Buy Augmentin powder for oral suspension 200mg+28.5mg/5ml 7.7g 70ml in pharmacies

Buy Augmentin powder for oral suspension 200mg+28.5mg/5ml 7.7g 70ml in pharmacies

Augmentin Buy Augmentin in pharmacies DOSAGE FORMS powder for the preparation of oral suspension 200mg+28 5mg/5ml powder for the preparation of suspension for oral administration 200mg+28 5mg/5ml

MANUFACTURERS Smithkline Beacham (Great Britain) Smithkline Beacham PLC (Great Britain)

GROUP Combined antimicrobial agents

COMPOSITION Active substance: amoxicillin + clavulanic acid.

INTERNATIONAL NON-PROPENTED NAME Amoxicillin + Clavulanic acid

SYNONYMS Amoxiclav, Amoxiclav Quiktab, Arlet, Augmentin EU, Augmentin SR, Clamosar, Medoclav, Panclave, Ranclave, Rapiclav, Sinulox, Sinulox RTU, Flemoclav Solutab, Ecoclave

PHARMACOLOGICAL ACTION Broad spectrum antibacterial. Blocks the synthesis of peptidoglycan of the membrane of microbial cells (amoxicillin), inhibits beta-lactamases (clavulanic acid). Clavulanic acid forms a stable inactivated complex with these enzymes and protects amoxicillin from the loss of antibacterial activity caused by the production of beta-lactamases by the main pathogens and opportunistic microorganisms. Active against gram-positive aerobes: Streptococcus pneumoniae, S.pyogenes, S.viridans, S.bovis, Staphylococcus aureus (except methicillin-resistant strains), S.epidermidis (except methicillin-resistant strains), Listeria spp., Enterococcus spp. Gram-negative aerobes: Bordetella pertussis , Brucella spp., Campylobacter jejuni, E.coli, Gardnerella vaginalis, H.influenzae, H.ducreyi, Klebsiella spp., Moraxella catarrhalis, N.gonorrhoeae, N.meningitidis, Pasteurella multocida, Proteus spp., Salmonella spp., Shigella spp., Vibrio cholerae, Yersinia enterocolitica. Anaerobes: Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Bacteroides spp., Actinomyces israelii. Rapidly absorbed after oral administration (food intake does not affect absorption). The maximum concentration is reached 1 hour after administration. The maximum plasma concentration after a bolus injection of 1.2 g is 105.4 mg/l (for amoxicillin) and 28.5 mg/l (for clavulanic acid). It has a large volume of distribution - high concentrations are found in body fluids and tissues (lungs, pleural, peritoneal, synovial fluid, tonsils, bronchial secretions, prostate gland, peritoneal abscess, muscle tissue, adipose tissue, paranasal sinus secretions, middle ear, etc. .). Peak concentrations in body fluids are observed 1 hour after peak plasma concentrations are reached. Does not pass through the BBB when the meninges are not inflamed, passes through the placental barrier and penetrates into breast milk in trace concentrations. Weakly binds to plasma proteins. Amoxicillin is partially metabolized, clavulanic acid undergoes intensive metabolism. Amoxicillin is excreted by the kidneys almost unchanged by tubular secretion and glomerular filtration; clavulanic acid - by glomerular filtration, partly in the form of metabolites. Small amounts are excreted by the intestines and lungs. The half-life is 1-1.5 hours, with severe renal failure it increases to 7.5 (for amoxicillin) and 4.5 hours (for clavulanic acid). It is removed during hemodialysis, and slightly - during peritoneal dialysis.

INDICATIONS FOR USE Infectious diseases of the upper (acute and chronic sinusitis, acute and chronic otitis media, retropharyngeal abscess, tonsilopharyngitis) and lower respiratory tract (acute and chronic bronchitis, pneumonia, pleural empyema); urinary tract infections (including cystitis, urethritis, pyelonephritis), gynecological infections (including salpingitis, salpingoophoritis, endometritis, septic abortion, pelvioperitonitis); biliary tract (cholecystitis, cholangitis), bone and connective tissue (including chronic osteomyelitis), skin and soft tissue (phlegmon, wound infection), odontogenic infections (periodontitis); sexually transmitted infections (gonorrhea, chancroid).

CONTRAINDICATIONS Hypersensitivity; history of allergic reactions to antibiotics of the penicillin and cephalosporin group; cholestatic jaundice, hepatitis caused by taking penicillin antibiotics (in history); liver failure; infectious mononucleosis, lymphocytic leukemia. Use during pregnancy and breastfeeding: possible if the expected effect of therapy exceeds the potential risk to the fetus. Breastfeeding should be stopped during treatment.

SIDE EFFECTS In most cases, side effects are weak and transient, most often affecting the gastrointestinal tract: loss of appetite, nausea, vomiting, diarrhea. Possible development of superinfection, stomatitis, vaginitis; in rare cases - pseudomembranous colitis with severe diarrhea. Allergic reactions may occur: itching, skin rashes; in sensitive patients, immediate hypersensitivity reactions may develop (angioedema, bronchospasm, rarely - anaphylactic shock). It is extremely rare that a transient increase in the level of transaminases in the blood plasma can be observed. There are isolated reports of cholestatic jaundice, hepatitis, and liver dysfunction.

INTERACTION When used simultaneously with methotrexate, the toxicity of methotrexate increases, with allopurinol - the incidence of exanthema, and with anticoagulants - the prothrombin time is prolonged. Reduces the effectiveness of oral contraceptives. Concomitant use with disulfiram should be avoided. The effectiveness of Amoxiclav is weakened by combination with bacteriostatic antibiotics (macrolides, tetracyclines), combination with rifampicin is antagonistic. Probenecid reduces the excretion of amoxicillin, increasing its serum concentration. Pharmaceutically incompatible with solutions containing blood, proteins, lipids, glucose, dextran, bicarbonate. Do not mix in a syringe or infusion bottle with other drugs. Incompatible with aminoglycosides.

DOSAGE AND ADMINISTRATION The dose of the drug depends on age, body weight and kidney function.

OVERDOSE Symptoms: in most cases nausea, diarrhea, vomiting, possible agitation, insomnia, dizziness, and in some cases seizures. There are no reports of deaths or life-threatening side effects. Treatment: symptomatic, in case of recent use (less than 4 hours), remove the drug from the gastrointestinal tract (gastric lavage, taking activated charcoal to reduce absorption), hemodialysis is effective.

SPECIAL INSTRUCTIONS Prescribe with caution to patients prone to allergic reactions to cephalosporins and other beta-lactam antibiotics (risk of cross-sensitivity), with severe impairment of liver and kidney function (dosage regimen adjustment is necessary). High concentrations give a false positive reaction for glucose in urine when using Benedict's reagent or Felling's solution (it is recommended to use enzymatic reactions with glucose oxidase).

STORAGE CONDITIONS List B. At room temperature.

Augmentin, 1 piece, 7.7 g, 200 mg+28.5 mg/5 ml, powder for oral suspension

Inside.

The dosage regimen is set individually, depending on the age, body weight, kidney function of the patient, as well as the severity of the infection.

To reduce potential gastrointestinal disturbances and to optimize absorption, the drug should be taken at the beginning of a meal. The minimum course of antibacterial therapy is 5 days.

Treatment should not continue for more than 14 days without reviewing the clinical situation.

If necessary, it is possible to carry out stepwise therapy (initially, parenteral administration of the drug, followed by switching to oral administration).

It must be remembered that 2 tables. Augmentin® drug, 250 mg+125 mg is not equivalent to 1 tablet. Augmentin® drug, 500 mg + 125 mg.

Adults and children aged 12 years and older or weighing 40 kg or more.

It is recommended to use 11 ml of suspension at a dosage of 400 mg + 57 mg in 5 ml, which is equivalent to 1 tablet. Augmentin® drug, 875 mg + 125 mg.

1 table each 250 mg+125 mg 3 times a day for mild to moderate infections. For severe infections (including chronic and recurrent urinary tract infections, chronic and recurrent lower respiratory tract infections), other dosages of Augmentin® are recommended.

1 table each 500 mg+125 mg 3 times a day.

1 table each 875 mg+125 mg 2 times a day.

Children aged 3 months to 12 years weighing less than 40 kg.

The dose is calculated depending on age and body weight, indicated in mg/kg/day or in ml of suspension. The daily dose is divided into 3 doses every 8 hours (125 mg + 31.25 mg) or 2 doses every 12 hours (200 mg + 28.5 mg, 400 mg + 57 mg). The recommended dosage regimen and frequency of administration are presented in the table below.

Table 6

Augmentin® dosage regimen (dose calculation based on amoxicillin)

Low doses of Augmentin® are recommended for the treatment of skin and soft tissue infections, as well as recurrent tonsillitis.

High doses of Augmentin® are recommended for the treatment of diseases such as otitis media, sinusitis, lower respiratory tract and urinary tract infections, bone and joint infections.

There is insufficient clinical data to recommend the use of Augmentin® at a dose of more than 40 mg + 10 mg/kg in 3 doses (4:1 suspension) in children under 2 years of age.

Children from birth to 3 months.

Due to the immaturity of the excretory function of the kidneys, the recommended dose of Augmentin® (calculated according to amoxicillin) is 30 mg/kg/day in 2 doses in the form of a 4:1 suspension.

Children born prematurely.

There are no recommendations regarding dosage regimen.

Special patient groups

Elderly patients.

No adjustment of the dosage regimen is required; the same dosage regimen is used as in younger patients. In elderly patients with impaired renal function, appropriate doses are prescribed for adult patients with impaired renal function.

Patients with impaired liver function.

Treatment is carried out with caution; regularly monitor liver function. There is insufficient data to change the dosage recommendations in these patients.

Patients with impaired renal function.

Correction of the dosage regimen is based on the maximum recommended dose of amoxicillin and the creatinine clearance value.

Table 7

Augmentin® dosage regimen

In most cases, whenever possible, parenteral therapy should be preferred.

Patients on hemodialysis. Powder for oral solution:

15 mg+3.75 mg/kg/day.

Before a hemodialysis session, one additional dose of 15 mg + 3.75 mg/kg should be administered.

To restore the concentrations of the active components of the drug Augmentin® in the blood, a second additional dose of 15 mg + 3.75 mg/kg should be administered after a hemodialysis session.

Film-coated tablets, 250 mg+125 mg:

adjustment of the dosage regimen is based on the maximum recommended dose of amoxicillin.

2 tables 250 mg + 125 mg in 1 dose every 24 hours.

During a dialysis session, an additional 1 dose (1 tablet) and 1 more tablet. at the end of the dialysis session (to compensate for the decrease in serum concentrations of amoxicillin and clavulanic acid).

Film-coated tablets, 500 mg+125 mg:

adjustment of the dosage regimen is based on the maximum recommended dose of amoxicillin.

1 table 500 mg + 125 mg in 1 dose every 24 hours.

During a dialysis session, an additional 1 dose (1 tablet) and 1 more tablet. at the end of the dialysis session (to compensate for the decrease in serum concentrations of amoxicillin and clavulanic acid).

Method of preparing the suspension

The suspension is prepared immediately before the first use. Add approximately 60 ml of boiled water, cooled to room temperature, to the bottle with the powder, then close the bottle with a lid and shake until the powder is completely diluted, let the bottle stand for 5 minutes to ensure complete dilution. Then add water up to the mark on the bottle and shake the bottle again. In general, the suspension requires approximately 92 ml of water for the 125 mg + 31.25 mg dosage and 64 ml of water for the 200 mg + 28.5 mg and 400 mg + 57 mg dosages.

The bottle should be shaken well before each use. For accurate dosing of the drug, you should use a measuring cap, which must be rinsed well with water after each use. After dilution, the suspension should be stored for no more than 7 days in the refrigerator, but not frozen.

For children under 2 years of age, a measured single dose of Augmentin® suspension can be diluted with water in a 1:1 ratio.