Compound
- 1 ml of Nazivin Sensitive in the form of drops for children contains 100 mcg of oxymetazoline hydrochloride . Additional substances: citric acid monohydrate, glycerol 85%, water, sodium citrate dihydrate.
- 1 ml of Nazivin Sensitive in the form of a spray for children contains 250 mcg of oxymetazoline hydrochloride. One dose contains 11.25 mcg of oxymetazoline hydrochloride . Additional substances: citric acid monohydrate, glycerol 85%, water, sodium citrate dihydrate.
Release form
- Nasal drops 0.01% is a transparent solution of pale yellow color, 5 ml of solution in a polyethylene bottle with a dispenser, one bottle in a paper box.
- Nasal spray is a transparent solution of pale yellow color, 10 ml of solution (includes 220 doses) in a polyethylene bottle with a dispenser, one bottle in a paper box.
Note: in numerous descriptions and references to these medicines on the Internet you can find such names as “Nazivin for children”, “Nazivin for baby”, “Nazivin for babies”, “Nazivin for children under one year old”. Officially, there are no drugs with these names. The first name includes both described forms of the drug: spray used in children 1-6 years old and drops used in children under one year of age. And the rest of the listed names, including “Nazivin for babies”, “Nazivin for children up to one year old”, correspond only to the drug in the form of drops.
Reviews
- Margarita, 34 years old
: “When the child had a runny nose, I immediately began to wash her nose with saline solution. But he only allowed him to quickly remove the mucus, but only Nazivin was able to cope with nasal congestion. I used the drug for only 3 days and such an unpleasant symptom as a runny nose disappeared.” - Elena, 25 years old:
“I have been using Nazivin for a long time to treat my daughter’s runny nose. During all this time, we did not experience any side effects. Although my friend's situation is the opposite. When they used the drug, her son had a severe headache and a burning sensation.” - Veronica, 45 years old
: “Nazivin for children copes well with my grandson’s nasal congestion. He is 5 years old, but trips to the garden in the cold season always end with him getting sick. I tried many drops: Pinosol, Otrivin, but we were unable to get the same effect as from Nazivin. All we have to do is drip the child’s nose for 3-4 days and the cold will immediately go away.”
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Local vasoconstrictor drug. When applied to the inflamed mucous membranes of the nasal cavity, it significantly reduces its swelling and the volume of nasal discharge. Normalizes nasal breathing. Reducing swelling of the nasal mucosa helps restore ventilation of the paranasal sinuses and middle ear spaces, which reduces the likelihood of infectious complications ( sinusitis, sinusitis, otitis media ). When applied locally intranasally in therapeutic concentrations, it does not cause hyperemia or irritation of the mucous membranes.
When used intranasally, topical oxymetazoline has no systemic effect.
Pharmacokinetics
The active substance begins to act in 1-2 minutes. The duration of action of the drug reaches 12 hours. The half-life of oxymetazoline when applied topically in the nasal cavity is 34-36 hours. About 2.1% of the dose is evacuated in the urine, 1.1% in feces.
Mechanism of action
Oxymetazoline in the medication affects the capillary network of the nasal mucosa, causing the walls of blood vessels to narrow. As a result, microcirculation improves, swelling is eliminated, the accumulation of exudate is reduced, and the risk of numerous complications of rhinitis in children, including acute otitis and sinusitis, is reduced.
The product begins to act after 1–2 minutes of contact with the nasal sinuses: normal breathing is restored and the outflow of mucous secretions improves. Oxymetazoline penetrates into the bloodstream in small quantities, but its tiny concentration does not allow the development of any systemic reactions and does not cause harm to the body. The effect of one dose of Nazivin lasts up to 10–12 hours. The components of the drug are excreted in the urine and intestinal contents within 1–1.5 days. They do not accumulate in body tissues. Proper use of the product does not lead to irritation of the mucous membrane or increased symptoms.
Nazivin does not affect the general course of the disease and its causes. It is used only to eliminate the main sign of pathology and restore breathing.
Contraindications
- angle-closure glaucoma;
- hypersensitivity to the components of the drug;
- atrophic rhinitis;
- age less than 1 year (for all forms of the drug except Nazivin Sensitive in the form of drops);
- age less than 6 years (for the drug in the form of a spray with a dosage of 500 mcg/ml).
It is necessary to prescribe the drug with caution in case of increased intraocular pressure, arterial hypertension , heart failure or chronic renal failure, angina pectoris, pheochromocytoma , severe atherosclerosis , arrhythmia , prostatic hyperplasia with signs of urinary retention, diabetes mellitus , hyperthyroidism , as well as in persons taking MAO inhibitors over the past 2 weeks (and another 2 weeks after stopping their use), Bromocriptine , tricyclic antidepressants .
Contraindications to the use of Nazivin
Atrophic rhinitis; angle-closure glaucoma; hypersensitivity to the components of the drug.
You should adhere to the recommended concentrations of the drug intended for different age categories.
Carefully
In patients taking monoamine oxidase inhibitors and other drugs that increase blood pressure for up to 10 days after their use; with increased intraocular pressure, during pregnancy and lactation, with severe forms of cardiovascular diseases (hypertension, angina); with thyrotoxicosis and diabetes mellitus.
Side effects
- Local reactions: sneezing, burning of the nasal mucous membranes, blurred vision in case of accidental contact with the eyes, dry nasal mucous membranes, a feeling of stuffiness ( reactive hyperemia ) after the effect of using the drug disappears. Long-term continuous use of vasoconstrictors can lead to atrophy of the mucous membranes of the nasal cavity, tachyphylaxis , and repeated swelling of the mucous membranes of the nasal cavity ( rhinitis of drug etiology).
- Reactions from the circulatory system: increased blood pressure, tachycardia , palpitations.
- Reactions from nervous activity: dizziness, sleep disturbance, headache, anxiety, insomnia , irritability.
- Other reactions: exanthema , nausea.
Instructions for children's Nazivin Sensitive (Method and dosage)
All described forms of release of the drug are used intranasally.
Instructions for drops for children (Nazivin baby)
The age for using the drug in the form of Nazivin drops for children is up to one year.
Children under 4 weeks of age are recommended to take 1 drop of the product in each nostril up to three times a day. Children from the fifth week of life to 12 months of age are prescribed to instill 1-2 drops of the medicine into each nostril up to three times a day.
1 drop of the drug in this release form includes 2.8 mcg of oxymetazoline hydrochloride . Before use, the bottle must be turned over and the product should be instilled, tilting the sick child's head back.
The following application has also been proven effective: apply 1-2 drops of Nazivin Sensitive to cotton wool (depending on the patient’s age) and wipe each nasal passage from the inside.
At the recommended dose, the medicine can be used for up to a week without a doctor’s prescription. If the symptoms of the disease intensify or there are no signs of improvement within 3 days, you should consult a doctor. In doses exceeding those recommended, the drug is allowed to be used only under the supervision of the attending physician.
Instructions for use of baby spray
One 45 µl spray contains 11.25 µg of oxymetazoline hydrochloride .
A spray with a dosage of 11.25 mcg/dose is used in children 1-6 years old: spray 1 dose of the product in each nasal passage up to three times a day. The drug is used for 5-7 days. The drug can be re-prescribed only after a few days.
Buy Nazivin Sensitive nasal spray 22.5 mcg/dose 0.05% 10 ml in pharmacies
Instructions for use Nazivin Buy at the pharmacy Nazivin Sensitive spray called. 22.5 µg/dose 0.05% 10 ml
Dosage forms nasal spray 0.05%
Synonyms Afrin moisturizing Afrin extra Vicks Active Sinex Nazivin Nazol Nazol Advance Nesopin Noxprey Sialor rhino Group Agents that stimulate alpha-adrenergic receptors International nonproprietary name Oxymetazoline Composition Active substance: oxymetazoline hydrochloride 0.100 mg. Manufacturers Ursafarm Arzneimittel GmbH (Germany) Pharmacological action Pharmacodynamics. The drug has a vasoconstrictor effect. When applied topically to the inflamed mucous membrane of the nasal cavity, it reduces swelling and nasal discharge. Restores nasal breathing. Elimination of swelling of the nasal mucosa helps restore aeration of the paranasal sinuses and middle ear cavity, which reduces the likelihood of bacterial complications (sinusitis, sinusitis, otitis media). When used locally intranasally in therapeutic concentrations, it does not irritate or cause hyperemia of the nasal mucosa. Oxymetazoline begins to act quickly, within 15 minutes. Duration of action is up to 12 hours. Pharmacokinetics. When administered locally intranasally, the drug does not have a systemic effect. The half-life of oxymetazoline when administered intranasally is 35 hours. 2.1% of oxymetazoline is excreted in the urine and about 1.1% in the feces. Side effects: Burning or dryness of the nasal mucosa, sneezing, a strong feeling of “stuffiness” in the nose (reactive hyperemia). Increased blood pressure, tachycardia. Headache, insomnia. Side effects caused by the systemic effect of the drug: dizziness, palpitations, anxiety, irritability, sleep disturbance (in children), nausea, exanthema, blurred vision (if it gets into the eyes). Long-term or continuous use of vasoconstrictors can lead to tachyphylaxis, atrophy of the nasal mucosa and recurrent swelling of the nasal mucosa (rhinitis medicamentosa). Indications for use: Acute respiratory diseases with symptoms of rhinitis; acute allergic rhinitis; exacerbation of vasomotor rhinitis; to facilitate the outflow of discharge from the paranasal sinuses, with sinusitis, eustachitis, otitis media; to eliminate swelling before diagnostic manipulations in the nasal passages. Contraindications Atrophic rhinitis; angle-closure glaucoma; hypersensitivity to the components of the drug. Carefully. With increased intraocular pressure, chronic heart failure, arterial hypertension, angina pectoris; arrhythmias; chronic renal failure, in patients with prostatic hyperplasia with clinical symptoms (urinary retention), severe atherosclerosis, hyperthyroidism, diabetes mellitus, pheochromocytoma, as well as in patients taking monoamine oxidase inhibitors (MAOIs) during the previous 2 weeks and during 2 weeks after their withdrawal, tricyclic antidepressants, bromocriptine. Use during pregnancy and lactation. When used during pregnancy or breastfeeding, do not exceed the recommended dose. The drug can only be used in cases where the potential benefit to the mother outweighs the potential risk to the fetus and child. Directions for use and dosage
Adults and children over 6 years of age: 1 injection of Nazivin® Sensitive nasal spray dosed 22.5 mcg/dose in each nostril 2-3 times/day.
If symptoms worsen or improvement does not occur within 3 days, you should consult your doctor. Use the recommended dose for no more than 7 days without consulting a doctor. The drug in doses exceeding the recommended ones can only be used under medical supervision.
One 45 µl injection contains:
— 22.5 mcg of oxymetazoline hydrochloride — for the drug Nazivin® Sensitive nasal spray dosed 22.5 mcg/dose.
Overdose Symptoms: nausea, increased blood pressure, tachycardia, depression of the central nervous system. Treatment: symptomatic. Interaction Slows down the absorption of local anesthetic drugs and prolongs their effect. In patients taking monoamine oxidase inhibitors (MAOIs) during the previous 2 weeks and within 2 weeks after their discontinuation, tricyclic antidepressants, or other drugs that increase blood pressure - increased blood pressure. Co-administration of other vasoconstrictor drugs increases the risk of side effects. Special instructions Avoid getting the drug in the eyes. To avoid the spread of infection, it is necessary to use the drug individually. Impact on the ability to drive vehicles and equipment. After long-term use of cold remedies containing oxymetazoline in doses higher than recommended, a general effect on the cardiovascular system and central nervous system cannot be excluded. In these cases, it is recommended to be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions. Storage conditions Store out of the reach of children at a temperature not exceeding 30 C.
Interaction
The medicine slows down the absorption of local anesthetics and increases their duration of action.
When using Nazivin Sensitive for 2 weeks before using MAO inhibitors and for 2 weeks after completing their use, as well as during therapy with tricyclic antidepressants or other drugs that provoke an increase in blood pressure , a noticeable increase in blood pressure is observed.
Simultaneous administration of other vasoconstrictors increases the risk of adverse reactions.
Overdose
Symptoms (after a significant overdose or accidental ingestion): constriction of the pupils, nausea, vomiting, cyanosis, increased body temperature, tachycardia, arrhythmia, vascular insufficiency, arterial hypertension, respiratory disorders, pulmonary edema, cardiac arrest; in addition, mental disorders may appear, as well as depression of central nervous system functions, accompanied by drowsiness, decreased body temperature, bradycardia, arterial hypotension, respiratory arrest and possible development of coma.
Treatment: gastric lavage, taking activated carbon and urgently consulting a doctor.
special instructions
Avoid contact of this product with eyes.
It is recommended to use the drug individually to avoid the spread of a viral or bacterial infection.
After prolonged use of drugs for the common cold, including oxymetazoline in large doses, the appearance of effects on cardiovascular and nervous activity cannot be ruled out. In these cases, patients should be careful when driving.
Analogs
Level 4 ATX code matches:
Xymelin Eco
Xymelin
Nazivin
Galazolin
Lazorin
Otrivin
Naphthyzin
Sanorin
Knoxprey
For the nose
Lazolvan Rino
Afrin
Rhinorus
Eucazoline Aqua
Rinazolin
Grippostad Reno
Farmazolin
Xylometazoline
Nazol Advance
Nazol Baby
Vicks Active Sinex, Afrin Extra, Nazol Advance, 4-Way, Nazol Baby, Afrin, Nazol Kids, Nazospray, Nesopin, Oxymetazoline, Noxprey, Nazol, Fazin, Sanorinchik, Fervex.
