Types of local anesthesia: ointment, gel, cream, spray
Bibliography
1 GRLS, r/u LP-004175 dated 03/03/2017
2 Certificate GMP-0036-000221/18
3 Greveling K, Prens EP, Ten Bosch N, van Doorn MB. Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials. Br J Dermatol. 2016 Jul 5. doi:10.1111/bjd.14848 Hernandez E.;
4 J. Cassuto, R. Sinclair, M. Bonderovic, Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand 2006; 50; 265-282]
5 Based on IQVIA report March 2022 - September 2022
6 Russian medical journal. Zhigultsova T.I., Parkaeva L.V., Ilyina E.E., Vissarionov V.A.: “Experience of using 5% Emla cream in the practice of dermatocosmetologists”
7 Instructions for use of the medicinal product for medical use Acriol Pro
8 T.N. Calvey, N.E. Williams. Pharmacology for anesthesiologists. Publishing house Binom, Moscow, 2007, 119-128
9 Based on the report “Anesthetics in injection cosmetology for 2016” Vademecum Analytical Center for sales volume.
10 T.I. Zhigultsova, Ph.D. L.V. Parkaeva, E.E. Ilyina, professor V.A. Vissarionov: “Experience of using 5% Emla cream in the practice of dermatocosmetologists” Cosmetology and plastic surgery. Vol. 16, No. 9, 2008
11 On the Russian market there are so-called cosmetic products containing lidocaine and not registered as medicines
12 Cling film can be used as an occlusive dressing
13 Drug Release Studies on an Oil-Water Emulsion Based on a Eutectic Mixture of Lidocaine and Prilocaine as the Dispersed Phase
14 Federal Law-61 “On the Circulation of Medicines” dated April 12, 2010, Federal Law-323 “On the Fundamentals of Protecting the Health of Citizens in the Russian Federation” dated November 21, 2011 and Federal Law-532 “On Amendments to Certain Legislative Acts of the Russian Federation Regarding Counteraction to Trafficking falsified, counterfeit, substandard and unregistered medicines, medical devices and counterfeit dietary supplements" dated December 31, 2014.
15 Federal Law-532, Technical Regulations of the Customs Union on the safety of perfumery and cosmetic products, Federal Law 61, Federal Law 532, Criminal Code of the Russian Federation, Art. 235, 238, 227
16 V.V. Osipova.MMA named after. I.M. Sechenov. Psychological aspects of pain. Lecture. №1/2010
17 According to GMP News. Analysis of the market for local anesthetics used in cosmetic injections in 2022.
18 One type of occlusive dressing, namely: bandage, cling film, adhesive tape or rubberized fabric
19 The combination of lidocaine and prilocaine in concentrations above 0.5-2% has bactericidal and antiviral properties. In Akriol Pro the concentration is 5%.
20 A.A. Stepanov, G.V. Yatsyk, L.S. Namazova Method of preventing pain in young children during vaccination // Into the practice of pediatricians - 09.14.2006 -
21 N.V. Klipinina, RMJ, Some features of the perception and experience of pain by children: a psychologist’s view, reprint. 2007.1-7
22 E.A. Ranneva. The use of EMLA® cream in the complex correction of cosmetic imperfections. Experimental and clinical dermatocosmetology 2010, No. 2: 48-53.
23 Gonzalez S. Evaluation of Topical Anesthetics by Laser-Induced Sensation. Lasers in Surgery and Medicine 23:167–171(1998));
24 V.G. Lebedyuk et al. Anesthesia in dermatocosmetology. Experimental and clinical dermatocosmetology, 2010 No. 5
25 Meltem F. Söyleva Nilüfer Koçaka Bahar Kuvakia Seyhan B. Özkanb Erkin Ki˙rb; Anesthesia with Cream for Botulinum A Toxin Injection into Eyelids. Ophthalmologica 2002;216:355–358
26 E.V. Matuszewska and authors. Topical local anesthetics in cosmetology. Clinical Dermatology and Venereology. 03.2017 pp. 89-96
27 Therapeutics and Clinical Risk Management 2006:2(1) 99 – 113
28 F. Michael Ferrante, Timothy R. Wade Bopcore Postoperative Pain. Management. Per. from English/Ed. M.: Medicine, 1998.- 640 pp., p. 243
29 Lakhin R.E. Local anesthetics. Department of Anesthesiology and Reanimatology of the Military Medical Academy named after. S.M.Kirova, St. Petersburg, 2013, Committee on Ultrasound Technologies of the All-Russian public organization “Federation of Anesthesiologists and Resuscitators.” Clinical guidelines “Intensive therapy for systemic toxicity with local anesthetics. Moscow - St. Petersburg 2015 Page. 10 https://www.far.org.ru/recomendation
30 Wetter DA et al. J American Acad. Dermatol. 2010;63(5):789-98
31 https://www.1nep.ru/articles/issledovanie-sostava-populyarnykh-mestnykh-anestetikov/
32 ORDER OF THE MINISTRY OF HEALTH OF THE RUSSIA dated 08.10.2015 No. 707n
33 Davydov O.S. Peripheral and central mechanisms of the transition of acute pain to chronic pain and the possible role of cyclooxygenase 2 inhibition in the prevention of chronic pain syndrome. Neurology, neuropsychiatry, psychosomatics. 2016;8(2):10-16.
34 J. ALASTAIR CARRUTHERS, MD, JEAN DA CARRUTHERS, MD. Safety of Lidocaine 15% and Prilocaine 5% Topical Ointment Used as Local Anesthesia for Intense Pulsed Light Treatment. Dermatologic Surgery 2010;36:1130–1137
35 Ya-Xian et al. The number of cells in the stratum corneum of normal skin depending on the anatomical location on the body, age, gender and physical parameters Archives Dermatol Res 1999; 291:555–559.
36 J. Morgan, Magid S. Michael. Clinical anesthesiology, Book 1. Binomial. Moscow St. Petersburg, 2001
37 Arendt-Nielsen L, Bjerring P, Nielsen J. Acta Derm Venereol 1990;70:314-318
38 Belarusian State Medical University. 2nd Department of Therapeutic Dentistry. Therapeutic dentistry. Part 1. Ed. A.G. Tretyakovich, L.G. Borisenko.
39 Dermatol Surg 1999;25:950-954
40 K. Greveling et al. Br J Dermatol 176(1), 81-86. 2016 Dec 10
41 Juhlin and Evers Adv Dermatol 1990;5:75-92
42 Arendt-Nielsen L, Bjerring P, Nielsen J. Acta Derm Venereol 1990;70:314-318
43 Study Desensor 001. Wahlgren CF, Quiding H. J Am Acad Dermatol 2000;42:584-8.
44 https://www.1nep.ru/estetic/articles/13952/
45 Guide to dermatocosmetology, edited by E.R. Arabia and E.V. Sokolovsky. St. Petersburg: Foliant Publishing House LLC, 2008 - 632 pp.
46 https://www.1nep.ru/estetic/articles/132197/
47 https://medside.ru/dikain
48 https://medi.ru/instrukciya/novokain_9473/
49 https://medside.ru/anestezin
50 https://grls.rosminzdrav.ru/Default.aspx
51 Radman et al.2002, Yamashita., 2003
52 https://www.krasotaimedicina.ru/diseases/hematologic/methemoglobinemia
53 Evers H, Scott B, Dahlquist AC. Dermal analgesia after epicutaneous application of 5% cream, 5% prilocaine cream, 5% lidocaine cream and placebo cream, to volunteers. Study 89EM03 (n= 21, cross-over). CSR 802-10AC088-2,1989.
54 MASMI. A study of users of skin anesthetics. June 2018
55 O.M. Burylina, A.V. Karpova. Cosmetology. Clinical guidelines. GEOTAR-Media. Moscow, 2018
56 Postoperative pain: the role of peripheral and central sensitization mechanisms. https://rsra.rusanesth.com/publ/posleoperatcionnaya_bol.html
57 Paul M. Friedman, MD, Jushua P. Fogelman, MD and others. Comparative Study of the Efficacy of Four Topical Anesthetics. Dermatolog Surg 1999; 25:950-954
58 https://www.1nep.ru/articles/rynok-kosmeticheskikh-anestetikov-dlya-kozhi/
59 https://www.rlsnet.ru/mnn_index_id_879.htm
60 https://yandex.ru/health/pills/product/ultrakain-ds-2195
61 https://grls.rosminzdrav.ru/Default.aspx on 02/15/2021
62 Ziganshin O.R. Comparison of the effectiveness and safety of topical local anesthetics for superficial surgical interventions in dermatology. Clinical dermatology and venereology. 2018;17(6):53-60. https://doi.org/10.17116/klinderma 20181706153
63 Comparison of Topical Anesthetics for Radiofrequency Ablation of Achrocordons: Eutectic Mixture of Lignocaine/Prilocaine versus Lidocaine/Tetracaine Pratik Gahalaut,1 Nitin Mishra,1 Sandhya Chauhan,2 and Madhur Kant Rastogi11Department of Dermatology, Venereology and Leprosy, Shri Ram Murti Smarak Institute of Medical Sciences, Nainital Road, Bareilly 243001, India2Department of Pediatrics, Shri Ram Murti Smarak Institute of Medical Sciences, Nainital Road, Bareilly 243001, India
64 https://www.gazeta.ru/science/2012/11/01_kz_4837701.shtml
65 https://www.kp.md/daily/23716.3/53610/
66 https://doktorbel.livejournal.com/29873.html
67 https://politeka.net/zdorovye/870023-uchenye-vyjasnili-kak-muzhchiny-i-zhenshhiny-zapominajut-bol-kto-vynoslivee/
68 https://spacefacts.ru/news/people-and-medicine/psychology/792-udovolstvie-ili-bol.html
69 https://tattooinfo.ru/raznoe/foto-prokolotoj-guby-vidy-kak-delat-uxod-za-mestom-prokola.html
70 https://tatuazhpro.ru/pirsing/indastrial.html
71 https://sprs-therapy.ru/faq/V-kakih-sluchayah-nuzhno-primenyat-SPRS-terapiyu_i-v-kakih-nelzya
72 https://sprs-therapy.ru/faq/Kakim-obrazom-provoditsya-SPRS-terapiya
73 https://cosmetology-info.ru/6425/Metody-udaleniya-vtorogo-podborodka/
74 https://beauty.net.ru/public/inektsionnaya_konturnaya_plastika_nososleznoy_borozdy/
75 https://www.1nep.ru/articles/131016/
76 Morrison A.V., Bocharova Yu.M., Morrison V.V. Botulism toxin - a therapeutic effect in cosmetology (review). Saratov Scientific and Medical Journal 2016; 12(3):521–524.
77 A.V. Gara, V.G. Zolotareva, Features of botulinum therapy for aesthetic indications for patients over 45 years old, Injection methods in cosmetology No. 4-2011 – 54-60 s
78 Methodological manual on mesotherapy for students of postgraduate and additional professional education. / Shamov B.A., Dyadkin V.Yu., Zhelonkina T.I./ – Kazan: KSMU, 2011. – 60 p.
79 https://www.1nep.ru/estetic/articles/119953/
80 Evers H, Scott B, Dahlquist AC. Dermal analgesia after epicutaneous application of EMLA 5% cream, 5% prilocaine cream, 5% lidocaine cream and placebo cream, to volunteers. Study 89EM03 (n= 21, cross-over). CSR 802-10AC088-2,1989.
81 https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=019941
82 Superficial, medium or deep peeling: what to choose - https://medbooking.com/blog/post/
83 Features of medium peels – https://www.1nep.ru/estetic/articles/190169/
84 Facial peeling – https://cosmetology-info.ru/668/Piling-litsa/
85 Plastic surgery of cheekbones with fillers – https://cheap-fillers.ru/articles/plastika-skul-fillerami
86 Ozone therapy (O3) for the face - a revolutionary beauty technology - https://plastichno.com/cosmetology/ozonoterapiya-dlya-litsa#i-7
87 Effective face lift with liquid mesothreads: what is it and what are the popular brands? – https://beautyexpert.pro/kosmetologiya/inektsionnaya/tredlifting/vidy-nitej/zhidkie-mezoniti.html
88 Mesotherapy of the periorbital area using peptide cocktails – https://www.manuolog.ru/info/about/articles/stati-po-kosmetologii/mezoterapiya-periorbitalnoy-oblasti-s-primeneniem-peptidnykh-kokteyley/
89 Enzyme hair removal: getting rid of excess vegetation – https://plastikaplus.ru/kosmetologiya/epilyaciya/enzimnaya.html
90 Liquid mesothreads and traditional threadlifting: advantages and disadvantages – https://aesthetic-futures.com.ua/zhidkie-mezoniti-i-tradicionnyj-tredlifting-preimushhestva-i-nedostatki
91 Cannula in cosmetology and medicine – https://ladysdream.ru/kanyulya.html
92 7 myths about anesthesia: what are we afraid of? – https://www.psychologies.ru/articles/7-mifov-o-narkoze-chego-myi-boimsya/
93 Medium peeling - an uncompromising method of rejuvenation - https://plastichno.com/cosmetology/sredinnyj-piling#i-3
94 Khunger N. Standard guidelines of care for chemical peels. Indian J Dermatol Venereol Leprol 2008;74(Suppl):S5-S12 – https://pro.bhub.com.ua/cosmetology/himiceskie-pilingi-standartnye-rekomendacii-po-primeneniu#
95 Kim Lawless - 10 secrets of successful hair removal - https://www.cosmo.ru/beauty/body/10-sekretov-udachnoy-epilyacii/
96 All about Sugaring - https://www.gabbi-shugaring.ru/vse-o-shugaringe#rec61612476
97 Hirsutism – https://www.krasotaimedicina.ru/diseases/zabolevanija_endocrinology/hirsutism
98. Intralesional interferon therapy for recurrent warts, G. E. Bagramova, T.G. Sedova, A.N. Khlebnikova // Russian Journal of Skin and Venereal Diseases No. 1, 2013 – 23-26 p.
99. Korolkova T.N., Goma S.E. Study of the effect of mesotherapy with pineal gland peptides on skin moisture and elasticity, Russian Journal of Skin and Venereal Diseases. 2017; 20(5) – 305-310 p.
100. S.V. Klyuchareva, S.M. Nikonova, I.V. Ponomarev, Laser treatment of benign pigmented skin tumors, experimental and clinical dermatocosmetology No. 3, 2006 – 22-31 p.
101. Photorejuvenation in the complex correction of age-related skin changes, N.I. Tsisanova, Journal of Applied Aesthetics No. 1, 2007
102. https://plastichno.com/cosmetology/fotoomolozhenie
103. Current state of the problem of human papillomavirus infection / L. A. Yusupova, E. I. Yunusova, Z. Sh. Garayeva, G. I. Mavlyutova, K. A. Salakhutdinova // Attending physician No. 7/2019; Page numbers in the issue: 64-67 – https://www.lvrach.ru/2019/07/15437345
104. Human papillomavirus infection of the genitals in women, S.I. Rogovskaya, V.N. Prilepskaya, E.A. Mezhevitinova, M.N. Kostava // Bulletin of Dermatology and Venereology, N 6-1998, pp. 48-51. – https://nature.web.ru/db/msg.html?mid=1178539&uri=index.html
105. https://www.1nep.ru/estetic/articles/183501/
106. https://www.1nep.ru/articles/208888/
107. https://cosmetology-info.ru/6925/salon-procedures-Lipolitiki-dlya-litsa/
108. https://www.1nep.ru/articles/204894/
109. https://www.verywellhealth.com/stratum-corneum-anatomy-1069189
110. Turkin P.Yu., Rodionov S.V., Somov N.O., Mirgatia I.O. Venous trophic ulcers: current state of the issue // General Medicine. 2022. No. 1. URL: https://cyberleninka.ru/article/n/venoznye-troficheskie-yazvy-sovremennoe-sostoyanie-voprosa
111. Kruglova Larisa Sergeevna, Panina Anastasia Nikolaevna, Strelkovich Tatyana Igorevna Trophic ulcers of venous origin // Russian Journal of Skin and Venereal Diseases. 2014. No. 1. URL: https://cyberleninka.ru/article/n/troficheskie-yazvy-venoznogo-geneza
112. Yu.M. Stoiko, A.I. Kirienko, I.I. Zatevakhin, A.V. Pokrovsky, A.A. Karpenko et al., Russian clinical guidelines for the diagnosis and treatment of chronic venous diseases // Phlebology No. 3, 2022 – 143-240 pp. — https://webmed.irkutsk.ru/doc/pdf/ven2009.pdf
113. Dovnar R.I., Smotrin S.M. Trophic ulcers of the lower extremities: modern aspects of etiology and pathogenesis // Journal of GrSMU. 2009. No. 4 (28). URL: https://cyberleninka.ru/article/n/troficheskie-yazvy-nizhnih-konechnostey-sovremennye-aspekty-etiologii-i-pathogeneza
114. Burleva E.P., Babushkina Yu.V. Experience in outpatient treatment of trophic foot ulcers that complicated the course of diabetes mellitus // Hospital-replacing technologies: Outpatient surgery. 2022. No. 3-4. URL: https://cyberleninka.ru/article/n/opyt-ambulatornogo-lecheniya-troficheskih-yazv-stop-oslozhnivshih-techenie-saharnogo-diabeta
115. Kutsenko I.V., Andrashko Yu.V. Conservative treatment of trophic ulcers of the lower extremities in chronic venous insufficiency // Methodological recommendations. 2007. https://medinfo.center/wp-content/uploads/2019/12/metodichka-tya.pdf
116. Trophic ulcers of the lower extremities in outpatient clinic practice//Methodological recommendations for fourth-year students of the Faculty of Medicine. 2020 https://rsmu.ru/fileadmin/templates/DOC/Faculties/LF/fsurg2/algoritm_dignost/UP/3._UP_Troficheskie_rasstroi__stva_kozhi_nizhnikh_konechnostei__.pdf
117. Russian clinical guidelines for the diagnosis and treatment of chronic venous diseases. Phlebology, issue No. 2. 2013 https://www.mrckb.ru/files/flebologii.pdf
118. I. L. Mikitin, G. Z. Karapetyan, L. V. Kochetova, S. V. Yakimov, R. A. Pakhomova Modern view on the treatment of trophic ulcers // Creative surgery and oncology. 2013. No. 4. URL: https://cyberleninka.ru/article/n/sovremennyy-vzglyad-na-lechenie-troficheskih-yazv
119. Aralova M.V. Personalized technology for regional treatment of patients with trophic ulcers of the lower extremities. dis. for the academic degree of Doctor of Medical Sciences Voronezh, 2019
120. Lok et al. J Amer Acad Derm 1999;40:208-13. (Study EM9405)
121. Hansson C et al. Acta Derm Venereol (Stockh) 1993;73:231-233.
122. Order of the Ministry of Health of Russia dated October 13, 2017 No. 804n “On approval of the range of medical services.
123. Order of the Ministry of Health dated October 8, 2018 No. 707n “On approval of qualification requirements for medical and pharmaceutical workers with higher education in the field of training “Health and Medical Sciences”
124. 124. Starostina L.S. Helping control pain in children: advice from a pediatrician. Medical advice. 2021;(1):263–268. doi: 10.21518/2079-701X-2021-1-263-268
Experts choose
The problem of choosing a drug for rapid healing and pain relief from damage to the oral mucosa is very relevant, both for adults and young patients, doctors and pharmacists. But why?
Many of these products require repeated use because they are quickly washed off with saliva, which is not very convenient to use. Meanwhile, in order to ensure regeneration, the drug must remain in the oral cavity for a long time without losing its effectiveness. What is the choice of specialists?
At first glance, it may seem that it is mainly children who suffer from stomatitis: learning the world by heart, they put foreign objects into their mouths, which, as a rule, are not very clean and can damage the oral mucosa. However, the microflora of the child’s oral cavity resists infection much more strongly. Therefore, stomatitis is a problem faced not only by children, but also by adults.
Common causes of stomatitis include lack of vitamins, decreased immunity, diseases of the digestive, cardiovascular and endocrine systems. Stomatitis can appear due to connective tissue diseases, viral infections, or be of an allergic nature. Local causes of stomatitis are often associated with some traumatic factor. For example, during the period of getting used to orthopedic prostheses, bedsores may appear. Or correcting a bite using a brace system often results in injury to the inner surface of the lips. Damage to the oral mucosa is possible after surgical interventions, implantation, professional hygienic cleanings, consumption of hot foods and drinks, etc.
Dentists also “cry”
Among professionals, stomatitis is considered one of the most difficult pathologies. First, saliva makes it difficult to maintain dryness. Secondly, it is impossible to isolate the oral cavity from various irritants by prohibiting the patient from eating. An effective regenerating agent must remain on the mucous membrane for a sufficient time, relieve pain and accelerate the healing process. Therefore, professionals prefer Solcoseryl® dental adhesive paste.
Solcoseryl® dental adhesive paste is designed specifically for rapid healing and pain relief of mucosal injuries. It took into account all the anatomical and physiological features of the oral mucosa. Solcoseryl® improves microcirculation, reduces swelling, shortens healing time and restores the mucous membrane. In addition, the dental adhesive paste contains the anesthetic polidocanol, which begins to act within 1-5 minutes after application and relieves pain within 3-5 hours. This is very important, given that any, even the most minor, damage to the oral mucosa is very painful.
Resilience is the key to recovery
Solcoseryl® dental adhesive paste is resistant to being washed off by saliva and forms a protective film that can remain on the surface of the wound for 2-5 hours. All this time, the paste protects the mucous membrane from irritants, and its active ingredients absorb discharge from the wound and promote a rapid healing process.
Does not contain antiseptics, hormones and sugar, which minimizes the risk of unwanted reactions and allows the paste to be used by patients with concomitant diseases.
At the reception and at home
Adhesive paste is used not only in the dentist's office - it can also be used at home. The paste is available in 5 g tubes - this is usually enough for the full course of treatment. A 0.5 cm strip of paste is applied to the previously dried area of the mucous membrane and slightly moistened with water.
What are the advantages of Solcoseryl® paste compared to other oral products?
SDAP is a universal dental paste that can be used in all cases associated with violations of the integrity of the oral mucosa. This is its main advantage. In addition, Solcoseryl® paste does not contain the antiseptic chlorhexidine, which makes it possible to use it for a long time, has a quick and long-lasting local analgesic effect, adsorbs discharge from the wound well, creates conditions for the fastest tissue regeneration, and has a cytoprotective and membrane-stabilizing effect.
What exactly is your recommendation for Solcoseryl® dental adhesive paste based on?
I recommend drugs based on data on their effectiveness, safety, and also take into account customer reviews. Dental adhesive paste Solcoseryl can be recommended for many indications - it is convenient. Solcoseryl®, unlike other oral products, adheres well to the mucous membrane and allows food intake, which patients really like. I keep some statistics on reviews, and everyone who used the adhesive paste was satisfied.
To which groups of patients and in what cases can Solcoseryl® dental adhesive paste be used?
To protect mucosal damage, relieve pain, and promote rapid healing, Solcoseryl® can be used by almost all age groups of patients. For diseases such as gingivitis, periodontitis, conditions after surgical interventions, installation of implants, removal of dental plaque, trauma to the mucous membrane during the period of adaptation to orthopedic and orthodontic structures. In addition, dental adhesive paste is also effective for damage to the mucous membrane caused by general diseases of the body. The paste can be used by children with stomatitis, as well as by pregnant women and nursing mothers - the drug is quite safe.
So, the choice of specialists is obvious - for professionals, Solcoseryl® dental adhesive paste is the means of choice in the treatment of inflammatory diseases and damage to the oral mucosa.
Source: Pharmacy Council Magazine
