Pharmacy No. 84. Delivery of medicines to your home and office.

Delivery on Sundays and holidays does not work!

Medicines

my basket

Apteka84.kz is an online pharmacy that offers its customers medicines, medicinal and decorative cosmetics, dietary supplements, vitamins, baby food, intimate products for adults, medical equipment and thousands of other medical and cosmetic products at low prices. All data presented on the Apteka84.kz website is for informational purposes only and is not a substitute for professional medical care. Apteka84.kz strongly recommends that you carefully read the instructions for use contained in each package of medicines and other products. If you currently have any symptoms of the disease, you should seek help from a doctor. You should always tell your doctor or pharmacist about all the medicines you take. If you feel you need further help, please consult your local pharmacist or contact our GP online or by telephone.

FLUIMUCIL (solution)

and an antibiotic, because without it we couldn’t even cope with the temperature.
In general, at the beginning of June 2022, we “met” a completely new antibiotic for us - Fluimucil Antibiotic IT. In general, I knew about Fluimucil before, but I never thought that there was also “”... an IT antibiotic.” A new ENT-audiologist (we had never been to this doctor before, we came to her as the one on duty) prescribed us inhalations with this “IT”. And she warns that it smells foul (for example, her husband shrinks from the smell), but it is extremely effective! Dosing method according to its scheme: mix the contents of the bottle and ampoule with each other,

leave the resulting solution for 3 days,

Mix 1 part with some other drug (I don’t remember which one) in a nebulizer and breathe only once a day. And that our temperature will drop in 2 days. In general, they started giving the child inhalations. How he screamed! The husband and grandmother or husband and grandfather held the child (sometimes the grandmother was also the third “fighter”), and I held the mask to my mouth. The child was struggling! I don’t know how this antibiotic smelled to my child, but on the 2nd day my husband said that even he was starting to choke. We did NOT complete the course of treatment (it seems like 6 inhalations were prescribed); we barely managed to get through the first 3 days. But they canceled it because on the 2nd day the child started bleeding from the nose. On the third day, during the third inhalation, my nose started bleeding even more! But just a couple of hours after the first inhalation, the child’s temperature dropped sharply to 37.5, and the next day there was no temperature at all.

As a mother, I was confused by the fact that the ENT-audiologist told us that the ready-made solution in the bottle should be divided into 3 days, but the instructions say that this cannot be done:

After some time, I again went to see an ENT specialist, who prescribed this antibiotic for us, and she said that this was the first time she had heard that inhalations with this antibiotic had a side effect in the form of nosebleeds. I am NOT claiming that the child bled twice precisely because of the inhaled vapors. But I admit it. I also admit that the child could have been disgusted by the smell of this drug, or he, like the husband, had difficulty breathing and that’s why he screamed and struggled so wildly, and blood began to flow from the screams, roars and tension. Let me remind you once again that it was always held by at least 2 adults. And the child struggled and screamed like never before! (Before that time he had not liked inhalations before, but we had never seen or heard such hysterics). I will also note that after that antibiotic (3-day course) we never had otitis media, but we did put tubotitis (checked several times in the summer). Well, recently we removed the cause of otitis and tubotitis - adenoids. The ENT specialists insisted. I hope that we will forget about otitis media and that my hearing will gradually return to normal. If anything, I dosed the drug using a syringe - it’s very convenient to measure the required dosage. I also note that the drug is difficult to find. Even some pharmacists in completely different pharmacies either have not heard of it at all, or have heard of it, but have never brought it to the pharmacy. But it seems that I found this drug in the 5th or 6th pharmacy. By the way, it is not cheap, especially if used according to the instructions - for inhalation, use only a freshly opened bottle.

Fluimucil solution for and/or inhalation. 100mg/ml 3ml amp 5 pcs

Pharmacological group:

Expectorant mucolytic agent.
Pharmacodynamics:
Mucolytic agent, dilutes sputum, increases its volume, facilitates sputum separation. The action is associated with the ability of free sulfhydryl groups of acetylcysteine to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolymerization of mucoproteins and a decrease in viscosity/sputum. Remains active against purulent sputum.

Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs. It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins. Acetylcysteine easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant, cytoprotector that traps endogenous and exogenous free radicals and toxins. Acetylcysteine prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, thus promoting the detoxification of harmful substances. This explains the effect of acetylcysteine as an antidote for paracetamol poisoning.

Protects alpha1-antitrypsin (elastase inhibitor) from the inactivating effects of HOC1, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).

Pharmacokinetics:

With intravenous administration of 600 mg of acetylcysteine, the maximum plasma concentration is 300 mmol/l, the plasma half-life is 2 hours. The total clearance is 0.21 l/h/kg, and the volume of distribution at the plateau is 0.34 l/kg.

In the liver it is deacetylated to cysteine. In the blood, a mobile equilibrium of free acetylcysteine and its metabolites (cysteine, cystine, diacetylcysteine) is observed, free and bound to plasma proteins. Acetylcysteine penetrates into the intercellular space and is predominantly distributed in the liver, kidneys, lungs, and bronchial secretions.

It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged through the intestines.

Penetrates through the placental barrier.

Buy Fluimucil-antibiotic IT powder for injection 500 mg No. 3 in pharmacies

Brief description FLUIMUCIL ANTIBIOTIC is a mucolytic agent that thins sputum, increases its volume, and facilitates the separation of sputum.

Pharmacological action Thiamphenicol glycinate acetylcysteinate is a complex compound that combines the antibiotic thiamphenicol and the mucolytic acetylcysteine. After absorption of thiaminephenicol, glycinate acetylcysteinate is split into acetylcysteine and thiamphenicol. Thiamphenicol is a derivative of chloramphenicol, the mechanism of action is associated with inhibition of bacterial cell protein synthesis. Thiamphenicol has a wide spectrum of antibacterial action and is effective in vitro against bacteria that most often cause respiratory tract infections: gram-positive (Streptococcus pneumoniae, Corynebacterium diphtheriae, Staphylococcus spp., Streptococcus pyogenes, Listeria spp., Clostridium spp.) and gram-negative (Haemophilus influenzae, Neisseria spp., Salmonella spp., Escherichia coli, Shigella spp., Bordetella pertussis, Yersinia pestis, Brucella spp., Bacteroides spp.). Acetylcysteine, by breaking the disulfide bonds of mucoproteins, quickly and effectively dilutes sputum and pus, reduces their viscosity and promotes discharge. Acetylcysteine facilitates the penetration of the antibiotic thiamphenicol into lung tissue and inhibits the adhesion of bacteria to the epithelium of the respiratory tract.

Indications: diseases of the upper respiratory tract and ENT organs: exudative otitis media, sinusitis, laryngotracheitis; - diseases of the lower respiratory tract: acute and chronic bronchitis, prolonged pneumonia, lung abscess, emphysema, bronchiectasis, cystic fibrosis, bronchiolitis, whooping cough; — prevention and treatment of bronchopulmonary complications after thoracic surgery (bronchopneumonia, atelectasis); — prevention and treatment of obstructive and infectious complications of tracheostomy, preparation for bronchoscopy, bronchoaspiration; — with concomitant nonspecific forms of respiratory infections to improve drainage, including cavernous lesions, with mycobacterial infections. Method of administration and dosage Fluimucil® antibiotic IT is administered intramuscularly, used for inhalation, application, and cavity rinsing. Inhalation: adults - 250 mg 1-2 times a day; children - 125 mg 1-2 times a day. Endotracheal: through a bronchoscope, endotracheal tube, tracheostomy - 1-2 ml of solution (for adults, dissolve in 4 ml of water for injection - 500 mg of dry matter, for children - 250 mg). Locally: for administration into the paranasal sinuses, as well as for washing cavities after surgical interventions in the area of the nose and mastoid process, 1-2 ml of solution (for adults, dissolved in 4 ml of water for injection - 500 mg of dry matter, for children - 250 mg ). For diseases of the nasopharynx and ear, instill 2-4 drops into each nasal passage or external auditory canal. Intramuscularly: adults - 500 mg 2-3 times a day; children under 3 years old - 125 mg 2 times a day; 3-7 years - 250 mg 2 times a day; 7-12 years - 250 mg 3 times a day. For premature and newborn babies up to 2 weeks, the average dose is 25 mg/kg per day. If necessary, the dose can be increased by 2 times (in the first 2-3 days of treatment in particularly severe cases). Do not increase the dose in premature and newborn children, as well as in patients over 65 years of age. The course of treatment is no more than 10 days.

Side effects Allergic reactions. With intramuscular administration, a slight burning sensation at the injection site is possible, rarely - reticulocytopenia, anemia, leukopenia, neutropenia, thrombocytopenia. With inhalation administration - reflex cough, local irritation of the respiratory tract, stomatitis, rhinitis, nausea. Bronchospasm is possible, in which case bronchodilators are prescribed.

Contraindications - anemia; - leukopenia; - thrombocytopenia; - hypersensitivity to one of the components of the drug. With caution: with liver failure and chronic renal failure. In children of the first two years of life due to age-related characteristics of kidney function.

Overdose Symptoms: changes in bacterial flora, superinfections. It is possible that the side effects of the drug may increase (with the exception of allergic reactions). Maintenance therapy is recommended.

Special instructions During treatment, the peripheral blood picture should be monitored. If the number of leukocytes (less than 4 thousand/μl) and granulocytes (by more than 40%) decreases, the drug is discontinued. Fluimucil IT antibiotic solution should not come into contact with metal and rubber surfaces. Fluimucil® antibiotic IT does not affect the ability to drive vehicles and other mechanisms.

Interaction with other drugs The simultaneous administration of antitussives may increase sputum stagnation due to suppression of the cough reflex. It is not recommended to mix with other aerosol medications.

Storage conditions At temperatures from 15°C to 25°C. Keep out of the reach of children.

Shelf life: lyophilisate for the preparation of solution for injection and inhalation 500 mg (bottles) - 3 years; solvent: water for injection (ampoules) - 5 years; set - 3 years.