AnviMax, effervescent tablets, raspberry (sugar-free), 10 pcs.

Composition of AnviMax

Oral powder (the dosage of biologically active substances is calculated for 1 sachet for one-time use) consists of the following components:

• paracetamol – 360 mg;
• ascorbic acid – 300 mg;
• calcium gluconate monohydrate – 100 mg;
• rimantadine hydrochloride – 50 mg;
• rutoside trihydrate – 20 mg;
• Loratadine – 3 mg.

The following are used as excipients that allow the main components to have a more complete pharmaceutical effect:

• lactose monohydrate – 4.086 g;
• aspartame – 30 mg;
• colloidal silicon dioxide – 20 mg;
• hypromellose – 10 mg;
• food flavoring with the taste of lemon, honey, blackcurrant or raspberry – 21 mg.

Active components of capsule P:

• paracetamol – 360 mg;
• pregelatinized starch – 9 mg;
• colloidal silicon dioxide – 3 mg;
• lactose monohydrate – 4.2 mg;
• Magnesium stearate – 3.8 mg.

The P type capsule itself contains:

• gelatin – 94.795 mg;
• titanium dioxide (E171) – 1.94 mg;
• blue patent dye (E131) – 0.265 mg.

Composition of AnviMax in capsule P:

• ascorbic acid – 300 mg;
• calcium gluconate monohydrate – 100 mg;
• rimantadine hydrochloride – 50 mg;
• rutoside trihydrate in terms of pure rutoside – 20 mg;
• Magnesium stearate – 4.8 mg;
• loratadine – 3 mg;
• potato starch – 2.2 mg.

The type P capsule consists of the following components:

• gelatin – 94.064 mg;
• yellow dye iron oxide (E172) – 0.97 mg;
• crimson dye (Ponceau 4R) (E124) – 0.511 mg;
• red dye iron oxide (E172) – 0.485 mg;
• titanium dioxide (E171) – 0.97 mg.

Compound

Name

Most anti-cold combinations contain three components: paracetamol, phenylephrine hydrochloride and ascorbic acid, less often they contain antihistamines pheniramine or chlorphenamine maleate, which stop the allergic component of colds, reducing a runny nose, discomfort in the throat, itching in the nose and eyes, as well as lacrimation . The stimulant caffeine is sometimes used as an additional component, which reduces fatigue and drowsiness, and increases the mental and physical performance of the person with a cold. The secretolytic guaifenesin contained in the drug makes it possible to recommend the complex for ARVI and influenza, which are accompanied by a wet cough.

The most “complex” combination of six ingredients, including the antiviral rimantadine, the 2nd generation antihistamine loratadine, as well as the angioprotector rutoside and calcium gluconate, is contained in the drug “Anvimax”.

Minimum concentrations of paracetamol contain drugs intended for use in pediatrics. Its average content in anti-cold combinations for adults is 500–650 mg. Paracetamol in a maximum single dose of 1000 mg is included in three drugs. Let us remind you that the maximum daily dose of paracetamol is 4 g, and therefore the buyer should be warned that anti-cold combinations with a dosage of 1000 mg of paracetamol are extremely dangerous to take more than four times a day.

Release form

The pharmaceutical drug can be found on pharmacy shelves in the following form:

• Powder used for solution and oral administration. Available in different flavors, for example, lemon, lemon with honey, blackcurrant, raspberry. The medicinal powder is placed in a heat-resistant bag, 3, 6, 12 or 24 pieces in a cardboard pack.
• Capsules for oral administration, 10 pieces in a cell package. A cardboard box contains 2 contour plates. Capsules can be of two types: marked P - hard, gelatinous, blue, the contents of which are a mixture of granules and white powder, sometimes with a creamy or pinkish tint; P-capsules are hard, gelatinous, red, containing a mixture of granules and yellow-green or milky-white powder.

Description of the dosage form

The contents of the sachet are a mixture of powder and granules from almost white to yellow with a greenish tint with a characteristic smell (cranberry or lemon, or lemon with honey, or raspberries, or black currants).
The presence of single pink granules is allowed. The solution after dissolving the powder is colorless or with a yellowish tint, slightly cloudy, with a characteristic odor (lemon, lemon with honey, raspberries, black currants). The presence of undissolved yellow particles is allowed.

P hard gelatin capsules No. 0, blue. The contents of the capsules are a mixture of powder and granules of white or white with a creamy or pinkish tint, the presence of lumps is allowed.

Capsules P hard gelatin No. 0, red. The contents of the capsules are a mixture of powder and granules from yellow to yellow with a greenish tint and white, the presence of lumps is allowed.

pharmachologic effect

The drug has a wide range of pharmaceutical effects:

• antipyretic;
• analgesic (pain reliever);
• antihistamine;
• antiviral;
• interferonogenic;
• angioprotective.

AnviMax is a combination drug , as it contains several biologically active components. Thus, therapy with this drug is complex, even when only one position is included in the conservative treatment regimen, and therefore attention should be paid to the mechanisms of action of each component separately.

Ascorbic acid (a chemical analogue of natural vitamin C) – regulates the normal course of redox reactions, thereby helping to normalize the permeability of the capillary vascular bed . It has a stimulating effect on the body's immune systems and activates natural tissue regeneration. The acid also supports the normal functioning of the plasma coagulation system and the ability of platelets to coagulate.

Calcium gluconate acts as a donor of ions that are built into the wall of blood vessels. This prevents the development of increased permeability and fragility of the capillary bed. In this way, the hemorrhagic link of the inflammatory process during influenza or respiratory viral infection is eliminated.

Rimantadine is a substance with a high level of specificity of pharmaceutical action, the antiviral activity of which is aimed exclusively at the influenza virus type A. Thanks to its chemical properties, the M2 channels of the virus are blocked, which disrupts the ability of ribonucleoproteins to be released and further penetrate into the cell of a living organism. Thanks to such pharmaceutical abilities of Rimantadine, the main pathway of viral reproduction is inhibited, which has a beneficial effect on the state of the human macro organism. Also, the biologically active component induces the targeted production of alpha and gamma interferons , thereby stimulating the humoral component of immunity.

Loratadine is a typical H1 histamine receptor blocker . As an integral component of AnviMax, it prevents the development of edema of tissues adjacent to those affected by harmful microflora, as it prevents the generalized release of histamine (a biologically active amine that provides the main manifestations of the inflammatory process - swelling, redness, hyperthermia, and so on).

Rutoside is a pharmaceutical angioprotector , that is, the action of this substance is primarily aimed at maintaining the integrity of the vascular wall. To fulfill its task, the constituent component of the powder reduces the fragility and permeability of capillaries, inhibits the aggregation of red blood cells, and increases the degree of their deformation when passing through the microvasculature. It also relieves swelling and inflammation in the local area, which further strengthens the vascular wall.

What does Anvimax help with?

The basis of the principle of action is a complex effect consisting of an antipyretic, analgesic, and antihistamine effect. Considering what Anvimax helps with, the main area is the possibility of relieving symptomatic elements of ARVI and influenza. The principle of action is due to the composition, which is rich and varied.

1. Paracetamol. This remedy has an analgesic and antipyretic effect. In this regard, it helps with pain and fever.
2. Ascorbic acid. It takes an active part in the regulation of redox processes and reactions. Provides normalization of capillary permeability and blood clotting. Has a positive effect on all immune reactions.
3. Calcium. It supplies the body with ions, which is an excellent prevention of vascular fragility and hemorrhagic reactions. Another effect is anti-allergic, but the exact mechanism of influence of the composition remains unclear.
4. RIMANTADINE. It has a high level of antiviral activity against different strains. It blocks their channels and creates obstacles to penetration into cellular elements.

This is not the entire list of elements included in the composition, but the basic substances have been listed. This explains why it is so bitter and unpleasant to the taste. To achieve the effect, it is important to consider how to take this composition. And this must be done in accordance with special instructions. It should not be prescribed to adolescents under 18 years of age and, accordingly, to children. This is due to the fact that the product is endowed with a huge number of side effects and has a significant impact on the liver. Before taking the drug, you need to know its indications. They consist of the treatment of influenza, acute respiratory viral infections and all diseases where the symptoms are headaches, chills and fever.

Pharmacodynamics and pharmacokinetics

As with the pharmacological action, in order to understand the pharmacokinetic abilities of AnviMax, the metabolic pathways of each of the components of the combination drug should be traced.

Paracetamol is well absorbed from the gastrointestinal tract, the maximum plasma concentration is reached within half an hour after administration and is 4.8 mcg/ml. The substance is able to penetrate the blood-brain barrier and affect brain structures. The constituent component of AnviMax is metabolized in the liver, conjugating with sulfates, glucuronides or being oxidized by microsomal enzymes. Toxic intermediate metabolic products are formed only if paracetamol undergoes transformation through the third chemical pathway with the obligatory participation of glutathione , cysteine ​​and mercapturic acid . If there is an insufficient amount of cytochrome P450 enzymes, metabolites can have a damaging effect on hepatocytes , which leads to necrosis of liver cells. Metabolic products are excreted by the kidneys; the half-life is 2.8 hours, but with individual characteristics it can reach 3.5 hours. In old age, the clearance of the active substance decreases slightly, which is manifested by an increase in the half-life.

Ascorbic acid is absorbed mainly in the jejunum. Its absorption can be inhibited by diseases of the gastrointestinal tract, consumption of fresh fruits or vegetable juices, and copious amounts of alkaline drinks. The maximum concentration in blood plasma is reached after 4 hours from the moment of taking the drug and is approximately 10-20 mcg/ml. 25 percent of the acid binds to plasma proteins , the rest easily penetrates into blood cells, especially platelets and leukocytes. The chemical is deposited in the glandular organs, liver and lens of the eye. Ascorbic acid is able to penetrate the placental barrier and affect the fetus.

The active component is metabolized in the liver, excreted by the kidneys and through the intestines. Some of the acid may be excreted unchanged in sweat. The destruction of “ascorbic acid” is sharply accelerated due to smoking and excessive consumption of ethanol, which leads to a decrease in the physiological reserves of the body.

Calcium gluconate , like ascorbic acid, is absorbed primarily through the jejunum. Adsorption capacity depends on the acidity of the contents of the gastrointestinal tract and the presence of ergocalciferol . The ability to absorb calcium ions is greatly enhanced by their deficiency in the blood plasma. The active component is excreted 80 percent by the intestines and 20 percent by the kidneys.

Rimantadine is slowly absorbed from the digestive tract, its maximum concentration in the blood plasma is reached only 5-7 hours after taking the pharmaceutical drug. About 40 percent of a single dose taken after absorption is able to bind to plasma proteins, which ensures a constant concentration in the range of 50-80 ng/ml in the blood. Metabolized in the liver, after which more than 90 percent of the metabolic products are excreted by the kidneys over the next 72 hours. The half-life ranges from 20 to 45 hours. In old age, renal clearance of creatinine decreases, which contributes to the accumulation of rimantadine in toxic concentrations , therefore, the conservative treatment regimen in this age category should be strictly regulated taking into account individual metabolic parameters.

The metabolism of rutoside largely depends on the state of the gastrointestinal tract and the macroorganism as a whole. The time to reach its maximum concentration in plasma can range from 1 to 9 hours, and the half-life can range from 10 to 25 hours. The metabolic products of rutoside are excreted in the bile and, to a lesser extent, in the kidneys.

Loratadine is similar to ascorbic acid in its metabolic abilities. It is quickly and fairly completely absorbed from the intestine, which ensures its accumulation in the blood plasma within 2-4 hours after taking the drug. The maximum concentration is approximately 1-3 ng/ml, which is provided by 97 percent of a single dose due to binding to plasma proteins. Loratadine is not able to penetrate the blood-brain barrier, and accordingly, side effects of central origin should not be expected after taking it.

is metabolized in the liver under the influence of isoenzymes of the cytochrome . Excreted with bile or kidneys. The half-life is 5-15 hours, depending on the individual characteristics of the body. In patients with chronic renal failure or during hemodialysis, the pharmacokinetics of Loratadine do not change significantly. In older adults taking AnviMax, maximum plasma concentrations will increase by approximately 50 percent.

Pharmacokinetics

Paracetamol. Absorption is high. Communication with plasma proteins - 15%. Penetrates through the BBB. Metabolized in the liver in three main ways: conjugation with glucuronides, conjugation with sulfates, oxidation by microsomal liver enzymes. In the latter case, toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine ​​and mercapturic acid. The main isoenzymes of cytochrome P450 for this metabolic pathway are isoenzymes CYP2E1 (mainly), CYP1A2 and CYP3A4 (minor role). With glutathione deficiency, these metabolites can cause damage and necrosis of hepatocytes. Additional metabolic pathways include hydroxylation to 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates. In adults, glucuronidation predominates. Conjugated metabolites of paracetamol (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity. Excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged. In elderly patients, drug clearance decreases and T1/2 increases.

Based on the results of clinical studies, the following pharmacokinetic parameters of paracetamol were established: Cmax in blood plasma is achieved when using the powder after (0.7±0.39) hours and is (4.79±1.81) mcg/ml, T1/2 is equal to ( 2.73±0.76) h; Cmax in blood plasma is achieved when using capsules after (1.2±0.72) hours and is (5.01±1.7) mcg/ml, T1/2 is (3.04±1.01) hours.

Ascorbic acid is absorbed in the gastrointestinal tract (mainly in the jejunum). Communication with plasma proteins - 25%. Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbic acid in the intestine. The normal plasma ascorbic acid concentration is approximately 10–20 µg/ml. Tmax in blood plasma after oral administration is 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations. Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic acid and ascorbate-2-sulfate. It is excreted by the kidneys, through the intestines, with sweat, unchanged and in the form of metabolites. Smoking and drinking ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body. Excreted during hemodialysis.

Calcium gluconate. Approximately 1/5–1/3 of orally administered calcium gluconate is absorbed in the small intestine; this process depends on the presence of ergocalciferol, pH, diet and the presence of factors capable of binding calcium ions. The absorption of calcium ions increases with calcium deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) by the intestines.

Rimantadine. After oral administration, it is almost completely absorbed from the intestines. Absorption is slow. Communication with plasma proteins is about 40%. Vd - 17–25 l/kg. The concentration in nasal secretions is 50% higher than the plasma concentration. Metabolized in the liver. More than 90% is excreted by the kidneys within 72 hours, mainly in the form of metabolites, 15% unchanged. With chronic renal failure, T1/2 increases 2 times. In persons with renal insufficiency and the elderly, it may accumulate in toxic concentrations if the dose is not adjusted in proportion to the decrease in creatinine Cl. Hemodialysis has little effect on the clearance of rimantadine.

Based on the results of clinical studies, the following pharmacokinetic parameters of rimantadine were established: Cmax in blood plasma is achieved when using the powder after (5.28 ± 2.54) hours and is (69 ± 19.7) ng/ml, T1/2 - (33. 26±12.76) h; Cmax in blood plasma is achieved when using capsules after (4.53±2.52) hours and is (68.2±26.6) ng/ml, T1/2 - (30.51±9.83) hours.

Rutoside. Tmax in blood plasma after oral administration is 1–9 hours. It is excreted mainly through bile and to a lesser extent by the kidneys. T1/2 - 10–25 hours.

Loratadine. Quickly and completely absorbed into the gastrointestinal tract. Cmax in older people increases by 50%. Communication with plasma proteins - 97%. Metabolized in the liver to form an active metabolite (descarboethoxyloratadine) with the participation of cytochrome isoenzymes CYP3A4 and, to a lesser extent, CYP2D6. Does not penetrate the BBB. Excreted by the kidneys and bile. In patients with chronic renal failure and during hemodialysis, the pharmacokinetics remain virtually unchanged.

Based on the results of clinical studies, the following pharmacokinetic parameters of loratadine were established: Cmax in blood plasma when taking the powder is achieved after (3.28±1.25) hours and is (1.85±0.95) ng/ml, T1/2 is ( 11.29±5.52) h; Cmax in blood plasma when taking capsules is achieved after (2.92±1.31) hours and is (2.36±1.53) ng/ml, T1/2 is equal to (12.36±6.84) hours.

Indications for use

AnviMax serves as the main pharmaceutical drug that provides etiotropic treatment of influenza type A, that is, the drug provides conservative therapy aimed at eliminating the causative factors in the development of the nosological unit.

As a symptomatic treatment, AnviMax can be used in the following clinical situations:

• colds;
• acute respiratory viral infections;
• pathological conditions, the course of which is accompanied by fever, muscle pain, headache , and chills.

Advantages

• Complex treatment with one drug. There is no need to buy symptomatic, antiviral, angioprotective* and antihistamine** drugs separately, which allows you to save money. Everything is already included. It’s more convenient to take one drug!
• Unlike conventional symptomatic drugs, it has a powerful antiviral effect
• Ease of use: there is a sachet form for preparing the solution - for those who like hot drinks, as well as a capsule format, which is convenient to take even if you are at work and feel the first symptoms of a “cold”.

Contraindications

• hypersensitivity , idiosyncrasy , acquired or hereditary intolerance to the constituent components of a pharmaceutical drug;
• pathologies of the gastrointestinal tract (especially in the acute stage);
• hemorrhagic diathesis;
• vitamin K deficiency ;
• hemophilia;
• portal hypertension ;
• thyroid diseases;
• insufficient platelet count;
• acute diseases of the liver and kidneys (glomerulonephritis, pyelonephritis, nephrourolithiasis , renal failure, hepatitis) or chronic pathologies in the acute stage;
• severe hypercalcemia and hypercalciuria ;
• chronic alcoholism;
• sarcoidosis;
• phenylketonuria;
• period of pregnancy and lactation (breastfeeding);
• lactose intolerance , malabsorption of glucose and galactose.

There are a number of diseases when, if there are absolute indications for the use of a pharmaceutical drug, it should be included in the conservative therapy regimen, but the drug must be taken under the supervision of qualified medical personnel (it is recommended to undergo treatment in a 24-hour hospital). Such pathologies include:

• epilepsy;
• cerebral atherosclerosis;
• diabetes;
• sideroblastic anemia;
• increased amount of oxalates in blood plasma;
• glucose-6-phosphate dehydrogenase deficiency;
• malabsorption syndrome;
• dehydration and exicosis;
• thalassemia;
• disturbances in the electrolyte composition of the blood;
• old age (especially with pathologies of the cardiovascular system accompanied by arterial hypertension ).

Side effects

Conservative treatment with AnviMax can cause the following undesirable consequences:

• From the central nervous system: drowsiness or increased excitability, tremor, excessive mobility ( hyperkinesia ), dizziness and headache, arterial hyperemia of the skin of the face.
• From the gastrointestinal tract: dyspeptic disorder, damage to the mucous membrane of the duodenum and stomach, dry mouth, flatulence (bloating due to intestinal gases), diarrhea, loss of appetite.
• Regarding the hematopoietic organs: changes in blood counts (regular diagnostic tests are required during conservative treatment).
• From other organ systems: – inhibition of insulin by b-cells of the pancreas, glucosemia , glucosuria and pronounced manifestations of diabetes mellitus , as a consequence. Also, the complex drug can cause allergic reactions, which manifest themselves in the form of skin itching, pigmented rashes, and urticaria.

Adverse reactions

With conservative therapy, undesirable effects may occur:

• from the central nervous system: weakness, drowsiness or agitation, dizziness, headache;
• from the gastrointestinal tract: upset stomach, dry mouth, bloating, lack of appetite;
• from the circulatory system: changes in blood parameters:
• other reactions: allergies in the form of urticaria and skin itching.

Instructions for use of AnviMax (Method and dosage)

The drug is used, regardless of the pharmaceutical form, orally , that is, for oral administration.

If AnviMax is in powder form, then prepare a solution by adding half a glass (about 100 ml) of boiled warm water to the contents of the package and mix the contents. Consume orally immediately. Daily dosage – 1 sachet 2-3 times a day. It is recommended to take AnviMax after meals, since the adsorption capacity of the gastrointestinal tract is stimulated by the passage of the bolus. The course of treatment is usually about 5 days. It is strictly forbidden to prolong treatment on your own.

The instructions for AnviMax capsules require taking 1 capsule 2-3 times a day. Like the powder, you should take the medicine after meals, drinking plenty of water with the capsules. The therapeutic course is 5 days. If you do not feel better, you should stop treatment and contact your doctor or qualified pharmacist. Under no circumstances should you voluntarily prolong conservative rehabilitation.

Directions for use and doses

Inside.

Powder for solution for oral administration

Dissolve the contents of 1 pack. in half a glass of boiled warm water. Use immediately after dissolution. Stir the solution before use.

Adults take 1 pack. 2-3 times a day after meals for 3-5 days (no more than 5 days) until the symptoms of the disease disappear.

Capsules

For adults. 1 caps. P blue and 1 caps. Red red (single dose) 2-3 times a day after meals, washed down with water, for 3-5 days, until the symptoms of the disease disappear.

If you do not feel better, you should stop taking the drug and consult a doctor.

Overdose

During the first 24 hours after taking an increased dose of AnviMax, the following symptoms of overdose :

• pale skin;
• dyspeptic syndrome (vomiting, nausea, pain in the epigastric region);
• arrhythmia type tachycardia;
• metabolic acidosis;
• exacerbation of concomitant chronic diseases.

In case of severe overdose, symptoms may appear 48 hours after taking the drug and be aggravated by liver failure with encephalopathy and even coma (due to the accumulation of metabolic products). , renal failure with necrosis of the tubular apparatus may develop .

The etiotropic treatment for increased concentrations of the active components of the drug is the introduction of sulfhydryl group donors and precursors for glutathione synthesis ( products containing methionine and acetyl cysteine ) during the first eight hours. As a symptomatic treatment, you can use gastric lavage or induce vomiting with medication. The need for additional therapeutic measures is determined by the attending physician.

Interaction

Paracetamol is an extremely active component of the drug AnviMax, which is why the list of positive and not so positive interactions of the biological drug covers such a wide range of drugs. First of all, the metabolism of Paracetamol is affected by inducers of microsomal oxidation in the liver, ethanol and hepatotoxic drugs . They significantly increase the production of hydroxylated metabolic products, which, if their elimination rate is insufficient, can cause the development of severe intoxication even with a small daily dosage. Inhibitors of microsomal oxidation act strictly opposite, reducing the risk of damage to liver cells and allowing the active component to circulate in the bloodstream for a longer period.

The concomitant use of Paracetamol and anticoagulants in complex therapy, which is often found in severe respiratory pathologies, increases the effectiveness of the latter, and accordingly, a lower dosage of drugs that affect the blood coagulation system is required.

Long-term treatment with barbiturates may reduce the effectiveness of Paracetamol. Simultaneous use with Metoclopramide increases the rate of its absorption.

Ascorbic acid is no less active than Paracetamol. Its chemical effects make it possible to accelerate the metabolic pathways of iron preparations . Thus, by reducing the valency from three to two, their absorption in the gastrointestinal tract is improved, and simultaneous use with Deferoxamine increases the rate of elimination of ferrum-based drugs.

When treated with alicylates and sulfonamide drugs, the risk of developing crystalluria increases, since the elimination of drugs and natural metabolites is accelerated by the alkaline reaction. Alkaloids , both plant and animal origin, are also more actively removed

Pharmacy textbooks describe a very complex interaction between ascorbic acid and ethanol . Their combination during conservative therapy is strictly contraindicated, since the concentration of the vitamin analogue in the blood decreases, and the renal clearance of ethanol, on the contrary, increases. This creates an additional load on the urinary apparatus of the kidneys, which can manifest itself as an increase in daily diuresis and nonspecific nephrotoxic effect , as a consequence. Barbiturates and Primidone also increase the excretion of ascorbic acid in urine .

Ascorbic acid reduces the blood concentration of oral contraceptives, which should be taken into account by women during active abstinence from pregnancy. However, it is also not recommended to increase the dose of drugs on your own; the best way out of this situation would be an additional consultation with your doctor.

Separately, it is worth noting the possibility of interaction between ascorbic acid and antipsychotic drugs . Neuroleptics, which make up the group of phenothiazine , reduce their therapeutic effects, which requires immediate intervention in the conservative treatment regimen for disorders of the central nervous system.

Rimantadine is not as chemically active a component of AnviMax as Paracetamol or Ascorbic acid. Of the clinically important interactions, only the increased stimulating effect of caffeine , brain stimulants, and the fact that cimetidine reduces the renal clearance of rimantadine by 18 percent should be noted. This can be used to reduce the daily dosage of the drug, so as not to once again induce increased liver function, thus avoiding possible hepatic effects.

special instructions

Paracetamol can have a damaging effect on the liver, therefore, if you have chronic diseases of this organ or people who are prone to drinking ethanol, you should definitely undergo additional consultation with your doctor before starting to take AnviMax.

The complex drug has no visible effect on the ability to concentrate, attention or the speed of psychomotor reactions, however, during the treatment period you should be careful when driving a vehicle or engaging in other potentially hazardous activities.

Analogs

Level 4 ATC code matches:
Aflubin

Kofex

TeraFlu Bro

Suprima-Broncho

Sinupret

Bronchostop

Doctor Mom

Tonsilgon N

Pentaflucin

Tonsipret

Insti

Imupret

Antigrippin-Maximum

Antigrippin-ANVI

Atma

Viburkol

Travisil

RiniCold Broncho

Umkalor

Stodal

Antigrippin, Brustan, Voltaren Acti, GrippoFlu for colds and flu, Coldrex MaxGripp , Nalgesin forte, Tempalgin, Theraflu, Fervex.

Reviews about AnviMax

There is a lot and often written about the drug on pharmaceutical forums and information sites. Reviews are predominantly positive, because the complex remedy allows you to eliminate the causative factors of pulmonary disease, also providing additional symptomatic therapy, effectively stopping the manifestations of pathology that reduce the quality of life during the period of illness. By destroying harmful microorganisms, AnviMax helps to cope with the flu in a short course of conservative sanitation, which is not the case with every pharmaceutical drug nowadays.

Reviews of AnviMax are rarely overshadowed by side effects. Many, of course, write about drowsiness, dizziness or headaches, but in the vast majority of these symptoms they are a derivative of the action of toxic substances of harmful microorganisms, and not an undesirable reaction due to treatment. Some patients treated with AnviMax report dyspeptic disorders, but the frequency of their manifestations barely exceeds even one-fifth of all those treated with this pharmaceutical drug, so you should not take them, as they say, to heart.

Qualified specialists are also satisfied with the complex drug. Both attending physicians and pharmacists unanimously recommend the active use of AnviMax, because such a wide range of active ingredients is not found in every drug, and the indications for the use of this particular set of biologically active substances are strictly absolute for influenza type A or acute respiratory disease caused by infectious microflora.

AnviMax price, where to buy

The price of AnviMax in the Russian Federation ranges from 100 to 250 rubles.

The cost of the drug in Ukraine is about 50 hryvnia per package.

• Online pharmacies in RussiaRussia

ZdravCity

• Anvimax powder for pryg solution for internal use.
  approx. lemon lemon 5g 12 pcs. LLC NPO PharmVilar / Pharmproekt CJSC 361 rub. order
• Anvimax powder for pryg solution for internal use. approx. cranberry 5g 12 pcs NPO PharmVilar LLC / Pharmproekt CJSC

  RUB 396 order

• Anvimax powder for pryg solution for internal use. approx. lemon with honey 5g 3 pcs. LLC NPO PharmVilar / Pharmproekt CJSC

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• Anvimax powder for pryg solution for internal use. approx. lemon 5g 6 pcs NPO PharmVilar LLC / Pharmproekt CJSC

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• Anvimax powder for pryg solution for internal use. approx. blackcurrant 5g 12 pcs NPO PharmVilar LLC / Pharmproekt CJSC

  RUB 396 order