Dalatsin 100 mg 3 pcs. vaginal suppositories

Dalatsin 100 mg 3 pcs. vaginal suppositories

pharmachologic effect

Antibiotic of the lincosamide group for topical use.
Clindamycin phosphate is not active in vitro, but is rapidly hydrolyzed in vivo to form clindamycin, which has antibacterial activity. Clindamycin inhibits protein synthesis in microbial cells due to interaction with the 50S ribosomal subunit.

In vitro, the following microorganisms that cause bacterial vaginosis are sensitive to clindamycin: Gardnerella vaginalis, Mobiluncus spp., Mycoplasma hominis, Bacteroides spp., Peptostreptococcus spp.

Composition and release form Dalatsin 100 mg 3 pcs. vaginal suppositories

Vaginal suppositories are solid, torpedo-shaped, with a smooth surface, white or almost white.

1 sup.:

• Active substance: clindamycin (in phosphate form) - 100 mg;
• Excipients: solid fat (Witepsol H-32, a mixture of triglycerides, diglycerides and monoglycerides) - about 2.4 g.

3 pcs. — strips made of laminated foil — cardboard packs.

3 pcs. — strips made of laminated foil complete with an applicator — cardboard packs.

Directions for use and doses

The recommended dose is 1 suppository intravaginally, preferably at bedtime, for 3 consecutive days.

Pharmacokinetics

Suction

After using clindamycin intravaginally at a dose of 100 mg 1 time / day (in the form of suppositories) for 3 days, approximately 30% (6-70%) of the administered dose of clindamycin is absorbed into the systemic circulation, with an AUC of 3.2 mcg / h / ml (0.42 -11 mcg/h/ml). Cmax in the blood serum is achieved approximately 5 hours (1-10 hours) after administration of the vaginal suppository and averages 0.27 mcg/ml (0.03-0.67 mcg/ml) on the 3rd day of therapy.

The systemic effect of clindamycin when administered intravaginally is significantly weaker than when administered in therapeutic doses orally or intravenously.

Removal

On average, T1/2 is 11 hours (4-35 hours).

Pharmacokinetics in special groups of patients

Clinical studies of clindamycin vaginal suppositories included insufficient numbers of patients aged 65 years and older to evaluate the difference in clinical response to therapy between this age group and younger patients.

Indications for use Dalatsin 100 mg 3 pcs. vaginal suppositories

Bacterial vaginosis.

Contraindications

• hypersensitivity to clindamycin, lincomycin or any component of the drug;
• history of antibiotic-associated colitis;
• age under 18 years (data on safety and effectiveness are not available).

Application of Dalacin 100 mg 3 pcs. vaginal suppositories during pregnancy and breastfeeding

When clindamycin was used intravaginally in the second or third trimester of pregnancy, no increase in the incidence of congenital anomalies of the fetus was observed. If Dalatsin® vaginal suppositories are used during the second or third trimesters of pregnancy (although no official studies have been conducted on the use of suppositories in pregnant women), then an adverse effect on the fetus seems unlikely. The use of the drug in the II-III trimester of pregnancy is possible if the potential benefit to the mother outweighs the risk to the fetus.

There have been no adequate controlled studies on the use of the drug in the first trimester of pregnancy, therefore Dalatsin® vaginal suppositories can be prescribed to women in the first trimester of pregnancy only for absolute indications, i.e. when the potential benefit of drug therapy outweighs the potential risk to the fetus.

In animal studies, when clindamycin was administered subcutaneously or orally, no negative effects on the fetus were found, except when the drug was taken in doses toxic to the mother.

It is unknown whether clindamycin is excreted in breast milk after intravaginal use. Clindamycin is found in breast milk after oral or parenteral administration, therefore, during breastfeeding, the drug should either be discontinued or breastfeeding should be discontinued, taking into account the importance of the drug for the mother.

The use of the drug is contraindicated in people under 18 years of age (data on safety and effectiveness are lacking).

special instructions

Before prescribing the drug, vulvovaginitis caused by Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, Candida albicans and the Herpes simplex virus should be excluded using appropriate laboratory methods.

Intravaginal use of clindamycin may lead to increased growth of nonsusceptible microorganisms, especially yeast-like fungi.

The use of clindamycin (like almost all antibiotics) orally or parenterally is associated with the development of severe diarrhea and, in some cases, pseudomembranous colitis. If severe or prolonged diarrhea develops, the drug should be discontinued and, if necessary, appropriate diagnostic and therapeutic measures should be taken.

Patients should be warned that during drug therapy they should avoid sexual intercourse, as well as the use of other means for intravaginal administration (tampons, douching).

The drug contains components that can reduce the strength of latex or rubber products (condoms, contraceptive vaginal diaphragms). Therefore, the use of such products during treatment with Dalatsin and within 72 hours after use is not recommended.

The use of Dalatsin® vaginal suppositories during menstruation is not recommended. The initiation of therapy should be delayed until after menstruation.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive vehicles or engage in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Overdose

With intravaginal use of Dalacin® suppositories, absorption of clindamycin is possible in quantities sufficient to cause systemic reactions.

Accidental exposure of the drug to the gastrointestinal tract may cause systemic effects similar to those that occur after oral administration of clindamycin in therapeutic doses. Possible systemic side effects include diarrhea, hemorrhagic diarrhea, including pseudomembranous colitis.

Treatment: symptomatic and supportive therapy.

Side effects Dalacin 100 mg 3 pcs. vaginal suppositories

The safety of clindamycin in the form of vaginal suppositories was assessed in non-pregnant women.

Table. Adverse drug reactions

Drug interactions

There is cross-resistance between clindamycin and lincomycin.

Antagonism between clindamycin and erythromycin has been demonstrated in vitro.

It has been established that clindamycin disrupts neuromuscular transmission and, therefore, can enhance the effect of peripherally acting muscle relaxants, so the drug should be used with caution in patients receiving drugs of this group.

Since there is no information on use with other drugs for intravaginal administration, combined use of the drug with other intravaginal drugs is not recommended.

Antibiotic Dalatsin Suppositories 100 mg - reviews

Yagadinochka
https://irecommend.ru/content/mne-pomog-na-100-no-byl-odin-pobochnyi-effekt

I haven’t written anything for a long time, but I want to share information about the drug. These suppositories were prescribed to me by the head of the housing complex, after I visited many doctors, none of whom paid attention to my complaint. And my main complaint was that I was bothered by heavy discharge; it was not critical, but it caused inconvenience. I took a lot of tests, but out of all of them, the only abnormality was shown by a smear in the form of a slight inflammation. I even began to think that such discharge is the norm. But finally at least one doctor paid attention to my problem and prescribed me these suppositories for a course of 3 days, and after them lactagel was prescribed to restore the microflora. You should not neglect the means to restore the microflora; tactics, dalacin is an antibiotic, it kills everything, and after it you need to populate the body with beneficial bacteria.

I noticed the effect after Dalacin the very next day, my discharge noticeably decreased. I didn’t have any unpleasant sensations; in the morning the remains of the candle leaked a little, but this is the norm for any candle.

The only unpleasant thing that I don’t consider is a minus, because... Dalacin is an antibiotic; on the fourth day after using the suppositories, a side effect began in the form of diarrhea. This lasted almost a week. Probiotics will help, there’s nothing you can do about it. But after Dalacin and Lactagel, I forgot about my problem.

Vitti

https://irecommend.ru/content/chto-mozhet-byt-priyatnee-svechei-pobochnye-deistviya

Local antibiotic. I was prescribed a gynecologist, I don’t know the diagnosis, I know that there was some kind of inflammation.

There are 3 pieces in the package, I needed 6, these candles cost about 600 rubles, which in my opinion is not little.

In addition to the candles in the package there is a stick-insert) I did not use it, because... I think it’s not hygienic to stand three candles with one stick for three days, after all, this is an intimate area...

The candles themselves are well packaged and difficult to remove) this has the plus of sterility and the minus of the possibility of breaking the candle.

Like all antibiotics, it has the property of killing all bacteria, both harmful and beneficial! After the second suppository, I was overtaken by an upset stomach or intestines... so I underwent treatment and went on a diet) so after the course of treatment it is necessary to restore the flora with the help (unfortunately) of other suppositories... Also, from the entire list of side effects (by the way, it’s not small), I was affected by acne, and on my back and buns... I’ve never had this before...

I used Lactozhenal for 10 days, it just so happens that in order to spoil something you need less time... to restore it much more... (they need to be stored in the refrigerator). Also, if you have a need for candles, then buy a daily diet at the same time, no one warned me... And it turned out that on the second day I went to the pharmacy not only for goodies to help the intestines, but also tried to feel the sensations from this treatment... Personally, I felt a little burning and something ached, I suspect it was the kidneys... Since it hit the intestines, it also hit the kidneys.

And all these torments are dwarfed by the fact that it is impossible to have intercourse (((14 days without coitus, but then complete pleasure without problems.

This drug did its job! But there were side effects ((I had to get rid of them for about a week...

al1-11

https://otzovik.com/review_2058570.html

Advantages:

efficiency

Flaws:

antibiotic

I have never bought vaginal cream in order to fight thrush and various types of candida, I fought with the help of tablets and vaginal suppositories. But recently the gynecologist suggested trying this one. And although I had no complaints, she said that there was some small discharge, and it was better to remove it, and this particular cream Dalacin 2% was very effective. I bought it. It is available with a prescription, but if it weren’t for the discount from the health insurance company, it would even be very expensive, but it cost 600 rubles :-) In addition to the tube of cream, the package also contains 7 applicators, with the help of which the cream is inserted into the vagina. Since this is an antibiotic, it is recommended to take it all days in a row, from 3 to 7 days, as needed, the doctor says. It is better not to take it during menstruation, as it is not as effective. Personally, the cream helped me remove discharge, and I was satisfied. After use, there was a slight discomfort in the lower abdomen, but it quickly passed. I will definitely recommend it to others, the only thing you need to do is consult a doctor before using it.

Lada

https://zhivizdorovim.ru/lekarstva/antibiotik/756-dalatsin.html

I had bacterial vaginosis. I tried to be treated with Dalacin, but it seemed okay. But when a relapse began a month later, the doctor prescribed vaginal Metrogyl. This is where I felt the difference, all the unpleasant phenomena passed very quickly. Since then I haven’t had vaginosis again, pah-pah!

ZS

https://flap.rf/Medicine/Suppositories_Dalacin/Reviews/7277652

but there are side effects.

Before the operation, I took a lot of tests, no matter what laboratories I visited. I came to my gynecologist with the results, and after looking at them, she said that the smear was not very clean, so she prescribed treatment so that everything would be clean before the operation. Prescribed me with Dalatsin suppositories

and said that this drug copes well with various infections, including bacterial vaginitis.
Dalatsin candles
are quite expensive; I paid about 600 rubles for 3 candles. The package also contains an applicator that is used to insert the suppository, but I did without this auxiliary tool.

Candles "Dalacin"

are considered an antibiotic, and therefore have a bacteriostatic effect. The candles are odorless and convenient to use, as they do not melt on your hands and are quite solid. After the first dose, I did not feel anything, but after the second and third, symptoms of side effects appeared, which were described in the instructions. I developed nausea, flatulence and bad breath or some kind of taste in my mouth. After 3-4 days all this passed, so for the sake of the result you can be patient.

Candles "Dalacin"

I recommend it because he coped with the main task perfectly. And having taken the tests again, they found nothing, everything was clean.