Grammidin spray for local use dosage 112DOZ with anesthetic

Grammidin spray for local use dosage 112DOZ with anesthetic

Compound

Active substances:

Excipients: ethanol 96% - 19 mg, sucralose - 0.2 mg, glycerol - 33.2 mg, mint flavor - 0.82 mg, citric acid monohydrate - 0.058 mg, sodium citrate - 0.022 mg, polysorbate 80 - 0.4 mg, methyl parahydroxybenzoate (methylparaben) - 0.184 mg, propyl parahydroxybenzoate (propylparaben) - 0.02 mg, purified water - up to 0.2 ml.

Pharmacokinetics

When applied topically, the active substances are practically not absorbed from the oral mucosa.

Indications for use

Infectious and inflammatory diseases of the mouth and throat: pharyngitis, tonsillitis, periodontitis, gingivitis, stomatitis.

Contraindications

• Hypersensitivity to gramicidin C, oxybuprocaine, cetylpyridinium chloride and other components of the drug;
• breastfeeding period;
• children under 18 years of age.

Use with caution during pregnancy (see “Use during pregnancy and breastfeeding”).

Directions for use and doses

Locally, by spraying onto the mucous membrane of the mouth and throat. Used after meals.

Before using the spray for the first time, shake the can and press the pressure device twice.

Dosage for adults: 4 injections per application 3 times a day for 7 days. Immediately after using the drug, you should refrain from eating and drinking for 1 hour.

If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.

Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.

Storage conditions

In original packaging, at a temperature not exceeding 25 °C. Keep out of the reach of children.

Best before date

2 years. Do not use after the expiration date stated on the packaging.

special instructions

The drug should not be used if there are open wounds in the oral cavity, since cetylpyridinium chloride slows down wound healing.
The drug contains ethanol. In the maximum single dose of the drug, the ethanol content is up to 0.08 g.

Description

Antibiotic + antiseptic + local anesthetic.

Pharmacodynamics

A combined drug for the treatment of infectious and inflammatory diseases of the throat and oral cavity.
The drug contains an antimicrobial agent - gramicidin C, a local anesthetic (pain reliever) - oxybuprocaine and an antiseptic - cetylpyridinium chloride.

The mechanism of action of gramicidin C is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which disrupts its stability and causes death. Gramicidin C has an antibacterial effect against a wide range of gram-positive and gram-negative microorganisms.

The anesthetic oxybuprocaine has a local anesthetic effect on the mucous membrane of the mouth and throat. Causes a reversible blockade of the propagation and conduction of nerve impulses through the axons of nerve cells.

Cetylpyridinium chloride is an antiseptic that inhibits the growth and reproduction of pathogens that cause infectious diseases of the mouth and throat.

The drug has an antimicrobial effect, an analgesic effect, reduces inflammation, softens discomfort in the throat, and makes swallowing easier.

Side effects

Allergic reactions to the components of the drug, temporary loss of sensitivity of the tongue are possible.

If you experience the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Use during pregnancy and breastfeeding

The use of the drug is possible if the potential benefit to the mother outweighs the possible risk to the fetus. Before using the drug, if you are pregnant or think you might be pregnant, or are planning a pregnancy, you should consult your doctor.

There is no data on the penetration of drug components into breast milk. If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Interaction

Currently, there are no cases of clinically significant interactions with other drugs.

Overdose

Symptoms: use of the drug in doses exceeding the recommended ones may cause nausea, vomiting, diarrhea, and loss of tongue sensitivity.

Treatment: You should stop taking the drug and consult a doctor.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to perform potentially hazardous activities that require special attention and speed of reactions (driving a car and other vehicles, working with moving mechanisms, working as a dispatcher and operator, etc.).

Grammidin spray dosed for topical use, 112 doses

Registration Certificate Holder

VALENTA PHARMACEUTICS (Russia)

Dosage form

Medicine - Grammidin® (Grammidin)

Description

Spray for topical use, dosed

in the form of a clear or opalescent, colorless or yellowish solution with a characteristic mint odor.

1 dose

gramicidin C dihydrochloride 0.0638 mg, which corresponds to the content of gramicidin C 0.06 mg cetylpyridinium chloride 0.1 mg

Excipients

: ethanol 96% - 19 mg, sucralose - 0.2 mg, glycerol - 33.2 mg, mint flavor - 0.82 mg, citric acid monohydrate - 0.058 mg, sodium citrate - 0.022 mg, polysorbate 80 - 0.4 mg, methyl parahydroxybenzoate (methylparaben) - 0.184 mg , propyl parahydroxybenzoate (propylparaben) - 0.02 mg, purified water - up to 0.2 ml.

112 doses - bottles (1) - cardboard packs.

Indications

Infectious and inflammatory diseases of the oral cavity and pharynx: sore throat; pharyngitis; tonsillitis; periodontal disease; gingivitis; stomatitis.

Contraindications for use

Children under 4 years of age; I trimester of pregnancy; hypersensitivity to the components included in the drug.

pharmachologic effect

Combined drug for local use.

Gramicidin C is an antimicrobial agent. The mechanism of action is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which violates its stability and causes cell death. Gramicidin C has a pronounced antimicrobial effect against pathogens of infectious diseases of the oral cavity and pharynx.

Cetylpyridinium chloride is an antiseptic. Suppresses the growth and reproduction of pathogens of infectious diseases of the oral cavity.

The combined drug reduces inflammation, has an antimicrobial effect, softens discomfort in the throat, facilitates swallowing, and when absorbed causes hypersalivation, which promotes mechanical cleansing of the oral cavity and pharynx from microorganisms.

Drug interactions

Enhances the effects of other antimicrobial agents of local and systemic action.

Dosage regimen

For resorption or treatment of the oral cavity. Use 1-4 times a day, depending on the indications, the age of the patient and the dosage form.

Immediately after use, you should refrain from eating and drinking for 1-2 hours.

Side effect

Maybe:

in some cases - allergic reactions.

special instructions

If there is no therapeutic effect within 7 days of use, you should consult a doctor.

Use during pregnancy and breastfeeding

Restrictions during pregnancy - Contraindicated. Restrictions when breastfeeding - Contraindicated.

Use is contraindicated in the first trimester of pregnancy.

If it is necessary to use it during lactation, breastfeeding should be stopped during use.

Use in children

Restrictions for children - With caution.

Grammidin spray for topical use 0.06 mg+0.1 mg/dose 112 doses, 1 pc.

Manufacturer

Famar Netherlands B.V., Netherlands

Briefly about the product

Compound

One dose of the drug contains:
Active substances:

• Gramicidin C dihydrochloride - 0.0638 mg (in terms of gramicidin C - 0.06 mg)
• Cetylpyridinium chloride - 0.10 mg

Excipients:

• Ethanol 96% - 19.00 mg
• Sucralose - 0.20 mg
• Glycerol - 33.20 mg
• Mint flavor - 0.82 mg
• Citric acid monohydrate - 0.058 mg
• Sodium citrate - 0.022 mg
• Polysorbate 80 – 0.40 mg
• Methyl parahydroxybenzoate (methylparaben) - 0.184 mg
• Propyl parahydroxybenzoate (propylparaben) - 0.02 mg
• Purified water - up to 0.2 ml.

pharmachologic effect

A combined drug for the treatment of infectious and inflammatory diseases of the throat and oral cavity.

The drug contains the antimicrobial agent gramicidin C and the antiseptic agent cetylpyridinium chloride. The mechanism of action of gramicidin C is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which disrupts its stability and causes death.

Gramicidin C has an antibacterial effect against a wide range of gram-positive and gram-negative microorganisms. Cetylpyridinium chloride is an antiseptic that inhibits the growth and reproduction of pathogens that cause infectious diseases of the mouth and throat. The drug has an antimicrobial effect, reduces inflammation, softens discomfort in the throat, and makes swallowing easier.

Pharmacokinetics Local drug. According to preclinical pharmacokinetic studies, absorption is practically absent.

Indications

Infectious and inflammatory diseases of the mouth and throat: pharyngitis, tonsillitis, periodontitis, gingivitis, stomatitis.

Use during pregnancy and breastfeeding

Pregnancy (II-III trimester). Before using the drug, if you are pregnant or think you might be pregnant, or are planning a pregnancy, you should consult your doctor. There have been no adequate controlled studies of the use of the drug during pregnancy. The use of the drug in the first trimester of pregnancy is contraindicated. The use of the drug in the II-III trimester of pregnancy is possible if the potential benefit to the mother outweighs the possible risk to the fetus. There is no data on the penetration of drug components into breast milk. If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Contraindications

- hypersensitivity to gramicidin C, cetylpyridinium chloride and other components of the drug; -pregnancy (first trimester); -breastfeeding period; -children up to 6 years old.

Side effects

Allergic reactions to the components of the drug are possible.

If you experience the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Currently, there are no cases of clinically significant interactions with other drugs.

How to take, course of administration and dosage

Locally, by spraying onto the mucous membrane of the mouth and throat. Used after meals.

Dosage for adults: 4 injections per application 3 times a day for 7 days. Immediately after using the drug, you should refrain from eating and drinking for 1 hour.

If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.

Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.

Overdose

Symptoms:
use of the drug in doses exceeding the recommended ones may cause disorders of the gastrointestinal tract: nausea, vomiting, diarrhea.
Treatment:
Stop using the drug and consult a doctor.

Description

A clear or opalescent colorless or yellowish solution with a characteristic mint odor.

Special instructions

The drug should not be used if there are open wounds in the oral cavity, since cetylpyridinium chloride slows down wound healing. The drug contains ethanol. In the maximum single dose of the drug, the ethanol content is up to 0.08 g.

Release form

Spray for topical use dosed 0.06 mg + 0.1 mg/dose. 112 doses each in aluminum or glass bottles, coated with plastic, equipped with a pump and a pressure device with a folding cannula. 1 bottle along with instructions for use in a cardboard box.

Storage conditions

In original packaging at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Best before date

2 years. Do not use after the expiration date stated on the packaging.

Active substance

Gramicidin C, Cetylpyridinium chloride

Dosage form

pills

Purpose

For adults

Indications

Sore throat, Cough, Laryngitis, Respiratory tract infections, Gum inflammation, Pharyngitis, Periodontitis, Tonsillitis

Barcode and weight

Barcode: 4602193012462 Weight: 0.200 kg