure, increase in heart rate (tachycardia). In isolated cases, allergic reactions such as bronchospasm (mainly in patients with bronchial hyperreactivity), skin rash, itching and urticaria are observed. In addition, there are isolated reports of bleeding due to hypersensitivity reactions. If side effects develop, you should stop taking the drug and consult a doctor.
INTERACTION With the simultaneous use of acetylcysteine and antitussives, mucus stagnation may occur due to suppression of the cough reflex. Therefore, such combinations should be selected with caution. The simultaneous use of acetylcysteine and nitroglycerin can lead to an increase in the vasodilatory effect of the latter. Pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes. Upon contact with metals and rubber, sulfides with a characteristic odor are formed. Reduces the absorption of penicillins, cephalosporins, tetracycline (they should be taken no earlier than 2 hours after ingestion of acetylcysteine).
METHOD OF APPLICATION AND DOSAGE In the absence of other prescriptions, it is recommended to adhere to the following dosages: Mucolytic therapy. Adults and adolescents over 14 years of age are recommended to take 1 sachet 2 - 3 times a day (400 - 600 mg per day). Children aged 6 to 14 years are recommended to take ACC® 200 mg 3 times a day, 1 sachet or 2 times a day, 1 sachet (300 - 400 mg per day). Children aged 2 to 5 years are recommended to take 2-3 times a day, 1/2 sachet (200-300 mg per day). Cystic fibrosis. Children over 6 years of age are recommended to take 1 sachet (600 mg per day) 3 times a day. Children aged 2 to 5 years are recommended to take 1/2 sachet (400 mg per day) 4 times a day. For patients with cystic fibrosis and a body weight of more than 30 kg, if necessary, the dose can be increased to 800 mg of acetylcysteine per day. The granules should be dissolved in water, juice or iced tea and taken after meals.
OVERDOSE In case of erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed. To date, no severe or life-threatening side effects have been observed.
SPECIAL INSTRUCTIONS With caution - peptic ulcer of the stomach and duodenum in the acute stage; hemoptysis, pulmonary hemorrhage, esophageal varices, bronchial asthma, adrenal diseases, liver and/or kidney failure. Pregnancy and breastfeeding For safety reasons, due to insufficient data, the use of the drug during pregnancy and breastfeeding is only possible if the expected benefit to the mother outweighs the potential risk to the fetus or infant. For patients with bronchial asthma and obstructive bronchitis, acetylcysteine should be prescribed with caution under systematic monitoring of bronchial patency. When treating patients with diabetes, it is necessary to take into account that the drug contains sucrose. When working with the drug, you must use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.
STORAGE CONDITIONS Store in a dry place, protected from light, at a temperature not exceeding 25 C.
Interaction
If ACC 100 is taken with other cough suppressants, mucus stagnation may develop due to suppression of the cough reflex. This combination of drugs should be used with caution.
Acetylcysteine enhances the vasodilatory effect of nitroglycerin when these drugs are taken simultaneously.
Acetylcysteine is not pharmaceutically compatible with antibiotics ( cephalosporins , penicillins , amphotericin B , Tetracycline , Erythromycin ) and proteolytic enzymes .
With simultaneous use, acetylcysteine reduces the absorption of cephalosporins, tetracycline, and penicillins. It is necessary to maintain an interval of at least two hours between taking these medications.
When acetylcysteine comes into contact with metals, rubber, etc., sulfides are formed.
Description of the medicine
ACC is available in several dosage forms:
- effervescent tablets with a dosage of 100 and 200 mg;
- effervescent tablets with an increased dosage of 600 mg (ACC Long);
- syrup with a dosage of 20 mg in 1 ml;
- powder for preparing a solution with a dosage of 100, 200 and 600 mg.
All types of the drug contain acetylcysteine as the main active ingredient.
Effervescent tablets have the shape of a flat cylinder and a score, white color and blackberry aroma. The finished medicine is colorless, transparent with a light berry aroma. Sold in cylindrical tubes of 10 or 20 pieces, which are placed in a cardboard box along with instructions.
The powder is white granules without inclusions, with a characteristic orange aroma. Sachets with powder are placed in boxes of 6 or 20 pieces, depending on the dosage of the main substance.
ACC syrup is colorless, transparent, and has a cherry aroma. Sold in 100 ml darkened glass bottles, placed in boxes, with an additional syringe or measuring cup.
special instructions
It is important to use glass containers when diluting the drug to avoid contact with rubber, flammable substances, and metals.
In very rare cases, severe allergic reactions have been reported when taking acetylcysteine. If changes in the skin and mucous membranes are noted, you should definitely consult a doctor and immediately stop taking it.
ACC 100 should be taken with caution by people who suffer from obstructive bronchitis and bronchial asthma , and it is important to constantly monitor bronchial patency.
It is not recommended to take ACC 100 before bed; it is advisable to take it before 18:00.
It does not affect a person’s ability to work with dangerous mechanisms or drive vehicles.
ACC for children powder for preparation of solution 100 mg pack of 20 pcs
In patients with bronchial asthma and obstructive bronchitis, acetylcysteine should be prescribed with caution under systemic monitoring of bronchial patency. The use of acetylcysteine, especially in the initial stages of treatment, leads to dilution and, consequently, an increase in the volume of bronchial secretions. If the patient is unable to cough effectively, drainage or aspiration of secretions should be performed.
When dissolving acetylcysteine, you must use glass containers and avoid contact with metal and rubber surfaces.
When treating patients with diabetes, it is necessary to take into account that the drug contains sucrose.
Caution should be exercised when using acetylcysteine in patients with a history of peptic ulcer disease, especially with the concomitant use of other drugs that can irritate the mucous membranes of the gastrointestinal tract.
Cases of severe allergic reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell's syndrome) have been very rarely reported with the use of acetylcysteine. If changes occur in the skin and mucous membranes, you should immediately consult a doctor and stop taking the drug.
Caution should be exercised when used in patients with histamine intolerance. Long-term treatment with acetylcysteine should be avoided in such patients, since acetylcysteine affects histamine metabolism and may lead to the development of intolerance symptoms (such as headache, vasomotor rhinitis, itching).
You should not take the drug immediately before bedtime (it is recommended to take the drug before 18.00).
The use of the drug should be avoided in patients with renal and/or liver failure to avoid additional formation of nitrogenous compounds.
Effect on laboratory data. Acetylcysteine may affect the results of colorimetric determination of the concentration of salicylates in blood plasma. In urine analysis, acetylcysteine can affect the results of determining ketone bodies.
Instructions for patients with diabetes: 1 sachet weighing 3 g corresponds to 0.24 XE.
Effect on the ability to drive vehicles and machinery: There is no data on the negative effect of the drug ACC® in recommended doses on the ability to drive vehicles and perform other activities that require concentration and speed of psychomotor reactions.
Analogs
Level 4 ATX code matches:
Mukolik
Abrol
Ambrosan
Bronchorus
ACC 200
ACC Long
ACC
Mukolwan
Lazolvan
Bromhexine 8
Bromhexine 8 Berlin-Chemie
Bromhexine
Bronchobos
Carbocisteine
Erdomed
Pulmozyme
Pectolvan C
Halixol
Ambrobene
Acetylcysteine
Analog drugs of ACC 100 - ACC Long , Fluimucil , Acetylcysteine , Acetal , Acestad , Acestin etc. Only a specialist should choose the optimal drug.
Price ACC 100, where to buy
The price of ACC 100 is on average 250 rubles for 20 pieces.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
Pharmacy Dialogue
- ACC 100 (spike tab. 100 mg No. 20 for children) Hermes
RUB 233 order
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Pharmacy24
- ACC 100 mg No. 20 powder Salutas Pharma GmbH, Nimechchina / Lindopharm GmbH, / Zambon Switzerland Ltd, Switzerland
121 UAH. order - ACC 100 No. 20 tablets Salutas Pharma GmbH., Nimechchina/Hermes Pharma Ges.m.b.H., Austria/Hermes Arznaimittel Gmb.H.Nimechchina
116 UAH order
