Compound
- Composition of one capsule A of the drug Antigrippin-ANVI: 300 mg of ascorbic acid , 250 mg of acetylsalicylic acid , 20 mg of rutoside (in the form of trihydrate ). Additional substances: calcium stearate , potato starch. Ingredients of gelatin capsules: yellow quinoline dye, black diamond dye, azorubine dye, proprietary blue or blue brilliant dye, gelatin, titanium dioxide.
- One capsule B contains: 20 mg diphenhydramine hydrochloride , 250 mg metamizole sodium monohydrate , 100 mg calcium gluconate monohydrate. Additional substances: calcium stearate, potato starch. Ingredients of gelatin capsules: titanium dioxide , gelatin.
Sources
- Ibuklin // Vidal Medicines Directory // 2021;
- Anisimova I.E., Solomatin E.N., Pleteneva T.V., Popov P.I. // Non-steroidal anti-inflammatory drugs on the issue of toxicity // Forensic medical examination // 2004.
- Bershtein I.Ya., Kaminsky Yu.L. // Spectrophotometric analysis in organic chemistry // Chemistry // 1986.
- Bulatov M.I., Kalinkin I.P. // Practical guide to photometric and spectrophotometric methods of analysis. // Chemistry // 1986.
Instructions for use and analogues of the drug Ibuklin
Release form
The drug Antigrippin-ANVI includes capsules of two types:
- capsules A are usually green, hard; contents - a mixture of amorphous and crystalline mass of light yellow color with a slight green tint, the presence of lumps is possible;
- capsules B are usually white and also hard; contents - a mixture of small granules and white powder, the presence of a yellow tint or lumps is allowed.
Ten capsules A in a contour package and ten capsules B in a contour package; one package of each capsule in a paper pack.
Advantages of the drug Ibuklin
Very often, doctors notice that medications for ARVI symptoms with one component (paracetamol or ibuprofen) do not work effectively enough. In these situations, they recommend Ibuklin, it provides relief quickly, side effects rarely occur with the correct dosage regimen. Ibuklin for children is also mild in action, but it should be prescribed by a doctor. The risks are associated with the fact that patients do not always know what the medicine consists of. They can take, for example, Ibuklin for fever, and Ibuprofen for back pain, and this will lead to an overdose. You cannot combine several types of anti-inflammatory, antipyretic and painkillers. It must be remembered that external products are also produced with these components. You need to be treated with only one type of NSAID, especially complex Ibuklin. With this approach, you can only get benefits from it and not be afraid of negative consequences.
Pharmacodynamics and pharmacokinetics
Combined drug.
Ascorbic acid regulates redox reactions, carbohydrate metabolism, tissue regeneration processes, blood clotting, and increases the body's resistance.
Acetylsalicylic acid (aspirin) has antipyretic, analgesic, anti-inflammatory, and antiplatelet effects.
Rutoside (or rutin ) is a powerful angioprotector . Reduces capillary permeability, symptoms of inflammation, stabilizes the vascular wall. Reduces aggregation and increases deformation of red blood cells.
Diphenhydramine has antiallergic and anti-edematous effects. Reduces vascular permeability, relieves hyperemia and swelling of the nasal mucosa, manifestations of hypersensitivity reactions in the respiratory tract.
Metamizole sodium has analgesic, antipyretic and minor anti-inflammatory effects associated with inhibition of prostaglandin .
Calcium gluconate regulates the exchange of phosphorus and calcium, has an antiallergic effect, and reduces vascular permeability. In the treatment of allergic diseases, its use in conjunction with antihistamines is recommended.
Antigrippin-ANVI
INSTRUCTIONS
on the use of a medicinal product for medical use
,ANTIGRIPPIN-ANVI®
Registration number: P N000277/01 Trade name of the drug: Antigrippin-ANVI®
Dosage form: Capsules.
Composition per capsule.
Capsule A.
Active ingredients: ascorbic acid - 300 mg, acetylsalicylic acid - 250 mg, rutoside trihydrate (in terms of rutoside) - 20 mg.
Excipients: calcium stearate - 1.0 mg, potato starch - 9.0 mg.
Hard gelatin capsule: gelatin - 90.723 mg, azorubine dye (E 122) - 0.003 mg, brilliant black dye (E 151) - 0.184 mg, patented blue dye (E 131) or brilliant blue dye (E 133) - 0.315 mg, dye quinoline yellow (E 104) - 2.207 mg, titanium dioxide (E 171) - 2.560 mg.
Capsule B.
Active ingredients: metamizole sodium monohydrate - 250 mg, calcium gluconate monohydrate - 100 mg, diphenhydramine hydrochloride - 20 mg.
Excipients: calcium stearate - 3.8 mg, potato starch - 6.2 mg.
Hard gelatin capsule: gelatin - 91.944 mg, titanium dioxide (E 171) -4.055 mg.
Description.
Capsules A are hard gelatin No. 0 green. The contents of capsules A are a mixture of crystalline and amorphous powder from light yellow to yellow with a greenish tint, the presence of lumps is allowed.
Capsules B are hard gelatin No. 0, white. The contents of capsules B are a mixture of powder and granules of white or white with a yellowish tint, the presence of lumps is allowed.
Pharmacotherapeutic group: a remedy for eliminating the symptoms of acute respiratory infections and “colds”.
ATX Code: [R05X]
Pharmacological properties
Combined drug. Acetylsalicylic acid has an analgesic, antipyretic and anti-inflammatory effect, inhibits platelet aggregation.
Ascorbic acid plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and helps increase the body's resistance.
Rutoside (rutin) is an angioprotector. Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall. Inhibits aggregation and increases the degree of deformation of red blood cells.
Metamizole sodium (analgin) has an analgesic, antipyretic and weak anti-inflammatory effect, the mechanism of which is associated with inhibition of prostaglandin synthesis.
Diphenhydramine (diphenhydramine) has an antiallergic, decongestant, local anesthetic (reduces vascular permeability, eliminates swelling and hyperemia of the nasal mucosa, sore throat, allergic reactions from the upper respiratory tract).
Calcium gluconate is a regulator of calcium and phosphorus metabolism, has an antiallergic effect (the mechanism is unclear), and reduces vascular permeability. For the treatment of allergic diseases or complications, its combined use with antihistamines is recommended.
Indications for use
Symptomatic treatment in adults and children over 15 years of age for colds, flu, ARVI.
Contraindications
Hypersensitivity to the components of the drug, erosive and ulcerative lesions (in the acute phase) of the gastrointestinal tract, gastrointestinal bleeding, increased tendency to bleeding, bronchial asthma, diseases accompanied by bronchospasm, “aspirin asthma”, inhibition of hematopoiesis (agranulocytosis, neutropenia, leukopenia), severe liver or kidney dysfunction, hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase, hemorrhagic diathesis (hemophilia, von Willebrand disease, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura), dissecting aortic aneurysm, portal hypertension, hypercalcemia ( the concentration of calcium ions should not exceed 12 mg% or 6 mEq/l), hypercalciuria, nephrolithiasis (calcium), sarcoidosis, intoxication with cardiac glycosides (risk of arrhythmia) Vitamin K deficiency, glucose-6-phosphate dehydrogenase deficiency. Pregnancy and breastfeeding, children under 15 years of age.
With caution - hyperuricemia, urate nephrolithiasis, gout, peptic ulcer of the stomach and/or duodenum (history), decompensated heart failure.
Directions for use and doses
Orally, after meals, with water, 2-3 times a day for 3-5 days until the symptoms of the disease disappear.
Adults and children over 15 years of age are prescribed 2 capsules per dose: 1 green capsule (from blister A) and 1 white capsule (from blister B).
If you do not feel better, you should stop taking the drug and consult a doctor.
Side effect
Anorexia, nausea, vomiting, gastralgia, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal tract, cervical bleeding, liver and/or renal failure, increased blood pressure, tachycardia. Allergic reactions: skin rash, Quincke's edema, bronchospasm.
With long-term use (more than 7 days) - dizziness, headache, visual impairment, tinnitus, leukopenia, thrombocytopenia, agranulocytosis, with a tendency to bronchospasm, an attack may be provoked, decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (nosebleeds, bleeding gums, purpura, etc.), kidney damage with papillary necrosis, deafness, anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), Reye's syndrome in children (hyperpyrexia, metabolic acidosis, nervous system and mental disorders, vomiting, liver dysfunction). Possible renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, red staining of urine due to the release of a metabolite.
All side (unusual) effects, including those not listed above, should be reported to your doctor and stop taking the drug.
Overdose
Nausea, vomiting, stomach pain, sweating, pale skin, tachycardia. With mild intoxication - ringing in the ears, severe intoxication - drowsiness, collapse, convulsions, bronchospasm, difficulty breathing, anuria, bleeding, progressive respiratory paralysis and uncoupling of oxidative phosphorylation, causing respiratory acidosis.
If you suspect poisoning, you should immediately seek medical help.
Treatment: induce vomiting, perform gastric lavage, take saline laxatives, activated charcoal. In a medical institution - forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous administration of diazepam and barbiturates.
Interaction with other drugs
If it is necessary to take it together with other medications, consult your doctor first.
Strengthens the effect of heparin, oral anticoagulants, reserpine, steroid hormones and hypoglycemic agents. Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, anti-gout drugs that promote the excretion of uric acid.
Increases the side effects of glucocorticosteroids, sulfonylurea derivatives, methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs.
Combination of the drug with barbiturates, antiepileptic drugs, zidovudine, rifampicin and alcohol-containing drinks should be avoided (the risk of hepatotoxic effect increases).
Ascorbic acid improves the absorption of iron preparations in the intestines.
Tricyclic antidepressants, oral contraceptives and allopurinol interfere with the metabolism of metamizole in the liver and increase its toxicity.
Metamizole enhances the effects of alcohol-containing drinks.
Radiocontrast agents, colloidal blood substitutes and penicillin should not be used during treatment with metamizole.
The simultaneous use of metamizole with cyclosporine reduces the level of the latter in the blood. Thiamazole and sarcolysin increase the risk of developing leukopenia.
Sedatives and tranquilizers enhance the analgesic effect of metamizole.
special instructions
The drug is not prescribed as an antipyretic for children under 15 years of age with acute respiratory diseases caused by viral infections, due to the risk of developing Reye's syndrome (encephalopathy and acute fatty liver with acute development of liver failure).
With prolonged use of the drug, monitoring of peripheral blood and the functional state of the liver is necessary. Since acetylsalicylic acid has an antiaggregation effect, the patient, if he is undergoing surgery, must notify the doctor in advance about taking the drug.
Acetylsalicylic acid in low doses reduces the excretion of uric acid. This can in some cases provoke a gout attack.
During treatment, you should avoid drinking alcohol-containing drinks (increased risk of gastrointestinal bleeding).
Acetylsalicylic acid has a teratogenic effect: when used in the first trimester of pregnancy it leads to a malformation - cleft palate, in the third trimester - inhibition of labor (inhibition of prostaglandin synthesis), closure of the ductus arteriosus in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the small vessels circle of blood circulation. Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in the baby due to impaired platelet function.
Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor renal function and blood pressure.
Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, liver transaminase activity, LDH).
Patients suffering from bronchial asthma and hay fever may develop hypersensitivity reactions. During the period of use of the drug, you should refrain from vigorous activities associated with the need for concentration and increased speed of psychomotor reactions.
Release form
Capsules A. 10 capsules per blister pack.
Capsules B. 10 capsules per blister pack.
2 blister packs (one with green capsules - blister pack A, the other with white capsules - blister pack B) along with instructions for use in a cardboard pack.
Storage conditions
In a dry place, protected from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life: 2 years.
Do not use after the expiration date stated on the packaging.
Conditions for dispensing from pharmacies Without a prescription.
Russia, 192236, St. Petersburg, st. Sofiyskaya, 14, lit. A.
Tel/fax or
CJSC "ZiO-Zdorovye"
Russia, 142103, Moscow region, Podolsk, st. Zheleznodorozhnaya, 2.
Tel., fax.
Name and address of the legal entity in whose name the registration certificate was issued/organization receiving claims
AnviLab LLC
Russia, 141302, Moscow region, Sergiev Posad municipal district, urban settlement Sergiev Posad, Sergiev Posad, st. Festivalnaya, 10.
Tel/fax
Contraindications
The drug has the following contraindications for use:
- bleeding from the digestive tract;
- bronchial asthma and diseases accompanied by bronchospasm;
- erosive and ulcerative changes in the digestive tract;
- tendency to bleed;
- pronounced changes in liver or kidney function;
- hemorrhagic diathesis ( thrombocytopenic purpura, hemophilia, thrombocytopenia, hypoprothrombinemia, telangiectasia, von Willebrand disease );
- hereditary hemolytic anemia anemia caused by deficiency of glucose-6-phosphate dehydrogenase );
- suppression of hematopoiesis ( neutropenia, agranulocytosis, leukopenia );
- dissecting aortic aneurysm;
- hypercalcemia, hypercalciuria;
- portal hypertension;
- calcium nephrolithiasis;
- sarcoidosis;
- overdose of cardiac glycosides;
- lack of vitamin K ;
- age less than 15 years;
- pregnancy and lactation ;
- deficiency of glucose-6-phosphate dehydrogenase ;
- hypersensitivity to any of the components of the drug.
It is recommended to prescribe Antigrippin-ANVI with caution for gout, urate nephrolithiasis, hyperuricemia, peptic ulcer, decompensated cardiac failure.
How to take for children
The original "antigrippin" is prohibited for use by persons under 15 years of age. Therefore, there is a special version of this drug intended for children aged three years and older. The dose and frequency of administration varies depending on the age of the children:
- From 3 to 5 years – 0.5 tablets 2 times a day
- From 5 to 10 years – 1 tablet 2 times a day
- From 10 to 15 years – 1 tablet 2-3 times a day
The rest of the use is the same as in adult patients. Indications and contraindications are identical to the original medication. The difference lies only in the smaller quantity and dosage of the main and auxiliary components in the composition of the children's medicine.
Side effects
- Phenomena from the digestive system: gastralgia, anorexia, diarrhea, bleeding, erosive and ulcerative changes , vomiting, nausea, liver failure.
- Phenomena from the system: increased pressure, tachycardia .
- Phenomena from the genitourinary system: renal failure.
- Allergic phenomena: angioedema , rash, bronchospasm.
Side effects observed when using the drug for longer than one week
- Nervous system effects: headache , dizziness .
- Phenomena from the organs of hearing and eyes: tinnitus, visual impairment, deafness.
- Phenomena from the hematopoietic system: thrombocytopenia, leukopenia, agranulocytosis.
- Respiratory system effects: bronchospasm.
- Allergic phenomena: possible development of anaphylactic shock , Lyell's syndrome or Stevens-Johnson syndrome.
- Phenomena from the blood coagulation system: hypocoagulation , weakening of platelet aggregation, hemorrhagic syndrome.
- Phenomena from the genitourinary system: papillary necrosis of the kidneys, interstitial nephritis , impaired renal function, anuria , oliguria, proteinuria, red coloration of urine.
- Other phenomena: the development of Reye's syndrome is possible in children ( metabolic acidosis, hyperpyrexia , vomiting, mental changes, liver damage).
How does Ibuklin affect the kidneys and liver?
In case of any problems with these organs, you need to be especially careful. If renal clearance is less than 30 ml/min, it is prohibited to use Ibuklin. Liver diseases in the active phase and proven failure of this organ are a contraindication.
- The drug for adults should not be confused with other types; Ibuklin for children, available in pharmacies with a prescription, was created for younger patients.
- Elderly patients should use the medicine with caution because their kidney and liver functions are not as active as in young people.
Overdose
Symptoms of overdose: vomiting, nausea, sweating , stomach pain, pale skin, tachycardia ; with a slight overdose, ringing in the ears may occur; in case of severe overdose - collapse , drowsiness , convulsions , difficulty breathing, bronchospasm, anuria , progressive respiratory paralysis , bleeding.
Therapy: gastric lavage, use of activated charcoal and saline laxatives ; If seizures , intravenous diazepam ; if necessary, perform forced diuresis or hemodialysis .
What should you pay attention to when treating with Ibuklin?
- Ibuklin does not combine with all antibiotics. You should tell the doctor about all the medications the patient is using or avoid harmful interactions yourself. Antibiotics from the cephalosporin group are at risk.
- The common drug Aspirin (acetylsalicylic acid) loses its effectiveness while taking the drug Ibuklin. This is especially noticeable when the patient takes aspirin as an antiplatelet drug for the heart.
- Important! Concomitant use with alcoholic beverages is contraindicated, as erosion may begin in the stomach or intestines.
- The effectiveness of anticoagulants is significantly increased when taken together.
- Insulin and other drugs that lower blood sugar also increase their effect.
- The effect of antihypertensive drugs and diuretics is reduced
- Other negative combinations: myelotoxic drugs, antacids, valproic acid, cefamandole, cefoperazone, drugs with gold, caffeine, plicamycin, cefotitan, digoxin. Increases the blood concentration of digoxin, lithium and methotrexate.
- Important! The patient should ensure that Ibuklin is not accidentally combined with other anti-inflammatory drugs.
- Two days before blood tests, you should stop taking Ibuklin (this applies to diagnosing the level of sugar, uric acid and steroid derivatives).
- It is undesirable to drive vehicles and mechanisms where increased attentiveness and reaction speed are required.
Ibuklin, 400 mg+325 mg, film-coated tablets, 10 pcs.
Dr. Reddy_s Laboratories, India
Price from 123₽
Ibuklin, 400 mg+325 mg, film-coated tablets, 20 pcs.
Dr. Reddy_s Laboratories, India
Not available
There are contraindications. Specialist consultation is required.
Interaction
When used together with indirect anticoagulants, heparin, reserpine, hypoglycemic agents and steroid hormones, their effect is enhanced.
When used simultaneously with Furosemide, Spironolactone, uricosuric and antihypertensive drugs, their effectiveness is reduced.
The drug enhances undesirable reactions of glucocorticosteroids , methotrexate derivatives, sulfonylureas, non-opioid analgesics and non-steroidal anti-inflammatory drugs.
Ascorbic acid enhances the absorption of iron preparations in the intestine.
When used simultaneously with barbiturates, zidovudine, antiepileptic drugs, rifampicin and alcohol-containing drugs, hepatotoxicity increases .
Metamizole sodium stimulates the effects of alcoholic beverages.
Tricyclic antidepressants, Allopurinol and oral contraceptives alter the metabolism of metamizole and increase its toxicity.
The simultaneous use of Metamizole with Cyclosporine reduces the level of the latter in the blood.
Tranquilizers and sedatives stimulate the analgesic effect of the drug.
When used together, Thiamazole sodium and Melphalan increase the risk of leukopenia.
X-ray contrast agents, Penicillin and colloidal blood substitutes should not be used while taking Metamizole sodium.
Instructions for use of Ibuklin tablets
A few words about pharmacology and dosage combinations. Ibuklin - tablet composition: ibuprofen 400 mg, paracetamol 325 mg. Anti-inflammatory, antipyretic and analgesic effects are the basis of the drug’s activity.
In the body, Ibuklin reduces the activity of various types of prostaglandins involved in the inflammatory response - ibuprofen is responsible for this. Paracetamol, in turn, reduces elevated temperature, acting through the thermoregulation center. Both remedies relieve pain, and the spectrum is so wide that it even helps eliminate pain after surgery.
special instructions
With long-term use of the drug, it is necessary to perform an analysis of peripheral blood and indicators of liver condition.
Acetylsalicylic acid in small doses reduces the evacuation of uric acid - this can provoke an exacerbation of gout.
During the period of use of the drug, patients should avoid drinking alcoholic beverages due to the increased risk of bleeding from the digestive system.
Taking ascorbic acid by patients with intensively metastasizing cancer can cause a worsening of the process.
During the period of use of the product, driving should be avoided.
Use of the drug Ibuklin
The combination of two analgesics and antipyretics puts an increased burden in the form of side effects on the kidneys, liver, blood vessels, heart and other systems of the immature body of a small patient. In this regard, only a doctor prescribes Ibuklin for children with fever.
Here are some mistakes that patients make. The drug removes inflammation so effectively that people think that Ibuklin is an antibiotic, and there is no point in seeing a doctor. However, Ibuklin does not affect bacteria. Temporary disappearance of symptoms does not always mean complete recovery. It is important to check the blood and lungs in order to exclude the erased form of pneumonia and other diseases. The therapist will tell you how to better and faster assess your health status, especially since the risk of pneumonia increases during a pandemic.
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Level 4 ATC code matches:
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Tonsilgon N
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Antigrippin , Antigrippin-Maximum, FluZiOZ-F, AntiFlu Kids.
