Compound
Chondroxide tablets contain 1 pc. chondroitin sulfate 250 mg, as well as calcium stearate, crospovidone, microcrystalline cellulose, magnesium hydroxycarbonate - in the form of excipients.
1 g of gel for external use contains chondroitin sulfate 50 mg and additional substances: dimethyl sulfoxide, propylene glycol, isopropanol, ethanol, sodium disulfite, nipazole, nipagin, carbomer, orange food flavoring, water.
1 g of ointment for external use contains 50 mg of chondroitin sulfate
pharmachologic effect
Regulation of metabolism in cartilage tissue. Provides regeneration of cartilage tissue, chondrostimulation, anti-inflammatory effect.
Takes part in the construction of cartilage and bone tissue, improves metabolism in hyaline and fibrous cartilage. Inhibits degenerative changes in connective tissue and cartilage, ensures inhibition of enzymes that damage cartilage tissue.
Activates the synthesis of proteoglycans , regenerates the surface of the joints and joint capsule, stimulates the production of intra-articular fluid. Inhibits bone resorption, restores bone tissue and protects against calcium loss.
The drug slows down the development of osteochondrosis and osteoarthrosis, reduces pain in the affected joints. When taking the drug, the range of motion in the affected joints increases.
The use of the drug makes it possible to reduce the dosage of NSAIDs.
The gel relieves pain and inflammation.
Chondroxide 250 mg No. 60 tablets
Chondroxide 250 mg No. 60 tablets
Trade name Chondroxide® International nonproprietary name No Dosage form Tablets 250 mg Composition One tablet contains the active substance - chondroitin sulfate sodium 250 mg, excipients: calcium stearate monohydrate, crospovidone, povidone K-30, microcrystalline cellulose, magnesium hydroxycarbonate pentahydrate. Description Tablets from white with a yellowish tint to white with a creamy tint, interspersed, scored and chamfered. Pharmacotherapeutic group Other non-steroidal anti-inflammatory drugs. Chondroitin sulfate. ATC code M01AX25 Pharmacological properties Pharmacokinetics Absorption With a single oral administration of an average therapeutic dose, the maximum concentration in the blood plasma is achieved after 3-4 hours, in the synovial fluid - after 4-5 hours. Bioavailability of the drug is 13% Distribution Accumulates mainly in cartilage tissue (maximum concentration in articular cartilage is achieved after 48 hours); the synovial membrane is not an obstacle to its penetration into the joint cavity. Excretion Excreted by the kidneys within 24 hours. Pharmacodynamics Chondroxide® has a chondrostimulating, regenerating and anti-inflammatory effect, participates in the construction of the basic substance of cartilage and bone tissue; affects metabolic processes in hyaline and fibrous cartilage. Inhibits the processes of degeneration (destruction) of cartilage tissue and stimulates restoration processes in articular cartilage. Chondroxide® stimulates the biosynthesis of proteoglycans, promotes the regeneration of the joint capsule and cartilaginous surfaces of the joints, and has an anti-inflammatory effect. Slows down bone resorption and reduces calcium loss, accelerates bone tissue restoration processes. Chondroxide® slows down the progression of osteoarthritis and osteochondrosis. When using the drug Chondroxide®, pain decreases and mobility of the affected joints improves, while the therapeutic effect persists for a long time after the end of the course of therapy. Possessing structural similarity to heparin, it can potentially prevent the formation of fibrin thrombi in the synovial and subchondral microvasculature. Indications for use - degenerative-dystrophic diseases of the joints and spine (osteoarthrosis, including osteoarthritis of the temporomandibular joint, spondyloarthrosis, osteochondrosis, osteoporosis, cheiroarthropathy) Method of administration and dose Orally, 0.5 g (2 tablets) 2 times per day. The tablets are taken with a small amount of water. The recommended duration of the initial course is 6 months. It should be taken into account that the therapeutic effect of the drug persists for 3-5 months after its discontinuation, depending on the location and stage of the disease. If necessary, repeated courses of treatment are possible, the duration of which is determined individually. Side effects Rarely (from > 0.01% to - allergic reactions - nausea, vomiting - diarrhea Contraindications - hypersensitivity to the components of the drug - childhood and adolescence under 18 years of age - pregnancy - lactation period Drug interactions Possible increased effect of indirect anticoagulants, antiplatelet agents, fibrinolytics Special instructions 's effect on the ability to drive a car or potentially dangerous mechanisms. Does not affect the ability to drive a vehicle. means or potentially dangerous mechanisms. Overdose Symptoms: rarely - nausea, vomiting, diarrhea, with prolonged use in excessively high doses (more than 3 g / day), hemorrhagic rashes are possible. Treatment: symptomatic therapy. Release form and packaging 10 tablets are placed in a blister pack made of polyvinyl chloride film or polyvinyl chloride/polyvinylidene chloride or polyvinyl chloride/polyethylene/polyvinylidene chloride or oriented polyamide/aluminum/polyvinyl chloride laminate and printed varnished aluminum foil. 6 contour packages together with instructions for medical use in the state and Russian languages are placed in a cardboard pack. Storage conditions Store in a dry place, protected from light, at a temperature not exceeding 25 °C. Keep out of the reach of children! Shelf life: 2 years Do not use after expiration date. Conditions for dispensing from pharmacies Without a prescription
Pharmacodynamics and pharmacokinetics
Oral administration provides maximum concentration in the blood plasma within 4 hours, after 4-5 hours - in the joint cavities. Bioavailability is 13%.
The maximum concentration in joint cartilage is achieved within 48 hours. It is excreted in urine within 24 hours.
The use of the gel, due to the content of dimethyl sulfoxide, ensures effective penetration of chondroitin sulfate deep into the tissues. The maximum concentration for external use occurs after 30 minutes. The drug remains in the joint for 5 hours.
Instructions for use of Chondroxide (Method and dosage)
Take 2 tablets orally with a small amount of water twice a day. It is recommended to continue the initial course of treatment for up to six months. After stopping treatment, the therapeutic effect lasts for 4-5 months. depending on the development of the disease.
When applied topically (ointment, gel), apply up to 3 times a day to the affected area. The gel is applied with patting movements until completely absorbed. The course of treatment can range from 2 to 8-12 weeks. The instructions for use of the ointment recommend applying the drug by rubbing into the skin, the course of treatment is up to 3 weeks.
It is possible to prescribe, if necessary, repeated courses of treatment on an individual basis.
Which is better: gel or ointment?
The gel relieves pain well and does not require rubbing. It also does not stain clothes or leave marks on the skin; it is quickly absorbed, so you do not need to spend a lot of time on application. Fat-based ointment, well suited for use in massage and self-massage.
Chondroxide injections are not available, but if necessary, injectable analogues are used to supplement treatment.
How to take it correctly
The tablets must be taken orally twice a day. Take a small amount of liquid. Initially, the duration of the therapeutic course averages 5-6 months. Upon completion of taking the drug, the result lasts for approximately the same time, taking into account the severity of the condition.
Topical medicine (gel, ointment) is applied three times a day. The gel should be applied to the affected area, rubbing in smooth movements until completely absorbed. The therapeutic course can last from 2 weeks to 3 months.
You can use the ointment for no longer than 3 weeks. The product should also be rubbed into the skin with smooth movements.
Taking into account the patient’s condition, the attending physician may prescribe another course of therapy.
Chondroxide analogs
Level 4 ATX code matches:
Nimulid
Diacerein
Aponil
Chondroitin sulfate
Sigan
Don
Nimegesic
Artiflex
Nimesil
Nimika
Artron Hondrex
Artron Flex
Artron Complex
Arthroker
Arthrodarin
Nemulex
Chondroitin
Glucosamine Hydrochloride
Glucosamine
Nimid Forte
There are cheap analogs of tablets - these are Chondroitin - Akos and a large number of biologically active additives, their cost is from 65 rubles, and expensive ones - Teraflex (contains glucosamine ) - cost 966 rubles, Structum (chondroitin sulfate) - cost from 1100 rubles .
The price of ointment analogues is from 64 rubles. ( Chondroitin ) up to 150 rub. ( Arthro-Active ).
Chondroguard and Mucosat injections are injection analogues - they contain chondroitin.
Analogs
Cheap but effective analogues of tablets include Chondroitin - Akos. More expensive are Structum and Teraflex. Analogues of the ointment are Arthro-Active and Chondroitin.
Treaflex. The price starts from 350 rubles. This is a drug that is prescribed for osteochondrosis and osteoarthritis. Can be given to children from 15 years of age. Contraindicated during pregnancy and breastfeeding.
Structum. The price of the drug is 1400 rubles. Has anti-inflammatory and regenerating effects. Contraindicated during pregnancy, lactation, and children under 15 years of age.
Reviews of Chondroxide
Numerous reviews suggest that the tablets are effective when taken for a very long time over several months and in the early stages of diseases. There are reviews of the gel as an effective remedy for relieving swelling and pain in the joints.
The ointment is actively used in physiotherapy - phonophoresis using ointment is used to treat osteoarthritis as an effective and safe remedy that does not cause side effects.
Contraindications
The medicine in tablet form should not be taken if:
- bearing a child;
- during breastfeeding;
- children;
- personal intolerance to constituent elements.
External agents should not be taken:
- children;
- with excessive sensitivity to the constituent components;
- if the skin is damaged in the area where the product is applied.
Price, where to buy tablets
Price of Chondroxide tablets 60 pcs. ranges from 367 to 436 rubles. The price of the gel in Russia is from 239 rubles. per tube 30 grams, in Ukraine – 71 UAH.
The price of ointment in Russia is 30 g - 235 rubles.
How much does ointment cost in Ukraine? The price of a 30 g tube is 70 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Chondroxide ointment 5% 30 gAO "Nizhpharm"
363 rub. order - Chondroxide gel 5% 30 gAO "Nizhpharm"
RUB 381 order
Pharmacy Dialogue
- Chondroxide gel (tube 5% 30g) Nizhpharm JSC
RUB 359 order
- Chondroxide ointment (tube 5% 30g) Nizhpharm JSC
RUB 346 order
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Pharmacy24
- Chondroxide 5% 30 g gel
103 UAH. order
PaniPharmacy
- Chondroxide gel Chondroxide gel 5% for external use 30g tube Russia, Nizhpharm
107 UAH order
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