Genferon light 250000IU sup.vagin/rect.No.10
Indications
- as part of complex therapy for the treatment of acute respiratory viral infections and other infectious diseases of bacterial and viral etiology in children;
- for the treatment of infectious and inflammatory diseases of the urogenital tract in children and women, incl. pregnant women.
pharmachologic effect
The drug contains recombinant human interferon alpha-2b, produced by a strain of the bacterium Escherichia coli, into which the human interferon alpha-2b gene has been introduced using genetic engineering methods.
Interferon alpha-2b has antiviral, immunomodulatory, antiproliferative and antibacterial effects. The antiviral effect is mediated by the activation of a number of intracellular enzymes that inhibit viral replication. The immunomodulatory effect is manifested, first of all, by enhancing cell-mediated reactions of the immune system, which increases the effectiveness of the immune response against viruses, intracellular parasites and cells that have undergone tumor transformation. This is achieved through the activation of CD8+ T killer cells, NK cells (natural killer cells), increased differentiation of B lymphocytes and their production of antibodies, activation of the monocyte-macrophage system and phagocytosis, as well as increased expression of molecules of the major histocompatibility complex type I, which increases the likelihood recognition of infected cells by cells of the immune system. Activation under the influence of interferon of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of pathological foci; in addition, due to the influence of interferon, restoration of the production of secretory immunoglobulin A is achieved. The antibacterial effect is mediated by reactions of the immune system, enhanced under the influence of interferon.
Taurine helps normalize metabolic processes and tissue regeneration, has membrane-stabilizing and immunomodulatory effects. Being a strong antioxidant, taurine directly interacts with reactive oxygen species, the excessive accumulation of which contributes to the development of pathological processes. Taurine helps maintain the biological activity of interferon, enhancing the therapeutic effect of the drug.
Drug interactions
When combined with antibacterial, fungicidal and antiviral drugs, mutual potentiation of action is observed, which makes it possible to achieve a high total therapeutic effect.
Dosage regimen
Use vaginally and rectally. The route of administration, dose and course duration depend on age, the specific clinical situation and are determined by the attending physician.
In adults and children over 7 years of age, use a dose of 250,000 IU of interferon alfa-2b per suppository. In children under 7 years of age, it is safe to use a dose of 125,000 IU of interferon alfa-2b per suppository. In women who are 13-40 weeks pregnant , a dose of 250,000 IU of interferon alfa-2b is used per suppository.
Recommended dosages and treatment regimens
Acute respiratory viral infections and other acute diseases of a viral nature in children: 1 suppository rectally 2 times a day with a 12-hour interval parallel to the main therapy for 5 days. If symptoms persist, the course of treatment is repeated after a 5-day interval.
Chronic infectious and inflammatory diseases of viral etiology in children: 1 suppository rectally 2 times a day with a 12-hour interval parallel to standard therapy for 10 days. Then for 1-3 months - 1 suppository rectally at night every other day.
Acute infectious and inflammatory diseases of the urogenital tract in children: 1 suppository rectally 2 times a day with a 12-hour interval for 10 days.
Infectious and inflammatory diseases of the urogenital tract in pregnant women: 1 suppository vaginally 2 times a day with a 12-hour interval for 10 days.
Infectious and inflammatory diseases of the urogenital tract in women: 1 suppository (250,000 IU) vaginally or rectally (depending on the nature of the disease) 2 times a day with a 12-hour interval for 10 days. For prolonged forms, 1 suppository 3 times a week, every other day, for 1-3 months.
Contraindications for use
- individual intolerance to interferon and other substances included in the drug;
- I trimester of pregnancy.
With caution: exacerbation of allergic and autoimmune diseases.
Use in children
Use according to indications.
Restrictions for children
Possible use
Use during pregnancy and breastfeeding
Clinical studies have proven the effectiveness and safety of use in women at 13-40 weeks of pregnancy. Use in the first trimester of pregnancy is contraindicated.
There are no restrictions for use during lactation.
Restrictions when breastfeeding
Possible use
Restrictions during pregnancy
Use with caution
special instructions
Impact on the ability to drive vehicles and machinery
Does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving vehicles, machinery, etc.).
Side effect
Local allergic reactions (itching and burning sensation in the vagina) are possible. These phenomena are reversible and disappear within 72 hours after cessation of administration. Continuation of treatment is possible after consultation with a doctor.
To date, no severe or life-threatening side effects have been observed. Phenomena that occur with the use of all types of interferon alfa-2b, such as chills, fever, fatigue, loss of appetite, muscle and headaches, joint pain, sweating, as well as leukemia and thrombocytopenia, may be observed, but they occur more often when exceeding daily dose over 10,000,000 IU. In these cases, it is recommended to consult your doctor to decide whether to discontinue the drug or reduce the dose.
Possible product names
- Genferon light 250000IU supp. No. 10
- GENFERON LIGHT 250,000 IU SUPPOZ. No. 10
- GENFERON LIGHT 250000ME+0.005 N10 SUPP
- GENFERON LIGHT SOUP VAGIN AND RECT. 250000 IU+5MG. X10
- GENFERON LIGHT SOUP. VAG. AND REKT. 250000IU No. 10
- GENFERON LIGHT 250000IU+5MG SUPP. VAG. AND REKT. X10
- (Genferone Ligxt) Genferon light 250000IU supp. No. 10
Genferon, 10 pcs., 1,000,000 IU+10 mg+55 mg, vaginal and rectal suppositories
Immunobiological properties
Genferon® is a combination drug, the effect of which is determined by the components included in its composition. Has local and systemic effects.
The composition of the drug Genferon® includes recombinant human interferon alpha-2b, produced by a strain of the bacterium Escherichia coli,
into which the human interferon alpha-2b gene was introduced using genetic engineering methods.
Interferon alpha-2b
has antiviral, immunomodulatory, antiproliferative and antibacterial effects. The antiviral effect is mediated by the activation of a number of intracellular enzymes that inhibit viral replication. The immunomodulatory effect is manifested primarily by an increase in cell-mediated reactions of the immune system, which increases the effectiveness of the immune response against viruses, intracellular parasites and cells that have undergone tumor transformation. This is achieved through the activation of CD8+ T killer cells, NK cells (natural killer cells), increased differentiation of B lymphocytes and their production of antibodies, activation of the monocyte-macrophage system and phagocytosis, as well as increased expression of molecules of the major histocompatibility complex type I, which increases the likelihood recognition of infected cells by cells of the immune system. Activation under the influence of interferon of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of pathological foci; in addition, due to the influence of interferon, the production of secretory IgA is restored. The antibacterial effect is mediated by immune system reactions enhanced by interferon.
Taurine
promotes the normalization of metabolic processes and tissue regeneration, has membrane-stabilizing and immunomodulatory effects. Being a strong antioxidant, taurine directly interacts with reactive oxygen species, the excessive accumulation of which contributes to the development of pathological processes. Taurine helps maintain the biological activity of interferon, enhancing the therapeutic effect of the drug.
Benzocaine (anesthetic)
is a local anesthetic. Reduces the permeability of the cell membrane to sodium ions, displaces calcium ions from receptors located on the inner surface of the membrane, and blocks the conduction of nerve impulses. Prevents the occurrence of pain impulses at the endings of sensory nerves and their conduction along nerve fibers. It has an exclusively local effect, without being absorbed into the systemic circulation.
Genferon light vaginal/rectal suppositories 250t IU No. 10
Genferon light vaginal/rectal suppositories 250t IU No. 10
Genferon Light Buy Genferon Light in pharmacies
DOSAGE FORMS suppositories for vaginal or rectal administration 250000IU+5mg
MANUFACTURERS Biocad CJSC (Russia)
GROUP Antiviral - interferons
COMPOSITION Interferon alpha-2b, taurine.
INTERNATIONAL NON-PROPENTED NAME Interferon alpha-2b+Taurine
PHARMACOLOGICAL ACTION Has local and systemic effects. The drug contains recombinant human interferon alpha-2b. Interferon alpha-2b has antiviral, immunomodulatory, antiproliferative and antibacterial effects. The immunomodulatory effect is manifested, first of all, by enhancing cell-mediated reactions of the immune system, which increases the effectiveness of the immune response against viruses, intracellular parasites and cells that have undergone tumor transformation. Activation under the influence of interferon of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of pathological foci; in addition, due to the influence of interferon, restoration of the production of secretory immunoglobulin A is achieved. The antibacterial effect is mediated by reactions of the immune system, enhanced under the influence of interferon. Taurine helps normalize metabolic processes and tissue regeneration, has membrane-stabilizing and immunomodulatory effects. Taurine helps maintain the biological activity of interferon, enhancing the therapeutic effect of the drug. With rectal administration of the drug, high bioavailability of interferon is observed, and therefore both local and pronounced systemic immunomodulatory effects are achieved; when used intravaginally, due to the high concentration at the site of infection and fixation on the cells of the mucous membrane, a pronounced local antiviral, antiproliferative and antibacterial effect is achieved, while the systemic effect is insignificant due to the low absorption capacity of the vaginal mucosa. The maximum concentration of interferon in the blood serum is achieved 5 hours after administration of the drug. The main route of elimination of β-interferon is renal catabolism. The half-life is 12 hours, which necessitates the use of the drug 2 times a day.
INDICATIONS FOR USE For the treatment of infectious and inflammatory diseases of the urogenital tract in children and women, including pregnant women. As a component of complex therapy - for the treatment of other infectious diseases of viral etiology.
CONTRAINDICATIONS Individual intolerance to interferon and other substances included in the drug. With caution: Exacerbation of allergic and autoimmune diseases. Use during pregnancy and lactation: Clinical studies have proven the effectiveness and safety of using the drug in the second and third trimesters of pregnancy. The safety of using the drug in the first trimester of pregnancy has not been studied.
SIDE EFFECTS Local allergic reactions (itching and burning sensation in the vagina). These phenomena are reversible and disappear within 72 hours after cessation of administration. Continuation of treatment is possible after consultation with a doctor. Phenomena that occur with the use of all types of interferon alfa-2b may be observed, such as chills, fever, fatigue, loss of appetite, muscle and headaches, joint pain, sweating, as well as leukemia and thrombocytopenia. In these cases, it is recommended to consult your doctor to decide whether to discontinue the drug or reduce the dose.
INTERACTION The drug is most effective as a component of complex therapy. When combined with antibacterial, fungicidal and antiviral drugs, mutual potentiation of action is observed, which makes it possible to achieve a high total therapeutic effect
METHOD OF APPLICATION AND DOSAGE The drug can be used both vaginally and rectally. The method of administration, dosage and course duration depend on age, the specific clinical situation and are determined by the attending physician.
OVERDOSE In case of accidental simultaneous administration of more suppositories than prescribed by the doctor, further administration should be suspended for 24 hours, after which treatment can be resumed according to the prescribed regimen.
SPECIAL INSTRUCTIONS The drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving vehicles, machinery, etc.).
STORAGE CONDITIONS Store at a temperature of 2 to 8 degrees. C. Keep out of the reach of children.
