Artoxan Liof for prepared solution for intravenous and intramuscular administration 20 mg N3

Composition and dosage form

The drug is produced in the form of a lyophilized concentrate - a dense mass of greenish-yellow color. In some cases - in the form of large tablets sold together with a solvent. The drug is intended for parenteral administration: making intramuscular and intravenous injections. The cardboard packaging of Artoxan contains 3 sealed glass bottles of lyophilisate and ampoules with water.

The active substance is tenoxicam, which has a complex antipyretic, analgesic and antiplatelet effect. A dose of Artoxan contains 20 mg. tenoxicam, auxiliary and stabilizing components.

Artoxan or Texared – which is better?

Manufacturer: Dr. Reddis, India
Release form: tablets, lyophilisate for preparation of injection solution

Active ingredient: Tenoxicam

Synonyms: Artoxan, Texamen, Tikotil, Tobitil

The analogue of Artoxan Texared is the original tenoxicam, it contains the same active ingredient, but unlike Artoxan, it is also available in the form of tablets for internal use.

Texared analogue tablets are prescribed one per day after meals. The course of treatment is from 5–10 days, then at the discretion of the doctor.

In case of an acute attack of gout in the first two days - 2 tablets per day, then one at a time. The general course is one week.

Mechanism of action

Artoxan inhibits the production of prostaglandins and the accumulation of enzymes in lesions, including in the cartilaginous elements of the skeleton. The drug has a cumulative effect. A pronounced anti-inflammatory and analgesic effect develops 5–7 days after the first injection. Therefore, the drug is used for joint pathologies.

In addition to eliminating the symptoms of inflammation and pain, the drug reduces platelet aggregation, preventing the formation of blood clots and thrombi. When the active substance enters the blood, it quickly penetrates into all tissues and fluids and interacts with albumin almost 100%. Metabolism occurs in liver cells. Excretion of the drug is regulated by the intestines and kidneys.

pharmachologic effect

Manufacturer: Rotapharm, UK / Egypt
Release form: lyophilisate for the preparation of injection solution

Active ingredient: Tenoxicam

Synonyms: Texamen, Texared, Tikotil, Tobitil

Artoxan is part of the oxicam subgroup, the mechanism of action is associated with inhibition of cyclooxygenase enzymes with a subsequent decrease in the synthesis of prostaglandins, which cause an inflammatory process. In addition, the drug reduces the activity of enzymes that contribute to the destruction of cartilage tissue.

The maximum therapeutic effect occurs approximately 5-7 days from the start of use.

When is Artoxan needed?

The scope of application of non-steroidal anti-inflammatory drug injections is pathology of the musculoskeletal system: the pain syndrome they cause. Injections are prescribed:

• for osteoarthritis;
• degenerative processes in the area of ​​hard tissues of the spine and joints;
• exacerbations of osteochondrosis;
• for rheumatoid arthritis;
• for gout;
• tendovaginitis, bursitis, consequences of mechanical injuries to joints and ligaments.

Artoxan is also used to relieve pain of various origins: headaches, dental pain, neuralgic attacks, migraines, pathologically painful periods. And also for burns and soft tissue injuries.

Artoxan or Diclofenac – which is better?

Manufacturer: Microgen, Dalkhimfarm, Biokhimik, Russia/Kadila, India
Release form: tablets, injection solution, suppositories, cream and gel for external use.

Active ingredient: Diclofenac

Synonyms: Voltaren, Diclak, Ortofen, Diclovit, Diclogen, Diclonate, Dicloran, Naklofen

Artoxan's analog Diclofenac is a non-steroidal anti-inflammatory drug of non-selective action, the active substance and generic name for Voltaren and Naklofen. It is used in injections, tablets, and in the form of ointment and gel.

The advantage of the Diclofenac analogue over Artoxan is its lower price. It is prescribed less and less due to its negative effect on the gastrointestinal tract.

How to use Artoxan: instructions

The drug does not affect the progress of the general disease; it is used only to reduce symptoms. The solution is prepared a few minutes before administration; the diluted medication cannot be stored.

• The contents of the bottle are combined with the liquid and thoroughly shaken several times until the mass is completely dissolved, becomes homogeneous, and yellowish in color.
• The needle in the syringe is replaced after mixing the drug.
• With an intramuscular injection, the drug is injected deep into the gluteal or other large muscle.
• For intravenous injection, the drug is injected as slowly as possible.

The frequency of Artoxan injections is 1 time per day, one dose of the drug. The duration of pain relief is no more than two days in a row. In the future, you need to use oral medications containing tenoxicam to avoid intoxication of the body.

Artoxan's analogs

Artoxan injections can be replaced with its synonyms, for example, injections of Texarel, Tenoxicam, Texamen, or other anti-inflammatory drugs - Movalis, Xefocam, Voltaren, Ketoprofen.

Chondroprotectors such as Chondroguard, Drastop, Chondroitin can also be considered substitutes for Artostan, but it is better to use them in the complex treatment of the articular system.

There are analogues of the drug Artoxan not only for injections, but also for internal use, for example, tablets Texared, Diclofenac, Arcoxia, Celebrex, Tenoctil in capsules, Nimesil in powder.

Prices for Artoxan analogues in different dosage forms are presented in the table:

Arthrozan

Manufacturer: Pharmstandard, Russia
Release form: tablets, solution for intramuscular injection

Active ingredient: Meloxicam

Synonyms: Movalis, Amelotex, Movasin, Mirlox, Movix, Melox, Melbek

Analogue Artrosan is a domestic anti-inflammatory drug, a substitute for Artoxan injections in the form of ampoules with an injection solution. It is used as an analgesic for inflammatory diseases of the joint apparatus, both in the form of injections and in the form of tablets.

Movalis

Manufacturer: Boehringer Ingelheim, Germany
Release form: tablets and suspension for internal use, injection solution and suppositories

Active ingredient: Meloxicam

Synonyms: Artrosan, Amelotex, Movasin, Mirlox, Melbek

The Movalis analogue is a selective NSAID, that is, it selectively reduces the activity of cyclooxygenase, does not affect COX-1 in the gastric mucosa and kidneys, therefore side effects are less pronounced, unlike Artostan and other non-selective NSAIDs. Used orally and intramuscularly as an analgesic and anti-inflammatory agent.

Arcoxia

Manufacturer: Merck, Netherlands
Release form: film-coated tablets

Active ingredient: Etoricoxib

Synonyms: STREGA, Ethoriax, Bixitor, Atorica

Arcoxia is an analogue of Artostane in tablets; it selectively inhibits cyclooxygenase-2, acting only at the site of inflammation, without touching the stomach, kidneys and platelets. Therefore, the analogue of Artostan Arcoxia is less dangerous than other NSAIDs.

The drug is used for the same joint diseases and also relieves pain and inflammation.

Meloxicam

Manufacturer: Dalkhimfarm, Kanonpharma, Slavyanskaya Pharmacy, Russia
Release form: tablets, solution for intramuscular injection

Active ingredient: Meloxicam

Synonyms: Movalis, Artrosan, Amelotex, Movasin, Mirlox, Melbek

Meloxicam is the active substance and international non-proprietary name of many analogues cheaper than Artostan, for example, Amelotex or Movasin, as well as the original Movalis.

The analogue of Artostane Meloxicam is used in the form of injections and tablets to relieve pain and inflammation. One tablet or one injection per day is enough. The course of treatment for tablets is 5–10 days, for injections – 3–6 days.

Side effects

When using Artoxan, reactions from internal organs and systems are possible:

• from the digestive tract: heaviness in the abdomen, gastritis, nausea, abdominal cramps, heartburn, diarrhea;
• from the central nervous system: dizziness, asthenia, increased drowsiness, weakness, decreased mood, apathy, tinnitus, blurred vision;
• from the heart: tachycardia, arrhythmic manifestations;
• changes in blood count, high levels of liver tests, leukocytosis.

Skin symptoms are also likely: itching, erythema, rashes.

The drug is prescribed with caution to patients with low body weight, inflammatory diseases of the heart, kidneys, autoimmune pathologies, diabetes mellitus, and other chronic somatic disorders.

Artoxan

Tenoxicam has a high degree of binding to albumin and can, like all NSAIDs, enhance the anticoagulant effect of warfarin and other anticoagulants. It is recommended to monitor indicators when used together with anticoagulants and hypoglycemic drugs for oral administration, especially in the initial stages of using Artoxan.

No possible interaction with digoxin was noted.

As with other NSAIDs, it is recommended to use the drug with caution concomitantly with cyclosporine due to an increased risk of nephrotoxicity.

Concomitant use with quinolones may increase the risk of seizures.

Salicylates can displace tenoxicam from its binding to albumin and, accordingly, increase the clearance and volume of distribution of the drug. The simultaneous use of salicylates or two or more NSAIDs should be avoided (increased risk of gastrointestinal complications).

There is evidence that NSAIDs reduce lithium excretion. Therefore, patients receiving lithium therapy should monitor lithium blood concentrations more frequently.

NSAIDs may cause sodium, potassium, and fluid retention in the body, interfering with the action of natriuretic diuretics. This must be remembered when used together with such diuretics in patients with CHF and arterial hypertension.

It is recommended to use NSAIDs with caution in combination with methotrexate; NSAIDs reduce the elimination of methotrexate and may increase its toxicity.

NSAIDs should not be used within 8-12 hours after using mifepristone, because may reduce its effect.

It is necessary to take into account the increased risk of gastrointestinal bleeding when used together with corticosteroids.

Reduces the effectiveness of uricosuric drugs, enhances the effect of anticoagulants, fibrinolytics, side effects of mineralocorticosteroids and glucocorticosteroids, estrogens; reduces the effectiveness of antihypertensive drugs and diuretics.

Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites. Combined use with antiplatelet agents and selective serotonin reuptake inhibitors increases the risk of gastrointestinal bleeding.

Cardiac glycosides, when taken together with NSAIDs, can worsen heart failure, reduce glomerular filtration rate and increase plasma levels of cardiac glycosides.

No interaction has been identified when using tenoxicam with cimetidine. No clinically significant interaction has been identified during treatment with tenoxicam and penicillamine or parenteral gold.

The risk of nephrotoxicity increases when NSAIDs are used concomitantly with tacrolimus.

The risk of hematological toxicity increases when using NSAIDs with zidovudine.

Contraindications

It is necessary to stop using Artoxan:

• with high sensitivity of the body to ibuprofen, acetylsalicylic acid and other NSAIDs;
• allergic reactions to the components of the drug: skin itching, severe rashes;
• gastric ulcer, erosive lesions of the intestinal mucosa;
• for bronchial asthma in combination with other pathologies of the respiratory tract;
• in preparation for heart bypass surgery and during the recovery period after surgery;
• severe form of renal or liver failure;
• with heart failure (uncompensated);
• for pathologies of the hematopoietic system, low coagulability.

Artoxan is also contraindicated during pregnancy and for mothers who are breastfeeding, since its active substance penetrates the placenta and into milk.

The drug should not be used by patients under 18 years of age.