Pharmacodynamics and pharmacokinetics
The active ingredient, gramicidin C, is an antibiotic of the tyrothricine group , which is active against most Gram+ and Gram- microorganisms that cause infectious diseases in the oral cavity and pharynx. By increasing the permeability of microbial cell membranes for the penetration of inorganic cations, osmotic instability of the cells is achieved. In addition, during the resorption process, salivation increases, which promotes natural cleansing of inflammatory exudate and microorganisms, starting from the throat, oral cavity and ending with the tonsils.
Since gramicidin C is characterized by low systemic absorption, there are no data on pharmacokinetics.
How does Grammidin work?
The active substance of the drug violates the integrity of the membranes of bacterial cells, provoking their destruction. Grammidin has a local antiseptic effect in the oral cavity, slows down the proliferation of pathogens and stimulates the secretion of saliva, which softens inflamed mucous membranes. As a result of several applications, pain and swelling are reduced, swallowing becomes easier, and normal health is restored. The effectiveness of the drug is higher with initial signs of infection.
Grammidin with an anesthetic has an additional analgesic effect, smoothing out acute symptoms of inflammation. Gramicidin is not absorbed into the general bloodstream, so one should not expect a systemic effect from the drug.
Contraindications
Contraindications include groups of patients who are not recommended to take the drug:
- having hypersensitivity to the components of the tablets;
- pregnant and breastfeeding women, as well as children under 12 years of age.
Milk sugar - lactose is included in Grammidin tablets, which is why they should not be prescribed to people with galactose lactase enzyme deficiency or glucose-galactose malabsorption syndrome .
Is Grammidin safe for pregnant women and breastfeeding?
Grammidin cannot be used in the first trimester, as its components may be toxic to the tissues of the embryo. In exceptional cases, with severe inflammation of the gums or throat, you can use children's tablets or spray. But only with the prior permission of the doctor.
In the second and third trimester, pregnancy is not a contraindication for Grammidin. But self-medication should not be allowed.
Breastfeeding women are not recommended to use the drug, as the risk of it passing into breast milk cannot be completely ruled out. If treatment is necessary, children should be transferred to mixed or artificial nutrition.
Grammidin's analogs
Matches by level 4 ATC code: Grammidin with anesthetic Neo
Grammidin for children
Grammidin with anesthetic
Grammidin Neo
Bioparox
Gramicidin S
Trachisan
The price of Grammidin analogues ranges from 200-270 rubles, among them are Valenta Pharmaceuticals tablets with different compositions of active ingredients:
- Grammidin Neo (the drug is supplemented with active ingredients - oxybuprocaine and cetylpyridinium chloride ) No. 18 - 210-230 rubles;
- Grammidin Neo with anesthetic (supplemented with the anesthetic lidocaine hydrochloride ) No. 18 – 240-270 rubles;
- Children's with raspberry flavor (with cetylpyridinium chloride ) No. 18 - 180-200 rub.
How to use Grammidin
The drug is approved for treatment from 4 years of age. It is dissolved in the mouth after eating like a candy, without chewing, until completely dissolved:
- patients under 12 years old: 1 pc. 2 times a day;
- from 12 years and older: 2 pcs. up to 4 times a day;
- course of therapy: 5–6 days.
To ensure that the active substance remains on the mucous membranes for as long as possible, after taking the medicine you should not drink or eat food for 1 hour. Otherwise, Grammidin will not have any effect.
Grammidin price, where to buy
The cost of Grammidin tablets ranges from 270 rubles. The price of Grammidin starts from 180 rubles - for children and ends with Neo with Anesthetic (pain reliever) - 280 rubles. The best place to buy the drug is in Moscow pharmacies and other pharmaceutical companies working directly with ValentaPharm.
You can find out how much an analogue of the drug costs and other information on the manufacturer’s official website.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Grammidin spray dosage.
for places approx. 0.06 mg+0.1 mg/dose vial. 112 doses Delpharm Bladel B.V./JSC Valenta Pharm RUB 335 order - Grammidin NEO with anesthetic tablets for rassas. 3mg+0.2mg+1mg 18 pcs. JSC Valenta Pharmaceuticals
RUB 359 order
- Grammidin NEO tablets for rassas. 3mg+1mg 18 pcs. JSC Valenta Pharmaceuticals
RUB 296 order
- Grammidin children's tablets for rassas. 1.5mg+1mg 18 pcs. JSC Valenta Pharmaceuticals
RUB 317 order
- Grammidin with anesthetic spray for places. approx. fl. 112 doses Delpharm Bladel B.V./JSC Valenta Pharm
RUR 379 order
Pharmacy Dialogue
- Grammidin NEO with anesthetic lozenges No. 18 Valenta Pharmaceuticals OJSC
RUB 354 order
- Grammidin spray for children 0.03 mg+0.1 mg/dose 112 dosesValenta Pharmaceuticals
RUR 542 order
- Grammidin NEO lozenges No. 18 Valenta Pharm JSC
RUB 299 order
- Grammidin spray 0.06 mg+0.1 mg/dose 112 doses Famar Netherlands B.V./Valenta Pharm JSC
RUB 354 order
- Grammidin spray 0.06 mg+0.1 mg/dose 112 doses Valenta Pharmaceuticals OJSC
RUR 358 order
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List of main indications and contraindications for prescribing the drug
In therapeutic and otorhinolaryngological practice, Grammidin is used to treat a wide range of diseases, such as:
- Acute pharyngitis. This is an inflammation of the pharyngeal mucosa.
- Acute tonsillitis. Otherwise, this disease is called angina. It is characterized by inflammation of the tonsils.
- Stomatitis (disease of the mucous membranes of the mouth).
- Periodontitis.
- Gingivitis.
- Other inflammatory processes of this localization, caused by infection and other damaging factors.
Conditions that are contraindications to taking Grammidin:
- The entire period of pregnancy.
- Breast-feeding.
- Children's age up to 12 years.
- History of allergic reactions to the main or excipients of the drug.
- Enzyme deficiency (lactase deficiency).
- Malabsorption syndrome (galactose-glucose).
Grammidin NEO with anesthetic lozenges No. 18
A country
Russia
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Gramicidin C + Oxybuprocaine + Cetylpyridinium chloride
Compound
Gramicidin C, oxybuprocaine, cetylpyridinium chloride.
pharmachologic effect
Antibacterial combined drug for local use in the oral cavity and pharynx. The drug contains the antibiotic gramicidin C, the local anesthetic oxybuprocaine and the antiseptic cetylpyridinium chloride. The drug has a pronounced antibacterial effect against pathogens of infectious and inflammatory diseases of the pharynx and oral cavity. Increases the permeability of the microbial cell membrane, which disrupts its barrier functions and leads to its death. The anesthetic oxybuprocaine, causing a reversible block of axonal conduction of nerve impulses, has an analgesic effect on the mucous membrane of the oral cavity and pharynx. Cetylpyridinium chloride, being an antiseptic, inhibits the growth and reproduction of pathogens of infectious diseases of the oral cavity. The drug has antimicrobial, analgesic and anti-inflammatory effects, reduces discomfort in the oral cavity and pharynx, and facilitates the swallowing process. When absorbed, the drug stimulates hypersalivation, which promotes mechanical cleansing of the oral cavity and pharynx from microorganisms. The drug has a local effect.
Indications for use
Infectious and inflammatory diseases of the oral cavity and pharynx: sore throat, pharyngitis, tonsillitis, periodontal disease, gingivitis, stomatitis.
Mode of application
For adults and children over 12 years of age, the drug is prescribed 1 tablet 3-4 times a day; children aged 4 to 12 years - 1 tablet 1-2 times a day. The tablets are used after meals, dissolving in the mouth without chewing. Immediately after using the drug, you should refrain from eating and drinking for 1-2 hours. If there is no therapeutic effect within 7 days of taking the drug, the patient should consult a doctor.
Interaction
The drug, when taken together, increases the effectiveness of other antimicrobial agents of local and systemic action.
Side effect
In some cases: allergic reactions, temporary loss of sensitivity of the tongue.
Contraindications
I trimester of pregnancy, children under 4 years of age, hypersensitivity to the components of the drug.
Overdose
No data.
special instructions
No data.
Reviews about Grammidin
Comments about the drug from patients and doctors are full of variety. There are both positive and negative reviews about it. However, this is typical for any product.
Most experts recommend this remedy, because it has been tested for years, acts quickly and does not have a systemic effect. With its help, you can quickly get rid of a sore throat and suppress the resulting inflammatory process.
There are various variants of Grammidin, intended for children and adults and differing from each other in different tastes and aromas. This will make your treatment as pleasant as possible.
