Remedy No. 10
Polygynax
- an antifungal and antibacterial drug, available in the form of vaginal and intravaginal capsules with an emulsion. It is not recommended to use the drug without consulting a doctor during pregnancy and lactation.
Do not forget that all drugs for thrush, despite the fact that they are intended to treat the same disease, have different side effects and contraindications. Therefore, treatment should only be prescribed by a doctor, based on the individuality of the patient.
Natamycin vaginal suppositories 100 mg 3 pcs (Tula Pharmaceutical Factory)
Registration Certificate Holder
TULA PHARMACEUTICAL FACTORY (Russia)
Dosage form
Medicine - Primacin
Description
Vaginal suppositories
from light yellow to light brown, torpedo-shaped; there should be no foreign inclusions on the longitudinal section; an air rod or funnel-shaped recess is allowed.
1 sup.
natamycin 100 mg
Excipients
: macrogol glyceryl hydroxystearate - 75 mg, colloidal silicon dioxide - 20 mg, solid fat - up to 1.5 g.
1 PC. — cellular contour packages (1) — cardboard packs. 1 PC. — contour cell packaging (2) — cardboard packs. 1 PC. — cellular contour packages (3) — cardboard packs. 1 PC. — contour cell packaging (4) — cardboard packs. 1 PC. — contour cell packaging (5) — cardboard packs. 1 PC. — contour cell packaging (6) — cardboard packs. 1 PC. — contour cell packaging (7) — cardboard packs. 1 PC. — contour cell packaging (8) — cardboard packs. 1 PC. — contour cell packaging (9) — cardboard packs. 1 PC. — contour cell packaging (10) — cardboard packs. 2 pcs. — cellular contour packages (1) — cardboard packs. 2 pcs. — contour cell packaging (2) — cardboard packs. 2 pcs. — cellular contour packages (3) — cardboard packs. 2 pcs. — contour cell packaging (4) — cardboard packs. 2 pcs. — contour cell packaging (5) — cardboard packs. 2 pcs. — contour cell packaging (6) — cardboard packs. 2 pcs. — contour cell packaging (7) — cardboard packs. 2 pcs. — contour cell packaging (8) — cardboard packs. 2 pcs. — contour cell packaging (9) — cardboard packs. 2 pcs. — contour cell packaging (10) — cardboard packs. 3 pcs. — cellular contour packages (1) — cardboard packs. 3 pcs. — contour cell packaging (2) — cardboard packs. 3 pcs. — cellular contour packages (3) — cardboard packs. 3 pcs. — contour cell packaging (4) — cardboard packs. 3 pcs. — contour cell packaging (5) — cardboard packs. 3 pcs. — contour cell packaging (6) — cardboard packs. 3 pcs. — contour cell packaging (7) — cardboard packs. 3 pcs. — contour cell packaging (8) — cardboard packs. 3 pcs. — contour cell packaging (9) — cardboard packs. 3 pcs. — contour cell packaging (10) — cardboard packs. 4 things. — cellular contour packages (1) — cardboard packs. 4 things. — contour cell packaging (2) — cardboard packs. 4 things. — cellular contour packages (3) — cardboard packs. 4 things. — contour cell packaging (4) — cardboard packs. 4 things. — contour cell packaging (5) — cardboard packs. 4 things. — contour cell packaging (6) — cardboard packs. 4 things. — contour cell packaging (7) — cardboard packs. 4 things. — contour cell packaging (8) — cardboard packs. 4 things. — contour cell packaging (9) — cardboard packs. 4 things. — contour cell packaging (10) — cardboard packs. 5 pieces. — cellular contour packages (1) — cardboard packs. 5 pieces. — contour cell packaging (2) — cardboard packs. 5 pieces. — cellular contour packages (3) — cardboard packs. 5 pieces. — contour cell packaging (4) — cardboard packs. 5 pieces. — contour cell packaging (5) — cardboard packs. 5 pieces. — contour cell packaging (6) — cardboard packs. 5 pieces. — contour cell packaging (7) — cardboard packs. 5 pieces. — contour cell packaging (8) — cardboard packs. 5 pieces. — contour cell packaging (9) — cardboard packs. 5 pieces. — contour cell packaging (10) — cardboard packs. 6 pcs. — cellular contour packages (1) — cardboard packs. 6 pcs. — contour cell packaging (2) — cardboard packs. 6 pcs. — cellular contour packages (3) — cardboard 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packs. 8 pcs. — contour cell packaging (2) — cardboard packs. 8 pcs. — cellular contour packages (3) — cardboard packs. 8 pcs. — contour cell packaging (4) — cardboard packs. 8 pcs. — contour cell packaging (5) — cardboard packs. 8 pcs. — contour cell packaging (6) — cardboard packs. 8 pcs. — contour cell packaging (7) — cardboard packs. 8 pcs. — contour cell packaging (8) — cardboard packs. 8 pcs. — contour cell packaging (9) — cardboard packs. 8 pcs. — contour cell packaging (10) — cardboard packs. 9 pcs. — cellular contour packages (1) — cardboard packs. 9 pcs. — contour cell packaging (2) — cardboard packs. 9 pcs. — cellular contour packages (3) — cardboard packs. 9 pcs. — contour cell packaging (4) — cardboard packs. 9 pcs. — contour cell packaging (5) — cardboard packs. 9 pcs. — contour cell packaging (6) — cardboard packs. 9 pcs. — contour cell packaging (7) — cardboard packs. 9 pcs. — contour cell packaging (8) — cardboard packs. 9 pcs. — contour cell packaging (9) — cardboard packs. 9 pcs. — contour cell packaging (10) — cardboard packs. 10 pieces. — cellular contour packages (1) — cardboard packs. 10 pieces. — contour cell packaging (2) — cardboard packs. 10 pieces. — cellular contour packages (3) — cardboard packs. 10 pieces. — contour cell packaging (4) — cardboard packs. 10 pieces. — contour cell packaging (5) — cardboard packs. 10 pieces. — contour cell packaging (6) — cardboard packs. 10 pieces. — contour cell packaging (7) — cardboard packs. 10 pieces. — contour cell packaging (8) — cardboard packs. 10 pieces. — contour cell packaging (9) — cardboard packs. 10 pieces. — contour cell packaging (10) — cardboard packs.
Indications
For oral administration: treatment and prevention of non-invasive intestinal candidiasis (including after taking antibiotics, cytostatics, corticosteroids).
For external and local use: infections of the skin and mucous membranes caused by Candida or other sensitive yeasts, yeast-like fungi or dermatophytes (including balanoposthitis, otomycosis).
For intravaginal use: vulvovaginal candidiasis.
Contraindications for use
Hypersensitivity to natamycin.
pharmachologic effect
Antifungal polyene antibiotic of the macrolide group, has a wide spectrum of antifungal action. Has a fungicidal effect. Natamycin binds sterols of cell membranes, disrupting their integrity and functions, which leads to the death of microorganisms. Sensitive to natamycin
most pathogenic yeasts, especially Candida albicans.
are less sensitive
to natamycin.
Resistance to natamycin has not been observed in clinical practice.
Dosage regimen
When taken orally, a single dose is 100 mg. The frequency of administration for adults is 4 times a day, for children - 2 times a day.
Externally and locally applied 1 time or several times a day.
Intravaginally - 1 time/day at night for 3-6 days.
The duration of the course of treatment is determined individually. After the symptoms of the disease disappear, it is recommended to continue treatment for several more days.
Side effect
From the digestive system:
Nausea and diarrhea are possible (occur in the first days when taken orally and go away on their own during treatment).
Local reactions:
mild irritation and burning sensation are possible.
special instructions
In case of chronic or recurrent infection, local treatment can be supplemented with systemic use.
During menstruation, natamycin is not used intravaginally.
When used intravaginally, there is no need to avoid sexual intercourse. However, it is recommended to examine sexual partners and, if candidiasis is detected, to conduct a course of treatment with natamycin. Also during the treatment period you should use barrier contraception.
Natamycin can be prescribed to newborns.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - No restrictions. Restrictions when breastfeeding - No restrictions.
Can be used during pregnancy and lactation according to indications in recommended doses.
Use in children
Restrictions for children - No restrictions.
Natamycin can be prescribed to newborns.
Natamycin sup vag 100 mg No. 3
Compound
Active substance: natamycin - 100 mg.
Excipients: macrogol glyceryl hydroxystearate - 75 mg, colloidal silicon dioxide - 20 mg, solid fat - to obtain a suppository weighing 1.5 g.
Pharmacokinetics
Natamycin is practically not absorbed from the vaginal mucosa and does not have a systemic effect.
Indications for use
Vaginitis, vulvitis, vulvovaginitis caused by fungi of the genus Candida.
Contraindications
Hypersensitivity to the components of the drug.
With caution: no special precautions are required when using the drug.
Directions for use and doses
Intravaginally.
Suppositories, having previously been freed from the contour packaging, while in a lying position, are inserted into the vagina as deeply as possible 1 time per day at night for 3-6 days.
The duration of the course is individual.
If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor. Use the drug only according to the indications, the method of use and in the doses indicated in the instructions for use.
Storage conditions
In a place protected from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Best before date
2 years. Do not use after expiration date.
special instructions
During vaginal application, under the influence of body temperature, the suppositories turn into a foamy mass, which facilitates the uniform distribution of natamycin throughout the vaginal mucosa.
During the treatment period, there is no need to exclude sexual contacts, however, it is recommended to examine sexual partners and, if candidal lesions are detected, undergo a course of treatment with natamycin. During treatment, barrier methods of contraception should be used.
In case of chronic or recurrent infection, local treatment can be supplemented by the administration of natamycin in the form of tablets for oral administration to sanitize the focus of candidal infection in the intestine. If clinical signs of infection persist after completion of treatment, repeat microbiological testing should be performed to confirm the diagnosis.
When treating vaginal infections, the drug should not be used during menstruation; it is advisable to start treatment after menstruation.
When using the drug during pregnancy, you should not use the applicator.
Description
Antifungal agent.
Pharmacodynamics
Mechanism of action
Natamycin is an antifungal polyene antibiotic from the macrolide group with a wide spectrum of action. Has a fungicidal effect. Binds to sterols of cell membranes, disrupting their integrity and functions, which leads to the death of microorganisms.
Active against most pathogenic yeast-like fungi (especially Candida albicans), yeast (Torulopsis and Rhodotorula), as well as other pathogenic fungi (Aspergillus, Penicillium). Less active against dermatophytes (Trichophyton, Microsporum, Epidermophyton).
Sensitivity in vitro
Does not affect gram-positive and gram-negative bacteria in vitro.
Resistance
Resistance to natamycin does not occur in clinical practice.
Side effects
When applied topically, mild irritation and a burning sensation at the injection site may occur.
If you experience the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
Use during pregnancy and breastfeeding
The drug can be used in pregnant women and during breastfeeding.
Interaction
Drug interactions between Natamycin and other drugs have not been described.
Overdose
To date, no cases of drug overdose have been reported.
Impact on the ability to drive vehicles and operate machinery
The use of the drug does not affect the ability to drive vehicles and machinery.
