Premature ejaculation can be caused by increased sensitivity of the head of the penis. In order to increase the duration of intimacy, you should use special condoms with an anesthetic. You can also reduce the sensitivity of the head of the genital organ using a product such as lidocaine spray.
Good day, here is Alexander Burusov, an expert at the Viva Man men’s club. Today we will talk about this method of prolonging sexual intercourse by using lidocaine in the form of a spray.
Indications for use, contraindications
Medicines intended to prolong intimacy should be used if the following indications exist:
- ejaculation occurs within the first ten seconds after erection;
- The duration of sexual intercourse is less than one minute. In this case, an erection without intimacy persists for a long time.
There are certain contraindications to the use of the medication. Lidocaine spray must not be applied if the stronger sex has an allergic reaction to the components of the product. It is not recommended for use in severe diseases of the cardiovascular system. If a man has chronic pathologies of the kidneys or liver, the dosage of the medicine should be reduced (to one spray).
Lidocaine spray for external and local use 10% 38g
Compound
Active substance:
| 1 dose | 1 fl. | |
| lidocaine | 4.6 mg | 3.8 g |
Excipients: peppermint leaf oil, propylene glycol, ethanol 96%.
Pharmacokinetics
Rapidly absorbed from mucous membranes (especially the pharynx and respiratory tract). The degree of absorption is determined by the degree of blood supply to the mucous membrane, the total dose, the localization of the site and the duration of application, the dosage form used. After application to the mucous membrane of the upper respiratory tract, it is partially swallowed and inactivated in the gastrointestinal tract. The time to reach Cmax when applied to the mucous membrane of the oral cavity and upper respiratory tract is 10-20 minutes.
Protein binding depends on the concentration of the drug and is 60-80% at a drug concentration of 1-4 μg/ml (4.3-17.2 μmol/l). It is distributed quickly (T1/2 distribution phase - 6-9 minutes), first enters well-supplied tissues (heart, lungs, brain, liver, spleen), then into adipose and muscle tissue. Penetrates the BBB and placental barrier, secreted into breast milk (40% of the concentration in maternal plasma).
Metabolized in the liver (90-95%) with the participation of microsomal enzymes by dealkylation of the amino group and cleavage of the amide bond with the formation of metabolites that are less active compared to lidocaine (monoethylglycine xylidine and glycine xylidine), T1/2 of which is 2 hours and 10 hours, respectively.
Excreted with bile and kidneys (up to 10% unchanged).
In liver diseases, the metabolic rate decreases and ranges from 50% to 10% of the normal value.
In chronic renal failure, accumulation of metabolites is possible.
Indications for use
For terminal (superficial) anesthesia of mucous membranes: in dentistry, in otorhinolaryngology, in obstetrics and gynecology, for instrumental and endoscopic studies, in surgery and dermatology.
Contraindications
The use of lidocaine in aerosol form for tonsillectomy and adenotomy in children under 8 years of age; hypersensitivity to lidocaine.
Caution should be used during instrumental studies (rectoscopy) in patients with hemorrhoidal bleeding, local infection in the area of application, trauma to the mucous membrane or skin in the area of application, severe somatic pathology, epilepsy, bradycardia, cardiac conduction disorders, impaired liver function, severe shock , in young children, elderly patients, during pregnancy and lactation.
Directions for use and doses
Apply locally, externally. The dose depends on the indications and the area of the anesthetized surface.
Storage conditions
At temperatures from 15 to 25°C. out of the reach of children.
Best before date
5 years. Do not use after the expiration date stated on the packaging.
special instructions
Use with caution in patients with epilepsy, as well as bradycardia, cardiac conduction disturbances, impaired liver function and severe shock, especially when significant amounts of the drug can be expected to be absorbed when large areas of tissue are treated with high doses.
It is important to prevent lidocaine from entering the respiratory tract (risk of aspiration).
Application to the buccal mucosa is associated with a risk of dysphagia and subsequent aspiration, especially in children. If the sensitivity of the tongue and mucous membrane of the cheeks is impaired, the risk of biting them increases.
Lidocaine is well absorbed through mucous membranes (especially in the trachea) and damaged skin. This should be taken into account, especially when treating large areas of tissue in children.
In cases of use during surgical operations in the pharynx or nasopharynx, it should be taken into account that lidocaine, suppressing the pharyngeal reflex, enters the larynx and trachea and suppresses the cough reflex, which can lead to bronchopneumonia. This is especially important in children, as they are more likely to trigger their swallowing reflex. In this regard, the spray is not recommended for local anesthesia before tonsillectomy and adenotomy in children under 8 years of age.
Caution should be exercised when applying lidocaine to damaged mucous membranes and/or infected areas.
Lower doses should be used in weakened and elderly patients, in acute diseases, as well as in children - in accordance with age and general condition.
Description
Local anesthetic.
Use in children
Use with caution in children. Lidocaine in aerosol form is not recommended for local anesthesia before tonsillectomy and adenotomy in children under 8 years of age.
Pharmacodynamics
Local anesthetic for superficial anesthesia. The action is due to the blockade of voltage-dependent sodium channels, which prevents the generation of impulses at the endings of sensory nerves and the conduction of pain impulses along nerve fibers.
When applied topically, it dilates blood vessels and does not have a local irritating effect. Has an analgesic effect.
The effect develops 1-5 minutes after application to mucous membranes or skin and lasts 30-60 minutes.
Side effects
Local reactions: a slight tingling sensation that disappears as the anesthetic effect develops (within 1 minute); Transient erythema, swelling and sensory disturbances may occur.
Allergic reactions: very rarely - urticaria, angioedema, bronchospasm; in exceptional cases - anaphylactic shock. The use of the drug should be stopped immediately if any allergic reaction occurs.
The frequency of systemic effects after topical application, because Only a very small amount of the active substance can enter the bloodstream.
From the side of the central nervous system: very rarely - nervous excitement, systemic dizziness, insomnia, loss of consciousness and respiratory paralysis.
From the cardiovascular system: decreased blood pressure, depression of myocardial function, bradycardia, cardiac arrest.
Use during pregnancy and breastfeeding
If local anesthesia is necessary and no safer treatment is available, lidocaine can be used during pregnancy.
Lidocaine is excreted in breast milk, but after topical use in normal therapeutic doses, the amount excreted in milk is too small to cause any harm to a nursing infant.
Interaction
Cimetidine and propranolol reduce the hepatic clearance of lidocaine (decreased metabolism due to inhibition of microsomal oxidation and decreased hepatic blood flow) and increase the risk of toxic effects (including stunned state, drowsiness, bradycardia, paresthesia).
Barbiturates, phenytoin, rifampicin (inducers of microsomal liver enzymes) reduce effectiveness (an increase in dose may be required).
When prescribed with ajmaline, phenytoin, verapamil, quinidine, amiodarone, the negative inotropic effect may be enhanced. Co-administration with beta-blockers increases the risk of bradycardia.
Curare-like drugs enhance muscle relaxation.
Procainamide increases the risk of developing central nervous system excitation and hallucinations.
With the simultaneous administration of lidocaine and hypnotics and sedatives, their inhibitory effect on the central nervous system may be enhanced.
With intravenous administration of hexobarbital or sodium thiopental against the background of the action of lidocaine, respiratory depression is possible.
Under the influence of MAO inhibitors, the local anesthetic effect of lidocaine may be enhanced.
With the simultaneous use of lidocaine and polymyxin B, an increased inhibitory effect on neuromuscular transmission is possible, so in this case it is necessary to monitor the patient's respiratory function.
Impact on the ability to drive vehicles and operate machinery
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Pros and cons of the product
Lidocaine spray has the following advantages :
- the drug is fast acting;
- the cost of the spray is quite low;
- the product is convenient to use: it is easy to apply;
- the drug has passed appropriate clinical trials;
- the product eliminates discomfort during intimacy, improving the quality of sexual life;
- the medication extremely rarely causes side effects and has virtually no contraindications;
- the drug is used very sparingly, so one package of the medicine lasts for a long time.
The drug also has disadvantages :
- Some representatives of the stronger sex note that due to a decrease in the sensitivity of the head of the penis, the pleasure a man receives from the body decreases.
- With frequent use of the drug, its effectiveness may decrease.
Possible side effects
Like all medicines, lidocaine can cause side effects, although not everyone gets them.
Severe allergic reactions (rare, may affect 1 in 1,000 people)
If you have a severe allergic reaction, tell your doctor immediately.
Its symptoms may include sudden onset:
- Swelling of the face, lips, tongue, or throat. This may cause difficulty swallowing.
- Severe or sudden swelling of the arms, legs, and ankles.
- Difficulty breathing.
- Severe itching of the skin (with swelling).
Other side effects:
- skin irritation in areas where lidocaine is used,
- nervousness,
- dizziness,
- drowsiness,
- loss of consciousness,
- a sore throat,
- hoarse voice or loss of voice,
- lowering blood pressure. This may lead to dizziness or delirium,
- convulsions,
- difficulty or slow breathing,
- bradycardia,
- stopping breathing or heartbeat.
Side Effect Reporting:
If you notice any side effects, tell your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects by going to the website www.arpimed.com and filling out the appropriate form “Report a side effect or ineffectiveness of a drug” and to the Scientific Center for Expertise of Medicines and Medical Technologies named after. Academician E. Gabrielyan by going to the website www.pharm.am to the “Report a side effect of a drug” section and fill out the form “Card of reporting a side effect of a drug.” Scientific center hotline phone number: +37410237665; +37498773368
How to store Lidocaine
- Keep out of the reach of children.
- Shelf life – 3 years. Do not take Lidocaine after the expiration date indicated on the drug package. When indicating the expiration date, we mean the last day of the specified month.
- Store out of reach of children, protected from light at a temperature not exceeding 150C.
- Your doctor/dentist or other healthcare provider should ensure that lidocaine is stored properly. Appropriate hospital personnel are responsible for the proper storage, administration, and disposal of lidocaine.
- Medicines should not be disposed of in wastewater or sewer systems. Ask your pharmacist how to dispose of any medicine you no longer need. These measures are aimed at protecting the environment.
Package contents and additional information
What Lidocaine contains
active substance: lidocaine – 50 mg;
other components: light liquid paraffin, isopropyl myristate, propylparaben.
What Lidocaine looks like and contents of the pack
Transparent colorless solution.
Description of packaging
primary: 15 ml of a 5% solution (spray) is filled into a plastic bottle with a metered mechanical sprayer.
secondary: 1 bottle along with an insert leaflet is placed in a cardboard pack.
Vacation conditions
Dispensed by prescription.
Useful tips for use
There are certain rules for using products containing lidocaine:
- Before using the product, you should conduct a sensitivity test. To do this, the drug must be sprayed onto your hand. If irritation appears on the body within 20 minutes, you should stop using the medication.
- You need to know that Lidocaine spray does not interact well with medications that contain iodine.
- If side effects occur, you should stop using the drug.
Lidocaine spray for topical use 4.6 mg/dose 38 g 650 doses
Regional and local anesthesia should be carried out by experienced specialists in an appropriately equipped room with access to the equipment and medications necessary to manage adverse reactions. Personnel performing anesthesia should be qualified and trained in anesthesia techniques and should be familiar with the diagnosis and treatment of systemic toxicities, adverse events and reactions, and other complications. It is important to prevent lidocaine from entering the respiratory tract (risk of aspiration).
Application to the throat requires special attention.
Application to the buccal mucosa is associated with a risk of dysphagia and subsequent aspiration, especially in children. If the sensitivity of the tongue and mucous membrane of the cheeks is impaired, the risk of biting them increases.
Lidocaine is well absorbed through mucous membranes (especially in the trachea) and damaged skin. This should be taken into account, especially when treating large areas of tissue in children.
In cases of using the spray during surgical operations in the pharynx or nasopharynx, it should be taken into account that lidocaine, suppressing the pharyngeal reflex, enters the larynx and trachea and suppresses the cough reflex, which can lead to bronchopneumonia. This is especially important in children, as they are more likely to trigger their swallowing reflex. In this regard, the spray is not recommended for local anesthesia before tonsillectomy and adenotomy in children under 8 years of age.
Caution should be exercised when applying lidocaine to damaged mucous membranes and/or infected areas.
The drug should be used with caution in patients with epilepsy, as well as bradycardia, cardiac conduction disorders, liver dysfunction and severe shock, especially when significant amounts of the drug can be expected to be absorbed when large areas of tissue are treated with high doses.
Lower doses should be used in weakened and elderly patients, in acute diseases, as well as in children - in accordance with age and general condition.
In children under 2 years of age, it is recommended to apply Lidocaine spray with a cotton swab dipped in the drug.
During application of the drug, the bottle should be kept as vertical as possible. The spray should not come into contact with the eyes. Do not open the bottle or heat it.
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Effect on the ability to drive During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Lidocaine-Vial
When using, the bottle should be kept in an upright position.
Avoid contact with eyes and respiratory tract (risk of aspiration).
Application to the buccal mucosa is associated with a risk of dysphagia and subsequent aspiration, especially in children. If the sensitivity of the tongue and mucous membrane of the cheeks is impaired, the risk of biting increases. Lidocaine is well absorbed through mucous membranes (especially in the trachea) and damaged skin. This should be taken into account, especially when treating large areas of tissue in children. Requires special care when applying the drug to the back of the throat.
When using the spray during surgical operations in the pharynx and nasopharynx, it should be taken into account that lidocaine, suppressing the pharyngeal reflex, enters the larynx and trachea and suppresses the cough reflex, which can lead to bronchopneumonia. This is especially important in children, as they are more likely to trigger their swallowing reflex. In this regard, the spray is not recommended for local anesthesia before tonsillectomy and adenotomy in children under 8 years of age.
Caution should be exercised when applying lidocaine to damaged mucous membranes and/or infected areas.
The drug should be used with caution in case of hemorrhoidal bleeding (during rectal examination), with concomitant acute diseases, in patients with epilepsy, as well as with bradycardia, conduction disturbances in the heart, impaired liver function and severe shock, especially when absorption of a significant amount can be expected during treating large areas of tissue with high doses.
In weakened and elderly patients, in children, lower doses should be used.
In children under 2 years of age, the spray should be applied with a cotton swab dipped in the drug. Do not open the bottle or heat it.
Regional and local anesthesia should be carried out by experienced specialists in an appropriately equipped room with access to the equipment and medications necessary to manage adverse reactions. Personnel performing anesthesia should be qualified and trained in anesthesia techniques and should be familiar with the diagnosis and treatment of systemic toxicities, adverse reactions, and other complications. Use of the drug should be discontinued if any allergic reaction occurs.
