In case of sore throat, tonsillitis, stomatitis and other pathologies, inflammatory processes develop and damage the mucous membrane of the throat and neighboring areas. One of the effective and affordable drugs for treatment is Grammidin. It is used externally in the form of lozenges and spray.
Pharmacodynamics and pharmacokinetics
The active ingredient, gramicidin C, is an antibiotic of the tyrothricine group , which is active against most Gram+ and Gram- microorganisms that cause infectious diseases in the oral cavity and pharynx. By increasing the permeability of microbial cell membranes for the penetration of inorganic cations, osmotic instability of the cells is achieved. In addition, during the resorption process, salivation increases, which promotes natural cleansing of inflammatory exudate and microorganisms, starting from the throat, oral cavity and ending with the tonsils.
Since gramicidin C is characterized by low systemic absorption, there are no data on pharmacokinetics.
Buy Grammidin neo with anesthetic lozenges No. 18 in pharmacies
Grammidin with anesthetic neo Buy Grammidin with anesthetic neo in pharmacies DOSAGE FORMS lozenges 3mg+0 2mg+1mg
MANUFACTURERS Valenta Pharmaceuticals (Russia)
GROUP Combined antibiotics
COMPOSITION Gramicidin C, oxybuprocaine, cetylpyridinium chloride.
INTERNATIONAL NON-PROPENTED NAME Gramicidin C + Oxybuprocaine + Cetylpyridinium chloride
PHARMACOLOGICAL ACTION Antibacterial combined drug for local use in the oral cavity and pharynx. The drug contains the antibiotic gramicidin C, the local anesthetic oxybuprocaine and the antiseptic cetylpyridinium chloride. The drug has a pronounced antibacterial effect against pathogens of infectious and inflammatory diseases of the pharynx and oral cavity. Increases the permeability of the microbial cell membrane, which disrupts its barrier functions and leads to its death. The anesthetic oxybuprocaine, causing a reversible block of axonal conduction of nerve impulses, has an analgesic effect on the mucous membrane of the oral cavity and pharynx. Cetylpyridinium chloride, being an antiseptic, inhibits the growth and reproduction of pathogens of infectious diseases of the oral cavity. The drug has antimicrobial, analgesic and anti-inflammatory effects, reduces discomfort in the oral cavity and pharynx, and facilitates the swallowing process. When absorbed, the drug stimulates hypersalivation, which promotes mechanical cleansing of the oral cavity and pharynx from microorganisms. The drug has a local effect.
INDICATIONS FOR USE Infectious and inflammatory diseases of the oral cavity and pharynx: sore throat, pharyngitis, tonsillitis, periodontal disease, gingivitis, stomatitis.
CONTRAINDICATIONS First trimester of pregnancy, children under 4 years of age, hypersensitivity to the components of the drug.
SIDE EFFECTS In some cases: allergic reactions, temporary loss of sensitivity of the tongue.
INTERACTION The drug, when taken together, increases the effectiveness of other antimicrobial agents of local and systemic action.
METHOD OF APPLICATION AND DOSAGE For adults and children over 12 years of age, the drug is prescribed 1 tablet 3-4 times a day; children aged 4 to 12 years - 1 tablet 1-2 times a day. The tablets are used after meals, dissolving in the mouth without chewing. Immediately after using the drug, you should refrain from eating and drinking for 1-2 hours. If there is no therapeutic effect within 7 days of taking the drug, the patient should consult a doctor.
OVERDOSE No data available.
SPECIAL INSTRUCTIONS No data available.
STORAGE CONDITIONS Store out of reach of children, in a dry place, protected from light at a temperature not exceeding 25 degrees. WITH.
Contraindications
Contraindications include groups of patients who are not recommended to take the drug:
- having hypersensitivity to the components of the tablets;
- pregnant and breastfeeding women, as well as children under 12 years of age.
Milk sugar - lactose is included in Grammidin tablets, which is why they should not be prescribed to people with galactose lactase enzyme deficiency or glucose-galactose malabsorption syndrome .
What diseases does Grammidin help with?
The drug is prescribed for the treatment of bacterial diseases of the throat and oral cavity, accompanied by inflammatory processes:
- pharyngitis - damage to the mucous and lymphoid tissue of the pharynx;
- tonsillitis - infection of the mucous membrane, inflammation of the annular part, tonsils;
- tonsillitis - damage to the palatine tonsils;
- stomatitis – ulcerative formations in the oral cavity, damage to the mucous membrane;
- gingivitis – inflammatory processes in the gum tissue;
- periodontitis is inflammation of the bone and soft tissues of the tooth.
The medicinal effect is based on the destruction of bacteria that cause diseases. This leads to inhibition of inflammatory processes and a decrease in pain symptoms in the throat, which makes swallowing easier.
Grammidin's analogs
Matches by level 4 ATC code: Grammidin with anesthetic Neo
Grammidin for children
Grammidin with anesthetic
Grammidin Neo
Bioparox
Gramicidin S
Trachisan
The price of Grammidin analogues ranges from 200-270 rubles, among them are Valenta Pharmaceuticals tablets with different compositions of active ingredients:
- Grammidin Neo (the drug is supplemented with active ingredients - oxybuprocaine and cetylpyridinium chloride ) No. 18 - 210-230 rubles;
- Grammidin Neo with anesthetic (supplemented with the anesthetic lidocaine hydrochloride ) No. 18 – 240-270 rubles;
- Children's with raspberry flavor (with cetylpyridinium chloride ) No. 18 - 180-200 rub.
"Grammidin": description, types, composition
"Grammidin" is a medical product for the treatment of infections of the throat and mouth. It is produced in the form of a spray and tablets and is taken externally. The product contains 2 active ingredients:
- Gramicidin C dihydrochloride is an antibiotic that has an antibacterial effect (impairs the permeability of bacterial cell membranes).
- Cetylpyridinium chloride is an antiseptic that destroys microorganisms and suppresses colony reproduction.
Today they produce 5 forms of the drug - this is “Grammidin”:
- for children;
- for children (in the form of a spray);
- Neo;
- with anesthetic Neo;
- in the form of a spray.
The active ingredients are the same in all cases.
Grammidin price, where to buy
The cost of Grammidin tablets ranges from 270 rubles. The price of Grammidin starts from 180 rubles - for children and ends with Neo with Anesthetic (pain reliever) - 280 rubles. The best place to buy the drug is in Moscow pharmacies and other pharmaceutical companies working directly with ValentaPharm.
You can find out how much an analogue of the drug costs and other information on the manufacturer’s official website.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Grammidin spray dosage.
for places approx. 0.06 mg+0.1 mg/dose vial. 112 doses Delpharm Bladel B.V./JSC Valenta Pharm RUB 335 order - Grammidin NEO with anesthetic tablets for rassas. 3mg+0.2mg+1mg 18 pcs. JSC Valenta Pharmaceuticals
RUB 359 order
- Grammidin NEO tablets for rassas. 3mg+1mg 18 pcs. JSC Valenta Pharmaceuticals
RUB 296 order
- Grammidin children's tablets for rassas. 1.5mg+1mg 18 pcs. JSC Valenta Pharmaceuticals
RUB 317 order
- Grammidin with anesthetic spray for places. approx. fl. 112 doses Delpharm Bladel B.V./JSC Valenta Pharm
RUR 379 order
Pharmacy Dialogue
- Grammidin NEO with anesthetic lozenges No. 18 Valenta Pharmaceuticals OJSC
RUB 354 order
- Grammidin spray for children 0.03 mg+0.1 mg/dose 112 dosesValenta Pharmaceuticals
RUR 542 order
- Grammidin NEO lozenges No. 18 Valenta Pharm JSC
RUB 299 order
- Grammidin spray 0.06 mg+0.1 mg/dose 112 doses Famar Netherlands B.V./Valenta Pharm JSC
RUB 354 order
- Grammidin spray 0.06 mg+0.1 mg/dose 112 doses Valenta Pharmaceuticals OJSC
RUR 358 order
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"Grammidin Neo"
Available in the form of tablets that need to be dissolved (not swallowed) after meals. You should not eat or drink for 1-2 hours after this. The medicine is indicated for use at the age of 4+. The tablets act only locally, are not absorbed by the gastrointestinal tract, and are therefore safe for consumption.
The recommended dosage and frequency of administration depends on age:
- age 12+: 1 tablet 3-4 times a day;
- age 4-12: 1 tablet 1-2 times a day.
The course of therapy lasts up to 7 days inclusive. If the effect is not achieved, treatment should be stopped and consult a doctor for advice.
Restrictions and contraindications
Preparations from the Grammidin line are contraindicated:
- children up to 3 years old inclusive;
- individual intolerance, allergic reactions;
- phenylketonuria;
- open, bleeding wounds in the mouth;
- pregnancy (1st trimester).
Restricted admission:
- pregnancy (II and III trimester) - only in consultation with a doctor;
- lactation - only with interrupted feeding.
Important!
"Grammidin for children" can also be used during the first trimester of pregnancy. In these products the concentration of active substances is reduced. Therefore, admission is possible, preferably in consultation with a doctor.
