Buy Mexidol solution intravenously and intramuscularly 50 mg/ml 2 ml No. 10 in pharmacies

We all need protection to one degree or another. External and internal. The body and mind are quite fragile and can be strengthened and supported in different ways. Even with medication.

If a person experiences negative effects (stress, shock, ischemia, intoxication, cerebrovascular accident, etc.), then the doctor may prescribe Mexidol.

Mexidol is a good helper in the fight against stress

Operating principle

The drug belongs to the group of heteroaromatic antioxidants and basically contains ethylmethylhydroxypyridine succinate, which in turn protects cell membrane lipids and reduces the level of free radicals in the body. This significantly expands the spectrum of pharmacological action. Mexidol has an antihypoxic (saturates the blood with oxygen), anti-stress, anticonvulsant effect. It also has nootropic properties, prevents and reduces memory impairment, increases concentration and performance, and reduces the manifestation of alcohol intoxication. Restores the sleep-wake cycle, improves the metabolism of brain tissue and their blood supply, improves microcirculation and rheological properties of blood (its fluidity), reduces the rate of dystrophic and morphological changes in the brain. It has a pronounced therapeutic effect in the treatment of Parkinson's disease. Mexidol improves the functional state of ischemic myocardium and the adaptive capabilities of the human body when exposed to various stress factors.

Mexidol also increases the content of dopamine, the so-called “hormone of joy”, in the brain.

Mexidol, tablets 0.125 g, 50 pcs.

Manufacturer

Pharmasoft, Russia

Compound

Active substance:
ethylmethylhydroxypyridine succinate (2-ethyl-6-methyl-3-hydroxypyridine succinate) – 125.0 mg

Excipients:

lactose monohydrate – 97.5 mg,

povidone – 25.0 mg,

magnesium stearate – 2.50 mg

Film casing:

opadry II white 33G28435 – 7.5 mg (hypromellose – 3.0 mg, titanium dioxide – 1.875 mg, lactose monohydrate – 1.575 mg, polyethylene glycol (macrogol) – 0.6 mg, triacetin – 0.45 mg)

pharmachologic effect

Mexidol® is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics (neuroleptics)).

The mechanism of action of Mexidol® is due to its antioxidant, antihypoxic and membrane protective effects. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Mexidol® modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, neurotransmitter transport and improve synaptic transmission.

Mexidol® increases the content of dopamine in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and low-density lipoproteins.

The anti-stress effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, reduction of dystrophic and morphological changes in various structures of the brain.

Mexidol® has a pronounced antitoxic effect in withdrawal symptoms. It eliminates the neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairment caused by long-term use of ethanol and its withdrawal. Under the influence of Mexidol®, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects. Mexidol® improves the functional state of ischemic myocardium. In conditions of coronary insufficiency, it increases collateral blood supply to the ischemic myocardium, helps maintain the integrity of cardiomyocytes and maintain their functional activity. Effectively restores myocardial contractility in reversible cardiac dysfunction.

Pharmacokinetics

Suction

Rapidly absorbed when taken orally. The maximum concentration at doses of 400 - 500 mg is 3.5 - 4.0 mcg/ml.

Distribution

Quickly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9 – 5.2 hours. Metabolized in the liver by glucuron conjugation. 5 metabolites have been identified: 3-hydroxypyridine phosphate - formed in the liver and, with the participation of alkaline phosphatase, breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, is formed in large quantities and is found in the urine 1 - 2 days after administration; 3rd - excreted in large quantities in the urine; 4th and 5th - glucuron conjugates. T1/2 when taken orally - 2.0 - 2.6 hours.

Removal

It is rapidly excreted in the urine, mainly in the form of metabolites and in small quantities unchanged. The most intensive elimination occurs during the first 4 hours after taking the drug. Rates of urinary excretion of unchanged drug and metabolites have individual variability.

Indications

• consequences of acute cerebrovascular accidents, including after transient ischemic attacks, in the subcompensation phase as preventive courses;
• mild traumatic brain injury, consequences of traumatic brain injury;
• encephalopathies of various origins (dyscirculatory, dysmetabolic, post-traumatic, mixed);
• autonomic dystonia syndrome;
• mild cognitive disorders of atherosclerotic origin;
• anxiety disorders in neurotic and neurosis-like conditions;
• conditions after acute intoxication with antipsychotic drugs;
• asthenic conditions, as well as for the prevention of the development of somatic diseases under the influence of extreme factors and stress;
• exposure to extreme (stress) factors.
• coronary heart disease as part of complex therapy;
• relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-withdrawal disorders

Use during pregnancy and breastfeeding

Strictly controlled clinical studies of the safety of the drug Mexidol® during pregnancy and breastfeeding have not been conducted.

Contraindications

Contraindications to the use of Mexidol are:

• acute liver failure;
• acute renal failure;
• hypersensitivity to the drug.

Due to insufficient knowledge of the effect of the drug:

• childhood;
• pregnancy;
• lactation period (breastfeeding).

Side effects

When using the drug the following are possible:

From the digestive system: individual adverse reactions of a dyspeptic or dyspeptic nature may occur.

Other: allergic reactions are possible.

Interaction

Mexidol® is combined with all drugs used to treat somatic diseases.

When used together, Mexidol® enhances the effect of benzodiazepine derivatives, antidepressants, anxiolytics, antiparkinsonian and anticonvulsants.

Mexidol® reduces the toxic effect of ethanol.

How to take, course of administration and dosage

Method of administration and dosage regimen depending on symptoms

Orally 125-250 mg 3 times/day; the maximum daily dose is 800 mg (6 tablets). Duration of treatment - 2-6 weeks; to relieve alcohol withdrawal - 5-7 days. Treatment is stopped gradually, reducing the dose over 2-3 days.

Initial dose - 125-250 mg (1-2 tablets) 1-2 times a day with a gradual increase until a therapeutic effect is obtained; the maximum daily dose is 800 mg (6 tablets).

The duration of therapy in patients with coronary artery disease is at least 1.5-2 months. It is advisable to carry out repeated courses (on the recommendation of a doctor) in the spring and autumn.

Overdose

In case of overdose, drowsiness may develop.

Special instructions

Precautions when taking the drug

Mexidol® can be combined with all drugs used to treat somatic diseases.

Use in pediatrics

Mexidol® is not prescribed to children due to insufficient knowledge of the drug's effect.

Impact on the ability to drive vehicles and other mechanisms that require increased concentration

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Interaction with alcohol

Mexidol® reduces the toxic effect of ethanol.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Best before date

3 years

Active substance

Ethylmethylhydroxypyridine succinate

Conditions for dispensing from pharmacies

On prescription

Dosage form

pills

Purpose

For adults as prescribed by a doctor

Indications

Stress, Vegetative-vascular disorders, Asthenia, Exposure to adverse factors, Consequences of stroke, Atherosclerosis, Hanover, Concussion and other traumatic brain injuries, Cerebrovascular accident, Neurosis

Information in the State Register of Medicines

Go

Barcode and weight

Barcode: 4607085314266, 4607085319445 Weight: 0.028 kg

Indications

In neurology, Mexidol is used in the following cases:

• acute cerebral circulatory disorders and discirculatory encephalopathy (otherwise – cerebral atherosclerosis);
• after transient ischemic attacks, in the subcompensation phase as preventive courses;
• vegetative-vascular dystonia;
• cognitive problems of atherosclerotic origin (impaired speech, memory, attention, intelligence and other symptoms associated with the development of atherosclerosis).

In psychiatry Mexidol is prescribed:

• to relieve withdrawal symptoms (otherwise known as withdrawal) due to alcohol and drug addiction;
• in case of intoxication with neuroleptics (drugs intended for the treatment of psychosis);
• to alleviate the impact of extreme (stress) factors;
• for anxiety disorders and neurotic and neurosis-like conditions.

Mexidol is also used for acute purulent-inflammatory processes of the peritoneum (necrotizing pancreatitis and peritonitis) as part of a complex of therapeutic treatments.

Side effects

One of the side effects after taking Mexidol may be nausea

Despite the body’s positive reaction to taking Mexidol and its low toxicity, the medicine still has side effects.

• from the cardiovascular system: increased blood pressure, decreased blood pressure;
• from the nervous system: drowsiness, difficulty falling asleep, anxiety, emotional reactivity, headache, loss of coordination;
• from the gastrointestinal tract: nausea, dry mouth;
• from the immune system: allergic reactions, including hyperemia, skin rash, itching;
• others: distal hyperhidrosis.

How to take Mexidol?

Mexidol in tablet form is taken orally. The tablet is not chewed or divided in half. You should drink it with plenty of water. Eating does not have any effect on the activity of the medication, so you can take Mexidol before, during or after meals.

The injection form is used for intramuscular injections or intravenous infusions (stream or drip). Before giving the injection, the drug is diluted in a 0.9% sodium chloride solution. It is injected slowly in a stream over 5 - 7 minutes, drip - at a rate of 40 - 60 drops per minute. The maximum daily dose for tablets is 800 mg, for injections - 1200 mg. Course therapy is canceled gradually, after achieving a stable clinical and laboratory effect.

Mexidol solution for intravenous administration

Please note that drowsiness may occur after taking Mexidol, so you should be careful while driving, as well as when engaging in other potentially dangerous activities.

*When taking pills. The method of administering the Mexidol injection in the same dosage is indicated in parentheses.

The duration of therapy for patients with coronary heart disease is at least 1.5-2 months. It is advisable to carry out repeated courses (on the recommendation of a doctor) in the spring and autumn.

In case of acute myocardial infarction, as part of complex therapy, it is administered intravenously (the first 5 days) and intramuscularly (the next 9 days) for 14 days against the background of traditional therapy for myocardial infarction, including nitrates, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, thrombolytics, anticoagulants and antiplatelet agents, as well as symptomatic agents according to indications.

Nosological classification (ICD-10)

• E63 Physical and mental overload
• F06.7 Mild cognitive impairment
• F07.2 Post-concussion syndrome
• F10.3 Withdrawal state
• F41.9 Anxiety disorder, unspecified
• F45 Somatoform disorders
• F48.9 Neurotic disorder, unspecified
• G45 Transient transient cerebral ischemic attacks [attacks] and related syndromes
• G90 Disorders of the autonomic nervous system
• G92 Toxic encephalopathy
• G93.4 Encephalopathy, unspecified
• I25.9 Chronic ischemic heart disease, unspecified
• I67.4 Hypertensive encephalopathy
• I67.9 Cerebrovascular disease, unspecified
• R41.8.0* Intellectual-mnestic disorders
• R45.7 State of emotional shock and stress, unspecified
• R53 Malaise and fatigue
• S06 Intracranial injury
• T43.3 Poisoning with antipsychotic and antipsychotic drugs
• T90.5 Consequences of intracranial injury

Mexidol during pregnancy and lactation

Often, medications for pregnant women and nursing mothers are prescribed with caution, and also in cases where the benefits to the mother outweigh the risks to the fetus and newborn. It’s the same story with Mexidol. There are no statistically reliable studies of the use of the drug in pregnant women, nursing mothers and children. That is, there are no clinical studies on which to rely, alas. Therefore, the drug is either prescribed as a last resort or is not recommended for use.

Mexidol is prescribed with caution during pregnancy

As for children, the use of Mexidol in pediatrics is indicated in the treatment of purulent neuroinfections, traumatic brain injuries, as well as for emergency care in case of childhood traumatic brain injuries (100 mg once).

Interaction with other drugs

Mexidol has proven itself to be a drug that is highly compatible with other medications, including those used to treat somatic diseases. But it is worth noting that Mexidol can enhance the effect of benzodiazepines, carbamazepine and drugs for the treatment of Parkinson's disease, analgesics, tranquilizers, neuroleptics and antidepressants, as well as substances with hypnotics and anticonvulsants. This allows you to reduce their doses and remove most side effects.

Mexidol reduces the toxicity of ethyl alcohol. This beneficial property is used in the treatment of alcohol withdrawal syndrome.

Mexidol and alcohol

As mentioned above, Mexidol is used as therapy for getting rid of alcohol addiction. The drug reduces the toxic effect of alcohol and removes it from the body. But this does not mean that you can drink alcohol while taking Mexidol. The active substance Mexidol, penetrating into the tissues of the liver and brain, only stops the signs of intoxication, but does not protect the cells themselves. That is, the effect of alcohol consumed by Mexidol is not neutralized and causes harm to the body.

Pharmacokinetics

Rapidly absorbed when taken orally. When taken orally in doses of 400–500 mg, Cmax is 3.5–4 mcg/ml. Quickly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9–5.2 hours.

Metabolized in the liver by glucuron conjugation. 5 metabolites have been identified: 3-hydroxypyridine phosphate - formed in the liver and, with the participation of alkaline phosphate, breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, formed in large quantities and found in urine 1–2 days after administration; 3rd - excreted in large quantities in the urine; 4th and 5th - glucuron conjugates.

T1/2 when taken orally - 2–2.6 hours. It is quickly excreted in the urine, mainly in the form of metabolites and in small quantities unchanged. The most intensive elimination occurs during the first 4 hours after taking the drug. Rates of urinary excretion of unchanged drug and metabolites have individual variability.

Analogs

The pharmaceutical market offers not only Mexidol, but also its analogues. The drugs differ in the main substance (although the synonyms of Mexidol still contain the same ethylmethylhydroxypyridine succinate), auxiliary components, manufacturers, and the quality of purification of the raw materials used. That is why, after consulting a doctor, you can select medications in pharmacies that are similar in their therapeutic effect to Mexidol tablets, but are suitable for a specific clinical picture.

Replacement of the drug with an analogue must be agreed with the attending physician

Mexidol analogue tablets include:

• Medomexy;
• Mexiprim;
• Mexidant;
• Mexipridol;
• Mexicofin;
• Neurox;
• Cerecard.

Analogues of Mexidol injections

In terms of therapeutic effect, the following drugs are similar to the solution:

• Medomexy;
• Armadin;
• Mexico;
• Astrox;
• Mexipridol;
• Mexiprim.

The therapeutic effect can be achieved by other active substances. But not always analogues in effect can ideally replace the drug chosen by the doctor, so replacement is possible only after consultation.

Thus, the following medications are considered analogous in effect:

• Kaviton (active ingredient - vinpocetine) improves metabolism in brain cells, helps improve blood circulation;
• Nootropil (active ingredient - piracetam) stimulates brain activity;
• Glycine (active ingredient - glycine) improves processes in the brain;
• Cytoflavin (active ingredient - succinic acid) stimulates brain activity, improves thought processes, etc.

Mexidol or Actovegin?

Often those who take Mexidol are faced with a choice between it and Actovegin. What's better? The drugs have similar uses and are often prescribed together. Both act on the central nervous system, eliminate hypoxia, restore metabolism and affect the circulatory system. But Mexidol has broader pharmacological properties, and it is used in most cases. Allergic reactions to Actovegin are more common, but it can be taken by pregnant women. Also, unlike Mexidol, Actovegin is used for disorders in peripheral vessels, and to treat the consequences of such disorders - trophic ulcers and angiopathy. As a result, the decision to prefer one of the drugs or take them together falls on the shoulders of the doctor.

Compound