Doxycycline ~ Antibiotic, tetracycline
Price in pharmacies from 300.00 to 647.00 rub.*
Doxycycline (the active ingredient of the drug) is a broad-spectrum antibiotic from the tetracycline group. It acts bacteriostatically, suppresses protein synthesis in the microbial cell by interacting with the 30S ribosomal subunit. Active against many gram-positive and gram-negative microorganisms: Streptococcus spp., Treponema spp., Staphylococcus spp., Klebsiella spp., Enterobacter spp. (including E. aerugenes), Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum, Listeria monocytogenes, Rickettsia spp., Typhus exanthematicus, Escherichia coli, Shigella spp., Campylobacter fetus, Vibrio cholerae, Yersinia spp. (including Yersinia pestis), Brucella spp., Francisella tularensis, Bacillus anthracis, Bartonella bacilliformis, Pasteurella multocida, Borrelia recurrentis, Clostridium spp. (except Clostridium difficile), Actinomyces spp., Fusobacterium fusiforme, Calymmatobacterium granulomatosis, Propionibacterium acnes, some protozoa (Entamoeba spp., Plasmodium falciparum). More about the drug »
ATTENTION! ALWAYS check with your doctor or pharmacist to see if the found analogue can serve as a full replacement for the drug prescribed to you or the drug you are looking for. This is due to the need to use the dosage forms and doses prescribed specifically for you, which may differ even among analogues (more about analogues of drugs).
Pharmacodynamics and pharmacokinetics
Is Unidox Solutab an antibiotic or not?
The active ingredient of the drug doxycycline is an antibiotic from the tetracycline group. It inhibits the activity of pathogenic bacteria, affecting the ribosomal membranes in the cell. It does not allow the processes of RNA synthesis of some organisms to occur.
The medicine is active against such gram-positive bacteria as Streptococcus haemolyticus, Streptococcus viridans, Listeria spp., Streptococcus faecalis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis.
The drug inhibits the vital activity of gram-negative bacteria: Bacillus anthracis, Neisseria meningitidis, Brucella spp., Escherichia coli, Neisseria gonorrhoeae, Haemophilus influence, Clostridium spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Entamoeba., Shigella spp. etc.
Doxycycline is also used to treat diseases caused by Mycoplasma spp., Rickettsia spp., Chlamydia spp. and Spirochaeta spp. .
Doxycycline is absorbed from the gastrointestinal tract. Within 2 hours after administration, it can be detected in almost all tissues of the body (teeth, saliva), with the exception of cerebrospinal fluid. About half of the drug is excreted by the kidneys, the rest through the gastrointestinal tract. The drug can be detected in blood plasma after 19 hours with a single dose and after 48 hours during a course.
Indications for use
What are Unidox Solutab tablets for?
The drug is prescribed for the treatment of diseases caused by microorganisms sensitive to doxycycline:
- ENT diseases: otitis media, tonsillitis , etc.;
- respiratory tract diseases: pharyngitis , tracheitis , lung abscess , acute and chronic bronchitis ;
- cystitis , prostatitis , pyelonephritis , urethritis , endometritis ;
- PPI: for ureaplasmosis , syphilis , gonorrhea , chlamydia ;
- gastrointestinal tract infections: cholera , cholecystitis , gastroenterocolitis , diarrhea , yersiniosis ;
- trachoma , sepsis , peritonitis , osteomyelitis ;
- prevention of malaria and postoperative suppuration.
What else does Unidox Solutab treat?
Yaws , rickettsiosis , legionellosis , Q fever , , first stage Lyme disease, Rocky Mountain spotted fever , tularemia , actinomycosis , plague , malaria , psittacosis , leptospirosis psittacosis, bartonellosis , anthrax , whooping cough , granulocytic ehrlichiosis , brucellosis , acne .
What are the contraindications?
The main contraindication is hypersensitivity to tetracyclines and other components of the drug. It is prohibited to carry out drug therapy during the entire period of pregnancy. The greatest risks of developing pathologies in the fetus occur in the 1st trimester, when the placenta has not yet formed. The active substance can accumulate in bone tissue, which will disrupt mineralization processes and lead to unpredictable consequences.
For the treatment of children under 8 years of age, Unidox Solutab tablets, the instructions for use confirm this, are not prescribed. They should be abandoned if there are serious problems with the liver and kidneys. They are not prescribed for the diagnosis of porphyria. This pathology is hereditary, it is characterized by disorders of pigment metabolism and other pathological symptoms.
Side effects
- nausea , vomiting , loss of appetite , enterocolitis , inflammation in the genital area due to increased growth of the Candida fungus, stomatitis ;
- dermatitis , urticaria , anaphylaxis , pericarditis and erythema ;
- renal and liver failure, albuminuria , lack of potassium in the blood, increased nitrogen levels in the blood plasma;
- anemia , porphyria , thrombocytopenia ;
- tinnitus , hallucinations ;
- fragility of bones and teeth, discoloration of enamel;
- hyperemia , anaphylactic shock , decreased blood pressure, tachycardia , difficulty breathing.
Instructions for use Unidox Solutab (Method and dosage)
The duration of use and dosage of the drug should be prescribed by a doctor, depending on the disease and its course. The tablets are swallowed whole or crushed into powder and mixed with water.
According to the instructions for Unidox Solutab, adults are prescribed 0.2 g of doxycycline per day (the first day), in one or two doses. In subsequent days, the dosage can be reduced to 0.1 g, at the discretion of the attending physician.
For gonorrhea , syphilis and other serious STDs, the daily dose is usually 0.3 g. Tablets are taken for 5-10 days.
For children over 8 years old, if their weight is less than 50 kg, the calculation is based on the principle of 0.004 g of antibiotic per 1 kg. Or half as much at the end of the first day of use.
special instructions
An overdose of a medicine poses a health risk and can increase negative side reactions of the body. First of all, serious problems occur in the liver. Typically, severe vomiting and fever begin. Jaundice appears, azotemia also develops, the level of transaminases increases, and the prothrombin time increases.
If an overdose is suspected, you should urgently induce repeated vomiting, removing a large amount of water. After gastric lavage, absorbents should be taken. If necessary, you can take an additional laxative. After this, you should drink plenty of clean water for several days.
Actibiotic Unidox Solutab is available only by prescription. The shelf life of the drug is 5 years. The medicine should be stored at a temperature below +25°C out of the reach of children.
Interaction
Taken together with magnesium-containing laxatives, iron preparations, sodium bicarbonate , calcium, magnesium and aluminum should occur at least 3 hours after the antibiotic.
The drug reduces the effectiveness of antibiotics such as penicillin and cephalosporin .
The medicine may cause a decrease in the prothrombin index and the effectiveness of hormonal contraceptives . Also, when taken simultaneously with retinol, in intracranial pressure may be observed .
The concentration of doxycycline in the blood will decrease if you combine the drug with ethanol , rifampicin , phenytoin , barbiturates and carbamazepine .
Analogues of Unidox Solutab
Level 4 ATC code matches:
Vibramycin
Doxycycline hydrochloride
Doxycycline
The most common analogues:
- Doxycycline
- Vidoccin
- Vibramycin
- Doxibene
- Doxa-M-Ratiopharm
- Tigacil
The price of analogues differs significantly from the original, most often it is lower.
Doxycycline or Unidox Solutab - which is better?
The main difference between the drugs is the fact that Unidox does not have such a strong effect on the stomach and does not cause side effects characteristic of Doxycycline ( stomach ulcer , gastritis ). Absorption of the active substance occurs in the intestines and almost 100% of the medicine is absorbed by the body. The only advantage of doxycycline is its extremely low cost compared to the original.
What is the difference between Unidox and Unidox Solutab?
The prefix “Solyutab” in the name of the drug means that the tablet can be crushed and dissolved in water to prepare a suspension for administration. This method of taking the medicine is preferable for children.
Unidox Solutab or Doxycycline - which is better, what is the difference
Manufacturer: BELMEDPREPRATY, Belarus
Release form: capsules
Active ingredient: doxycycline
Doxycycline Solution Tablets is a bacteriostatic antibiotic, which is a full-fledged analogue of Unidox tablets. Refers to a semi-synthetic tetracycline. It has a detrimental effect on pathogenic microorganisms that contribute to the development of infectious and inflammatory pathologies.
To a lesser extent than other tetracycline antibacterial agents, it inhibits intestinal microflora. Has a longer lasting effect. Absorbed quickly and completely. Metabolized in the liver. It is excreted along with bile.
Doxycycline is prescribed for infectious and inflammatory pathologies of the respiratory tract, ENT organs, genitourinary system, biliary tract and gastrointestinal tract, skin, eyes. Reviews about these drugs are equally positive, since they do not differ in effectiveness and composition. The main difference is the cost and degree of purification of the drug.
Reviews about Unidox Solutab
Reviews in gynecology. The drug has good reviews in the treatment of gynecological diseases, for example chlamydia . Patients who were prescribed the drug for chlamydia note that the antibiotic is easily tolerated and effective. Although sometimes side effects occur in the form of headaches and disruption of the digestive system.
Reviews for use against ureaplasma are also good, many are of the opinion that the drug is almost the only effective way to get rid of the disease.
Reviews of Unidox Solutab for acne. a dermatologist may prescribe antibiotics to treat acne For most patients, acne medication helps, but then other problems arise due to the medication's side effects. For many, following a therapeutic diet helped better than those taking an antibiotic.
Possible body reactions
While taking Solutab tablets, the instructions for use indicate this, health-threatening symptoms may occur. The most common problems occur in the digestive system. When taking the medicine the following is noted:
- Nausea.
- Vomit.
- Diarrhea.
- Dysbacteriosis.
The drug may cause:
- Anorexia, characterized by refusal to eat due to a neuropsychiatric disorder.
- Dysphagia, which is associated with disorders of the swallowing process.
- Enterocolitis, against the background of which inflammatory processes occur in the intestines.
- Pseudomembranous colitis, which provokes acute inflammation in the large intestine.
After taking Unidox Solutab tablets, allergies or dermatological problems of varying severity may occur. Very often there is urticaria and rash in various manifestations and places. If the patient suffers from autoimmune diseases, for example, lupus erythematosus, then the risks of developing exacerbations increase significantly. Sometimes treatment with the drug leads to the development of pericarditis and exfoliative dermatitis.
When therapy is carried out for a long time, the risks of malfunctions in the liver and kidneys increase. The drug poses an increased danger to patients with renal or liver failure.
Also, the instructions for the drug focus on other side effects. Malfunctions may occur:
- Hematopoietic systems.
- Nervous system.
- ·Endocrine system.
Unidox Solutab price, where to buy
The average price of tablets in Russia is about 300 rubles. per pack 10 pcs.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Unidox Solutab dispersible tablets 100 mg 10 pcs. ZiO-Zdorovye ZAO
300 rub. order - Unidox solutab dispersant tablets. 100 mg 20 pcs. ZiO-Zdorovye ZAO
RUR 591 order
Pharmacy Dialogue
- Unidox Solutab (table dispersant 100 mg No. 10) ZiO-Zdorovye CJSC/Astellas Pharma Europe B.V.
RUB 332 order
- Unidox Solutab (table dispersant 100 mg No. 20)Astellas Pharma/ZiO-Zdorovye CJSC
RUR 607 order
- Unidox Solutab (table dispersant 100 mg No. 20)Astellas Pharma/ZiO-Zdorovye CJSC
RUR 597 order
- Unidox Solutab (table dispersant 100 mg No. 10) ZiO-Zdorovye CJSC/Astellas Pharma Europe B.V.
RUB 327 order
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Pharmacy24
- Unidox Solutab 100 mg N10 tablets Astellas Pharma Europe B.V., Netherlands
141 UAH.order
PaniPharmacy
- Unidox solutab tablets Unidox salutab tablets. 100 mg No. 10 Netherlands, Astellas Pharma Europe
152 UAH order
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