Clindacin 100 mg 3 pcs. vaginal suppositories pharmaprim

Clindamycin ~ Antibiotic, lincosamide

Price in pharmacies from RUB 452.00*

A bacteriostatic antibiotic from the lincosamide group, has a broad spectrum of action, binds to the 50S subunit of the ribosomal membrane and inhibits protein synthesis in the microbial cell. Clindamycin may have a bactericidal effect against a number of gram-positive cocci. Active against Staphylococcus spp. (including Staphylococcus epidermidis, producing and non-producing penicillinase), Streptococcus spp. (excluding Enterococcus faecalis), Streptococcus pneumoniae, Corynebacterium diphtheriae, Mycoplasma spp., anaerobic and microaerophilic gram-positive cocci (including Peptococcus spp. and Peptostreptococcus spp.), Clostridium perfringens, Clostridium tetani, Bacteroides spp. (including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., eubacterium and Actinomyces israelii. Most strains of Clostridium perfringens are sensitive to clindamycin, but other Clostridium spp. (including Clostridium sporogenes, Clostridium tertium) are resistant to its action, and therefore for infections caused by Clostridium spp., it is recommended to determine an antibiogram. Cross-resistance exists between clindamycin and lincomycin. More about the drug »

ATTENTION! ALWAYS check with your doctor or pharmacist to see if the found analogue can serve as a full replacement for the drug prescribed to you or the drug you are looking for. This is due to the need to use the dosage forms and doses prescribed specifically for you, which may differ even among analogues (more about analogues of drugs).

Pharmacodynamics and pharmacokinetics

the lincosamide antibiotic clindamycin as an active ingredient , is a local remedy used in gynecology for the treatment of gardnerellosis (vaginosis) of bacterial origin. The mechanism of action of local dosage forms of the drug (cream, suppositories) is aimed at disrupting the processes of intracellular protein synthesis in the microbial cell, which occurs at the level of the large ribosomal subunit 50S.

The spectrum of action of clindamycin is quite wide. In medium doses, the drug exhibits bacteriostatic effectiveness against many microorganisms . At higher dosages, clindamycin is characterized by a bactericidal effect aimed at destroying certain bacterial strains .

The main activity of clindamycin is observed against microorganisms leading to the formation of bacterial vaginosis , including: Mobiluncus spp. (mobiluncus), Gardnerella vaginalis (Gardnerella vaginalis), Bacteroides spp. (bacteroides), Peptostreptococcus spp. (peptostreptococci), Mycoplasma hominis (mycoplasma hominis).

Strains of Candida albicans ( thrush ) and Trichomonas vaginalis ( Trichomonas vaginalis insensitive to the effects of clindamycin .

Intravaginal (inside the vagina) single administration of clindamycin at a dose of 100 mg leads to systemic absorption of approximately 4% of the drug (about 4 mg). Plasma Cmax of clindamycin is 20 ng/ml.

Substitute options

Clindacin b prolong analogues, cheap and expensive, have the same active ingredient as the main product. Some types of ointments, gels and creams are intended for external use, as an anti-acne treatment for acne.

Cheap analogues are presented in the table:

You can ask your doctor to replace Clindacin b prolong with a more inexpensive drug - the initial cost of the drug is 500 rubles, which for some patients is a financial problem. A large number of reviews indicate the high effectiveness of the product in a short period of time - within 72 hours or three days, all symptomatic signs of the disease disappear and a cure occurs. Some patients claim that normalization of the condition occurred after the first use of the drug.

Side effects

Some patients, when using Clindacin, experienced the development of negative side effects, including: a feeling of itching in the vagina , the formation of a maculopapular rash , the occurrence of urticaria , the development of cervicitis or colpitis (vaginitis), vulvovaginal irritation burning sensation .

In rare cases, the following were observed from the hematopoietic system: thrombocytopenia , reversible leukopenia , eosinophilia , neutropenia , agranulocytosis .

In case of significant systemic absorption of clindamycin, its inherent systemic side effects may occur, including the formation of pseudomembranous enterocolitis (very rare).

Overdose and negative reactions

The main side effects are associated with local reactions in the area of ​​administration - obsessive itching, swelling of the vaginal mucosa, discomfort, burning, spasms or pain in the lower abdomen.

Atypical deviations are recorded in isolated cases.

The drug can become a source of allergic reactions.

The manufacturer warns that if primary symptomatic signs of allergies or other non-standard responses of the body appear, the patient should stop therapy and seek professional help. Ignoring symptoms may lead to the need to use antihistamines. There have been no cases of overdose during use - there is no such information in the instructions.

Instructions for use of Clindacin (Method and dosage)

Clindacin cream, instructions for use

Clindacin cream is intended for intravaginal use using a special disposable applicator included in the package with the medicinal product. The recommended single daily dosage of the cream is 100 mg of clindamycin (the volume of a completely filled applicator). It is best to administer the drug in the evening (before bedtime). The duration of the treatment course, as a rule, takes from 3 to 7 days.

Using the applicator

For proper dosing and introduction of the cream into the vagina, it is recommended to use disposable applicators contained in the package with the drug and adhere to the technique for their use, namely:

• remove the protective cap from the tube of cream;
• screw a disposable plastic applicator into its place;
• squeeze the opposite end of the tube to completely fill the applicator (the applicator is considered completely filled when its independently moving piston reaches the stop);
• lying on your back, insert the applicator into the vagina as deeply as possible;
• Gently press the applicator piston until it is completely empty;
• Carefully remove the used applicator from the vagina and throw it away.

Clindacin suppositories, instructions for use

Clindacin suppositories are also used intravaginally, with a single daily administration of 1 suppository, preferably in the evening (before bedtime). The duration of the treatment course, as a rule, takes from 3 to 7 days.

For proper use of the drug, one suppository should be released from the outer contour packaging by cutting the protective film along the contours of the suppository. Then, in a lying position, insert the suppository into the vagina as deeply as possible.

Clindacin 100 mg 3 pcs. vaginal suppositories pharmaprim

pharmachologic effect

An antibiotic from the lincosamide group, it has a wide spectrum of antimicrobial action.
The mechanism of action is due to binding to the 50 S subunit of the ribosomal membrane and suppression of protein synthesis in the microbial cell. Acts bacteriostatically. A bactericidal effect is possible against a number of gram-positive cocci. Active against Staphylococcus spp. (including Staphylococcus epidermidis, producing and non-producing penicillinase), Streptococcus spp. (excluding Enterococcus faecalis), Streptococcus pneumoniae, Corynebacterium diphtheriae, Mycoplasma spp., anaerobic and microaerophilic gram-positive cocci (including Peptococcus spp. and Peptostreptococcus spp.), Clostridium perfringens, Clostridium tetani, Bacteroides spp. (including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubacterium spp. and Actinomyces israelii.

Most strains of Clostridium perfringens are sensitive to clindamycin, but other Clostridium spp. (including Clostridium sporogenes, Clostridium tertium) are resistant to its action, and therefore for infections caused by Clostridium spp., it is recommended to determine an antibiogram.

Cross-resistance exists between clindamycin and lincomycin.

Composition and release form Clindacin 100 mg 3 pcs. vaginal suppositories pharmaprim

Vaginal suppositories - 1 sup.:

• Active substance: clindamycin (in phosphate form) - 100 mg;
• Excipients: semi-synthetic glycerides (such as “Estarinum”, “Vitepsol” or “Suppotsir”).

3 pcs. — cellular contour packaging, cardboard packs.

Description of the dosage form

Vaginal suppositories are white or white with a yellowish tint, cylindrical-conical in shape; there are no inclusions on the longitudinal section; the presence of an airy and porous rod and a funnel-shaped recess is allowed.

Directions for use and doses

Prescribe intravaginally 1 suppository 1 time/day immediately before bedtime, for 3-7 days in a row.

Before use, one suppository is released from the contour packaging, having previously cut the film along the contour of the suppository, and inserted, if possible, deep into the vagina, in a lying position.

Pharmacokinetics

After a single intravaginal administration of clindamycin at a dose of 100 mg, 4% of the administered dose is subject to systemic absorption. Cmax in plasma - 20 ng/ml.

Indications for use Clindacin 100 mg 3 pcs. vaginal suppositories pharmaprim

Bacterial vaginosis caused by microorganisms sensitive to the drug.

Contraindications

• I trimester of pregnancy;
• hypersensitivity to the components of the drug.

Application of Clindacin 100 mg 3 pcs. vaginal suppositories pharmaprim during pregnancy and breastfeeding

Intravaginal use of Clindacin during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus. Clindamycin penetrates the placental barrier into the fetal circulatory system.

Clindamycin is excreted in breast milk. It is recommended to prescribe the drug with caution during lactation. Breastfeeding should be stopped during treatment.

special instructions

Vaginal suppositories are not recommended for use simultaneously with other intravaginal medications.

Influence on the ability to drive vehicles and operate machinery.

The drug does not affect the ability to concentrate and the speed of psychomotor reactions.

Overdose

Due to the low absorption of the drug, an overdose is unlikely.

Side effects Clindacin 100 mg 3 pcs. vaginal suppositories pharmaprim

From the reproductive system: cervicitis, vaginitis, vulvovaginal irritation.

From the hematopoietic organs: rarely - reversible leukopenia, neutropenia, eosinophilia, agranulocytosis, thrombocytopenia.

Allergic reactions: maculopapular rash, urticaria, itching.

Other: with systemic absorption, other systemic side effects are possible, incl. in rare cases - pseudomembranous enterocolitis.

Drug interactions

Clindacin® enhances the effect of drugs rifampicin, aminoglycosides - streptomycin, gentamicin.

Enhances muscle relaxation caused by n-cholinergic blockers.

Clindacin® is incompatible with erythromycin, ampicillin, diphenylhydantoin derivatives, barbiturates, aminophylline, calcium gluconate and magnesium sulfate.

Interaction

When used in combination with clindamycin, the effectiveness of aminoglycosides ( Streptomycin ), Rifampicin and Gentamicin .

Clindamycin is incompatible with Aminophylline , Erythromycin , Magnesium sulfate , Ampicillin , Calcium gluconate , diphenylhydantoin and barbiturates.

The effects of clindamycin increase muscle relaxation caused by the effects of n-cholinergic blockers .

special instructions

In case of prolonged use of the drug, the possibility of excessive growth of microorganisms insensitive to its active ingredient, especially fungal strains of Candida, is allowed.

The combined use of Clindacin with other intravaginal medications is not recommended.

Due to the minimal, but still systemic absorption of clindamycin (about 4%), against the background of its topical use, diarrhea , requiring discontinuation of the drug.

Analogs

Level 4 ATC code matches:
Ecofucin

Primafungin

Nystatin

Polygynax Virgo

Polygynax

Analogs of Clindacin are represented by local medicinal drugs used in gynecology for the treatment of similar bacterial infections: Nystatin , Polygynax , Sintomycin , Pimafucin , Natamycin , Ecofucin .

The price of analogues of suppositories of this drug varies widely, for example, 10 suppositories of the drug Sintomycin can be bought for 40-60 rubles, and 12 vaginal capsules of Polygynax for 600-650 rubles.

During pregnancy and lactation

According to the official instructions, clinical studies of the safety of Clindacin during pregnancy in the first trimester have not been conducted, and therefore its use in this period is not recommended. Treatment of women with Clindacin in the second and third trimester of pregnancy is allowed only in cases where the benefits of such therapy for the mother significantly exceed the possible negative consequences for the fetus.

Despite this, in gynecology there is a practice of prescribing Clindacin in the second and third trimester of pregnancy , since some vaginal infections undoubtedly require such treatment. Considering reviews of this drug in the form of a cream, as well as reviews of suppositories during pregnancy during these periods, it is worth noting that in the vast majority of cases, therapy with Clindacin led to relief from the infectious disease without any negative consequences for the expectant mother and fetus.

The excretion of intravaginally used clindamycin in the milk of a nursing mother has not been studied, and therefore, its administration during lactation is possible only with a positive comparison of the benefits of such treatment for the mother in comparison with the possible risks for the newborn.

general information

The product contains two key components: clindamycin phosphate, 2.376 mg, and butoconazole nitrate - 2 g. Secondary ingredients:

• cetostearyl alcohol;
• isopropyl myristate;
• propylene glycol;
• purified water;
• macrogol cetostearate;
• sodium hydroxide;

• hydroxypropyl distarch phosphate;
• preservatives.

The medicine is prepared in the form of vaginal cream and suppositories. For men, the main drug is used only in the form of a cream - the product is applied to the head of the genital organ. Due to the water-repellent base of the cream, the drug takes the form of a gel at temperatures above 35 degrees. When introduced into the vagina, the medicine does not melt; thanks to its peculiarity, all the main components of the medicine remain on the mucous membrane for 24-48 hours.

Reviews about Clindacin

Most women who use this drug to treat bacterial vaginosis leave positive reviews about Clindacin suppositories, including patients forced to resort to this drug during pregnancy in the second and third trimester . Reviews about Clindacin cream are not so numerous, but they are also positive in terms of the effectiveness and safety of this medicinal drug. Summarizing the general impression of patients about Clindacin therapy for bacterial vaginosis , we can confidently recommend it for use according to indications, but only after consulting a specialist doctor.

Features of use

The annotation for the cream states that the occurrence of irritation on the vaginal mucosa and painful sensations requires immediate cessation of treatment procedures. The simultaneous use of the drug with other drugs administered in the same way is prohibited. If the main clinical symptoms persist after a course of therapy, it is necessary to conduct a repeat diagnostic examination in order to secondary determine the invading pathogen and confirm the initial diagnosis.

Treatment with clindacin prolong in suppositories during menstruation is prohibited.

The medication must not be combined with medications containing subgroup B vitamins, aminoglycosides, Ampicillin, calcium gluconate, magnesium sulfate.

When taken simultaneously with erythromycin, their antagonistic interaction is noted.

Clindacin price, where to buy

In comparison with its analogues for topical use (including vaginal ointments, creams, suppositories, capsules, etc.), the cost of Clindacin is at a high level. For example, the price of Clindacin in candles No. 3 is about 650 rubles (accordingly, 6 candles can be purchased on average for 1,300 rubles). The price of Clindacin cream varies between 350-400 rubles per 20 gram tube.

• Online pharmacies in RussiaRussia

ZdravCity

• Clindacin B Prolong cream vaginal.
  2%+2% tube 20gAO Akrikhin RUR 570 order
• Clindacin cream vaginal. 2% 20gAO Akrikhin

  RUB 496 order

Indications and contraindications

Indications for the use of the drug Clindacin B recommend the use of the drug for vaginosis of bacterial or fungal origin. The medicine is used to treat diseases of the skin or mucous membrane of various locations. Widely used in the treatment of thrush.

The choice between vaginal cream and Clindacin B prolong suppositories remains with the attending physician.

Before starting therapeutic procedures, the patient must undergo a bacteriological culture test in order to identify the type of pathogen that has penetrated and caused the problem.

Testing determines not only the type of pathogenic microflora, but also its resistance to the drug. The drug is not used for the following indicators:

• pseudomembranous, ulcerative colitis or information about its presence in the medical history;
• before the patient reaches adulthood;
• with Crohn's disease - granulomatous inflammation of the digestive tract of unknown etiology;
• in case of intolerance to the components of the drug or allergic reactions to lincomycin, clindamycin, butoconazole.

Monitoring by medical personnel is required during treatment with Clindacin B prolong for documented allergies, when combining therapy with muscle relaxants, during pregnancy and breastfeeding.

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