Grammidin spray for children 0.03 mg+0.1 mg/dose 112 doses

A country

Netherlands, Russia
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Compound

Bottle of 112 doses
of Gramicidin C dihydrochloride 0.0638 mg, cetylpyridinium chloride 0.1 mg per 1 dose. Excipients: ethanol 96% - 19 mg, sucralose - 0.2 mg, glycerol - 33.2 mg, mint flavor - 0.82 mg, citric acid monohydrate - 0.058 mg, sodium citrate - 0.022 mg, polysorbate 80 - 0.4 mg, methyl parahydroxybenzoate (methylparaben) - 0.184 mg, propyl parahydroxybenzoate (propylparaben) - 0.02 mg, purified water - up to 0.2 ml. Spray for topical use dosed in the form of a clear or opalescent, colorless or yellowish solution with a characteristic mint odor.

pharmachologic effect

Combined drug for local use. Gramicidin C is an antimicrobial agent. The mechanism of action is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which violates its stability and causes cell death. Gramicidin C has a pronounced antimicrobial effect against pathogens of infectious diseases of the oral cavity and pharynx. Cetylpyridinium chloride is an antiseptic. Suppresses the growth and reproduction of pathogens of infectious diseases of the oral cavity. The combined drug reduces inflammation, has an antimicrobial effect, softens discomfort in the throat, facilitates swallowing, and when absorbed causes hypersalivation, which promotes mechanical cleansing of the oral cavity and pharynx from microorganisms.

Indications for use

Infectious and inflammatory diseases of the oral cavity and pharynx: - sore throat; - pharyngitis; - tonsillitis; - periodontal disease; - gingivitis; - stomatitis.

Side effects

Possible: in some cases - allergic reactions.

Contraindications

Children under 4 years of age;
I trimester of pregnancy; hypersensitivity to the components included in the drug. Use during pregnancy and breastfeeding Use in the first trimester of pregnancy is contraindicated. If it is necessary to use it during lactation, breastfeeding should be stopped during use.

Mode of application

The method of administration and dosage regimen of a particular drug depend on its release form and other factors. The optimal dosage regimen is determined by the doctor. The compliance of the dosage form of a particular drug with the indications for use and dosage regimen should be strictly observed. For resorption or treatment of the oral cavity. Use 1-4 times a day, depending on the indications, the age of the patient and the dosage form. Immediately after use, you should refrain from eating and drinking for 1-2 hours.

special instructions

If there is no therapeutic effect within 7 days of use, you should consult a doctor.

Interaction with other drugs

Enhances the effects of other antimicrobial agents of local and systemic action.

Grammidin children's dosed spray for topical use, 112 doses

Registration Certificate Holder

VALENTA PHARMACEUTICS (Russia)

Dosage form

Medicine – Grammidin® for children (Grammidin for children)

Description

Spray for topical use, dosed

in the form of a colorless or yellowish-tinged, transparent or opalescent solution with a characteristic raspberry odor.

1 dose

gramicidin C dihydrochloride 0.0319 mg, which corresponds to the content of gramicidin C 0.03 mg cetylpyridinium chloride 0.1 mg

Excipients

: ethanol 96% - 9.5 mg, sucralose - 0.2 mg, glycerol - 33.2 mg, raspberry flavor - 0.4 mg, citric acid monohydrate - 0.058 mg, sodium citrate - 0.022 mg, polysorbate 80 - 0.4 mg, methyl parahydroxybenzoate - 0.184 mg, propyl parahydroxybenzoate - 0.02 mg, purified water - up to 0.2 ml.

112 doses - aluminum bottles (1) - cardboard packs.

Indications

Infectious and inflammatory diseases of the oral cavity and pharynx: sore throat; pharyngitis; tonsillitis; periodontal disease; gingivitis; stomatitis.

Contraindications for use

Children under 4 years of age; I trimester of pregnancy; hypersensitivity to the components included in the drug.

pharmachologic effect

Combined drug for local use.

Gramicidin C is an antimicrobial agent. The mechanism of action is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which violates its stability and causes cell death. Gramicidin C has a pronounced antimicrobial effect against pathogens of infectious diseases of the oral cavity and pharynx.

Cetylpyridinium chloride is an antiseptic. Suppresses the growth and reproduction of pathogens of infectious diseases of the oral cavity.

The combined drug reduces inflammation, has an antimicrobial effect, softens discomfort in the throat, facilitates swallowing, and when absorbed causes hypersalivation, which promotes mechanical cleansing of the oral cavity and pharynx from microorganisms.

Drug interactions

Enhances the effects of other antimicrobial agents of local and systemic action.

Dosage regimen

For resorption or treatment of the oral cavity. Use 1-4 times a day, depending on the indications, the age of the patient and the dosage form.

Immediately after use, you should refrain from eating and drinking for 1-2 hours.

Side effect

Maybe:

in some cases - allergic reactions.

special instructions

If there is no therapeutic effect within 7 days of use, you should consult a doctor.

Use during pregnancy and breastfeeding

Restrictions during pregnancy - Contraindicated. Restrictions when breastfeeding - Contraindicated.

Use is contraindicated in the first trimester of pregnancy.

If it is necessary to use it during lactation, breastfeeding should be stopped during use.

Use in children

Restrictions for children - With caution.

Grammidin spray for topical use doser 112DOZ

Compound

Active ingredients: gramicidin C - 0.06 mg, cetylpyridinium chloride - 0.1 mg. Excipients: ethanol 96% - 19 mg, sucralose - 0.2 mg, glycerol - 33.2 mg, mint flavor - 0.82 mg, citric acid monohydrate - 0.058 mg, sodium citrate - 0.022 mg, polysorbate 80 - 0.4 mg, methyl parahydroxybenzoate (methylparaben) - 0.184 mg, propyl parahydroxybenzoate (propylparaben) - 0.02 mg, purified water - up to 0.2 ml.

Pharmacokinetics

The active substances have a local effect and are almost not absorbed from the gastrointestinal tract, which determines the almost complete absence of systemic effects.

Indications for use

Infectious and inflammatory diseases of the oral cavity and pharynx: sore throat; pharyngitis; tonsillitis; periodontal disease; gingivitis; stomatitis.

Contraindications

hypersensitivity to gramicidin C, cetylpyridinium chloride and other components of the drug;
pregnancy (first trimester);
lactation period;
children under 18 years of age.

Directions for use and doses

Locally, by spraying onto the mucous membrane of the mouth and throat. Used after meals.

Dosage for adults: 4 injections per application 3 times a day for 7 days. Immediately after using the drug, you should refrain from eating and drinking for 1 hour.

If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.

Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.

Storage conditions

In original packaging at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Best before date

2 years. Do not use after the expiration date stated on the packaging.

special instructions

The drug should not be used if there are open wounds in the oral cavity, since cetylpyridinium chloride slows down wound healing.

The drug contains ethanol. In the maximum single dose of the drug, the ethanol content is up to 0.08 g.

Description

Antiseptic for topical use in ENT practice and dentistry.

Dosage form

Spray for topical use dosed in the form of a clear or opalescent, colorless or yellowish solution with a characteristic mint odor.

Use in children

Contraindication: children under 18 years of age.

Pharmacodynamics

Combined drug for local use.

Cetylpyridinium chloride is an antiseptic. Suppresses the growth and reproduction of pathogens of infectious diseases of the oral cavity.

Side effects

Allergic reactions to the components of the drug are possible.

If you experience the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Use during pregnancy and breastfeeding

Use is contraindicated in the first trimester of pregnancy.

If it is necessary to use it during lactation, breastfeeding should be stopped during use.

Interaction

Currently, there are no cases of clinically significant interactions with other drugs.

Overdose

Symptoms: use of the drug in doses exceeding the recommended ones may cause disorders of the gastrointestinal tract: nausea, vomiting, diarrhea.
Treatment: Stop using the drug and consult a doctor.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to perform potentially hazardous activities that require special attention and speed of reactions (driving a car and other vehicles, working with moving mechanisms, working as a dispatcher and operator, etc.).

Grammidin for children

Grammidin for children is a combined drug for local use as part of the antibacterial drug gramicidin C and the disinfectant cetylpyridinium chloride. Used in dentistry and otorhinolaryngology for the treatment of acute or chronic tonsillitis (angina), inflammation of the mucous membrane of the pharynx, deep damage to the periodontal tissue (periodontal), inflammation of the gums without compromising the integrity of the dentogingival junction, inflammation of the mucous epithelium lining the oral cavity. Gramicidin C makes the cytolemma of the bacterial cell more permeable, as a result of which it becomes unstable and the cell dies. The effect of the drug extends to bacteria, most often acting as causative agents of infections of the oral cavity and upper respiratory tract. Cetylpyridinium chloride has a disinfecting effect, inhibits the growth of pathogenic and opportunistic microflora present in the oral cavity. Taken together, both active ingredients organically complement each other, reducing inflammation, exhibiting an antibacterial effect, eliminating discomfort in the mouth and throat, and eliminating pain when swallowing. When administered sublingually, the drug causes increased salivation, due to which the oral cavity and pharynx are cleared of bacteria. The active substances of the drug act locally and are practically not absorbed in the gastrointestinal tract, which eliminates the risk of systemic unwanted side reactions. Available in the form of a spray and tablets for sublingual use.

The frequency of use is from 1 to 4 times a day, depending on the clinical situation, therapeutic response, and the nature of the disease. Immediately after use, it is not recommended to eat or consume liquids. This restriction applies for 1-2 hours. The drug has a favorable safety profile and is well tolerated by patients. In rare cases, allergic reactions are possible. Grammidin for children is used in children after they reach the age of four. The drug is not used in case of individual intolerance to the active or auxiliary components. If, after completing seven days of regular pharmacotherapy, the patient has not experienced clinical improvement, it is necessary to seek medical advice. Both tablets and spray have a pleasant taste, which is especially important for drugs that are used in pediatric practice, because this increases compliance (patient adherence to treatment). It is important that the drug eliminates pain when swallowing, because this symptom accompanies most infections of the oral cavity and pharynx and is especially difficult for pediatric patients. The drug has low allergenicity and does not have an irritating effect on the mucous membrane of the upper respiratory tract. The therapeutic effect of the drug is localized exclusively at the site of pain and inflammation without absorption into the systemic bloodstream.